INSULIN HYPERPHAGIA IN RATS FED A LOW-PROTEIN DIET

1965 ◽  
Vol 43 (2) ◽  
pp. 225-233 ◽  
Author(s):  
J. R. Beaton ◽  
V. Feleki ◽  
J. A. F. Stevenson
Keyword(s):  
Food Intake ◽  
Body Fat ◽  
Normal Diet ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Eating Pattern ◽  
Low Protein ◽  
Running Activity ◽  
Male Wistar Rats ◽  
Rebound Increase

This investigation was undertaken to ascertain if daily treatment with insulin, known to increase lipogenesis, fat deposition, and food intake on a normal diet, could overcome or prevent, the hypophagia of rats fed a low-protein (5% casein) diet. Male Wistar rats on 20 or 5% casein diets were injected subcutaneously daily for 25 days with 2 units/100 g body weight of protamine zinc insulin (PZI) or saline. PZI increased the food intake and weight gain on both diets but not linear growth. It increased body fat markedly and protein slightly on the low-protein diet and body fat only on the normal diet. In a second similar experiment, in which treatment was continued for 17 days, PZI caused no change in resting oxygen consumption from that of the controls on either diet but did prevent the increase in running activity that rats on a low-protein diet show. In both experiments, although the insulin-treated rats on low-protein diet ate as many calories as the saline-treated controls on the normal diet, they gained significantly less weight. This paradox remains unexplained.The rebound increase in blood sugar following injection of PZI was relatively much faster in the low-protein animals. This was associated with a more immediate and greater food intake suggesting a "meal-eating" pattern of food intake in these animals which may have also enhanced lipogenesis.

Effect of High-Salt, High-Carbohydrate, Low-Protein Diet on Hypertension in the Rat

1973 ◽  
Vol 45 (s1) ◽  
pp. 99s-102s
Author(s):  
Hideo Ueda
Keyword(s):  
Blood Pressure ◽  
High Protein Diet ◽  
Normal Diet ◽  
High Salt ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Heart Weight ◽  
Hypertensive Rats ◽  
High Carbohydrate ◽  
Low Protein

1. High-salt, high-carbohydrate and low-protein diet induces remarkable elevation of blood pressure in spontaneous hypertensive rats (SHR). 2. These animals have low serum potassium, low blood urea nitrogen and high blood sugar. 3. Heart weight is increased in proportion to the elevation of blood pressure. 4. Kidney weight of rats receiving the high-salt, high-carbohydrate and low-protein diet was, by contrast, smaller than SHR receiving a normal diet. 5. The kidneys of SHR receiving a high-salt, high-protein diet were twice as heavy as the kidneys of normal rats. 6. Similar dietary modifications in Goldblatt hypertensive rats to those in SHR produced similar changes in blood pressure and heart weight.

scholarly journals Phosphorus Supplementation Mitigated Food Intake and Growth of Rats Fed a Low-Protein Diet

2017 ◽  
Vol 1 (8) ◽  
pp. e000943 ◽  
Author(s):  
Rola U Hammoud ◽  
Mark N Jabbour ◽  
Ayman N Tawil ◽  
Hala Ghattas ◽  
Omar A Obeid
Keyword(s):  
Food Intake ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

Erratum: Factors in the reduced food intake of rats fed a low-protein diet

1968 ◽  
Vol 46 (4) ◽  
pp. 702-702
Author(s):  
J. R. Beaton ◽  
V. Feleki ◽  
J. A. F. Stevenson
Keyword(s):  
Food Intake ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

ACTIVITY AND PATTERNS OF RATS FED A LOW-PROTEIN DIET AND THE EFFECTS OF SUBSEQUENT FOOD DEPRIVATION

1964 ◽  
Vol 42 (6) ◽  
pp. 705-718 ◽  
Author(s):  
J. R. Beaton ◽  
V. Feleki ◽  
J. A. F. Stevenson
Keyword(s):  
Food Deprivation ◽  
Weight Change ◽  
Activity Pattern ◽  
Caloric Intake ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Adequate Diet ◽  
Low Protein ◽  
Running Activity ◽  
Temperate Environment

Rats previously fed a low-protein diet (5% casein) survive deprivation of food for a shorter period than do animals fed an adequate diet (20% casein) even though this be fed in isocaloric amounts. The present investigation examined effects of feeding a low-protein diet and of subsequent survival during food deprivation under various conditions: in activity and standard cages, in temperate (23 °C) and cold (5 °C) environments. During feeding, those animals provided with the low-protein diet did not exhibit a total running activity or activity pattern markedly different than those of pair-fed controls. The results revealed that the shorter survival in cold or temperate environment after a low-protein diet is not attributable to differences in (a) total running activity or activity pattern, (b) feeding pattern, or (c) previous caloric intake and weight change. It was also noted that rats in activity cages do not eat or gain as much as rats in standard cages.

