Early diagnosis and treatment of spinal epidural metastasis in breast cancer: a prospective study.

Recently an increase in the incidence of mucormycosis is noticed in COVID-19 cases. The main aim of this study is to present our experience of rhino-orbito-cerebral mucormycosis in COVID-19 patients and thereby aid its early diagnosis and treatment. This is a prospective study of 12 cases diagnosed as Rhino-orbito-cerebral mucormycosis . Presentation of mucormycosis in COVID-19, their temporal association and outcome of treatment was studied. Pre-existing comorbidities were seen in 91.67% patients, Diabetes Mellitus (83.33%). Previous history of COVID-19 infection and treatment for the same in 41.67% cases, concomitant infection in 16.67% and asymptomatic undiagnosed covid (antibodies positive) was detected in 41.67%. All patients showed improvement in general and nasal condition (100%). Early diagnosis is must.

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Predictors of resilience in women treated for breast cancer: A prospective study.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.9044 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 9044-9044

Author(s):

Barbara Kaye Bennett ◽

Andrew R. Lloyd ◽

Kate Webber ◽

Michael Friedlander ◽

David Goldstein ◽

...

Keyword(s):

Breast Cancer ◽

Logistic Regression ◽

Prospective Study ◽

Cancer Diagnosis ◽

Adjuvant Treatment ◽

Somatic Symptoms ◽

Self Report ◽

Diagnosis And Treatment ◽

Post Surgery ◽

A Prospective Study

9044 Background: Because a cancer diagnosis may be regarded as a potentially traumatic event with untoward consequences, much research has focussed on negative aspects of cancer diagnosis and treatment, emphasising psychological outcomes. A recent paradigm shift recognises that such a psycho-pathological approach discounts the human capacity for resilience "the ability to maintain relatively stable functioning following an aversive life event" (Bonanno GA Curr Direct in Psychol Science 2005 14(3) 135). Predictors of resilience in women who recovered uneventfully from surgical and adjuvant treatment for early stage breast cancer were investigated in a prospective study. Methods: Validated self-report measures of mood, somatic symptoms, temperament, illness attitudes, and social support were completed post-surgery. Clinical, tumor and treatment details were recorded. At end treatment and subsequently at 1, 3, 6, 9 and 12 months, self-report measures of mood and somatic symptoms were completed. Resilience was defined as: no evidence of protracted psychological or somatic distress in the 12 months following treatment completion. Identified resilient and non-resilient groups were compared and predictors sought by logistic regression. Results: Of 218 women evaluated, 106 (49%) were classified as "resilient." They either reported no clinically significant psychological or other distress post-surgery (34%) and 12months following adjuvant treatment or recovered promptly (15%) and remained well. There were no significant differences in age (52 years); marital status; tumor size; treatment; treatment toxicity (nadir hemoglobin and neutrophil count) or mortality at 5 years post treatment (8 confirmed deaths in each group). Logistic regression identified low neuroticism (temperament or personality trait) as the most significant predictor of resilience. Conclusions: These findings suggest that without any intervention almost half the women treated for breast cancer adapt well to diagnosis and treatment. These outcomes warrant further research, to provide further insight into how individuals cope with major illness and to facilitate development of programs to aid those in whom outcomes are protracted.

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A prospective study of clinico-radiological assesment and management of obstructive jaundice in Mmimsr, Mullana

International Surgery Journal ◽

10.18203/2349-2902.isj20213694 ◽

2021 ◽

Author(s):

Karaninder Singh Wilku ◽

Himank Gandhi

Keyword(s):

Early Diagnosis ◽

Obstructive Jaundice ◽

Prospective Study ◽

Abdominal Ultrasound ◽

Vital Role ◽

Diagnosis And Treatment ◽

Female Ratio ◽

Cbd Stones ◽

Benign Pathology ◽

A Prospective Study

Background: Obstructive jaundice poses diagnostic and therapeutic challenges. This study was undertaken to highlight the clinical and radiological assessment of obstructive jaundice in our setting and to approach for early diagnosis and treatment before irreversible tissue insult sets in.Methods: Present study was prospective study conducted at Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala. Data were collected on prescribed proforma and analyzed stastically.Results: A total of 50 patients were studied. It is more common in productive adult with the mean age of 51.04±12.40 years. The male to female ratio was 1:1.08. Majority of the patients were having benign pathology (62%) and choledocholithiasis was the commonest benign cause. Abdominal ultrasound was the diagnostic imaging done in all patients and revealed dilated CBD (>1 cm) in 78% cases, dilated IHBR in 96%of cases and multiple CBD stones in 78.3% of cases. CT was reserved for suspected malignant and MRCP was planned in stone or benign causes. 70% patients were selected for ERCP and 62% of patients underwent definitive open procedure viz choledocholithotomy (40%), hepaticojejunostomy (12%).Conclusions: Obstructive jaundice in our study was more prevalent in females and the cause is mostly CBD stones. The result suggests that early diagnosis and treatment plays vital role in the prognosis of patients with obstructive jaundice.

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