Stochastic Sensitivity and Method of Principal Directions in Excitability Analysis of the Hodgkin–Huxley Model

2019 ◽  
Vol 29 (13) ◽  
pp. 1950186 ◽  
Author(s):  
Irina Bashkirtseva ◽  
Lev Ryashko

We study the probabilistic behavior of the Hodgkin–Huxley neuron model in the presence of random forcing of the external current parameter. The stochastic excitement in the zone of stable equilibria is illustrated by the statistics of interspike intervals and probabilistic distributions of mixed-mode oscillations. For the parametric analysis of this phenomenon, a constructive method for stochastic sensitivity and confidence ellipsoids is suggested. It is shown how to simplify this analysis using the principal direction approach. A constructive application of this technique is demonstrated by analyzing the stochastic excitement in the Hodgkin–Huxley model.

Author(s):  
I. Bashkirtseva ◽  
E. Slepukhina

Processes of the cold-flame combustion of a mixture of two hydrocarbons are studied on the base of a three-dimensional nonlinear dynamical model. Bifurcation analysis of the deterministic model reveals mono- and bistability parameter zones with equilibrium and oscillatory attractors. For this model, effects of random disturbances in the bistability parameter zone are studied. We show that random forcing causes transitions between coexisting stable equilibria and limit cycles with the formation of complex stochastic mixed-mode oscillations. Properties of these oscillatory regimes are studied by means of statistics of interspike intervals. A phenomenon of anti-coherence resonance is discussed. This article is part of the theme issue ‘Transport phenomena in complex systems (part 2)’.


Author(s):  
Jochen Jungeilges ◽  
Elena Maklakova ◽  
Tatyana Perevalova

AbstractWe study the price dynamics generated by a stochastic version of a Day–Huang type asset market model with heterogenous, interacting market participants. To facilitate the analysis, we introduce a methodology that allows us to assess the consequences of changes in uncertainty on the dynamics of an asset price process close to stable equilibria. In particular, we focus on noise-induced transitions between bull and bear states of the market under additive as well as parametric noise. Our results are obtained by combining the stochastic sensitivity function (SSF) approach, a mixture of analytical and numerical techniques, due to Mil’shtein and Ryashko (1995) with concepts and techniques from the study of non-smooth 1D maps. We find that the stochastic sensitivity of the respective bull and bear equilibria in the presence of additive noise is higher than under parametric noise. Thus, recurrent transitions are likely to be observed already for relatively low intensities of additive noise.


1969 ◽  
Vol 24 (11) ◽  
pp. 1746-1751 ◽  
Author(s):  
D. van Ormondt ◽  
R. de Beer ◽  
M. Brouha ◽  
F. de Groot

Abstract The elements of the hyperfine interaction (h.f.i.) between the manganese ion and the protons in the complex [Mn(H2O)6]++ in one of the two possible sites in La2(Mg, Mn)3(NO3)12 · 24 H2O have been measured with ENDOR at 15 to 20 K. The six water molecules in the complex at the chosen site are equivalent for reasons of symmetry.One principal direction of the h.f.i. tensor of each proton is found to be perpendicular to the Mn, O line. With the assumption that each proton is located in the plane of the other two principal directions of its interaction tensor the positions of the protons are evaluated from the anisotropic parts of the h.f.i. tensors. In this calculation the effect of covalency on the anisotropic h.f.i. is ac-counted for with the aid of a simple model.The isotropic h.f.i.'s with the two protons of a water molecule appear to be very nearly equal (+ 0.890 MHz for both). This latter result is remarkable in view of the fact that one proton is distinctly nearer to the manganese ion than the other.


Geophysics ◽  
1998 ◽  
Vol 63 (2) ◽  
pp. 692-706 ◽  
Author(s):  
Subhashis Mallick ◽  
Kenneth L. Craft ◽  
Laurent J. Meister ◽  
Ronald E. Chambers

In an azimuthally anisotropic medium, the principal directions of azimuthal anisotropy are the directions along which the quasi-P- and the quasi-S-waves propagate as pure P and S modes. When azimuthal anisotropy is induced by oriented vertical fractures imposed on an azimuthally isotropic background, two of these principal directions correspond to the directions parallel and perpendicular to the fractures. S-waves propagating through an azimuthally anisotropic medium are sensitive to the direction of their propagation with respect to the principal directions. As a result, primary or mode‐converted multicomponent S-wave data are used to obtain the principal directions. Apart from high acquisition cost, processing and interpretation of multicomponent data require a technology that the seismic industry has not fully developed. Anisotropy detection from conventional P-wave data, on the other hand, has been limited to a few qualitative studies of the amplitude variation with offset (AVO) for different azimuthal directions. To quantify the azimuthal AVO, we studied the amplitude variation with azimuth for P-wave data at fixed offsets. Our results show that such amplitude variation with azimuth is periodic in 2θ, θ being the orientation of the shooting direction with respect to one of the principal directions. For fracture‐induced anisotropy, this principal direction corresponds to the direction parallel or perpendicular to the fractures. We use this periodic azimuthal dependence of P-wave reflection amplitudes to identify two distinct cases of anisotropy detection. The first case is an exactly determined one, where we have observations from three azimuthal lines for every common‐midpoint (CMP) location. We derive equations to compute the orientation of the principal directions for such a case. The second case is an overdetermined one where we have observations from more than three azimuthal lines. Orientation of the principal direction from such an overdetermined case can be obtained from a least‐squares fit to the reflection amplitudes over all the azimuthal directions or by solving many exactly determined problems. In addition to the orientation angle, a qualitative measure of the degree of azimuthal anisotropy can also be obtained from either of the above two cases. When azimuthal anisotropy is induced by oriented vertical fractures, this qualitative measure of anisotropy is proportional to fracture density. Using synthetic seismograms, we demonstrate the robustness of our method in evaluating the principal directions from conventional P-wave seismic data. We also apply our technique to real P-wave data, collected over a wide source‐to‐receiver azimuth distribution. Computations using our method gave an orientation of the principal direction consistent with the general fracture orientation in the area as inferred from other geological and geophysical evidence.


