STUDIES ON THE IMMUNOLOGICAL SPECIFICITY OF AUTOLOGOUS GAMMA-GLOBULIN IN THE GLOMERULI OF RABBITS WITH EXPERIMENTALLY INDUCED GLOMERULONEPHRITIS
Keyword(s):
Experimental glomerulonephritis was induced in rabbits by the intravenous administration of chicken antirabbit glomerulus serum (nephrotoxic serum). These rabbits were simultaneously immunized, either actively or passively, with bovine serum albumin or ovalbumin. Autologous gamma-globulin was identified in the glomeruli of these nephritic rabbits by means of the fluorescent antibody technique. It was not possible to demonstrate the presence of an anti-BSA or anti-OA component in the gamma-globulin even though these antibodies were present in high titer in the blood. This suggests that the autologous gamma-globulin present in the lesions is entirely specific antibody rather than an accumulation of serum gamma-globulin.
1957 ◽
Vol 106
(5)
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pp. 627-640
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1947 ◽
Vol 85
(6)
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pp. 571-590
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1959 ◽
Vol 110
(5)
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pp. 715-730
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2006 ◽
Vol 6
(3)
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pp. 868-871
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1963 ◽
Vol 117
(4)
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pp. 691-704
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1962 ◽
Vol 10
(3)
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pp. 250-256
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