A maternal low-protein diet and neonatal overnutrition result in similar changes to glomerular morphology and renal cortical oxidative stress measures in male Wistar rats

2019 ◽  
Vol 44 (2) ◽  
pp. 164-171 ◽  
Author(s):  
Anderson Pedroza ◽  
Diorginis Soares Ferreira ◽  
David F. Santana ◽  
Pedro Thiago da Silva ◽  
Francisco Carlos Amanajás de Aguiar Júnior ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Renal Cortex ◽  
Protein Diet ◽  
Antioxidant Defenses ◽  
Low Protein Diet ◽  
Low Protein ◽  
Oxidative Balance ◽  
Male Wistar Rats ◽  
Glomerular Morphology

There is a strong correlation between inadequate gestational and postpartum nutrition and the occurrence of cardiovascular diseases. The present study investigated the effects of a maternal low-protein diet and neonatal overfeeding on the oxidative balance and morphology of the renal cortex of male Wistar rats. Two independent protocols were used. First, pregnant Wistar rats received diets containing either 17% (normal protein) or 8% (low protein) casein throughout pregnancy and lactation. Second, the litter size was reduced by one-third on the third postnatal day to induce overnourishment in offspring. At 30 days, the oxidative balance and morphology of the renal cortex were analyzed. There was a small but significant increase in renal corpuscle area in the low protein (LP, 5%) and overnutrition (ON, 8%) groups. Glomerular tuft area also increased in LP (6%) and ON (9%), as did glomerular cellularity (LP, +11%; ON, +12%). In the oxidative stress analyses, both nutritional insults significantly elevated lipid peroxidation (LP, +18%; ON, +135%) and protein oxidation (LP, +40%; ON, +65%) while significantly reducing nonenzymatic antioxidant defenses, measured as reduced glutathione (LP, –32%; ON, –45%) and total thiol content (LP, –28%; ON, –24%). We also observed a decrease in superoxide dismutase (LP, –78%; ON, –51%), catalase (LP, –18%; ON, –61%), and glutathione S-transferase (only in ON, –44%) activities. Our results demonstrate that nutritional insults, even those of a very different nature, during perinatal development can result in similar changes in oxidative parameters and glomerular morphology in the renal cortex.

Changes in coronary arteries of mice fed a high-fat, low-protein diet followed by a normal diet

1969 ◽  
Vol 165 (3) ◽  
pp. 379-389
Author(s):  
Allen D. Ashburn ◽  
George T. Smith-Vaniz ◽  
Jack L. Wilson ◽  
W. Lane Williams
Keyword(s):  
Coronary Arteries ◽  
Normal Diet ◽  
Protein Diet ◽  
Low Protein Diet ◽  
High Fat ◽  
Low Protein

scholarly journals Somatomedin-C and zinc status in rats as affected by Zn, protein and food intake

1986 ◽  
Vol 56 (1) ◽  
pp. 163-169 ◽  
Author(s):  
Zafrallah T. Cossack
Keyword(s):  
Food Intake ◽  
Body Weight Gain ◽  
Experimental Period ◽  
Optimal Level ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Control Group ◽  
Somatomedin C ◽  
Low Protein ◽  
Adequate Food

1. The objective of the present experiment was to study the level of plasma somatomedin-C (SM-C) and the status of zinc in rats as affected by three levels of Zn given in combinations with two levels of protein.2. Six groups of rats were fed, for 21 d, on six different diets based on combinations of two levels of dietary protein (low protein, 75 g/kg; high protein, 200 g/kg) and three levels of zinc (low Zn, 0.9 pglkg; moderate Zn, 55 pg/kg; high Zn, 110 pglkg). All groups were pair-fed with the group receiving the low-Zn-low-protein diet. An additional group of six rats served as an ad lib.-fed control group and was fed on a diet that contained 55 pg Zn/kg and 200 g protein/kg ad lib.3. Body-weight gain and food intake were recorded daily. Rats were killed at the end of the experimental period (21 d). Zn was assayed in plasma, tibia and liver by atomic absorption technique. Plasma SM-C was assayed by radioimmunoassay.4. In rats given the low-Zn-low-protein diet, the level of plasma SM-C increased in response to the increase in the amount of Zn or Zn and protein in the diet. However, no change was observed when the level of protein alone was increased.5. Among all groups tested, adlib.-fed rats showed the highest level of plasma SM-C. Thus it may be concluded that a balanced diet combined with adequate food intake is necessary to maintain an optimal level of plasma SM-C.

Immunohistochemical detection of changes in growth hormone cells in rat pituitaries in protein deficiency

1975 ◽  
Vol 33 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Therese Drummond
Keyword(s):  
Growth Hormone ◽  
Normal Diet ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Immunohistochemical Method ◽  
Deficient Diet ◽  
Low Protein ◽  
Gh Cells ◽  
Protein Free Diet ◽  
Cell Changes

1. An immunohistochemical method was used to study the effect of a low-protein diet on growth hormone (GH) cells in the pituitaries of developing rats. The deficient diet (80 g protein/kg) was administered during gestation and lactation, or during the time after weaning until 90 d of age, or during both periods.2. GH-cell changes were much more striking in males than in females.3. In males, GH-producing cells were usually reduced in size and number in all treatments. The effect was most intense when protein deprivation occurred throughout gestation and sucking, and continued until 90 d of age, but it was also evident in animals given the low protein diet only after weaning. Recuperation appeared to be almost complete when offspring of deprived dams were fed on a normal diet after weaning.4. It is concluded that a low-protein diet reduces the amount of GH in the rat pituitary in a way similar to that with a protein-free diet.

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