PS10:182 Nmda-positive neuropsychiatric lupus manifesting as weight increase and hyposmia

ABSTRACT The »early-androgen« syndrome in the rat – i. e. anovulatory ovaries in adult females after a single injection of testosterone propionate (TP) within a week of birth – may not become apparent until some time after the attainment of sexual maturity. Large doses (50 or 100 μg) of TP were effective earlier than lower doses (5 or 10 μg). Rats which received 5 μg TP were ovulating at 10 weeks of age, mated but were infertile at 13 weeks of age, and were anovulatory at 21 weeks. In rats between 10 and 13 weeks old there was a marked fall in the number of corpora lutea in the ovaries of animals which had been given 5 μg TP. Hemi-spaying was followed by compensatory growth of the remaining ovary which consisted of corpora lutea in ovulating, and of follicles in anovulatory rats; little or no compensatory weight increase occurred in animals which seemed to be in the transition stage from the ovulatory to the anovulatory condition.

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ANTIOESTROGENIC ACTIVITY IN FAHLI CLOVER HAY AND OAT HAY

Acta Endocrinologica ◽

10.1530/acta.0.0490090 ◽

1965 ◽

Vol 49 (1) ◽

pp. 90-96 ◽

Cited By ~ 6

Author(s):

J. H. Adler

Keyword(s):

Plant Extracts ◽

Avena Sativa ◽

Inhibitory Activity ◽

Weight Increase ◽

Trifolium Alexandrinum ◽

Uterine Weight ◽

Extraction Procedures ◽

Fodder Plants

ABSTRACT The presence of oestrogen inhibitory activity in oat hay (Avena sativa) and Fahli clover hay (Trifolium alexandrinum var. Fahli) has been established. The antioestrogenic effect was demonstrated by the inhibition of uterine weight increase in rats (Astwood test) in response to oestradiol injected together with the above mentioned plant extracts. The extraction procedures are described in detail and the possible biological implications of antioestrogenic and oestrogenic activity in fodder plants is discussed.

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Immunological Mechanisms of Neuropsychiatric Lupus

Current Immunology Reviews ◽

10.2174/1573395511666150707181943 ◽

2015 ◽

Vol 11 (2) ◽

pp. 93-106 ◽

Cited By ~ 1

Author(s):

Kyle Sinclair ◽

Jonathan Miner ◽

Alfred Kim

Keyword(s):

Neuropsychiatric Lupus ◽

Immunological Mechanisms

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FRI0128 The age distribution of the focal hyperintensities in brain mr in patients with neuropsychiatric lupus

10.1136/annrheumdis-2001.163 ◽

2001 ◽

Author(s):

V Peterová ◽

C Dostál ◽

Z Seidl ◽

T Viták ◽

J Obenberger ◽

...

Keyword(s):

Age Distribution ◽

Neuropsychiatric Lupus

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Lifestyle Changes and Determinants of Children’s and Adolescents’ Body Weight Increase during the First COVID-19 Lockdown in Greece: The COV-EAT Study

Nutrients ◽

10.3390/nu13030930 ◽

2021 ◽

Vol 13 (3) ◽

pp. 930

Author(s):

Odysseas Androutsos ◽

Maria Perperidi ◽

Christos Georgiou ◽

Giorgos Chouliaras

Keyword(s):

Physical Activity ◽

Body Weight ◽

Fast Food ◽

Online Survey ◽

Lifestyle Changes ◽

The Body ◽

Weight Increase ◽

Lifestyle Behaviors ◽

Lifestyle Habits ◽

Body Weight Increase

Previous studies showed that the coronavirus disease 2019 (COVID-19) lockdown imposed changes in adults’ lifestyle behaviors; however, there is limited information regarding the effects on youth. The COV-EAT study aimed to report changes in children’s and adolescents’ lifestyle habits during the first COVID-19 lockdown and explore potential associations between changes of participants’ lifestyle behaviors and body weight. An online survey among 397 children/adolescents and their parents across 63 municipalities in Greece was conducted in April–May 2020. Parents self-reported changes of their children’s lifestyle habits and body weight, as well as sociodemographic data of their family. The present study shows that during the lockdown, children’s/adolescents’ sleep duration and screen time increased, while their physical activity decreased. Their consumption of fruits and fresh fruit juices, vegetables, dairy products, pasta, sweets, total snacks, and breakfast increased, while fast-food consumption decreased. Body weight increased in 35% of children/adolescents. A multiple regression analysis showed that the body weight increase was associated with increased consumption of breakfast, salty snacks, and total snacks and with decreased physical activity. The COV-EAT study revealed changes in children’s and adolescents’ lifestyle behaviors during the first COVID-19 lockdown in Greece. Effective strategies are needed to prevent excessive body weight gain in future COVID-19 lockdowns.

