Seismic force modification factors for the proposed 2005 edition of the National Building Code of Canada

2003 ◽  
Vol 30 (2) ◽  
pp. 308-327 ◽  
Author(s):  
Denis Mitchell ◽  
Robert Tremblay ◽  
Erol Karacabeyli ◽  
Patrick Paultre ◽  
Murat Saatcioglu ◽  
...  
Keyword(s):  
Building Code ◽  
Masonry Building ◽  
Seismic Force ◽  
Two Factors ◽  
Selection Of

This paper describes the proposed changes to the 2005 edition of the National Building Code of Canada related to the force modification factors. A description of the ductility- and overstrength-related force modification factors is given. The selection of the values proposed for these two factors for the various seismic force resistance systems is given in light of the design and detailing provisions that are specified in the Canadian Standards Association standards for steel, concrete, timber, and masonry building structures.Key words: buildings, ductility, earthquakes, force modification factors, overstrength, seismic.

scholarly journals Influence of Subcellular Localization and Functional State on Protein Turnover

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1747
Author(s):  
Roya Yousefi ◽  
Kristina Jevdokimenko ◽  
Verena Kluever ◽  
David Pacheu-Grau ◽  
Eugenio F. Fornasiero
Keyword(s):  
Subcellular Localization ◽  
Functional State ◽  
Protein Turnover ◽  
Protein Localization ◽  
Small Gtpase ◽  
Turnover Rates ◽  
Cellular Behavior ◽  
Two Factors ◽  
Brain Creatine Kinase ◽  
Selection Of

Protein homeostasis is an equilibrium of paramount importance that maintains cellular performance by preserving an efficient proteome. This equilibrium avoids the accumulation of potentially toxic proteins, which could lead to cellular stress and death. While the regulators of proteostasis are the machineries controlling protein production, folding and degradation, several other factors can influence this process. Here, we have considered two factors influencing protein turnover: the subcellular localization of a protein and its functional state. For this purpose, we used an imaging approach based on the pulse-labeling of 17 representative SNAP-tag constructs for measuring protein lifetimes. With this approach, we obtained precise measurements of protein turnover rates in several subcellular compartments. We also tested a selection of mutants modulating the function of three extensively studied proteins, the Ca2+ sensor calmodulin, the small GTPase Rab5a and the brain creatine kinase (CKB). Finally, we followed up on the increased lifetime observed for the constitutively active Rab5a (Q79L), and we found that its stabilization correlates with enlarged endosomes and increased interaction with membranes. Overall, our data reveal that both changes in protein localization and functional state are key modulators of protein turnover, and protein lifetime fluctuations can be considered to infer changes in cellular behavior.

Spacing, movements, and habitat selection of the river otter in boreal Alberta

1994 ◽  
Vol 72 (7) ◽  
pp. 1314-1324 ◽  
Author(s):  
D. G. Reid ◽  
T. E. Code ◽  
A. C. H. Reid ◽  
S. M. Herrero
Keyword(s):  
Lontra Canadensis ◽  
Home Ranges ◽  
Adult Males ◽  
Movement Rates ◽  
River Otters ◽  
Aquatic Mammal ◽  
Adult Females ◽  
Two Factors ◽  
Bog Lakes ◽  
Selection Of

Seasonal spacing patterns, home ranges, and movements of river otters (Lontra canadensis) were studied in boreal Alberta by means of radiotelemetry. Adult males occupied significantly larger annual home ranges than adult females. Males' ranges overlapped those of females and also each other's. In winter, home ranges of males shrank and showed less overlap. Otters often associated in groups, the core members typically being adult females with young, or adult males. Otters tended to be more solitary in winter. In winter, movement rates of all sex and age classes were similar, and much reduced for males compared with those in other seasons. These data indicated a strong limiting effect of winter ice on behaviour and dispersion. We tested the hypothesis that otters select water bodies in winter on the basis of the suitability of shoreline substrate and morphology for dens with access both to air and to water under ice. Intensity of selection was greatest in winter, with avoidance of gradually sloping shorelines of sand or gravel. Adults selected bog lakes with banked shores containing semi-aquatic mammal burrows, and lakes with beaver lodges. Subadults selected beaver-impounded streams. Apart from human harvest, winter habitats and food availability in such habitats are likely the two factors most strongly limiting otter density in boreal Alberta.

