Pharmacological Studies on Substances of Plant Origin with Coronary Dilatating and Antiarrhythmic Action

1978 ◽  
Vol 06 (02) ◽  
pp. 123-130 ◽  
Author(s):  
V. PETKOV ◽  
P. MANOLOV
Keyword(s):  
Coronary Flow ◽  
Coronary Spasm ◽  
Rabbit Heart ◽  
Biologically Active ◽  
Antiarrhythmic Action ◽  
Oxygen Utilization ◽  
Coronary Insufficiency ◽  
Clear Cut ◽  
Natural Substances ◽  
Pharmacological Studies

Studies were made of the action of biologically active substances isolated from medicinal plants on the coronary circulation under normal conditions and under conditions of induced coronary insufficiency, as well as on models of rhythmic disturbances provoked by different methods. The substances tested were: iridoid Oleuropein isolated from the olive leaves (Olea europaea); valepotriatic fraction V pt2 isolated for the valerian roots (Valeriana officinalis), all the flavonoids named crataemon and the hyperoside isolated from it, obtained from the flowers and leaves of hawthorn (Crataegus monogina); and all the furocoumarines named peucordin isolated from Peucedanum officinale. The results of these studies suggest that oleuropein, the valepotratic fraction, carataemon, hyperoside, and peucordin produce a clear-cut coronary dilatory action. The coronary flow of a rabbit heart isolated after the method of Langendorf was found to increase by more than 160% by crataemon (2×10-5), hyperoside (1×10-5) and peucordin (2×10-5) and more than 50% by oleuropein and the valepotriatic fraction. This effect of cratemon, hyperoside, and peucordin showed them to be superior to prenylamine. The coronary dilatory effect was also evaluated in experiments on whole organism (cats). It was found that in a dose of 10 mg/kg, peucordin increased the coronary flow by 82% hyperoside by 47%; crataemon, by 37% and the valepotriatic fraction, by 30%. The natural substances tested also eliminated induced pituitrin coronary spasm (experiments on unanaesthetized rabbits). Some of these substances showed a marked antiarrhythmic action, too. Oleuropein was active against BaCl2-induced arrhythmia (in rabbits) and against calcium-induced arrhythmia (in rats); it weakened the aconitine-induced arrhythmia. Crataemon also exerted a clear-cut effect on some kinds of induced arrhythmia. Crataemon and peucordin decrease oxygen utilization in the myocardium.

scholarly journals Ethnobotanical, phytochemical and pharmacological aspects of Bengal Pogostemon (Pogostemon benghalensis)

2020 ◽  
Vol 9 (4) ◽  
pp. 318-327
Author(s):  
Sangeeta Dahiya ◽  
Daizy R. Batish ◽  
Harminader Pal Singh
Keyword(s):  
Molecular Level ◽  
Antioxidant Activities ◽  
Chemical Compounds ◽  
Biologically Active ◽  
Pharmacological Activities ◽  
Plant Parts ◽  
Chemical Structures ◽  
Traditional Uses ◽  
Traditional Remedies ◽  
Pharmacological Studies

Pogostemon benghalensis (Burm.f.) Kuntze (Lamiaceae) is an important aromatic plant. Multiple classes of phytochemicals such as flavonoids, phenols, phytosteroids, carbohydrates, fatty acids, glycosides, sterols, terpenoids, tannins, essential oil, and alkaloids have been isolated from the title species. Different plant parts have been used as traditional remedies for various ailments. The present review aims to update and coherent the fragmented information on botanical aspects, phytochemistry, traditional uses, and pharmacological activities. An extensive review of the literature was carried out by using various search engines like PubMed, Scopus, Science Direct, Google Scholar, Google, Scifinder for information. The articles were searched using the keywords "Pogostemon", "Parviflorus’, "benghalensis". Chemical structures of the chemical compounds were drawn using software Chem Draw ultra 8.0. Most of the plant parts have been used for the treatment of various ailments. Phytochemistry reveals that the plant is a rich source of various biologically active compounds. Pogostemon extracts exhibited numerous pharmacological effects like anticancer, anti-inflammatory, antimicrobial and antioxidant activities. In sum, P. benghalensis is a promising aromatic and medicinal plant as depicted by its various traditional uses and pharmacological studies. Bioactive compounds, responsible for its various pharmacological activities at the molecular level, need further detailed investigations. Future clinical studies are also required to validate the various traditional uses of P. benghalensis.

