scholarly journals CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES

2014 ◽  
Vol 07 (01) ◽  
pp. 1350029 ◽  
Author(s):  
JUNPING ZHONG ◽  
SIHUA YANG
Keyword(s):  
Indocyanine Green ◽  
Contrast Agents ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Signal Amplitude ◽  
Photoacoustic Signal ◽  
Infrared Wavelength ◽  
Contrast Enhanced ◽  
Human Use ◽  
Good Contrast

Contrast agents are attracting a great deal of attention in photoacoustic imaging. Here we introduce an exogenous contrast agent that provides high photoacoustic signal amplitude at the near-infrared wavelength. Our agents consist of Indocyanine green (ICG) and phospholipid–polyethylene glycol (PL–PEG), entitled ICG–PL–PEG nanoparticles. These nanoparticles have overcome numerous limitations of ICG, such as poor aqueous stability, concentration-dependent aggregation and lack of target specificity. ICG–PL–PEG nanoparticles are biocompatible and relatively nontoxic. All the components of ICG–PL–PEG nanoparticles have been approved for human use. Upon pulsed laser irradiation, the nanoparticles are more efficient in producing photoacoustic waves than ICG alone. The results showed that ICG–PL–PEG nanoparticles act as good contrast agents for photoacoustic imaging. These unique ICG–PL–PEG nanoparticles have great potential in clinical applications.

scholarly journals Cerebral perfusion and blood–brain barrier assessment in brain trauma using contrast-enhanced near-infrared spectroscopy with indocyanine green: A review

2020 ◽  
Vol 40 (8) ◽  
pp. 1586-1598 ◽  
Author(s):  
Mario Forcione ◽  
Antonio M Chiarelli ◽  
David J Davies ◽  
David Perpetuini ◽  
Piotr Sawosz ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Indocyanine Green ◽  
Blood Brain Barrier ◽  
Near Infrared Spectroscopy ◽  
Trauma Care ◽  
Near Infrared ◽  
Clinical Status ◽  
Brain Trauma ◽  
Future Studies ◽  
Contrast Enhanced

Contrast-enhanced near-infrared spectroscopy (NIRS) with indocyanine green (ICG) can be a valid non-invasive, continuous, bedside neuromonitoring tool. However, its usage in moderate and severe traumatic brain injury (TBI) patients can be unprecise due to their clinical status. This review is targeted at researchers and clinicians involved in the development and application of contrast-enhanced NIRS for the care of TBI patients and can be used to design future studies. This review describes the methods developed to monitor the brain perfusion and the blood–brain barrier integrity using the changes of diffuse reflectance during the ICG passage and the results on studies in animals and humans. The limitations in accuracy of these methods when applied on TBI patients and the proposed solutions to overcome them are discussed. Finally, the analysis of relative parameters is proposed as a valid alternative over absolute values to address some current clinical needs in brain trauma care. In conclusion, care should be taken in the translation of the optical signal into absolute physiological parameters of TBI patients, as their clinical status must be taken into consideration. Discussion on where and how future studies should be directed to effectively incorporate contrast-enhanced NIRS into brain trauma care is given.

Tumor homing indocyanine green encapsulated micelles for near infrared and photoacoustic imaging of tumors

2016 ◽  
Vol 104 (4) ◽  
pp. 825-834 ◽  
Author(s):  
Saji Uthaman ◽  
Joon-suk Bom ◽  
Hyeon Sik Kim ◽  
Johnson V. John ◽  
Hee-Seung Bom ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Tumor Homing

scholarly journals Melanin-dot–mediated delivery of metallacycle for NIR-II/photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy

2019 ◽  
Vol 116 (34) ◽  
pp. 16729-16735 ◽  
Author(s):  
Yue Sun ◽  
Feng Ding ◽  
Zhao Chen ◽  
Ruiping Zhang ◽  
Chonglu Li ◽  
...  
Keyword(s):  
Near Infrared ◽  
High Efficiency ◽  
Photoacoustic Imaging ◽  
Photoacoustic Signal ◽  
Single Treatment ◽  
Good Solubility ◽  
Potential Applications ◽  
Good Signal ◽  
Infrared Channel

Discrete Pt(II) metallacycles have potential applications in biomedicine. Herein, we engineered a dual-modal imaging and chemo-photothermal therapeutic nano-agent 1 that incorporates discrete Pt(II) metallacycle 2 and fluorescent dye 3 (emission wavelength in the second near-infrared channel [NIR-II]) into multifunctional melanin dots with photoacoustic signal and photothermal features. Nano-agent 1 has a good solubility, biocompatibility, and stability in vivo. Both photoacoustic imaging and NIR-II imaging in vivo confirmed that 1 can effectively accumulate at tumor sites with good signal-to-background ratio and favorable distribution. Guided by precise dual-modal imaging, nano-agent 1 exhibits a superior antitumor performance and less severe side effects compared with a single treatment because of the high efficiency of the chemo-photothermal synergistic therapy. This study shows that nano-agent 1 provides a promising multifunctional theranostic platform for potential applications in biomedicine.