scholarly journals Acceleration in the bilingual acquisition of phonological structure: Evidence from Polish–English bilingual children

2014 ◽  
Vol 18 (4) ◽  
pp. 713-725 ◽  
Author(s):  
MARCO TAMBURELLI ◽  
EIRINI SANOUDAKI ◽  
GARY JONES ◽  
MICHELLE SOWINSKA
Keyword(s):  
Nonword Repetition ◽  
Bilingual Children ◽  
Consonant Clusters ◽  
Phonological Structure ◽  
English Bilingual ◽  
Two Factors ◽  
New Evidence ◽  
Phonological Complexity ◽  
Repetition Task ◽  
Selection Of

This study examines the production of consonant clusters in simultaneous Polish–English bilingual children and in language-matched English monolinguals (aged 7;01–8;11). Selection of the language pair was based on the fact that Polish allows a greater range of consonant clusters than English. A nonword repetition task was devised in order to examine clusters of different types (obstruent-liquid vs. s + obstruent) and in different word positions (initial vs. medial), two factors that play a significant role in repetition accuracy in monolingual acquisition (e.g., Kirk & Demuth, 2005). Our findings show that bilingual children outperformed monolingual controls in the word initial s + obstruent condition. These results indicate that exposure to complex word initial clusters (in Polish) can accelerate the development of less phonologically complex clusters (in English). This constitutes significant new evidence that the facilitatory effects of bilingual acquisition extend to structural phonological domains. The implications that these results have on competing views of phonological organisation and phonological complexity are also discussed.

scholarly journals Modulation of Astrocytes on Mode Selection of Neuron Firing Driven by Electromagnetic Induction

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Zhongquan Gao ◽  
Zhixuan Yuan ◽  
Zuo Wang ◽  
Peihua Feng
Keyword(s):  
Membrane Potential ◽  
Resting State ◽  
Electromagnetic Induction ◽  
Neuron Model ◽  
Mode Selection ◽  
Neuron Firing ◽  
Two Factors ◽  
Selection Of ◽  
Strong Ability

Both of astrocytes and electromagnetic induction are magnificent to modulate neuron firing by introducing feedback currents to membrane potential. An improved astro-neuron model considering both of the two factors is employed to investigate their different roles in modulation. The mixing mode, defined by combination of period bursting and depolarization blockage, characterizes the effect of astrocytes. Mixing mode and period bursting alternatively appear in parameter space with respect to the amplitude of feedback current on neuron from astrocyte modulation. However, magnetic flux obviously plays a role of neuron firing inhibition. It not only repels the mixing mode but also suppresses period bursting. The mixing mode becomes period bursting mode and even resting state when astrocytes are hyperexcitable. Abnormal activities of astrocytes are capable to induce depolarization blockage to compose the mixing mode together with bursting mode. But electromagnetic induction shows its strong ability of inhibition of neuron firing, which is also illustrated in the bifurcation diagram. Indeed, the combination of the two factors and appropriate choice of parameters show the great potential to control disorder of neuron firing like epilepsy.