Factors regulating basal metabolism of the isolated perfused rabbit heart

1986 ◽  
Vol 250 (6) ◽  
pp. H998-H1007 ◽  
Author(s):  
C. L. Gibbs ◽  
G. Kotsanas
Keyword(s):  
Metabolic Rate ◽  
Coronary Flow ◽  
Constant Pressure ◽  
Rabbit Heart ◽  
Basal Metabolism ◽  
Papillary Muscles ◽  
O2 Consumption ◽  
Calcium Depletion ◽  
Experimental Conditions ◽  
High K

Basal metabolism has been measured in isolated whole hearts from rabbits and compared with myothermic and polarographic measurements on isolated papillary muscles. Hearts were perfused at constant pressure (Langendorff method) using a modified Krebs-Henseleit solution (KH) with glucose as substrate. Higher levels of basal O2 consumption (MVO2) and coronary flow (CF) were observed when arrest was induced by calcium depletion (low Ca; 0.1 mM CaCl2, 10.0 mM KCl) rather than by potassium excess (high K; 30.0 mM KCl). The metabolic rate of high K arrested hearts was close to earlier myothermic estimates (J. Mol. Cell. Cardiol. 16: 953-962, 1984); polarographic values, however, were about twofold higher, and somewhat higher than the value obtained in low Ca arrested hearts. The addition of erythrocytes, albumin, or dextran significantly reduced CF but did not substantially alter basal MVO2. Basal metabolic rate was substrate- and O2 tension-dependent, and under all experimental conditions there was linear relationship between MVO2 and CF. Extrapolations to zero flow showed that the basal MVO2 values so obtained were similar in low Ca or high K and were not altered by the presence of erythrocytes. Our results show that there are several factors regulating basal metabolism.

scholarly journals A New Hybrid δ-Lactone Induces Apoptosis and Potentiates Anticancer Activity of Taxol in HL-60 Human Leukemia Cells

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1479 ◽  
Author(s):  
Katarzyna Gach-Janczak ◽  
Joanna Drogosz-Stachowicz ◽  
Angelika Długosz-Pokorska ◽  
Rafał Jakubowski ◽  
Tomasz Janecki ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Anticancer Agents ◽  
Biologically Active ◽  
Human Leukemia ◽  
Apoptosis Induction ◽  
Hybrid Compound ◽  
Drug Candidates ◽  
Natural Substances ◽  
High Cytotoxic Activity ◽  
Induced Apoptosis

In the search for new drug candidates, researchers turn to natural substances isolated from plants which may be either used directly or may serve as a source for chemical modifications. An interesting strategy in the design of novel anticancer agents is based on the conjugation of two or more biologically active structural motifs into one hybrid compound. In this study, we investigated the anticancer potential of 4-benzyl-5,7-dimethoxy-4-methyl-3-methylidene-3,4-dihydro-2H-chroman-2-one (DL-247), a new hybrid molecule combining a chroman-2-one skeleton with an exo-methylidene bond conjugated with a carbonyl group, in human myeloid leukemia HL-60 cell line. The cytotoxicity of the new compound was tested using MTT assay. The effect of DL-247 on cell proliferation and apoptosis induction were studied by flow cytometry, fluorometric assay and ELISA analysis. DL-247 displayed high cytotoxic activity (IC50 = 1.15 µM, after 24 h incubation), significantly inhibited cell proliferation and induced apoptosis by both, the intrinsic and extrinsic pathways. A combination of DL-247 with taxol exhibited a strong synergistic effect on DNA damage generation, apoptosis induction and inhibition of cell growth.