Author(s):  
Yaping Zhao ◽  
Chenru Xi ◽  
Yimin Zhang

The computing formulae, in different forms, for the normal vector of the instantaneous contact line are summarized systematically. For some of them, the distinct and sententious proof techniques are put forward. Based on the normal vector of the transient contact line, the computing formulae for the induced normal curvature and the induced geodesic torsion are deduced laconically and strictly. Owing to making use of the normal vector of the transient contact line, the style of the obtained formulae is more elegant. Particularly, a novel developing approach for the computing formula of the induced geodesic torsion is proposed. On the basis of the induced geodesic torsion, the computing formulae for the induced principal directions are derived. From this, the calculating formulae for the induced principal curvatures are obtained rigorously and conveniently. All these work reveal the pivotal position of the normal vector of the momentary contact line in the meshing theory for the line conjugate gearing. By right of the meshing theory established, the meshing analysis for the modified TA worm drive is performed. A number of basic and important formulae are attained and the numerical outcome of the induced principal curvature is given out.


2021 ◽  
pp. 004051752110086
Author(s):  
Hasan Kamrul ◽  
Adeel Zulifqar ◽  
Yadie Yang ◽  
Shuaiquan Zhao ◽  
Minglonghai Zhang ◽  
...  

This paper reports a geometrical analysis of auxetic woven fabrics based on foldable geometry. Two fabrics having different geometrical parameters were first designed and fabricated and then subjected to tensile tests in two principal directions. Based on the experimental observations of the geometry of one fabric structural unit cell at different tensile strains, a geometrical model was first proposed and a relationship between the Poisson’s ratio and tensile strain was then established for each principal direction. Two semi-empirical equations are subsequently obtained for both principal directions by fitting the established relationships with experimental results. After validation by the experimental results of the other fabric, the obtained semi-empirical equations were finally used to predict the auxetic behavior of the fabric with a given geometrical parameter. The calculated and experimental results are found to be in excellent agreement with each other. Therefore, the semi-empirical equations obtained in this study could be useful in the design and prediction of the auxetic behavior of auxetic woven fabrics made with the same type of materials and foldable geometry but with different values of geometrical parameters.


2012 ◽  
Vol 28 (1) ◽  
pp. 385-399 ◽  
Author(s):  
Katsuichiro Goda

This study investigates the orientation dependency of the peak ductility demand of inelastic single-degree-of-freedom (SDOF) systems of known strengths by taking the record-to-record variability of seismic effects into account. The probabilistic characteristics of the peak ductility demand in recording directions on the horizontal plane are compared with those in the maximum elastic response direction and the major principal direction. The analysis results indicate that the peak ductility demand depends on how input ground motions are defined in terms of record orientation. The observed orientation dependency can be explained by noting the response spectral shapes of scaled ground motion records in specific directions. The results have important implications for current earthquake engineering practice, suggesting that separate peak ductility demand models should be used for different ground motion directions to evaluate the seismic performance of structures consistently and without bias.


Author(s):  
I. Bashkirtseva ◽  
A. Pankratov ◽  
E. Slepukhina ◽  
I. Tsvetkov

We study the effects of noise and diffusion in an excitable slow–fast population system of the Leslie–Gower type. The phenomenon of noise-induced excitement is investigated in the zone of stable equilibria near the Andronov–Hopf bifurcation with the Canard explosion. The stochastic generation of mixed-mode oscillations is studied by numerical simulation and stochastic sensitivity analysis. Effects of the diffusion are considered for the spatially distributed variant of this slow–fast population model. The phenomenon of the diffusion-induced generation of spatial patterns-attractors in the Turing instability zone is demonstrated. The multistability and variety of transient processes of the pattern formation are discussed. This article is part of the theme issue ‘Patterns in soft and biological matters’.


1993 ◽  
Vol 47 (12) ◽  
pp. 2135-2139 ◽  
Author(s):  
Bangshu Cao ◽  
Kevin Mar

An optical arrangement using two polarizers is proposed for FT-IR measurement of orientation. Compared with conventional FT-IR using a single polarizer, the new arrangement provides much better discrimination in searching for the principal directions of orientation.


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