BIOBOARD

AUSTRALIA – Centipede venom could lead to new class of pain drug. AUSTRALIA – Artificial nerves in prosthetic limbs to restore touch: study. SINGAPORE – Singapore scientists lead in the discovery of gene responsible for fatal drug allergy. SINGAPORE – ‘Jekyll-and-Hyde’ protein determines life and death of cancer cells. SINGAPORE – A*STAR researchers create novel assay to test for epigenetic abnormalities in pre-implanted mice embryos. SINGAPORE – New hydrogel from IBN and IBM improves delivery of anti-cancer drug. EUROPE – Novel family of natural products antibiotics with broad spectrum against Gram-negative pathogens. NEPAL – Blood proteins could help monitor malnutrition. UK – Developing world faces breast cancer surge, study suggests. US – Positive signs for malaria vaccine based on GM parasite. US – Could one cancer test find unrelated tumors? US – Study suggests blood test can differentiate between benign lung nodules and early stage lung cancer. US – New data obtained from Parkinson's disease program. US – Research study on PAZ320 initiated at University of Minnesota. US – 3D printed structures reveal bacterial ‘chit-chat’.

Download Full-text

Novel 3D printed device with integrated macroscale magnetic field triggerable anti-cancer drug delivery system

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2020.111068 ◽

2020 ◽

Vol 192 ◽

pp. 111068 ◽

Cited By ~ 2

Author(s):

Kejing Shi ◽

Rodrigo Aviles-Espinosa ◽

Elizabeth Rendon-Morales ◽

Lisa Woodbine ◽

Mohammed Maniruzzaman ◽

...

Keyword(s):

Magnetic Field ◽

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Cancer Drug ◽

Anti Cancer ◽

3D Printed ◽

Cancer Drug Delivery

Download Full-text

pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery

Nanomaterials ◽

10.3390/nano10101899 ◽

2020 ◽

Vol 10 (10) ◽

pp. 1899 ◽

Cited By ~ 1

Author(s):

Evgeny Apartsin ◽

Nadezhda Knauer ◽

Valeria Arkhipova ◽

Ekaterina Pashkina ◽

Alina Aktanova ◽

...

Keyword(s):

Drug Delivery ◽

Drug Loading ◽

Drug Carriers ◽

Ph Sensitive ◽

Cancer Drug ◽

Smart Vehicles ◽

New Class ◽

Self Assembling ◽

Anti Cancer ◽

Cancer Drug Delivery

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

Download Full-text

3D Printed Calcium Phosphate Cement (CPC) Scaffolds for Anti-Cancer Drug Delivery

Pharmaceutics ◽

10.3390/pharmaceutics12111077 ◽

2020 ◽

Vol 12 (11) ◽

pp. 1077

Author(s):

Yan Wu ◽

Lisa Woodbine ◽

Antony M. Carr ◽

Amit R. Pillai ◽

Ali Nokhodchi ◽

...

Keyword(s):

Drug Delivery ◽

Calcium Phosphate ◽

Bone Graft ◽

Bone Cancer ◽

Cancer Drug ◽

Anti Cancer ◽

3D Printed ◽

Polymeric Solutions ◽

Cancer Drug Delivery

One of the main applications of bone graft materials is filling the gap after the surgical removal of bone cancer or tumors. Insufficient healing commonly leads to non-union fracture which could lead to cancer resurgence or infection. Emerging 3D printing of on-demand bone graft biomaterials can deliver personalized solutions with minimized risk of relapse and recurrence of cancer after bone removal surgery. This research aims to explore 3D printed calcium phosphate cement (CPC) based scaffolds as novel anti-cancer drug delivery systems to treat bone cancer. For the study, various 3D printed CPC based scaffolds (diameter 5 mm) with interconnected pores were utilized. Various optimized polymeric solutions containing a model anticancer drug 5-fluorouracil (5-FU) was used to homogenously coat the CPC scaffolds. Both hydrophilic Soluplus (SOL) and polyethylene glycol (PEG) and a combination of both were used to develop stable coating solutions. The surface morphology of the coated scaffolds, observed via SEM, revealed deposition of the polymeric solution represented by a semi-smooth surface as opposed to the blank scaffolds that showed a smoother surface. An advanced surface analysis conducted via confocal microscopy showed a homogenous distribution of the drug throughout the coated scaffolds. Solid-state analysis studied by applying differential scanning calorimetry (DSC) and X-ray diffraction (XRD) revealed semi-crystalline nature of the drug whereas mechanical analysis conducted via texture analysis showed no evidence in the change of the mechanical properties of the scaffolds after polymeric solutions were applied. The FTIR analysis revealed no major intermolecular interactions between 5-FU and the polymers used for coatings except for F2 where a potential nominal interaction was evidenced corresponding to higher Soluplus content in the formulation. In vitro dissolution studies showed that almost 100% of the drug released within 2 h for all scaffolds. Moreover, in vitro cell culture using two different cell lines (Hek293T-human kidney immortalized cell line and HeLa-human bone osteosarcoma epithelial cell line) showed significant inhibition of cell growth as a function of decreased numbers of cells after 5 days. It can be claimed that the developed 5-FU coated 3D printed scaffolds can successfully be used as bone graft materials to potentially treat bone cancer or bone neoplasm and for personalized medical solutions in the form of scaffolds for regenerative medicine or tissue engineering applications.

Download Full-text

The Cell Cycle, Cyclins, Checkpoints and Cancer

Asian Journal of Research in Pharmaceutical Science ◽

10.52711/2231-5659.2021-11-2-14 ◽

2021 ◽

Vol 11 (2) ◽

pp. 175-183

Author(s):

Farha Fatma ◽

Anil Kumar

Keyword(s):

Cell Cycle ◽

Quality Control ◽

Normal Cell ◽

Therapeutic Strategies ◽

Cancer Drug ◽

Control Points ◽

Genomic Integrity ◽

New Class ◽

Anti Cancer ◽

Experimental Therapies

Cancer is a serious problem affecting the health of human and isone of the leading cause of mortality worldwide. A normal cell undergoes regulated cell division, differentiation and apoptosis (programmed cell death). When normal cell has lost the usual control over their division, differentiation and apoptosis they become tumor cells. Cancer arises mainly from mutations in somatic cells. Maintenance of genomic integrity is a pre-requisite for a safe and long lasting life. For this purpose, cell has quality control points, referred as checkpoints. The different mechanisms and multiple researchers involved in the field necessiatean understanding of the molecular mechanism to classify tumor and to assess the risk and treatment of disease. Certain therapeutic strategies exist and many more need to be explored. Different experimental therapies are currently in clinical trials and are raising hopes that a new class of anti-cancer drug may soon be available.

Download Full-text