Relation of coronary flow to oxygen supply

1960 ◽  
Vol 199 (1) ◽  
pp. 179-182 ◽  
Author(s):  
Abraham Guz ◽  
George S. Kurland ◽  
A. Stone Freedberg
Keyword(s):  
Heart Rate ◽  
Oxygen Consumption ◽  
Oxygen Content ◽  
Coronary Flow ◽  
Constant Pressure ◽  
Rabbit Heart ◽  
Hemoglobin Solution ◽  
Oxygen Capacity ◽  
Locke Solution ◽  
Solution Change

Coronary flow, heart rate, myocardial oxygen consumption and Walton strain gauge tension were determined in the isolated rabbit heart perfused with hemoglobin solutions of varying oxygen content. Perfusion was carried out under constant pressure and with the hemoglobin solution in equilibrium with 3% CO2 and 97% air under atmospheric tension. Oxygen content was varied from 2 to 18 vol. % by diluting hemoglobin with Ringer-Locke solution. Change from a higher to lower oxyhemoglobin concentration resulted in increased coronary flow; the reserve led to decreased flow. Heart rate, myocardial tension and oxygen consumption were constant at oxygen capacity above 2 vol. %.

scholarly journals Microalgal Biostimulants and Biofertilisers in Crop Productions

Agronomy ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 192 ◽  
Author(s):  
Domenico Ronga ◽  
Elisa Biazzi ◽  
Katia Parati ◽  
Domenico Carminati ◽  
Elio Carminati ◽  
...  
Keyword(s):  
Plant Growth ◽  
Abiotic Stresses ◽  
Crop Production ◽  
Crop Yields ◽  
Foliar Application ◽  
Crop Protection ◽  
Seed Priming ◽  
Biologically Active ◽  
Agricultural Sustainability ◽  
Natural Substances

Microalgae are attracting the interest of agrochemical industries and farmers, due to their biostimulant and biofertiliser properties. Microalgal biostimulants (MBS) and biofertilisers (MBF) might be used in crop production to increase agricultural sustainability. Biostimulants are products derived from organic material that, applied in small quantities, are able to stimulate the growth and development of several crops under both optimal and stressful conditions. Biofertilisers are products containing living microorganisms or natural substances that are able to improve chemical and biological soil properties, stimulating plant growth, and restoring soil fertility. This review is aimed at reporting developments in the processing of MBS and MBF, summarising the biologically-active compounds, and examining the researches supporting the use of MBS and MBF for managing productivity and abiotic stresses in crop productions. Microalgae are used in agriculture in different applications, such as amendment, foliar application, and seed priming. MBS and MBF might be applied as an alternative technique, or used in conjunction with synthetic fertilisers, crop protection products and plant growth regulators, generating multiple benefits, such as enhanced rooting, higher crop yields and quality and tolerance to drought and salt. Worldwide, MBS and MBF remain largely unexploited, such that this study highlights some of the current researches and future development priorities.

Tetraethylammonium induced coronary spasm in isolated perfused rabbit heart: a hypothesis for the mechanism of coronary spasm

1987 ◽  
Vol 21 (2) ◽  
pp. 130-139 ◽  
Author(s):  
M. IWAKI ◽  
S. MIZOBUCHI ◽  
Y. NAKAYA ◽  
K. KAWANO ◽  
T. NIKI ◽  
...  
Keyword(s):  
Coronary Spasm ◽  
Rabbit Heart ◽  
Perfused Rabbit Heart

scholarly journals Extensive unroofing of myocardial bridge: A case report and literature review

2019 ◽  
Vol 7 ◽  
pp. 2050313X1882338 ◽  
Author(s):  
Salvior Mok ◽  
David Majdalany ◽  
Gosta B Pettersson
Keyword(s):  
Fractional Flow Reserve ◽  
Aortic Surgery ◽  
Coronary Spasm ◽  
Management Decision ◽  
Fractional Flow ◽  
Myocardial Bridge ◽  
Coronary Insufficiency ◽  
Left Anterior Descending Artery ◽  
Flow Reserve ◽  
Multiple Imaging

