scholarly journals The impact of low-dose glucocorticoids on disease activity, bone mineral density, fragility fractures, and 10-year probability of fractures in patients with rheumatoid arthritis

2018 ◽  
Vol 66 (6) ◽  
pp. 1004-1007 ◽  
Author(s):  
Tien-Tsai Cheng ◽  
Han-Ming Lai ◽  
Shan-Fu Yu ◽  
Wen-Chan Chiu ◽  
Chung-Yuan Hsu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Disease Activity ◽  
Bone Mineral ◽  
Clinical Characteristics ◽  
Low Dose ◽  
Control Group ◽  
Study Group ◽  
Mineral Density ◽  
The Impact

This study aimed to investigate the effect of low-dose glucocorticoids (LDGs) on disease activity, bone density, and fractures in patients with rheumatoid arthritis (RA). This was an interim analysis of the RA Registry. Demographic data and clinical characteristics, including fracture risk assessment tool, were collected. 25(OH) Vitamin D, bone mineral density (BMD), and intact parathyroid hormone were measured at enrollment. The study group were those who took LDGs (2.5–7.5 mg/day prednisolone or equivalent dose), and the others were included as the control group. A total of 425 participants were enrolled, including 85 (20%) in the control group and 340 (80%) in the study group. The demographics and clinical characteristics were comparable between the two groups. Compared with the control group, the LDGs group had a significantly lower vertebral BMD (L 1–4) (g/cm2), (0.854 vs 0.896, p=0.046), significantly higher rate of previous fractures (103 (30.3%) vs 13 (15.3%), p=0.006), higher 10-year probability of major fractures (14 (15.5) vs 8 (8.6), p<0.0001), and higher 10-year probability of hip fractures (4.4 (8.4) vs 2 (3.9), p<0.0001). Disease activity appeared to be similar in the patients with RA regardless of whether or not they received LDG treatment. However, the patients with RA who received LDG treatment had a lower BMD at the spine (L1–4) and a higher rate of previous fractures that was associated with a significantly higher 10-year probability of fractures than those who did not receive LDG treatment.

Bone mineral density and disease activity in patients with rheumatoid arthritis treated with low dose prednisolone

2002 ◽  
Vol 14 (3) ◽  
pp. 235-241
Author(s):  
Saliha Karatay ◽  
Akin Erdal ◽  
Akin Levent ◽  
Kadir Yildirim ◽  
Kazim Şenel
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Disease Activity ◽  
Bone Mineral ◽  
Low Dose ◽  
Mineral Density

Anti-tumor Necrosis Factor Therapy Increased Spine and Femoral Neck Bone Mineral Density of Patients with Active Ankylosing Spondylitis with Low Bone Mineral Density

2015 ◽  
Vol 42 (8) ◽  
pp. 1413-1417 ◽  
Author(s):  
Haibo Li ◽  
Qiuxia Li ◽  
Xi Chen ◽  
Chen Ji ◽  
Jieruo Gu
Keyword(s):  
Bone Mineral Density ◽  
Ankylosing Spondylitis ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Tumor Necrosis ◽  
Control Group ◽  
Study Group ◽  
Type I ◽  
Mineral Density ◽  
Necrosis Factor

Objective.To evaluate the effect of anti-tumor necrosis factor (TNF) therapy on bone mineral density (BMD) in patients with active ankylosing spondylitis (AS) with low BMD.Methods.Eighty-nine patients with active AS with low BMD were randomly divided into either a study group or a control group. The study group received etanercept (50 mg/week) or adalimumab (40 mg/2 week) subcutaneously for 1 year. BMD of lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry, and bone turnover markers serum C telopeptide of type-I collagen (sCTX) and serum procollagen type-I N propeptide (PINP) were detected by ELISA at baseline and at end of study.Results.After 1 year, compared with baseline, there was a significant increase in spine and femoral neck BMD by a mean ± SD of 14.9% ± 15.6% (p < 0.0001) and 4.7% ± 7.9% (p < 0.0001) in the study group. In the control group, there was a significant decrease in spine and femoral neck BMD by a mean ± SD of −8.6% ± 9.7% (p < 0.0001) and −9.8% ± 11.5% (p < 0.0001). Compared with baseline, sCTX was significantly decreased in the study group (−40% at 1 yr, p < 0.0001), but bone-specific alkaline phosphatase and PINP increased (45.6%, p < 0.0001 and 30.8%, p < 0.0001, respectively).Conclusion.In patients with active AS with low BMD, the spine and femoral neck BMD increased after anti-TNF therapy for 1 year, and it was accompanied by a significant decrease in bone resorption markers and an increase in bone formation markers.

scholarly journals Effects of Dried Plum (Prunes) on Bone Density and Strength in Men

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 21-21
Author(s):  
Jonnatan Fajardo ◽  
Danielle Gaffen ◽  
Ashley Eisner ◽  
Mark Kern ◽  
Shirin Hooshmand
Keyword(s):  
Bone Mineral Density ◽  
Bone Density ◽  
Bone Mineral ◽  
Human Study ◽  
Control Group ◽  
Adult Women ◽  
Protective Effects ◽  
Mineral Density ◽  
Total Body ◽  
The Impact

Abstract Objectives Traditionally, osteoporosis has been viewed as a disease mostly affecting women, but cases in men are increasing. Fractures due to osteoporosis can lead to a decreased quality of life in vulnerable populations and lead to increased mortality in men. Although several studies of male and female animals and adult women have demonstrated bone protective effects of dried plum (prunes), no human study has evaluated the effect of dried plum on bone health in men. The objective of the current study was to examine the long-term effects of 100 g dried plum on bone density and strength in men. Methods Sixty-six men (50–79 years old) were randomly assigned into two treatment groups for 12 months: (1) 100 g/day of dried plums; (2) control (0 g/day dried plum). Bone mineral density was measured at baseline, 6- and 12-months at the total body, hip, lumbar spine, and ulna via dual-energy x-ray absorptiometry (DXA). Evaluation of volumetric bone density and strength of the left tibia occurred at baseline, 6- and 12-months using peripheral quantitative computed tomography (pQCT). Results There were no statistically significant changes in bone mineral density (BMD) from baseline to 6 months and 12 months for total body, spine (L1-L4), right and left hip BMD in the control group (0 g/day dried plum) or 100 g/day dried plum group. Modest beneficial effects of dried plums were observed for changes in bone geometry as detected by pQCT including a tendency for BMD to increase as well as increases in periosteal and endosteal circumferences at the 66% region of the tibia, which may promote greater bone strength. Conclusions Dried plums have the potential to improve bone morphometry of the proximal tibia in healthy adult men when consumed for 12 months. Future studies should examine the impact on men with low bone density to further evaluate the bone protective effects of dried plum in male populations. Funding Sources This study was funded by the California Dried Plum Board.

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