Occupational exposure to wood dust and risk of lung cancer: the ICARE study

ObjectivesIn a previous analysis of data from a French population-based case–control study (the Investigation of occupational and environmental CAuses of REspiratory cancers (ICARE) study), ‘having ever worked’ in wood-related occupations was associated with excess lung cancer risk after adjusting for smoking but not for occupational factors. The present study aimed to investigate the relationship between lung cancer risk and wood dust exposure after adjusting for occupational exposures.MethodsData were obtained from 2276 cases and 2780 controls on smoking habits and lifelong occupational history, using a standardised questionnaire with a job-specific questionnaire for wood dust exposure. Logistic regression models were used to calculate ORs and 95% CIs adjusted for age, area of residence, tobacco smoking, the number of job periods and exposure to silica, asbestos and diesel motor exhaust (DME).ResultsNo significant association was found between lung cancer and wood dust exposure after adjustment for smoking, asbestos, silica and DME exposures. The risk of lung cancer was slightly increased among those who were exposed to wood dust more than 10 years, and had over 40 years since the first exposure.ConclusionOur findings do not provide a strong support to the hypothesis that wood dust exposure is a risk factor for lung cancer. This study showed the importance of taking into account smoking and occupational coexposures in studies on lung cancer and wood dust exposure. Further studies evaluating the level and frequency of exposure during various tasks in woodwork are needed.

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Wood dust exposure and lung cancer risk: a meta-analysis

Occupational and Environmental Medicine ◽

10.1136/oemed-2014-102722 ◽

2015 ◽

Vol 72 (12) ◽

pp. 889-898 ◽

Cited By ~ 20

Author(s):

David G Hancock ◽

Mary E Langley ◽

Kwan Leung Chia ◽

Richard J Woodman ◽

E Michael Shanahan

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Lung Cancer Risk ◽

Meta Analysis ◽

Dust Exposure ◽

Wood Dust

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Role of occupational exposures in lung cancer risk among women

Occupational and Environmental Medicine ◽

10.1136/oemed-2020-106470 ◽

2020 ◽

pp. oemed-2020-106470

Author(s):

Mengting Xu ◽

Vikki Ho ◽

Jack Siemiatycki

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Lung Cancer Risk ◽

Working Women ◽

Occupational Exposures ◽

Population Based ◽

Multivariate Logistic Regression Model ◽

Work History ◽

Assessment Protocol

ObjectivesTo explore possible associations between selected occupational agents and lung cancer risk among women.MethodsA population-based case–control study on lung cancer was conducted from 1996 to 2001 in Montreal, Canada. Cases were individuals diagnosed with incident lung cancer and population controls were randomly selected from electoral lists and frequency-matched to age and sex distributions of cases. Questionnaires on lifetime occupational history, smoking and demographic characteristics were collected during in-person interviews. As part of a comprehensive exposure assessment protocol, experts reviewed each subject’s work history and assessed exposure to many agents. The current analysis, restricted to working women in the study, includes 361 cases and 521 controls. We examined the association between lung cancer and each of 22 occupational exposures, chosen because of their relatively high prevalences among these women. Each exposure was analysed in a separate multivariate logistic regression model, adjusted for smoking and other selected covariates.ResultsThere were few elevated OR estimates between lung cancer and any of the agents, and none were statistically significant, although the limited numbers of exposed women engendered wide CIs.ConclusionsThere was little evidence to suggest that women in this population had experienced excess risks of lung cancer as a result of their work exposures. However, the wide CIs preclude any strong inferences in this regard.

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Wood dust exposure and the association with lung cancer risk

American Journal of Industrial Medicine ◽

10.1002/ajim.20137 ◽

2005 ◽

Vol 47 (4) ◽

pp. 349-357 ◽

Cited By ~ 45

Author(s):

Carlos H. Barcenas ◽

George L. Delclos ◽

Randa El-Zein ◽

Guillermo Tortolero-Luna ◽

Lawrence W. Whitehead ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Lung Cancer Risk ◽

Dust Exposure ◽

Wood Dust

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Cardiorespiratory fitness, C-reactive protein and lung cancer risk: A prospective population-based cohort study

European Journal of Cancer ◽

10.1016/j.ejca.2015.04.020 ◽

2015 ◽

Vol 51 (11) ◽

pp. 1365-1370 ◽

Cited By ~ 6

Author(s):

Perfenia Paul Pletnikoff ◽

Jari A. Laukkanen ◽

Tomi-Pekka Tuomainen ◽

Jussi Kauhanen ◽

Rainer Rauramaa ◽

...

Keyword(s):

Lung Cancer ◽

Cohort Study ◽

Cancer Risk ◽

Cardiorespiratory Fitness ◽

Lung Cancer Risk ◽

Population Based ◽

C Reactive Protein ◽

Reactive Protein

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Sinonasal Cancer and Occupational Exposure in a Population-Based Registry

International Journal of Otolaryngology ◽

10.1155/2013/672621 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 14

Author(s):

Carolina Mensi ◽

Dario Consonni ◽

Claudia Sieno ◽

Sara De Matteis ◽

Luciano Riboldi ◽

...

Keyword(s):

Clinical Information ◽

Occupational Exposures ◽

Population Based ◽

Dust Exposure ◽

Wood Dust ◽

Sinonasal Cancer ◽

Complete Collection ◽

Lombardy Region ◽

Industrial Sectors ◽

Population Based Registry

We examined occupational exposures among subjects with sinonasal cancer (SNC) recorded in a population-based registry in the Lombardy Region, the most populated and industrialized Italian region. The registry collects complete clinical information and exposure to carcinogens regarding all SNC cases occurring in the population of the region. In the period 2008–2011, we recorded 210 SNC cases (137 men, 73 women). The most frequent occupational exposures were to wood (44 cases, 21.0%) and leather dust (29 cases, 13.8%), especially among men: 39 cases (28.5%) to wood and 23 cases (16.8%) to leather dust. Exposure to other agents was infrequent (<2%). Among 62 subjects with adenocarcinoma, 50% had been exposed to wood dust and 30.7% to leather dust. The proportions were around 10% in subjects with squamous cell carcinoma and about 20% for tumors with another histology. The age-standardized rates (×100,000 person-years) were 0.7 in men and 0.3 in women. Complete collection of cases and their occupational history through a specialized cancer registry is fundamental to accurately monitor SNC occurrence in a population and to uncover exposure to carcinogens in different industrial sectors, even those not considered as posing a high risk of SNC, and also in extraoccupational settings.

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