scholarly journals Assessing the association between bronchiolitis in infancy and recurrent wheeze: a whole English birth cohort case–control study

Thorax ◽  
2019 ◽  
Vol 74 (5) ◽  
pp. 503-505 ◽  
Author(s):  
Robin Marlow ◽  
Adam Finn ◽  
John Henderson
Keyword(s):  
Birth Cohort ◽  
Case Control Study ◽  
Late Onset ◽  
Case Control ◽  
Hospital Episode Statistics ◽  
First Year ◽  
Recurrent Wheeze ◽  
Syncytial Virus ◽  
First Year Of Life ◽  
Control Study

The precise association between bronchiolitis and predisposition to childhood wheeze is unclear. We assessed bronchiolitis aetiology and later wheeze phenotypes in the entire 2007 English birth cohort. All infants admitted to hospital in England during their first year of life with bronchiolitis or urinary tract infection (UTI) were followed using Hospital Episode Statistics to determine risk and characteristics of wheeze admission over the subsequent 8 years. In our cohort of 21 272 children compared with UTI, the risk of wheeze admission was higher with previous bronchiolitis (risk ratio (RR) 2.4), even higher in those with non-respiratory syncytial virus bronchiolitis (RR 3.1) and persisted into late-onset wheeze (RR 1.7).

scholarly journals Case-control study on infant mortality in Southern Brazil

2006 ◽  
Vol 40 (2) ◽  
pp. 240-248 ◽  
Author(s):  
Karina Giane Mendes ◽  
Maria Teresa Anselmo Olinto ◽  
Juvenal Soares Dias da Costa
Keyword(s):  
Multivariate Analysis ◽  
Infant Mortality ◽  
Case Control Study ◽  
Neonatal Period ◽  
Case Control ◽  
Infant Mortality Rate ◽  
First Year ◽  
Southern Brazil ◽  
First Year Of Life ◽  
Control Study

OBJECTIVE: To identify risk factors associated with infant mortality and, more specifically, with neonatal mortality. METHODS: A case-control study was carried out in the municipality of Caxias do Sul, Southern Brazil. Characteristics of prenatal care and causes of mortality were assessed for all live births in the 2001-2002 period with a completed live-birth certificate and whose mothers lived in the municipality. Cases were defined as all deaths within the first year of life. As controls, there were selected the two children born immediately after each case in the same hospital, who were of the same sex, and did not die within their first year of life. Multivariate analysis was performed using conditional logistic regression. RESULTS: There was a reduction in infant mortality, the greatest reduction was observed in the post-neonatal period. The variables gestational age (<36 weeks), birth weight (<2,500 g), and 5-minute Apgar (<6) remained in the final model of the multivariate analysis, after adjustment. CONCLUSIONS: Perinatal conditions comprise almost the totality of neonatal deaths, and the majority of deaths occur at delivery. The challenge for reducing infant mortality rate in the city is to reduce the mortality by perinatal conditions in the neonatal period.

scholarly journals An ADAM33 Polymorphism Associates with Progression of Preschool Wheeze into Childhood Asthma: A Prospective Case-Control Study with Replication in a Birth Cohort Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119349 ◽  
Author(s):  
Ester M. M. Klaassen ◽  
John Penders ◽  
Quirijn Jöbsis ◽  
Kim D. G. van de Kant ◽  
Carel Thijs ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Childhood Asthma ◽  
Case Control Study ◽  
Case Control ◽  
Birth Cohort Study ◽  
Control Study ◽  
Prospective Case Control Study

Lower Vitamin D Level as a Risk Factor for Late Onset Neonatal Sepsis: An Observational Case–Control Study

2021 ◽  
Author(s):  
Shaimaa Reda Abdelmaksoud ◽  
Mostafa Abdel-Azim Mostafa ◽  
Rana Atef khashaba ◽  
Effat Assar
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Late Onset ◽  
Case Control ◽  
Sepsis Group ◽  
Term Neonates ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
Control Study

Objective The aim of the study is to investigate the relation of neonatal and maternal vitamin D and late-onset sepsis (LOS) Study Design One-hundred twenty term neonates along with their mothers were enrolled in this case–control study. Sixty neonates who were admitted in the neonatal intensive care unit by LOS and had not been previously admitted for last 48 hours and did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the other hand, 60 healthy term neonates were referred as control group. Maternal and neonatal serum 25-OH vitamin D levels were assessed in both the cohorts. Results Maternal and neonatal 25-OH vitamin D levels in cases (17.2 and 16.1 ng/mL, respectively) were significantly lower than in controls (22.7 and 21 ng/mL, respectively) p = 0.001. In the study group, the neonatal 25-OH vitamin D was negatively correlated with C-reactive protein and length of hospital stay (r = −0.616 and −0.596, respectively) p <0.001 for both. With a cut-off value of 12.9 ng/mL, the specificity and positive predictive value of neonatal vitamin D were 83.3 and 74.4%, respectively. The odds ratio was 1.088 (95% CI = 1.034–1.144)) for LOS in vitamin D-deficient neonates. Conclusion Neonates with higher vitamin D level are at lower risk of LOS than those with vitamin D deficiency. Maternal vitamin D correlates with neonatal vitamin D. These data suggest that maternal vitamin supplementation during pregnancy may lower the risk of LOS. Key Points

scholarly journals Respiratory Syncytial Virus Epidemiology in a Birth Cohort from Kilifi District, Kenya: Infection during the First Year of Life

2004 ◽  
Vol 190 (10) ◽  
pp. 1828-1832 ◽  
Author(s):  
D. James Nokes ◽  
Emelda A. Okiro ◽  
Mwanajuma Ngama ◽  
Lisa J. White ◽  
Rachel Ochola ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Birth Cohort ◽  
First Year ◽  
Syncytial Virus ◽  
First Year Of Life

scholarly journals Pre-vaccination vulnerability and suspected adverse events following HPV vaccination. A case-control study nested in the Danish national birth cohort

Vaccine ◽  
2021 ◽  
Vol 39 (43) ◽  
pp. 6364-6369
Author(s):  
Anna Melgaard ◽  
Lene Wulff Krogsgaard ◽  
Tina Hovgaard Lützen ◽  
Oleguer Plana-Ripoll ◽  
Bodil Hammer Bech ◽  
...  
Keyword(s):  
Adverse Events ◽  
Birth Cohort ◽  
Case Control Study ◽  
Hpv Vaccination ◽  
Case Control ◽  
Danish National Birth Cohort ◽  
Control Study
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