An FT-ir study of cis study of trans-dichlorodiammineplatinum(II) bound to inosine-5′-monophosphate

1984 ◽  
Vol 62 (8) ◽  
pp. 1429-1440 ◽  
Author(s):  
H. A. Tajmir-Riahi ◽  
T. Theophanides
Keyword(s):  
Trans Isomer ◽  
Platinum Complexes ◽  
Disodium Salt ◽  
Spectral Changes ◽  
Ir Studies ◽  
Stretching Vibration ◽  
Ft Ir ◽  
Purine Ring ◽  
Ir Study ◽  
Cis And Trans

Inosine-5′-monophosphate disodium salt (5′-IMPNa2) reacts with cis-dichlorodiammineplatinum(II) (cis-DDP) and its trans-isomer (trans-DDP) to give complexes of the type cis- and trans-Pt(NH3)2(IMPNa2)nCl2•xH2O, n = 1 or 2 and Pt(IMPNa2)nCl2•xH2O, where n = 1, 2, or 3 and x = 0–6. In the 1:2 platinum complexes the nucleotide binds only to the N7-atom of the purine ring system, while in the 1:1 metal complexes there is indication for Pt–carbonyl interaction (bridging or chelation) in addition to the N7-bonding at neutral pH values with cis-DDP.Solution FT-ir studies (H2O and D2O) showed that the 1:1 species formed with cis-DDP at neutral pH's behaved differently from those with trans-DDP. The carbonyl stretching vibration of the free base at 1685 cm−1 (H2O) and 1670 cm−1 (D2O) exhibited marked spectral changes in intensity, shifting, and shape upon complexation, whereas the reaction with the trans-isomer produced only slight perturbations in the above region.

Synthesis, structure, proton-nuclear magnetic resonance, and Fourier transform infrared spectroscopy of several transition and nontransition metal–adenosine-5-triphosphate complexes

1986 ◽  
Vol 64 (5) ◽  
pp. 960-966 ◽  
Author(s):  
H. A. Tajmir-Riahi ◽  
M. J. Bertrand ◽  
T. Theophanides
Keyword(s):  
Metal Binding ◽  
Disodium Salt ◽  
Proton Nuclear Magnetic Resonance ◽  
Metal Phosphate ◽  
Nontransition Metal ◽  
Infrared Band ◽  
Spectral Changes ◽  
Anti Conformation ◽  
Marker Band ◽  
Cis And Trans

Several complexes of adenosine-5-triphosphate disodium salt (Na2H2ATP) with the metal ions, Na+, Mg2+, Ca2+, Mn2+, Co2+, Ni2+, Cu2+, and cis- and trans-Pt(NH3)2Cl2 and K2PtCl4 at pH = 3.5 and 7.2 have been isolated, identified, and studied. Marked spectral similarities have been observed for the structurally known metal–phosphate bonded compounds, [Cu(H2ATP)(phen)]2•7H2O and [Zn(H2ATP)(bipy)]2•4H2O and all the metal–ATP complexes studied here, except the Pt–ATP complexes. The metal binding is through the α, β, and γ phosphate oxygen atoms when the N1-position of adenine is protonated. Spectral changes have also been observed for the Pt–ATP complexes in which there is a Pt–N7 and –N1 coordination. The sugar pucker in the Na2H2ATP•3H2O crystal dimers is C3′-endo–anti (in one) and C2′-endo–anti (in the other) with a characteristic infrared band at 818 cm−1. In the corresponding Cu2+ and Zn2+ complexes the sugar has C3′-endo–anti conformation with the marker band at about 814 cm−1. The C2′-endo–anti conformation is observed for all the metal–ATP complexes prepared here with a marker band at 825–822 cm−1.

Synthesis and Characterization of Ligand and its Metal Complexes

2011 ◽  
Vol 699 ◽  
pp. 273-279
Author(s):  
A. Xavier ◽  
R Sathya ◽  
D. Usha ◽  
P.S. Harikrishnan
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Metal Ion ◽  
Wave Number ◽  
Lower Wave Number ◽  
Strong Absorption Band ◽  
Ir Studies ◽  
Stretching Vibration ◽  
Ft Ir

A series of metal complexes have been synthesized by the reaction of Schiff base with metal (II) salt solution. The complexes were characterized by UV and FT- IR studies. The study reveals that the geometry of the complexes were octahedral. The electronic spectra of these complexes show a strong absorption band in 550 – 580 nm region. This confirms the coordination of ligand with metal. The FT-IR shows a very strong band at 1606cm-1 assigned to C=N stretching vibration. It is shifted to lower wave number because of the complex formation, suggesting that coordination of the Schiff base groups through N- atoms with the metal ion. The band at 3056cm-1 is due to aromatic O-H stretching, the sharp peak at 750 cm-1 and 688 cm-1 are due to halogens substituted in the para position.