Background: Myocardial bridge is defined as a segment of a coronary artery that takes an intramyocardial course. The presence of myocardial bridge has been observed in as many as 40%–80% of cases on autopsy, angiographically from 0.5% to 16.0%, and often asymptomatic. However, it has been associated with angina, coronary spasm, myocardial infarction, arrhythmias, syncope, sudden cardiac arrest, and death. Conflicting opinions exist on the timing of surgical intervention for myocardial bridge. Methods: We present an unusual case of a young female, with prior aortic surgery, who had refractory chest pain despite optimal medical therapy. Stress testing revealed anterior ischemia. Cardiac catherization showed myocardial bridge of the left anterior descending artery with significant compromise of blood flow (fractional flow reserve = 0.75 with adenosine). We proceeded with surgery. Intraoperatively, we found an unusually long (10-cm) intramyocardial segment of the left anterior descending artery which was managed by surgically unroofing. Our patient felt better post procedure. Repeat cardiac catheterization showed no further narrowing of the left anterior descending artery with a fractional flow reserve of 0.87 in its distal segment. Results/discussion: Myocardial bridge is present mostly in female patients (74.5%), with median age at 56.2 years and mostly involving the left anterior descending artery (77.2%). The average length of myocardial bridge is 21.85 ± 16.10 mm (range: 5–70 mm). Our case is unique as the involved myocardial bridge was 10 cm in length, the longest ever reported. Multiple imaging modality revealed significant coronary insufficiency, with a subsequent clinical and angiographic improvement upon unroofing of the culprit coronary vessel. Conclusion: Management decision on myocardial bridge remains controversial. This is a case of the longest symptomatic myocardial bridge, with a subsequent improvement post unroofing.

Intrinsic changes on automatism, conduction, and refractoriness by exercise in isolated rabbit heart

2002 ◽  
Vol 92 (1) ◽  
pp. 225-229 ◽  
Author(s):  
L. Such ◽  
A. Rodriguez ◽  
A. Alberola ◽  
L. Lopez ◽  
R. Ruiz ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Coronary Flow ◽  
Sinus Node ◽  
Thiobarbituric Acid ◽  
Rabbit Heart ◽  
Conduction Time ◽  
Refractory Periods ◽  
Liver And Kidney ◽  
Acid Reagent ◽  
Retrograde Conduction

We have studied the intrinsic modifications on myocardial automatism, conduction, and refractoriness produced by chronic exercise. Experiments were performed on isolated rabbit hearts. Trained animals were submitted to exercise on a treadmill. The parameters investigated were 1) R-R interval, noncorrected and corrected sinus node recovery time (SNRT) as automatism index; 2) sinoatrial conduction time; 3) Wenckebach cycle length (WCL) and retrograde WCL, as atrioventricular (A-V) and ventriculoatrial conduction index; and 4) effective and functional refractory periods of left ventricle, A-V node, and ventriculoatrial retrograde conduction system. Measurements were also performed on coronary flow, weight of the hearts, and thiobarbituric acid reagent substances and glutathione in myocardium, quadriceps femoris muscle, liver, and kidney, to analyze whether these substances related to oxidative stress were modified by training. The following parameters were larger ( P < 0.05) in trained vs. untrained animals: R-R interval (365 ± 49 vs. 286 ± 60 ms), WCL (177 ± 20 vs. 146 ± 32 ms), and functional refractory period of the left ventricle (172 ± 27 vs. 141 ± 5 ms). Corrected SNRT was not different between groups despite the larger noncorrected SNRT obtained in trained animals. Thus training depresses sinus chronotropism, A-V nodal conduction, and increases ventricular refractoriness by intrinsic mechanisms, which do not involve changes in myocardial mass and/or coronary flow.

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