Cardiorespiratory fitness, C-reactive protein and lung cancer risk: A prospective population-based cohort study

2015 ◽  
Vol 51 (11) ◽  
pp. 1365-1370 ◽  
Author(s):  
Perfenia Paul Pletnikoff ◽  
Jari A. Laukkanen ◽  
Tomi-Pekka Tuomainen ◽  
Jussi Kauhanen ◽  
Rainer Rauramaa ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Cardiorespiratory Fitness ◽  
Lung Cancer Risk ◽  
Population Based ◽  
C Reactive Protein ◽  
Reactive Protein

Cardiorespiratory fitness and lung cancer risk: A prospective population-based cohort study

2016 ◽  
Vol 19 (2) ◽  
pp. 98-102 ◽  
Author(s):  
Perfenia Paul Pletnikoff ◽  
Tomi-Pekka Tuomainen ◽  
Jari A. Laukkanen ◽  
Jussi Kauhanen ◽  
Rainer Rauramaa ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Cardiorespiratory Fitness ◽  
Lung Cancer Risk ◽  
Population Based

Abstract 4162: Circulating C-reactive protein and lung cancer risk: A nested case-control study in the Southern Community Cohort Study

2014 ◽  
Author(s):  
Jie Wu ◽  
Wei Zheng ◽  
Wanqing Wen ◽  
Margaret K. Hargreaves ◽  
William J. Blot ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Case Control ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Nested Case Control ◽  
Control Study

scholarly journals C-Reactive Protein and Risk of Lung Cancer

2010 ◽  
Vol 28 (16) ◽  
pp. 2719-2726 ◽  
Author(s):  
Anil K. Chaturvedi ◽  
Neil E. Caporaso ◽  
Hormuzd A. Katki ◽  
Hui-Lee Wong ◽  
Nilanjan Chatterjee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Smoking Status ◽  
Lung Carcinogenesis ◽  
C Reactive Protein ◽  
Baseline Serum ◽  
Reactive Protein ◽  
Former Smokers

Purpose Chronic inflammation could play a role in lung carcinogenesis, underscoring the potential for lung cancer prevention and screening. We investigated the association of circulating high-sensitivity C-reactive protein (CRP, an inflammation biomarker) and CRP single nucleotide polymorphisms (SNPs) with prospective lung cancer risk. Patients and Methods We conducted a nested case-control study of 592 lung cancer patients and 670 controls with available prediagnostic serum and 378 patients and 447 controls with DNA within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (N = 77,464). Controls were matched to patients on age, sex, entry year, follow-up time, and smoking. We measured CRP levels in baseline serum samples and genotyped five common CRP SNPs. Results Elevated CRP levels were associated with increased lung cancer risk (odds ratio [OR], 1.98; 95% CI, 1.35 to 2.89; P-trend < .001 for fourth quartile [Q4, ≥ 5.6 mg/L] v Q1 [< 1.0 mg/L]). The CRP association did not differ significantly by histology, follow-up time, or smoking status, but was most apparent for squamous cell carcinomas (OR, 2.92; 95% CI, 1.30 to 6.54), 2 to 5 years before lung cancer diagnosis (OR, 2.33; 95% CI, 1.24 to 4.39), and among former smokers (OR, 2.48; 95% CI, 1.53 to 4.03) and current smokers (OR, 1.90; 95% CI, 1.06 to 3.41). Although CRP SNPs and haplotypes were associated with CRP levels, they were not associated with lung cancer risk. Ten-year standardized absolute risks of lung cancer were higher with elevated CRP levels among former smokers (Q4: 2.55%; 95% CI, 1.98% to 3.27% v Q1: 1.39%; 95% CI, 1.07% to 1.81%) and current smokers (Q4: 7.37%; 95% CI, 5.81% to 9.33% v Q1: 4.03%; 95% CI, 3.01% to 5.40%). Conclusion Elevated CRP levels are associated with subsequently increased lung cancer risk, suggesting an etiologic role for chronic pulmonary inflammation in lung carcinogenesis.

scholarly journals C-Reactive Protein, Interleukin 6 and Lung Cancer Risk: A Meta-Analysis