Economic Comparison of Mechanical and Chemical Weed Control

Weed Science ◽  
1968 ◽  
Vol 16 (3) ◽  
pp. 369-371 ◽  
Author(s):  
David L. Armstrong ◽  
J. K. Leasure ◽  
Mitchell R. Corbin
Keyword(s):  
Weed Control ◽  
Control Method ◽  
Economic Feasibility ◽  
Control Methods ◽  
Net Income ◽  
Small Item ◽  
Mechanical Methods ◽  
Two Factors ◽  
Complex Decision ◽  
Selection Of

The problem in determining the economic feasibility of mechanical, chemical, and combination weed control methods in corn (Zea mays L.) is a complex decision involving many factors. The effects of cost, yield, timeliness, and alternative uses of labor are the factors considered in comparing various methods of weed control in this study. Costs of weed control operations range from $2.84/A for two cultivations to $10.45/A for the most intensive, mechanical-chemical operation studied. Most common weed control methods have costs of approximately $3 to $4/A. Yields range from 83 bu/A for two cultivations to 96 bu/A with the highest cost chemical-mechanical weed control methods. All yields used in this study are supported by agronomic studies and are indexed on the basis of 100 bu/A for weed-free conditions. The consideration of both yields and costs does affect the selection of a weed control method. Considering only these two factors, mechanical methods have a slight advantage over chemical weed control methods. Penalizing mechanical methods because of delay or timeliness characteristics gives chemical methods an advantage by as much as $3.00/A. Alternative uses of labor, even though a common argument in selecting chemical or mechanical methods, is a very small item and has only moderate effects on the changes in net income.

Research on Calculation Method of Alternative Fuel Quantity for Natural Gas Bus

2014 ◽  
Vol 687-691 ◽  
pp. 415-418
Author(s):  
Xiao Li ◽  
Li Liu ◽  
Zhong Xiang Li
Keyword(s):  
Energy Efficiency ◽  
Natural Gas ◽  
Calculation Method ◽  
Calorific Value ◽  
Alternative Fuel ◽  
Correction Coefficient ◽  
Actual Situation ◽  
Two Factors ◽  
Natural Gas Vehicle ◽  
Selection Of

There is no more in-depth research in the amount of alternative between natural gas and tradition fuel. The paper consider two factors about gas calorific value and vehicle level and put forward the fuel calorific value correction coefficient and vehicle energy efficiency correction coefficient. On this basis, the coefficient table and calculation method was established. The paper proved that because of the influence of the factors, equivalent ratio in the range of 1.13~1.67. The method can indicate the gas replacement more scientific and real, because of consider of the actual situation of application of the enterprise.The research can guide the selection of natural gas vehicle reasonable and scientific.

scholarly journals Landscape Architects as Related to the Landscape/Nursery Industry: II. Selection of the Production Nursery and Plant Availability

1992 ◽  
Vol 10 (2) ◽  
pp. 73-77
Author(s):  
M.P. Garber ◽  
K. Bondari
Keyword(s):  
Firm Size ◽  
Small Firms ◽  
Large Firms ◽  
Sources Of Information ◽  
Plant Availability ◽  
Significant Difference ◽  
Two Factors ◽  
Survey Results ◽  
Selection Of

Abstract Information concerning the role of the landscape architect in verifying plant availability and selection of the production nursery where landscape contractors obtain plants can help growers develop effective marketing plans. A survey of Georgia landscape architects indicates that about 84% of the respondents confirm availability of plant material specified. A higher percentage of large firms (about 92%) confirm availability compared to medium (85.7%) and small (79.3%) firms. The three most frequently used sources of information for landscape architects to confirm plant availability are favorite local grower, nursery catalogs, and landscape contractor likely to install plants. The top three choices are the same regardless of firm size. Survey results demonstrate that landscape architects not only confirm availability of plants but also play an important role in selecting the production nursery where landscape contractors obtain plants. Approximately 61% of all respondents indicate they determine/recommend the nursery where landscape contractors obtain plants. There is a significant difference among firm size in response to this question with large firms most active in selecting the production nursery (about 92%) followed by medium (57%) and small (50%) firms. The two factors that most influence the decision of large firms are plant quality and plant varieties. Large firms are more price conscious than medium or small firms. The results suggest that growers can enhance their sales by marketing their product directly to landscape architects.

