Bulbospinal serotonergic activity during changes in thyroid status

1998 ◽  
Vol 76 (12) ◽  
pp. 1120-1131 ◽  
Author(s):  
William N Henley ◽  
Linda L Bellush ◽  
Marc Tressler
Keyword(s):  
Thyroid Hormone ◽  
Primary Hypothyroidism ◽  
Glycemic Status ◽  
Thyroid Status ◽  
Hormone Levels ◽  
Serotonergic Activity ◽  
Thyroid Hormone Levels ◽  
The Brain ◽  
Circulating Levels ◽  
Very High

A three-part study explored the basis for an interaction between changes in thyroid status and bulbospinal serotonin (5HT) metabolism. In experiment 1, three well-characterized models of primary hypothyroidism were all accompanied by significant increases in 5HT metabolism. In experiment 2, circulating thyroid hormone levels were experimentally varied from very low methimazole (Meth) treatment to very high (T3 implants: 2.5, 5.0, or 7.5 mg triiodothyronine). As in experiment 1, Meth led to elevated 5HT. Hyperthyroidism was accompanied by significant reductions in 5HT, while urinary norepinephrine excretion paralleled 5HT. In experiment 3, rats were subjected to Meth either 2 weeks before or after induction of diabetes with streptozotocin (Stz). Meth prevented Stz-associated reductions in 5HT and attenuated development of hyperphagia. Meth could not reverse established Stz-associated reduction in 5HT or hyperphagia, although both were slightly attenuated. Thus, although the first two experiments argue for a simple inverse relationship between circulating thyroid hormone levels and 5HT in the brain, experiment 3 demonstrated that Stz-associated decrements in 5HT could not be reversed by subsequent lowering of circulating thyroid hormone. Nor did accompanying measurements indicate that glycemic status or circulating levels of leptin were important predictors of 5HT. Thus the interaction between thyroid hormones and 5HT is both more subtle and more complex than previously thought.Key words: hypothyroidism, hyperthyroidism, serotonin, diabetes mellitus.

Thyroid hormone levels in flow-challenged adult salmon (Salmo salar L.)

1989 ◽  
Vol 67 (8) ◽  
pp. 1851-1855 ◽  
Author(s):  
A. F. Youngson ◽  
H. A. McLay
Keyword(s):  
Thyroid Hormone ◽  
Steroid Hormones ◽  
Salmo Salar ◽  
Water Velocity ◽  
Male Fish ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Circulating Levels

Circulating levels of thyroid and steroid hormones in salmon (Salmo salar) that had spent one winter in seawater have been determined in fish at rest and after a 4-h exposure to increased water velocity. The responses of fish of both sexes to this challenge were examined in April and June, while the fish were in seawater; sexually maturing males only were examined in freshwater in August and November. Mean thyroxine levels in resting controls ranged from 8.8 to 15.2 ng/mL. Mean thyroxine levels in challenged fish were significantly greater on each occasion. In male fish, 11-oxotestosterone levels were reduced after challenge, while androstenedione levels in females remained unchanged. In April, thyroxine levels after challenge were correlated with 11-oxotestosterone levels in males and with androstenedione levels in females.

scholarly journals Transthyretin Regulates Thyroid Hormone Levels in the Choroid Plexus, But Not in the Brain Parenchyma: Study in a Transthyretin-Null Mouse Model*

Endocrinology ◽  
2000 ◽  
Vol 141 (9) ◽  
pp. 3267-3272 ◽  
Author(s):  
Joana Almeida Palha ◽  
Rui Fernandes ◽  
Gabriella Morreale de Escobar ◽  
Vasso Episkopou ◽  
Max Gottesman ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Mouse Model ◽  
Choroid Plexus ◽  
Brain Parenchyma ◽  
Null Mouse ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
The Brain

scholarly journals Bone metabolism during substitution therapy of primary hypothyroidism

2009 ◽  
Vol 62 (9-10) ◽  
pp. 407-411
Author(s):  
Radoslav Pejin ◽  
Nikola Curic ◽  
Branka Kovacev-Zavisic ◽  
Ljiljana Todorovic-Djilas
Keyword(s):  
Thyroid Hormone ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Calcium Metabolism ◽  
Primary Hypothyroidism ◽  
Hormone Levels ◽  
Thyroxine Therapy ◽  
Euthyroid Status ◽  
Thyroid Hormone Levels ◽  
Hypothyroid Patients

Introduction. The relation between thyroid hormones and bone metabolism markers in hyperthyroidism is well known. Earlier studies indicate the possibility of bone metabolism acceleration during the excessive replacement therapy with l-thyroxin in hypothyroid patients especially in one with other risk factors for bone metabolism impairment. This study evaluated the effect of physiological l-thyroxine treatment on bone metabolism in patient with primary hypothyroidism. Material and methods. In the study group of 30 hypothyroid patients individual thyroxine replacement was performed targeting euthyroid status. Bone and calcium metabolism parameters (osteocalcin-OC, alkaline phosphates-ALP, C-terminal cross-linking telopeptide type I-CL, parathormone-PTH, Ca, ionized Ca, P), thyroid hormone levels (T3, T4, TSH) were measured before treatment and when euthyroid status was achieved. Results and discussion. A significant treatment effect was observed for bone formation and resorption parameters before and during the therapy; OC (p=0.000024), CL (p=0.002648). Ionized calcium levels also showed significantly higher values in euthyroid status confirming bone metabolism acceleration during the l-thyroxine therapy (p= 0.020). Thus, calcium metabolism hormone regulators were not significantly different before and after the therapy; PTH (p=0.27). Thyroid hormone levels showed significant correlation with bone metabolism parameters before the therapy whereas this correlation was not found during therapy because of different individual l-thyroxine doses. Conclusion. It can be concluded that physiological doses of l-thyroxine therapy accelerate bone metabolism in hypothyroid patients. Thus, the argument against bone loss during physiological substitution is highly specific mutual correlation between bone formation and resorption parameters. These assumptions require further investigations in long term prospective studies in patients on replacement l-thyroxine therapy.