Nanomaterials for photoacoustic imaging in the second near-infrared window

2019 ◽  
Vol 7 (2) ◽  
pp. 472-479 ◽  
Author(s):  
Kai Huang ◽  
Yifan Zhang ◽  
Jing Lin ◽  
Peng Huang
Keyword(s):  
Contrast Agents ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Tissue Penetration ◽  
Imaging Quality ◽  
Enhanced Imaging ◽  
Infrared Window

The use of nanomaterials as contrast agents for photoacoustic imaging in the NIR-II window enables enhanced imaging quality with deeper tissue penetration.

Indocyanine Green J Aggregates in Polymersomes for Near-Infrared Photoacoustic Imaging

2019 ◽  
Vol 11 (50) ◽  
pp. 46437-46450 ◽  
Author(s):  
Behzad Changalvaie ◽  
Sangheon Han ◽  
Ehsan Moaseri ◽  
Federica Scaletti ◽  
Lauren Truong ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
J Aggregates

scholarly journals A dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapy

2016 ◽  
Vol 4 (9) ◽  
pp. 1696-1703 ◽  
Author(s):  
Shuo Huang ◽  
Paul Kumar Upputuri ◽  
Hui Liu ◽  
Manojit Pramanik ◽  
Mingfeng Wang
Keyword(s):  
Small Molecules ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Photoacoustic Signal ◽  
Colloidal Nanoparticles ◽  
Theranostic Agent ◽  
Dual Functional ◽  
Narrow Bandgap ◽  
Theranostic Agents

Colloidal nanoparticles of BBT-based narrow-bandgap small molecules as theranostic agents show a strong near-infrared photoacoustic signal and high photothermal conversion efficiency.

Push–pull type meso-ester substituted BODIPY near-infrared dyes as contrast agents for photoacoustic imaging

2017 ◽  
Vol 15 (21) ◽  
pp. 4531-4535 ◽  
Author(s):  
Yong Ni ◽  
Ravi Kumar Kannadorai ◽  
Sidney W.-K. Yu ◽  
Young-Tae Chang ◽  
Jishan Wu
Keyword(s):  
Contrast Agents ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Nir Absorption ◽  
Photo Stability

Push–pull meso-ester BODIPYs with intense NIR absorption and good photo-stability were used for in vitro and in vivo photoacoustic imaging.

scholarly journals Degradable mesoporous semimetal antimony nanospheres for near-infrared II multimodal theranostics

2021 ◽  
Author(s):  
Yu Chen ◽  
Zhongzheng Yu ◽  
Yaguang Ren ◽  
Kai Zheng ◽  
Meng Wang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Degradation Mechanism ◽  
Mesoporous Structure ◽  
Photoacoustic Signal ◽  
Selective Etching ◽  
Pore Sizes ◽  
Hydrolytic Reaction ◽  
Mesoporous Structures

Abstract Metallic and semimetallic mesoporous frameworks are of great importance owing to their unique properties and broad applications. However, semimetallic mesoporous structures cannot be obtained by the traditional template-mediated strategies due to the inevitable hydrolytic reaction of semimetal compounds. Therefore, it is yet challenging to fabricate mesoporous semimetal nanostructures, not even mention controlling their pore sizes. Thus, we have developed a facile and robust selective etching route to synthesize monodispersed mesoporous antimony nanospheres (MSbNSs). This is the first report of semimetallic mesoporous structure to the best of our knowledge. The pore sizes of MSbNSs are tunable by carefully controlling the partial oxidation of Sb nuclei and the selective etching of the as-formed Sb2O3. MSbNSs showed a wide absorption from visible to second near-infrared (NIR-II) region. Moreover, PEGylated MSbNSs were degradable and the degradation mechanism was further explained. The NIR-II photothermal performance of MSbNSs was excellent with a high photothermal conversion efficiency of ~44% and intensive NIR-II photoacoustic signal. MSbNSs showed great potential as multifunctional nanomedicines for NIR-II photoacoustic imaging guided synergistic photothermal/chemo therapy in vivo. Our novel selective etching process would contribute to the development of various semimetallic mesoporous structures and efficient multimodal nanoplatforms for theranostics.

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