scholarly journals Contracturing Granulomatous Myositis with Recurrent Malignant Thymoma and Myasthenia Gravis: A Case Report

2021 ◽  
pp. 1-5
Author(s):  
Ching On Luk ◽  
Wai Ting Joyce Lo ◽  
Kitty Yan Kwok ◽  
Moon Ho Leung ◽  
Wing Chi Fong ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Clinical Features ◽  
Case Reports ◽  
Immunoglobulin A ◽  
Chemotherapy Treatment ◽  
Malignant Thymoma ◽  
History Of ◽  
Antibody Levels ◽  
Granulomatous Myositis ◽  
Anti Acetylcholine

Contracturing granulomatous myositis (CGM) is a very rare myopathic syndrome where patients present with slowly progressive muscle pain or weakness affecting mainly proximal muscles together with flexion contractures of the limbs. To date, there have only been several case reports of CGM, which have been reported to occur most commonly in association with sarcoidosis. We report a case of CGM associated with recurrent malignant thymoma and myasthenia gravis (MG). A gentleman with history of treated malignant thymoma presented with new onset proximal muscle weakness and pain that later evolved into contractures that persisted despite treatment with steroids and intravenous immunoglobulin. A malignancy workup revealed recurrence of his malignant thymoma warranting chemotherapy treatment. His contractures only resolved after addition of chemotherapy treatment. He later developed clinical features of MG 1 year after his initial elevation in Anti-acetylcholine (Anti-AChR) antibody levels. We postulate CGM to be a paraneoplastic phenomenon of underlying malignant thymoma. Treatment of thymoma together with immunosuppressive therapies led to clinical improvement of our patient’s CGM. The sole elevation of Anti-AChR levels without the accompanying clinical features does not equate to a MG diagnosis, but should raise the clinician’s vigilance for future development of the condition.

scholarly journals Myasthenia Gravis following Low-Osmolality Iodinated Contrast Media

2014 ◽  
Vol 2014 ◽  
pp. 1-2 ◽  
Author(s):  
Luca Bonanni ◽  
Michele Dalla Vestra ◽  
Andrea Zancanaro ◽  
Fabio Presotto
Keyword(s):  
Contrast Media ◽  
Myasthenia Gravis ◽  
Case Reports ◽  
Orotracheal Intubation ◽  
Myasthenic Crisis ◽  
Iodinate Contrast Agent ◽  
Iodinated Contrast ◽  
History Of ◽  
Total Body ◽  
Progressive Dysphagia

We describe the case of 79-year-old man admitted to our general hospital for a 6-week history of progressive dysphagia to solids and liquids associated with weight loss. To reach a diagnosis a total body CT scan with low-osmolality iodinate contrast agent was performed. Two hours later the patient developed an acute respiratory failure requiring orotracheal intubation and mechanical ventilation. The laboratory and neurological tests allow formulating the diagnosis of myasthenia gravis. In literature, other three case reports have associated myasthenic crisis with exposure to low-osmolality contrast media. This suggests being careful in administering low-osmolality contrast media in myasthenic patients.

Mania and Down's Syndrome

1993 ◽  
Vol 162 (6) ◽  
pp. 739-743 ◽  
Author(s):  
Sally-Ann Cooper ◽  
Richard A. Collacott
Keyword(s):  
Learning Disabilities ◽  
Family History ◽  
Affective Disorder ◽  
Clinical Features ◽  
Case Reports ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Atypical Presentation ◽  
Rapid Cycling ◽  
History Of

Until recently, it was considered that Down's syndrome precluded a diagnosis of mania, or gave rise to an atypical presentation. There have been seven case reports of mania in people with Down's syndrome and all these cases are reviewed. The clinical features of mania are noted to be similar to those previously described in individuals with learning disabilities due to other causes. However, all reported cases are male and none has a family history of affective disorder. In two of the seven men reported, the illness followed a rapid cycling pattern. Hypothyroidism and monoamine biochemistry in people with Down's syndrome are discussed in the context of these atypical features.

scholarly journals Body integrity identity disorder: clinical features and ethical dimensions

2018 ◽  
Vol 25 (3) ◽  
pp. 187-195
Author(s):  
Emma Barrow ◽  
Femi Oyebode
Keyword(s):  
Clinical Features ◽  
Physical Disability ◽  
Parietal Lobe ◽  
Case Reports ◽  
Treatment Options ◽  
List Type ◽  
Bodily Integrity ◽  
Body Integrity Identity Disorder ◽  
History Of ◽  
Self Harm

SUMMARYBody integrity identity disorder (BIID) is a rare and complex identity disorder described by the desire to acquire a physical disability and an associated sense of incompleteness at being able-bodied. Individuals with the disorder often delay presentation until later in life because of perceived stigma about wishing to acquire a physical disability, and may have sought amputation already through ‘underground’ means or self-harm (attempts at self-amputation). In this article we present an account of the recent history and origins of the disorder, from its early descriptions and case reports through to the current neuropsychiatric theory of right superior parietal lobe dysfunction as basis for the disorder. We consider the epidemiology, pathogenesis and clinical features of this identity disorder of bodily integrity, highlighting the associations with conditions such as gender identity disorder. With this we then discuss the ethical considerations for available treatment options, mainly elective surgical amputation.LEARNING OBJECTIVES•Understand the current definition and clinical features of body integrity identity disorder•Be familiar with the conceptual history of the disorder, epidemiology and current neuropsychiatric perspective•Be aware of the ethical aspects of elective surgical amputation as a treatment for the disorderDECLARATION OF INTERESTNone.

scholarly journals Juvenile Myasthenia Gravis: A Case Report and Review of Literatures