scholarly journals Varietas Non Hibrida Cabai Besar Anies IPB

2017 ◽  
Vol 1 (1) ◽  
pp. 56
Author(s):  
Muhamad Syukur ◽  
Sobir , ◽  
Siti Marwiyah ◽  
Awang Maharijaya ◽  
Anas D. Susila ◽  
...  
Keyword(s):  
Dynamic Stability ◽  
Block Design ◽  
Female Parent ◽  
West Java ◽  
Harvesting Time ◽  
Central Java ◽  
Randomized Complete Block Design ◽  
Two Factors ◽  
High Level ◽  
Selection Of

The pepper is very important horticultural commodities. The purpose of this research was to study the advantagesof Anies IPB varieties and develop the description. Anies IPB was the result of the selection of segregating populations from the crosses of IPB C120 (as the female parent) and IPB C5 (as the male parent). The experiments were performed in four locations namely Boyolali (Central Java), Sumedang (West Java), and Bogor (West Java). The experimental used the randomized complete block design (RCBD) two factors with three replications. The replications nested within the locations. The first factor was 9 lines and 2 open pollinated varieties, and the second factor was the three locations. Each lines on each replicate in each location were planted 24 plants. The results showed that the superiority of Anies IPB varieties were (1) The productivity of Anies IPB was higher than the check varieties. Productivity can reach 18.6 tons ha-1. (2) Anies IPB has fruit that was longer than the Tit Super and Trisula. (3) Anies IPB has early-harvesting time, ranged between 76.67 - 84.67 days after planting. (4) Anies IPB has a high level of stability and classified into the dynamic stability, which means that veryadaptive to the optimum environment.Keyword: non hybrid, pepper productivity superiority, variety

Optimizing the Size of Drug-Loaded Nanoparticles Using Design of Experiments

2020 ◽  
pp. 131-157
Author(s):  
Paola Cervantes-Covarrubias ◽  
Ayla Vea-Barragan ◽  
Aracely Serrano-Medina ◽  
Eugenia Gabriela Carrillo-Cedillo ◽  
José Manuel Cornejo-Bravo
Keyword(s):  
Particle Size ◽  
Design Of Experiments ◽  
Design Of Experiment ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Fractional Factorial ◽  
Solid Lipid ◽  
Two Factors ◽  
Nanoparticle System ◽  
Selection Of

Nanoparticles formed from lipids are currently applied successfully to deliver drugs. The particle size of the nanoparticle system is an essential characteristic to enhance the entrance of the drugs inside tissues and cells. Using design of experiment is appealing to find the specific conditions to optimize particle size of drug-loaded nanoparticles. Authors of this chapter applied a fractional factorial design of half fraction 24-1 with levels between continue factors, finding statistically significant differences for two factors such as concentrations of drugs and type of solvent where the organic phase is dissolved. This design shows the optimization of a formulation of capsaicin in solid lipid nanoparticles. The chapter also includes information on methods to prepare solid lipid nanoparticles (SLN), the variables involved, and a selection of studies about optimization of SLN formulations.

Physiology of Lymphatic Oedema

1994 ◽  
Vol 9 (1_suppl) ◽  
pp. 19-22
Author(s):  
J. A. Jimenez Cossio
Keyword(s):  
Protein Content ◽  
Lymphatic System ◽  
Data Extraction ◽  
Current Understanding ◽  
Therapeutic Management ◽  
Physiological Mechanisms ◽  
Data Synthesis ◽  
Anatomical Structures ◽  
Two Factors ◽  
Selection Of

Objective: To describe the physiological mechanisms implicated in lymph formation and drainage, and the pathophysiology of lymphoedema. Design: Historical steps leading to the current understanding of the physiology and pathophysiology of lymph formation. Data extraction: Selection of relevant articles from the literature. Data synthesis: After a summary of the anatomical structures involved in the lymphatic system, the physiology of lymph formation and transport is described with special emphasis on recent hypotheses. The pathophysiology of lymphoedema is explained based on a combination of two factors: protein content and fluid movements within the lymphatic system. Conclusion: The pathophysiology of lymphoedema is currently better understood, even if some aspects remain unclear. This can lead to an improved therapeutic management of lymphoedema.

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