Analyses of serum and urinary metabolites in individuals with peripheral artery disease (PAD) consuming a bean-rich diet: Relationships with drug metabolites

2021 ◽  
Author(s):  
Le Wang ◽  
Erin M Goldberg ◽  
Carla G Taylor ◽  
Peter Zahradka ◽  
Michel Aliani
Keyword(s):  
Peripheral Artery Disease ◽  
Urinary Metabolites ◽  
Mortality Rates ◽  
High Morbidity ◽  
Metabolomic Profile ◽  
Peripheral Artery ◽  
Biochemical Pathways ◽  
Urinary Levels ◽  
Artery Disease ◽  
Serum And Urine

Peripheral artery disease (PAD) has high morbidity and mortality rates. A metabolomics approach was employed to determine whether consumption of bean-rich diets for 8 weeks would impact the metabolomic profile of PAD individuals. Serum and urine, collected from 54 participants with clinical PAD at baseline and after 8 weeks on 0.3 cups beans/d (n=19), 0.6 cups beans/d (n= 20), or control (n=23) diet, and the beans were extracted and analyzed using LC-QTOF-MS. As a result, PGE2 p-acetamidophenyl ester, PGF2α diethyl amide and 5-L-glutamyl-L-alanine were significantly changed in the serum or urine of bean groups compared to control. Significant changes (P<0.05) in the profile and/or levels of 22 flavonoids present in bean extracts showed the potential importance of the mixture of beans used in this study. In a subset of participants taking metoprolol, after 8 weeks the bean-rich diets significantly elevated metoprolol in the serum while reducing it in urine compared to baseline. In addition, the diets significantly enhanced the urinary excretion of metformin. In conclusion, several biochemical pathways including prostaglandins and glutathione were affected by bean consumption. Significant changes in the metabolism of metoprolol and metformin with bean consumption suggested the presence of diet-drug interactions that may require adjustment of the prescribed dose. ClinicalTrials.gov Identifier: NCT01382056 Novelty: • Bean consumption by people with PAD alters the levels of certain metabolites in serum and urine • Different bean types (black, red kidney, pinto, navy) have unique flavonoid profiles • Metabolomics revealed potential diet-dug interactions as serum and/or urinary levels of metoprolol and metformin are modified by bean consumption

scholarly journals Cholesterol Efflux Capacity Associates with the Ankle-Brachial Index but Not All-Cause Mortality in Patients with Peripheral Artery Disease

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1407
Author(s):  
Robert K. Clemens ◽  
Monika Hunjadi ◽  
Andreas Ritsch ◽  
Lucia Rohrer ◽  
Thomas O. Meier ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Cholesterol Efflux ◽  
Ankle Brachial Index ◽  
Mortality Rates ◽  
High Density Lipoproteins ◽  
Peripheral Artery ◽  
Cholesterol Efflux Capacity ◽  
Hdl Function ◽  
All Cause Mortality ◽  
Artery Disease

Background: Cholesterol efflux is an important mechanism by which high-density lipoproteins (HDLs) protect against cardiovascular disease. As peripheral artery disease (PAD) is associated with high mortality rates, mainly due to cardiovascular causes, we investigated whether cholesterol efflux capacity (CEC) of apolipoprotein B (apoB)-depleted plasma, a widely used surrogate of HDL function, may serve as a predictive marker for mortality in this patient population. Methods: In this prospective single-center study (median follow-up time: 9.3 years), apoB-containing lipoproteins were precipitated from plasma of 95 patients with PAD and incubated with J744-macrophages, which were loaded with radiolabeled cholesterol. CEC was defined as the fractional radiolabel released during 4 h of incubation. Results: Baseline CEC was lower in PAD patients that currently smoked (p = 0.015) and had a history of myocardial infarction (p = 0.011). Moreover, CEC showed a significant correlation with HDL-cholesterol (p = 0.003) and apolipoprotein A-I levels (p = 0.001) as well as the ankle-brachial index (ABI, p = 0.018). However, CEC did not differ between survivors and non-survivors. Neither revealed Kaplan–Meier and Cox regression analyses any significant association of CEC with all-cause mortality rates. Conclusion: Taken together, CEC is associated with ABI but does not predict all-cause mortality in patients with PAD.

scholarly journals Deteksi Dini Penyakit Arteri Perifer pada Pasien Diabetes Melitus di Kota Mataram