scholarly journals THYROID STATUS IN CHILDREN WITH TYPE 1 DIABETES MELLITUS

2021 ◽  
Vol 06 (01) ◽  
pp. 71-72
Author(s):  
Zhanar Nurgaliyeva Zhanar Nurgaliyeva ◽  
Araily Manasbaeva Araily Manasbaeva ◽  
Sakhipzhamal Sabirova Sakhipzhamal Sabirova ◽  
Saiyara Nadyrova Saiyara Nadyrova ◽  
Alfira Muratkhan Alfira Muratkhan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Thyroid Hormone ◽  
Autoimmune Thyroiditis ◽  
Laboratory Data ◽  
Thyroid Status ◽  
Free T4 ◽  
Hormone Levels ◽  
Functional Changes ◽  
Free T3 ◽  
Thyroid Hormone Levels

The mutually aggravating effect of comorbid diseases of diabetes mellitus (DM) and autoimmune thyroiditis (AIT) is of scientific interest to researchers. Timely assessment of the thyroid status in children with DM and correction of thyroid pathology (TP) will improve metabolic control in these patients. Аmong 972 children with DM, 478 (49.2%) were assessed for thyroid status. It is noted that every year the determination of thyroid hormone levels in children increased from 7.6% (in 2014) to 92.1% (in 2019). Among 478 examined children, 319 (66.7%) had significantly revealed thyroid dysfunction. In the structure of thyroid pathologies, the frequency of hypothyroidism was 12.5% (in 11.3% - subclinical form), hyperthyroidism - 4%. functional changes in the concentration of thyroid hormones as Euthyroid sick syndrome were observed in 23.8%. The most common type of dysfunction was an isolated increase in free T3 (isolated T3 toxicosis) – in 43.3% of cases. In 2 cases out of 18 (0.6%), a complete picture of AIT was presented, and in the remaining 16 (5.1%), signs of AIT were observed only on ultrasound of the thyroid gland, and were not confirmed by the concentrations of anti-TPO Ab, anti-TG Ab. In 47 (14.7%) children, laboratory data on thyroid hormone levels showed elevated values of TSH, free T3, free T4. Keywords: children, diabetes mellitus, thyroid status, autoimmune thyroiditis

A Study of Thyroid Function in Psychiatric In-patients

1978 ◽  
Vol 133 (3) ◽  
pp. 211-218 ◽  
Author(s):  
D. G. McLarty ◽  
W. A. Ratcliffe ◽  
J. G. Ratcliffe ◽  
J. G. Shimmins ◽  
A. Goldberg
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Age Distribution ◽  
Psychiatric Hospitals ◽  
Primary Hypothyroidism ◽  
Hormone Levels ◽  
Total Thyroxine ◽  
Thyroid Hormone Levels

SummaryThe prevalence of abnormal serum total thyroxine (T4) and triiodothyronine (T3) concentrations were determined in 1,206 in-patients in two associated psychiatric hospitals. The biochemical pattern of primary hypothyroidism occurred in five females and one male (prevalence 0.5 per cent), but in only one patient was the diagnosis clinically obvious. Eight patients (all female) were clinically hyperthyroid (prevalence 0.7 per cent), of whom six were previously undiagnosed. There was no evidence that phenothiazines or benzodiazepine therapy had any significant effect on thyroid hormone levels. The small differences in thyroid hormone levels between psychiatric diagnostic groups could be explained by differences in age distribution.

Serum T3 and T4 Levels in Sick Children

PEDIATRICS ◽  
1976 ◽  
Vol 58 (5) ◽  
pp. 776-776
Author(s):  
J. N. Carter ◽  
J. M. Corcoran ◽  
C. J. Eastman ◽  
L. Lazarus ◽  
M. O'Halloran
Keyword(s):  
Thyroid Hormone ◽  
Normal Range ◽  
Hormone Levels ◽  
Serum T3 ◽  
The Mean ◽  
Thyroid Hormone Levels ◽  
Sick Children ◽  
Circulating Levels ◽  
Tsh Levels ◽  
Sick Euthyroid

We have reported that most adults with severe, chronic, nonthyroidal illnesses (i.e., sick euthyroid patients) have significantly decreased circulating levels of triiodothyronine (T3) and thyroxine (T4), whilst the thyrotropin (TSH) levels are not elevated.1 The T3 levels are usually reduced into the hypothyroid range, whilst the T4 levels generally remain within the normal range. The patients in that study were aged from 21 to 84 years. We have recently concluded a study of circulating thyroid hormone levels in children of various ages and have found that the mean levels of both T3 and T4 are higher than in adults.

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