Recent development in functionalized ionic liquids as reaction media and promoters

The recent development in the use of functionalized ionic liquids as both reaction media and promoters is reviewed. Ionic liquids designed with special functionality can enhance the reaction rate, selectivity, and productivity in various chemical reactions. In this context, some important chemical reactions involving C–C, C–O, C–N, and C–S bond formation in functionalized ionic liquids are discussed. These functionalized ionic liquids were found to provide distinct advantages over conventional organic solvents in these catalytic reactions.

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Advances of Application of Ionic Liquids in Catalytic Oxidation Reactions

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.233-235.499 ◽

2011 ◽

Vol 233-235 ◽

pp. 499-506 ◽

Cited By ~ 2

Author(s):

Yu Kun Shi ◽

Guang Fei Qu ◽

Ping Ning ◽

Jun Zhang ◽

Hui Feng

Keyword(s):

Catalytic Activity ◽

Ionic Liquids ◽

Catalytic Oxidation ◽

Organic Synthesis ◽

Organic Solvents ◽

Chemical Reactions ◽

Oxidation Reaction ◽

Oxidation Reactions ◽

Dual Functions

Advances of application of ionic liquids as solvents and catalysts in the catalytic oxidation reaction are summarized in this paper. Ionic liquids, as solvent, can provide an environment which is different from the traditional organic solvents for the chemical reactions, and make the catalytic activity and stability better, conversion and selectivity higher; Ionic liquids, as catalyst, not only play the function of promoting reaction, but also play a solvent/catalyst dual functions more directly. Currently ionic liquids in catalytic oxidation reaction are mostly used as solvent, Especially used widely in organic synthesis. The designability of ionic liquids provides a broad space for ionic liquids as catalyst.

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Ionic Liquid Promoted Eco-friendly and Efficient Synthesis of Six-membered Npolyheterocycles

Current Organic Synthesis ◽

10.2174/1570179415666180903102542 ◽

2018 ◽

Vol 15 (8) ◽

pp. 1124-1146 ◽

Cited By ~ 1

Author(s):

Navjeet Kaur

Keyword(s):

Organic Chemistry ◽

Ionic Liquid ◽

Ionic Liquids ◽

Organic Solvents ◽

Review Article ◽

Environmentally Benign ◽

Wide Range ◽

Catalyzed Reactions ◽

Metal Catalyzed ◽

Reaction Media

Background: The synthesis of N-polyheterocycles by environmentally benign method is highly attractive but challenging proposition. New strategies have been developed for the preparation of polycyclic heterocycles in the last decades. In this review article, the synthesis of nitrogen containing six-membered polycyclic heterocyclic compounds is presented with the application of ionic liquids. This contribution focuses on the literature related to the total synthesis of six-membered N-polyheterocycles. Objective: Ionic liquids not only acted as environmentally benign reaction media but also as catalysts which afforded the very promising replacements of traditional molecular solvents in organic chemistry due to their stability, non-flammability, non-volatility and ease of recyclability. Ionic liquids are utilized in metal catalyzed reactions in place of organic solvents in the last years. It has attracted considerable attention in recent years. Ionic liquids acted as alternatives of organic solvents and these ILs are environment friendly. Conclusion: In the area of green chemistry ionic liquid assisted synthesis is a very promising technique which afforded a flexible platform for the formation of heterocycles. The influence of ILs on the development of efficient and new synthetic protocols over the last decade for the construction of N-polyheterocycles is featured in this review article. These synthetic strategies will continue to attract more attention and will find a wide range of applications in organic synthesis. In conclusion, ionic liquids assisted syntheses have become an efficient and powerful tool in organic chemistry quickly.

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A Phosphine-mediated Synthesis of 2,3,4,5-tetra-substituted Nhydroxypyrroles from α-oximino Ketones and Dialkyl Acetylenedicarboxylates Under Ionic Liquid Green-media

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207321666180124094536 ◽

2018 ◽

Vol 21 (1) ◽

pp. 14-18

Author(s):

Ashraf S. Shahvelayati ◽

Maryam Ghazvini ◽

Khadijeh Yadollahzadeh ◽

Akram S. Delbari

Keyword(s):

Ionic Liquid ◽

Ionic Liquids ◽

Organic Solvents ◽

Condensation Reaction ◽

Reaction Medium ◽

Sustainable Chemistry ◽

Polyfunctional Compounds ◽

High Yields ◽

Work Up ◽

Reaction Media

Background: The development of multicomponent reactions (MCRs) in the presence of task-specific ionic liquids (ILs), used not only as environmentally benign reaction media, but also as catalysts, is a new approach that meet with the requirements of sustainable chemistry. In recent years, the use of ionic liquids as a green media for organic synthesis has become a chief study area. This is due to their unique properties such as non-volatility, non-flammability, chemical and thermal stability, immiscibility with both organic compounds and water and recyclability. Ionic liquids are used as environmentally friendly solvents instead of hazardous organic solvents. Objective: We report the condensation reaction between α-oximinoketone and dialkyl acetylene dicarboxylate in the presence of triphenylphosphine to afford substituted pyrroles under ionic liquid conditions in good yields. Result: Densely functionalized pyrroles was easily prepared from reaction of α-oximinoketones, dialkyl acetylene dicarboxylate in the presence of triphenylphosphine in a quantitative yield under ionic liquid conditions at room temperature. Conclusion: In conclusion, ionic liquids are indicated as a useful and novel reaction medium for the selective synthesis of functionalized pyrroles. This reaction medium can replace the use of hazardous organic solvents. Easy work-up, synthesis of polyfunctional compounds, decreased reaction time, having easily available-recyclable ionic liquids, and good to high yields are advantages of present method.