2020 ◽  
Vol 2 (3) ◽  
pp. 256-262
Author(s):  
Yanna Indrayana ◽  
Herpan Syafii Harahap ◽  
Ilsa Hunaifi
Keyword(s):  
Diabetes Mellitus ◽  
Early Detection ◽  
Peripheral Artery Disease ◽  
Blood Glucose Control ◽  
Public Health Problem ◽  
Diabetic Patients ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Peripheral Artery ◽  
Artery Disease

Diabetes mellitus is currently becoming a major public health problem in the world. The prevalence of diabetes mellitus globally in 2019 is estimated at 9.3% and will increase to 10.9% in 2040. Peripheral artery disease is one of the important complications of diabetes mellitus. Patients with diabetes mellitus accompanied by peripheral artery disease have high morbidity and. Therefore, early detection of peripheral artery disease in diabetic patients is important. This event is carried out with the aim of early detection of peripheral artery disease in diabetes mellitus sufferers in Mataram. A total of 183 diabetes mellitus patients at the Siti Hajar Hospital, Mataram, were participated in this event, with an average age of 57 years and 67.8% of them were women. Most of the patients (75.4%) had poor blood glucose control. Of these, 26.8% of patients had peripheral artery disease. Patients and/or caregivers showed high enthusiasm during the education regarding the detection results of the peripheral artery disease. This event was very useful in increasing the knowledge of diabetic patients, especially in terms of blood sugar control, prevention, and management of peripheral artery disease.

Risk models and scores in patients with peripheral artery disease and chronic limb threatening ischemia: a comprehensive review.

2020 ◽  
Vol 26 ◽  
Author(s):  
Damianos G Kokkinidis ◽  
Adarsh Katamreddy ◽  
Stefanos Giannopoulos ◽  
Dimitrios Schizas ◽  
Sotirios Georgopoulos ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
External Validation ◽  
Scoring Systems ◽  
High Morbidity ◽  
Peripheral Artery ◽  
Risk Models ◽  
Comprehensive Review ◽  
Asymptomatic Patients ◽  
Artery Disease ◽  
Personalized Approach

: Peripheral artery disease (PAD) affects more than 200 million patients worldwide and chronic limb threating ischemia (CLTI) is the most advanced stage of PAD with very high morbidity and mortality rates. Cardiovascular medicine is trending towards a more personalized approach where each individual patient will be managed according to specific risk factors, disease characteristics, expectations related to their disease and individualized assessment of potential outcomes. For this reason, a number of risk models and scores have been developed the last few years. Our aim with this comprehensive review article is to provide an overview of selected risk models and scores for patients with PAD and CLTI. Given that some of the published scores were of low quality (minimal discriminatory ability), we included scores that were already externally validated or scores that had promising initial findings. Available scoring systems were grouped in the five following categories according to their utility: i) scores that can detect asymptomatic patients who should be screened for PAD, ii) scores for assessment of functional status and quality of life in patients with PAD, iii) scores assessing risk for amputation and other major adverse limb events among patients with CLTI, iv) scores for the optimal revascularization strategy in each patient and scores predicting successful procedural outcomes; v) scores predicting short or long-term cardiovascular and limb related outcomes after either revascularization or at least angiographic assessment. Limitations of available scoring systems include development and validation in specific populations, lack of external validation (for some of them) and also lack of synchrony with current era endovascular technology. However, with further optimization of current scores and development of new scores, the field of PAD and CLI can be transitioned to a personalized medicine approach.

scholarly journals Altered Metabolomic Profile in Patients with Peripheral Artery Disease

2019 ◽  
Vol 8 (9) ◽  
pp. 1463 ◽  
Author(s):  
Ahmed Ismaeel ◽  
Marco E. Franco ◽  
Ramon Lavado ◽  
Evlampia Papoutsi ◽  
George P. Casale ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Limb Ischemia ◽  
Diagnostic Procedures ◽  
Serum Biomarkers ◽  
Cholesteryl Esters ◽  
Metabolomic Profile ◽  
Peripheral Artery ◽  
Metabolite Profiles ◽  
Artery Disease ◽  
Insight Into

Peripheral artery disease (PAD) is a common atherosclerotic disease characterized by narrowed or blocked arteries in the lower extremities. Circulating serum biomarkers can provide significant insight regarding the disease progression. Here, we explore the metabolomics signatures associated with different stages of PAD and investigate potential mechanisms of the disease. We compared the serum metabolites of a cohort of 26 PAD patients presenting with claudication and 26 PAD patients presenting with critical limb ischemia (CLI) to those of 26 non-PAD controls. A difference between the metabolite profiles of PAD patients from non-PAD controls was observed for several amino acids, acylcarnitines, ceramides, and cholesteryl esters. Furthermore, our data demonstrate that patients with CLI possess an altered metabolomic signature different from that of both claudicants and non-PAD controls. These findings provide new insight into the pathophysiology of PAD and may help develop future diagnostic procedures and therapies for PAD patients.