IN SITU HIGH TEMPERATURE FT-IR STUDY OF THE INTERLAYER NAPHTHALENE-2,6-DISULFONATE IN Mg AND Al LAYERED DOUBLE HYDROXIDE

2011 ◽  
Vol 25 (31) ◽  
pp. 4185-4189
Author(s):  
EIJI KANEZAKI ◽  
MASAHIRO KATOH
Keyword(s):  
High Temperature ◽  
Layered Double Hydroxide ◽  
Basal Spacing ◽  
Vibration Band ◽  
Stretching Vibration ◽  
Ft Ir ◽  
Ir Study ◽  
Double Hydroxide ◽  
Heating Up

In high temperature in situ FT-IR (HTFTIR) spectra of Mg and Al layered double hydroxide with interlayer naphthalene-2,6-disulfonate ( Mg / Al / N 26 DS - LDH ), one S - O stretching vibration band of the non-coordinating - SO 3 group in the interlayer N 26 DS dianion is observed below 400 °C at 1035 cm-1 with keeping intensity. High temperature in situ X-ray diffraction (HTXRD) indicates that the basal spacing remains also constant up to 400 °C, MgSO 4 appears after the LDH collapses at 500 °C and some metal oxides are formed at higher temperature. Both results in HTXRD and HTFTIR indicate that the layered structure in this LDH is stable against heating up to 400 °C.

Synthesis and Characterization of Schiff Base with Bivalence Transition Metal Complexes Namely Cu, Co, Ni, Mn and Fe

2011 ◽  
Vol 699 ◽  
pp. 265-271 ◽  
Author(s):  
A. Xavier ◽  
R Sathya ◽  
D. Usha ◽  
P.S. Harikrishnan
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Metal Ion ◽  
Broad Band ◽  
Wave Number ◽  
Bending Vibrations ◽  
Strong Absorption Band ◽  
Ir Studies ◽  
Stretching Vibration ◽  
Ft Ir

A series of metal complexes have been synthesized by the reaction of Schiff base with metal (II) salt solution. The complexes were characterized by UV and FT- IR studies. The study reveals that the geometry of the complexes were octahedral. The electronic spectra of these complexes show a strong absorption band in 550 - 580nm region. This confirms the coordination of ligand with metal. The FT-IR shows a very strong band at 1616cm-1assigned to C=N stretching vibration. It is shifted to lower wave number because of the complex formation, suggesting that coordination of the Schiff base groups through N- atoms with the metal ion. The band at 3496 cm-1is due to aromatic N-H stretching, It is noted that a broad band of the asymmetric and symmetric O-H stretching mode around the region 3400 cm-1presumably due to H-O-H bending vibrations are not observed in the spectrum of complexes, which are indicating of the absence of the water molecule.

Self-association of caffeine in aqueous solution: an FT-IR study

1990 ◽  
Vol 68 (8) ◽  
pp. 1293-1299 ◽  
Author(s):  
Michael Falk ◽  
Manuel Gil ◽  
Nerea Iza
Keyword(s):  
Infrared Spectroscopy ◽  
Molar Absorptivity ◽  
Polymer Model ◽  
Infrared Band ◽  
Caffeine Concentration ◽  
Spectral Changes ◽  
Ft Ir ◽  
Self Association ◽  
Association Equilibria ◽  
Ir Study

Spectra of caffeine in D2O solution (0.003 to 0.129 M) were studied by Fourier-transform infrared spectroscopy. Spectral changes in the carbonyl stretching region were interpreted in terms of the self-association equilibria resulting from the stacking of caffeine molecules. Absence of isosbestic points indicated the occurrence of more than two spectroscopically distinct caffeine species. A simple monomer–dimer–polymer model was employed, in which the successive equilibria are governed by two association constants, Kd for the formation of dimers and Kp for the formation of trimers and larger polymers. The value Kd = 158.1 L mol−1 was taken from a recent ultraviolet study by Iza etal. and the value Kp = 27 L mol−1 was derived from the analysis of infrared band profiles sharpened by Fourier self-deconvolution. From these values of Kd and Kp, the weight fractions of monomers, dimers, and polymers were calculated for every caffeine concentration and their individual molar absorptivity spectra were derived. In agreement with the earlier work of Maevsky and Sukhorukov, it was found that stacking association causes shifts of both C=O stretching fundamentals to higher wavenumbers. The monomer-dimer shifts are smaller than the dimer-polymer shifts. Analogous shifts were observed for the stacking self-association of 1,3-dimethyluracil in D2O. The shifts to higher wavenumbers are probably caused by the diminished hydrogen bonding of water to C=O groups of the stacked bases. Keywords: caffeine, self association, infrared spectroscopy, base stacking.