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43075 ◽  
Author(s):  
Bo Zhou ◽  
Jing Liu ◽  
Ze-Mu Wang ◽  
Tao Xi
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Interleukin 6 ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
C Reactive Protein ◽  
Reactive Protein

Increased Lung Cancer Risk Among Patients with Pneumococcal Pneumonia: A Nationwide Population-Based Cohort Study

Lung ◽  
2013 ◽  
Vol 192 (1) ◽  
pp. 159-165 ◽  
Author(s):  
Te-Yu Lin ◽  
Wen-Yen Huang ◽  
Jung-Chung Lin ◽  
Cheng-Li Lin ◽  
Fung-Chang Sung ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Pneumococcal Pneumonia ◽  
Lung Cancer Risk ◽  
Population Based

scholarly journals Statin use and lung cancer risk in chronic obstructive pulmonary disease patients: a population-based cohort study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
AJN Raymakers ◽  
D. D. Sin ◽  
M. Sadatsafavi ◽  
JM FitzGerald ◽  
C. A. Marra ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chronic Obstructive Pulmonary Disease ◽  
Cohort Study ◽  
Cancer Risk ◽  
Pulmonary Disease ◽  
Lung Cancer Risk ◽  
Population Based ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Statin Use

Circulating C‐reactive protein increases lung cancer risk: Results from a prospective cohort of UK Biobank

2021 ◽  
Author(s):  
Mengmeng Ji ◽  
Lingbin Du ◽  
Zhimin Ma ◽  
Junxing Xie ◽  
Yanqian Huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Prospective Cohort ◽  
Lung Cancer Risk ◽  
Uk Biobank ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract 3445: C-reactive protein and lung cancer risk: a Mendelian randomization analysis

2016 ◽  
Author(s):  
Orestis A. Panagiotou ◽  
Neil E. Caporaso ◽  
Maria T. Landi ◽  
Nilanjan Chatterjee ◽  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Mendelian Randomization ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Adherence to the Mediterranean diet and risk of lung cancer in the Netherlands Cohort Study

2018 ◽  
Vol 119 (6) ◽  
pp. 674-684 ◽  
Author(s):  
Maya Schulpen ◽  
Piet A. van den Brandt
Keyword(s):  
Lung Cancer ◽  
Cancer Research ◽  
Cohort Study ◽  
Cancer Risk ◽  
The Netherlands ◽  
Mediterranean Diet ◽  
Dietary Habits ◽  
Lung Cancer Risk ◽  
Cox Regression ◽  
The Mediterranean

AbstractThe evidence on a cancer-protective effect of the Mediterranean diet (MD) is still limited. Therefore, we investigated the association between MD adherence and lung cancer risk. Data were used from 120 852 participants of the Netherlands Cohort Study (NLCS), aged 55–69 years. Dietary habits were assessed at baseline (1986) using a validated FFQ and alternate and modified Mediterranean diet scores (aMED and mMED, respectively), including and excluding alcohol, were calculated. After 20·3 years of follow-up, 2861 lung cancer cases and 3720 subcohort members (case-cohort design) could be included in multivariable Cox regression analyses. High (6–8) v. low (0–3) aMED excluding alcohol was associated with non-significantly reduced lung cancer risks in men and women with hazard ratios of 0·91 (95 % CI 0·72, 1·15) and 0·73 (95 % CI 0·49, 1·09), respectively. aMED-containing models generally fitted better than mMED-containing models. In never smokers, a borderline significant decreasing trend in lung cancer risk was observed with increasing aMED excluding alcohol. Analyses stratified by the histological lung cancer subtypes did not identify subtypes with a particularly strong inverse relation with MD adherence. Generally, the performance of aMED and World Cancer Research Fund/American Institute for Cancer Research dietary score variants without alcohol was comparable. In conclusion, MD adherence was non-significantly inversely associated with lung cancer risk in the NLCS. Future studies should focus on differences in associations across the sexes and histological subtypes. Furthermore, exclusion of alcohol from MD scores should be investigated more extensively, primarily with respect to a potential role of the MD in cancer prevention.

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