Diabetic foot ulcer carries high amputation and mortality rates, particularly in the presence of advanced age, peripheral artery disease and anemia

2017 ◽  
Vol 11 ◽  
pp. S583-S587 ◽  
Author(s):  
Rafael Henrique Rodrigues Costa ◽  
Natália Anício Cardoso ◽  
Ricardo Jayme Procópio ◽  
Túlio Pinho Navarro ◽  
Alan Dardik ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Mortality Rates ◽  
Advanced Age ◽  
Peripheral Artery ◽  
Artery Disease

Anemia and Outcome in Outpatients With Peripheral Artery Disease

Angiology ◽  
2015 ◽  
Vol 67 (5) ◽  
pp. 484-489 ◽  
Author(s):  
Paulina Perez ◽  
Carlos Esteban ◽  
Pedro Enrique Jiménez Caballero ◽  
Juan Francisco Sánchez Muñoz-Torrero ◽  
María Teresa Pascual Soria ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Major Bleeding ◽  
Multivariable Analysis ◽  
Mortality Rates ◽  
Limb Amputation ◽  
Peripheral Artery ◽  
Increased Risk ◽  
Factores De Riesgo ◽  
Artery Disease ◽  
Ischemic Events

The influence of anemia on outcome in stable outpatients with peripheral artery disease (PAD) has not been consistently investigated. We used data from the Factores de Riesgo y ENfermedad Arterial (FRENA) Registry to compare ischemic events and mortality rates in stable outpatients with symptomatic PAD and anemia. Of 1663 patients with PAD, 208 (12.5%) had anemia. Over 18 months, patients with anemia had a higher rate of myocardial infarction (MI; rate ratio [RR]: 2.10; 95% confidence interval [CI]: 1.04-3.99), limb amputation (RR: 2.98; 95%CI: 1.70-5.05), and higher mortality (RR: 3.58; 95%CI: 2.39-5.28) than those without anemia. The rates of ischemic stroke (RR: 0.75; 95%CI: 0.23-1.93) and major bleeding (RR: 0.93; 95%CI: 0.15-3.51) were similar. On multivariable analysis, anemia was associated with an increased risk to die (hazard ratio [HR]: 2.32; 95%CI: 1.53-3.50) but not to develop MI (HR: 1.49; 95%CI: 0.73-3.05) or to have limb amputation (HR: 1.49; 95%CI: 0.86-2.59). In stable outpatients with PAD, anemia was associated with increased mortality but not with an increased rate of subsequent ischemic events or major bleeding.

scholarly journals Mortality rates and mortality predictors in patients with symptomatic peripheral artery disease stratified according to age and diabetes

2014 ◽  
Vol 59 (5) ◽  
pp. 1291-1299 ◽  
Author(s):  
Thomas Mueller ◽  
Franz Hinterreiter ◽  
Christian Luft ◽  
Werner Poelz ◽  
Meinhard Haltmayer ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Mortality Rates ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Mortality Predictors

Associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm – a grin without a cat!

VASA ◽  
2017 ◽  
Vol 46 (3) ◽  
pp. 151-158 ◽  
Author(s):  
Hisato Takagi ◽  
Takuya Umemoto
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Peripheral Artery Disease ◽  
Literature Search ◽  
Systematic Literature Search ◽  
Peripheral Artery ◽  
Epidemiological Evidence ◽  
Abdominal Aortic ◽  
Artery Disease ◽  
Meta Analyses

Abstract. Both coronary and peripheral artery disease are representative atherosclerotic diseases, which are also known to be positively associated with presence of abdominal aortic aneurysm. It is still controversial, however, whether coronary and peripheral artery disease are positively associated with expansion and rupture as well as presence of abdominal aortic aneurysm. In the present article, we overviewed epidemiological evidence, i. e. meta-analyses, regarding the associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm through a systematic literature search. Our exhaustive search identified seven meta-analyses, which suggest that both coronary and peripheral artery disease are positively associated with presence of abdominal aortic aneurysm, may be negatively associated with expansion of abdominal aortic aneurysm, and might be unassociated with rupture of abdominal aortic aneurysm.

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