An FT-IR Study of the Effect of Simulated Solar Radiation and Various Particulates on the Oxidation of SO2

1989 ◽  
Vol 43 (1) ◽  
pp. 103-107 ◽  
Author(s):  
D. M. Smith ◽  
J. R. Keifer ◽  
M. Novicky ◽  
A. R. Chughtai
Keyword(s):  
Water Vapor ◽  
Solar Radiation ◽  
Black Carbon ◽  
Ir Studies ◽  
Ft Ir ◽  
Short And Long Term ◽  
Simulated Solar Radiation ◽  
Ir Study ◽  
Long Term Studies

Short- and long-term studies of the effect of black carbon and other particulates on the oxidation of SO2 with and without the presence of oxygen, water vapor, and simulated solar radiation, have been carried out. FT-IR studies involving isotopic oxygen-18, sulfur dioxide-18, and D2O in these reactions confirm the requirement of water vapor and oxygen for this oxidation. Such experiments conducted at 298 K demonstrate only the formation of ionic sulfates, while the reactions conducted under simulated solar radiation show the formation of both covalent and ionic sulfate species. These observations have implications for the retention or diminution of catalytic activity by the soot. The reaction vessel walls, SiO2, and particulate black carbon, all act as catalysts for the conversion of S(IV) to S(VI), the amounts depending primarily on the surface area of the solid.

scholarly journals Reaction of cis- and trans-Dichlorotetra(Dimethylsulfoxide)Ruthenium(II) With the Antiviral Drug Acyclovir

2000 ◽  
Vol 7 (6) ◽  
pp. 325-334 ◽  
Author(s):  
Aglaia Koutsodimou ◽  
Giovanni Natile
Keyword(s):  
Trans Isomer ◽  
Early Stage ◽  
Antiviral Drug ◽  
Metallic Substrate ◽  
Purine Base ◽  
Coordination Environment ◽  
Molar Ratios ◽  
Discrete Amount ◽  
Cis And Trans ◽  
Cis Isomer

NMR was used to investigate the reaction of cis- and trans-[RuCl2(DMSO)4] with the antiviral drug acyclovir, a guanine derivative containing the acyclic (2-hydroxo) ethoxymethyl pendant linked to N(9). Studies were performed in aqueous solutions at ambient temperature and at 37 °C, and at various molar ratios. Both isomers yielded two compounds, a monoadduct and a bisadduct, the relative yields being dependent upon the metal to ligand concentration ratios. The products derived from the two Ru isomers displayed identical NMR spectra, suggesting that they have the same coordination environment, however the rate of formation of the monoadduct was higher in the case of the trans isomer than in the case of the cis isomer, while the rate of conversion of the monoadduct into the bisadduct appeared to be similar in both cases. As a consequence in the case of the trans isomer there is accumulation of monoadduct in the early stage of the reaction, whose concentration afterwards decreases with the progress of the reaction. As for platinum, also for ruthenium the preferred binding site is N(7) of the purine base, however, in the case of ruthenium a discrete amount of bisadduct is formed even in the presence of an excess of metallic substrate with respect to the acyclovir ligand; under similar conditions a platinum substrate would have given, nearly exclusively, the monoadduct.

An FT-IR Study on Packing Defects in Mixed β-Aggregates of Poly(l-glutamic acid) and Poly(d-glutamic acid): A High-Pressure Rescue from a Kinetic Trap

2012 ◽  
Vol 116 (17) ◽  
pp. 5172-5178 ◽  
Author(s):  
Yudai Yamaoki ◽  
Hiroshi Imamura ◽  
Aleksandra Fulara ◽  
Sławomir Wójcik ◽  
Łukasz Bożycki ◽  
...  
Keyword(s):  
High Pressure ◽  
Glutamic Acid ◽  
Kinetic Trap ◽  
Packing Defects ◽  
Ft Ir ◽  
Ir Study

Effects of ultra-high pressures (>3.6 GPa) on the electrical resistance of polyaniline by in situ FT-IR studies

1997 ◽  
Vol 280 (5-6) ◽  
pp. 469-474 ◽  
Author(s):  
Xing-Rong Zeng ◽  
Ke-Cheng Gong ◽  
Ke-Nan Weng ◽  
Wan-Sheng Xiao ◽  
Wen-Hong Gan ◽  
...  
Keyword(s):  
Electrical Resistance ◽  
High Pressures ◽  
Ir Studies ◽  
Ft Ir

AN ENHANCEMENT OF SOLUBILITY OF PIOGLITAZONE HYDROCHLORIDE USING LIQUISOLID TECHNIQUE

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (06) ◽  
pp. 36-39
Author(s):  
S Deshmane ◽  
◽  
K Gandhi ◽  
S. Nagpure ◽  
A. Sawant ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Drug Release ◽  
Dissolution Rate ◽  
In Vivo Study ◽  
Dimethyl Acetamide ◽  
Volatile Liquid ◽  
Ft Ir ◽  
Ir Study

The new mathematical model was developed by studying angle of slide using N, N-dimethyl acetamide, non-volatile liquid vehicle and prepared liquisolid tablets, in which the different concentrations of non-volatile liquid adsorbed over carrier and coating material separately. Both DSC and FT-IR study showed better compatibility and stability. The optimized formulation showed higher drug release during in-vitro and in-vivo study against conventional and marketed preparation. The present work concludes that N, N-dimethyl acetamide enhanced the solubility of pioglitazone HCl with higher dissolution rate through liquisolid technique.

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