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Single-course antenatal corticosteroids is related to faster growth in very-low-birth-weight infant

BMC Pregnancy and Childbirth ◽

10.1186/s12884-020-03510-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jiajia Jing ◽

Yiheng Dai ◽

Yanqi Li ◽

Ping Zhou ◽

Xiaodong Li ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Preterm Infants ◽

Gestational Age ◽

Very Low Birth Weight ◽

Postnatal Growth ◽

Weight Increase ◽

Antenatal Corticosteroids ◽

Lung Maturation ◽

Growth Outcomes

Abstract Background Antenatal corticosteroids (ACS) treatment is critical to support survival and lung maturation in preterm infants, however, its effect on feeding and growth is unclear. Prior preterm delivery, it remains uncertain whether ACS treatment should be continued if possible (repeated course ACS), until a certain gestational age is reached. We hypothesized that the association of single-course ACS with feeding competence and postnatal growth outcomes might be different from that of repeated course ACS in very-low-birth-weight preterm infants. Methods A multicenter retrospective cohort study was conducted in very-low-birth-weight preterm infants born at 23–37 weeks’ gestation in South China from 2011 to 2014. Data on growth, nutritional and clinical outcomes were collected. Repeated course ACS was defined in this study as two or more courses ACS (more than single-course). Infants were stratified by gestational age (GA), including GA < 28 weeks, 28 weeks ≤ GA < 32 weeks and 32 weeks ≤ GA < 37 weeks. Multiple linear regression and multilevel model were applied to analyze the association of ACS with feeding and growth outcomes. Results A total of 841 infants were recruited. The results, just in very-low-birth-weight preterm infants born at 28–32 weeks’ gestation, showed both single and repeated course of ACS regimens had shorter intubated ventilation time compared to non-ACS regimen. Single-course ACS promoted the earlier application of amino acid and enteral nutrition, and higher rate of weight increase (15.71; 95%CI 5.54–25.88) than non-ACS after adjusting for potential confounding factors. No associations of repeated course ACS with feeding, mean weight and weight increase rate were observed. Conclusions Single-course ACS was positively related to feeding and growth outcomes in very-low-birth-weight preterm infants born at 28–32 weeks’ gestation. However, the similar phenomenon was not observed in the repeated course of ACS regimen.

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Smoking and associated unhealthy lifestyle behaviours in patients with chronic cardiac diseases during COVID-19 related lockdown

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.293 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

F Chague ◽

M Boulin ◽

JC Eicher ◽

F Bichat ◽

M Saint-Jalmes ◽

...

Keyword(s):

Screen Time ◽

University Hospital ◽

Weight Increase ◽

Phone Call ◽

P Value ◽

Time Increase ◽

Unhealthy Lifestyle ◽

Lifestyle Behaviours ◽

Coronary Syndrome ◽

The Impact

Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Dijon University Hospital France OnBehalf CLEO-CD Background Lockdown can affect tobacco smoking (TS) behaviours. Purpose To evaluate the impact of lockdown on (TS) and associated lifestyle behaviours in patients with Chronic coronary syndrome (CCS) and congestive heart failure (CHF) Methods CCS and CHF patients were invited to answer to a phone-call questionnaire during the 1st COVID-19 lockdown start Results (Table) 343 questionnaires were fit for analysis, 43 (12.5%) were current smokers (CS). CS were younger (p < 0.001), none stopped and 13 increased their consumption (main reasons were stress and boredom). CS felt more often cramped (p = 0.023). CS who increased their TS consumption showed a trend toward a higher rate of unhealthy lifestyle behaviours Conclusions During the lockdown, more than ¼ of CS with CCS or CHF increased their TS consumption and none quitted. Moreover, TS was often associated with other deleterious behaviours increasing their risk for short and long term Main results Total Non-Smokers Smokers p* N(%) 344 301 43 Age, years 67.7 ± 12.8 69.2 ± 12.2 57.2 ± 12.1 <0.001 Men/Women 229/115 197/104 32/11 0.300 CCS/CHF 220/124 185/116 36/7 0.004 Urban/Rural 163/181 137/164 26/17 0.073 Living alone at home 83(24.3) 68(22.7) 15(34.9) 0.089 COVID screening (PCR) 11(3.2) 7(2.3) 4(9.3) 0.037 Feeling cramped 19(5.5) 13(4.4) 6(14.0) 0.023 Feeling less well 75(21.9) 65(21.7) 10(23.8) 0.842 K6 ≥ 5 81(23.7) 70(23.5) 11(25.6) 0.845 Physical activity decrease 146(42.6) 125(42.1) 21(48.8) 0.323 Screen time increase 154(45.0) 130(43.5) 24(55.8) 0.100 Alcohol consumption increase 14(5.5) 11(4.9) 3(7.5) 0.419 Sleep change 83(24.6) 68(22.5) 15(39.5) 0.083 Weight increase 77(22.4) 64(21.3) 13(30.2) 0.242 Smokers (n = 43) Smoking increase No smoking increase p** Feeling less well 5(38.5) 5(17.2) 0.238 Screen time increase 10(76.9) 14(46.7) 0.104 Weight increase 6(46.2) 7(23.3) 0.173 n(%) or mean ± SD. *p value: Smokers vs non smokers. **p value: Smoking increase vs no smoking increase

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