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Effect of the nature of the nucleophile and solvent on an SNAr reaction

New Journal of Chemistry ◽

10.1039/c7nj03212a ◽

2018 ◽

Vol 42 (1) ◽

pp. 260-264 ◽

Cited By ~ 8

Author(s):

Marcela Gazitúa ◽

Ricardo A. Tapia ◽

Renato Contreras ◽

Paola R. Campodónico

Keyword(s):

Ionic Liquids ◽

Organic Solvents ◽

Snar Reaction ◽

Reaction Media

The reaction of 2,4-dinitrobenzenesulfonyl chloride toward propylamine was kinetically evaluated in 19 organic solvents and 10 ionic liquids as reaction media.

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Deep eutectic solvents: alternative reaction media for organic oxidation reactions

Reaction Chemistry & Engineering ◽

10.1039/d0re00458h ◽

2021 ◽

Author(s):

Graziano Di Carmine ◽

Andrew P. Abbott ◽

Carmine D'Agostino

Keyword(s):

Ionic Liquids ◽

Organic Solvents ◽

Deep Eutectic Solvents ◽

Oxidation Reactions ◽

Reaction Media ◽

Organic Oxidation

Deep eutectic solvents (DESs) are a valid alternative to common organic solvents and ionic liquids (ILs) as solvent media for organic oxidation reactions.

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Synthesis, Characterization and Applications of Dicationic Ionic Liquids in Organic Synthesis

Mini-Reviews in Organic Chemistry ◽

10.2174/1570193x16666190508091231 ◽

2020 ◽

Vol 17 (4) ◽

pp. 450-464

Author(s):

Mohammad Javaherian ◽

Seyyed Jafar Saghanezhad

Keyword(s):

Ionic Liquids ◽

Organic Synthesis ◽

Chemical Properties ◽

Physical And Chemical Properties ◽

Dicationic Ionic Liquids ◽

Physical And Chemical ◽

Reaction Media ◽

And Chemical Properties

Dicationic ionic liquids are an emerging group of Ionic Liquids (ILs) that are currently receiving much attention as green reaction media and catalysts. Because of a great number of possible combinations of cations and anions, the physical and chemical properties of dicationic ionic liquids are more tunable and broader than monocationic ILs. Therefore, their unique properties have made them the target of many applied and fundamental researches. Actually, dicationic ionic liquids are more effective and rather fascinating than traditional monocationic ILs. So, due to greater versatility and diversity, their applications in organic synthesis have been extensively grown. In this review, we have focused on the synthesis, characterization and applications of dicationic ionic liquids, especially, in organic synthesis.

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Electrogenerated NHCs in Organic Synthesis: Ionic Liquids vs Organic Solvents Effects

The Chemical Record ◽

10.1002/tcr.202000178 ◽

2021 ◽

Author(s):

Fabrizio Vetica ◽

Martina Bortolami ◽

Rita Petrucci ◽

Daniele Rocco ◽

Marta Feroci

Keyword(s):

Ionic Liquids ◽

Organic Synthesis ◽

Organic Solvents

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Advances in Cryochemistry: Mechanisms, Reactions and Applications

Molecules ◽

10.3390/molecules26030750 ◽

2021 ◽

Vol 26 (3) ◽

pp. 750

Author(s):

Lu-Yan An ◽

Zhen Dai ◽

Bin Di ◽

Li-Li Xu

Keyword(s):

Low Temperature ◽

Chemical Reactions ◽

Common Sense ◽

Reaction Rate ◽

Concentration Effect ◽

Biological Products ◽

Freeze Concentration ◽

New Strategy ◽

The 1960S

It is counterintuitive that chemical reactions can be accelerated by freezing, but this amazing phenomenon was discovered as early as the 1960s. In frozen systems, the increase in reaction rate is caused by various mechanisms and the freeze concentration effect is the main reason for the observed acceleration. Some accelerated reactions have great application value in the chemistry synthesis and environmental fields; at the same time, certain reactions accelerated at low temperature during the storage of food, medicine, and biological products should cause concern. The study of reactions accelerated by freezing will overturn common sense and provide a new strategy for researchers in the chemistry field. In this review, we mainly introduce various mechanisms for accelerating reactions induced by freezing and summarize a variety of accelerated cryochemical reactions and their applications.

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