2013 ◽  
Vol 29 (1) ◽  
pp. 64-69
Author(s):  
Narayan Chandra Kundu ◽  
Moushumi Sen ◽  
KM Nazmul Islam Joy ◽  
Feroj Ahmed Quraish
Keyword(s):  
Myasthenia Gravis ◽  
Antibody Test ◽  
Autoimmune Disorder ◽  
Repetitive Nerve Stimulation ◽  
History Of ◽  
Congenital Myasthenia ◽  
Pediatric Presentation ◽  
Juvenile Myasthenia Gravis ◽  
Ice Pack ◽  
Anti Acetylcholine

Juvenile myasthenia gravis (JMG) is a rare autoimmune disorder of childhood. Pediatric presentation of MG is more common in Oriental than in Caucasian populations. JMG need to be differentiated from congenital myasthenia gravis which do not have haan autoimmune basis. An 11 years old girl presented with drooping of eye lids which was more marked at the later part of day and was gradually progressive . She had complained of double vision. She had no family history of myasthenia gravis. Ice pack test, repetitive nerve stimulation test, and anti acetylcholine receptor antibody test support the diagnosis. She was treated with pyridostigmine and was started as 30mg four times daily and increased to 60 mg/qds. Subsequently her symptoms improved gradually and she became stable. Bangladesh Journal of Neuroscience 2013; Vol. 29 (1) : 64-69

scholarly journals Myasthenia Gravis and Thymectomy

2022 ◽  
Author(s):  
V Bharath
Keyword(s):  
Myasthenia Gravis ◽  
Clinical Features ◽  
Intravenous Immunoglobulins ◽  
Neuromuscular Disorder ◽  
Pharmacological Agents ◽  
Diagnosis And Management ◽  
Video Assisted ◽  
History Of ◽  
Rational Management ◽  
Robotic Thymectomy

AbstractMyasthenia gravis (MG) is a rare autoimmune neuromuscular disorder. Though MG was diagnosed four centuries ago, its rational management started in 1930s. In the present era, MG is managed by multimodality care including pharmacological agents, plasmapheresis, intravenous immunoglobulins, and surgical thymectomy. Thymectomy has evolved from open trans-sternal to video-assisted thoracoscopic and robotic thymectomy. In this article, the concise history of MG, its clinical features, diagnosis, and management are described.

scholarly journals Submandibular sialolithiasis: A series of three case reports with review of literature

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sandeep Pachisia ◽  
Gaurav Mandal ◽  
Sudipto Sahu ◽  
Sucharu Ghosh
Keyword(s):  
Salivary Glands ◽  
Submandibular Gland ◽  
Clinical Features ◽  
Surgical Management ◽  
Case Reports ◽  
Palliative Therapy ◽  
Review Of Literature ◽  
History Of ◽  
History Of Pain ◽  
Treatment Procedures

One of the most common disorders of the salivary glands is sialolithiasis. A history of pain or/and swelling in the salivary glands, especially during meal suggests this diagnosis. For small and accessible stones conservative therapies like milking of ducts with palliative therapy can produce satisfactory results. Surgical management should be considered when the stone/stones are inaccessible or large in size as conservative therapies turned out to be unsatisfactory. In this paper, we present three cases of sialolithiasis in the submandibular gland along with a review of existing literature. The purpose of this paper is to add three more cases to the literature and review the theories of etiology, clinical features, available diagnostic and treatment procedures.

scholarly journals Case Report: Malignant Thymoma And Seronegative Myasthenia Gravis

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 2110
Author(s):  
Cláudia Sousa ◽  
Mafalda Cruz ◽  
Ana Neto ◽  
Kayla Pereira ◽  
Mónica Henriques ◽  
...  
Keyword(s):  
Case Report ◽  
Myasthenia Gravis ◽  
Multidisciplinary Approach ◽  
Thymic Carcinoma ◽  
Case Reports ◽  
Benign Diseases ◽  
Malignant Thymoma ◽  
Seronegative Myasthenia Gravis ◽  
Seronegative Mg

Myasthenia gravis (MG) is present in 50% of thymomas and is rarely associated with thymic carcinoma. We present the case of a 49-year-old woman with malignant thymoma, treated with surgery followed by radiotherapy, and a late seronegative MG diagnosis. This case reports the importance of a multidisciplinary approach to the management of the potential correlation of malignant and benign diseases.

scholarly journals Myasthenia Gravis Revealing Hodgkin’s Lymphoma

2021 ◽  
Author(s):  
Jaouad Yousfi ◽  
Fatimazahra Bensalek ◽  
Mouna Zahlane ◽  
Laila Benjilali ◽  
Lamiaa Essaadouni
Keyword(s):  
Autoimmune Disease ◽  
Neuromuscular Junction ◽  
Myasthenia Gravis ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Mixed Cellularity ◽  
History Of ◽  
Receptor Antibodies ◽  
Severe Weakness ◽  
Anti Acetylcholine

Introduction: Myasthenia gravis is a rare autoimmune disease caused by autoantibodies directed against the synapses of the neuromuscular junction. Patient and methods: We report the case of a young patient with myasthenia gravis associated with Hodgkin's lymphoma. Results: A 22-year-old patient presented with a 2-month history of severe weakness associated with muscle fatigability and intermittent ptosis without dysphonia or respiratory signs. Clinical examination revealed generalized myasthenia. The EMG did not show post-synaptic block, and anti-acetylcholine receptor antibodies were elevated at 3 nmol/l (normal ?0.3 nmol/l). CT of the thorax showed an anterior medial mass. Immunohistochemistry of the mass revealed mixed cellularity Hodgkin’s lymphoma. Conclusion: The association of lymphomas with myasthenia gravis has been rarely reported.

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