Myasthenia Gravis and Thymectomy

Myasthenia gravis (MG) is a rare autoimmune neuromuscular disorder. Though MG was diagnosed four centuries ago, its rational management started in 1930s. In the present era, MG is managed by multimodality care including pharmacological agents, plasmapheresis, intravenous immunoglobulins, and surgical thymectomy. Thymectomy has evolved from open trans-sternal to video-assisted thoracoscopic and robotic thymectomy. In this article, the concise history of MG, its clinical features, diagnosis, and management are described.

Prospective Mapping of Land Cover and Land Use in The Classified Forest of The Upper Alibori Based on Satellite Imagery

The dynamics of land cover and land use in the classified forest of the upper Alibori (FCAS) in relation to the disturbance of agro-pastoral activities is a major issue in the rational management of forest resources. The objective of this research is to simulate the evolutionary trend of land cover and land use in the FCAS by 2069 based on satellite images. Landsat images from 2009, 2014 and 2019 obtained from the earthexplorer-usgs archive were used. The methods used are diachronic mapping and spatial forecasting based on senarii. The MOLUSCE module available under QGIS remote sensing 2.18.2 is used to simulate the future evolution of land cover and land use in the FCAS. The land cover and use in the year 2069 is simulated using cellular automata based on the scenarios. The results show that natural land cover units have decreased while anthropogenic formations have increased between 2009 and 2014 and between 2014 and 2019. Under the "absence multi-criteria zoning (MZM)" scenario over a 50-year interval, land cover and use will be dominated by crop-fallow mosaics (88%). On the other hand, the scenario "implementation of a multicriteria zoning (MZE)", was issued with the aim of reversing the regressive trend of vegetation types by making a rational and sustainable management of resources.

THE ESSENCE OF ACCOUNTING PARADOXES

Accounting information serves as a primary source for the formation of financial statements, based on which further decisions are made. However, existing forms of financial reporting cannot fully meet the information needs of users. One of the reasons is the paradox of accounting information. Accounting paradoxes are a little-studied issue that requires proper coverage, first of all, the generation of theoretical and methodological framework, to better understand and optimize existing contradictions and controversial issues. The article describes the variety of methodological approaches to the scientific substantiation of the paradoxes of accounting information with their solutions and shortcomings. The paper highlights the economic essence of accounting paradoxes, their importance in the process of making effective management decisions, identifies the causes of formation, impact, and consequences of distortion of the information array in making rational management decisions. The role of the influence of accounting data paradoxes on the further activity of the enterprise is argued. The causal relationship between the possibility of distortion of accounting information at different stages of its formation depending on the object of accounting and its further transformation into management data is analyzed. As a result of the analysis of the outlined topic several solutions of problem questions are offered, namely: optimization of the accounting information, minimization of influence of paradoxes of the accounting information taking into account features of the account, expansion of the theoretical base.

ENVIRONMENTAL CITIZENSHIP FOR THE RATIONAL MANAGEMENT OF HOUSEHOLD AND SIMILAR WASTE IN THE CITY OF BEJAIA, ALGÉRIA (REPORT AND LIMITS)

The problematic of rational management of household and similar wasteis a responsibility shared between all the actors of the city. The citizen or user has a great contribution in the success of this management. This by contribution to the realization of their duty and right in the collection of household and similar waste (HSW). The objective of this study is to examine the degree of enrollment of environmental citizenship in relation to the management of (HSW) in the collection and pre-collection phase in the city of Bejaia. The amount of waste generated in this city continues to increase (0.84 Kg/d /Inhabitant), with a daily tonnage which reaches 191 tonnes. These quantities of household waste produced and thrown away daily appear dispersed and scattered randomly in the sectors of the city. This observation reflects the negative behavior of the inhabitants, and has caused several consequences on the living environment, and on the tourist vocation of the city in general. This does not allow the city to play its functionality and represents a discomfort in front of all users, and particularly a failure in front of the actors of this city. Resorting to the implementation of shared management will allow the city of Bejaia to strengthen the level of environmental citizenship. Thus, correct the level of offset in the collection phase.

Theory, methodology and practice of regional strategic planning

In the monograph, the region is presented as a complex, multilevel socio-economic system consisting of many heterogeneous, interacting economic entities of different levels (economic agents and markets, management, resources and economic processes), jointly organizing reproduction processes embedded in the economic space of the national economy on the local territory. Currently, the role of rational management of the socio-economic development of the region is increasing. In such conditions, it is advisable to use strategic planning, which, in turn, has increasingly been carried out using a simulation model. The simulation model in regional strategic planning allows government agencies to predict their activities in the presence of various controlled and uncontrolled factors of the external and internal environment. In this study, the list of principles of strategic planning focused on the processes of strategic planning of the region using the method of simulation modeling is supplemented. A methodology for organizing strategic planning processes at the meso-level using simulation modeling technology is proposed. For a wide range of readers interested in the problems of regional strategic planning.

Applied cultural studies and culture management: research methodology

The purpose of the article is to study the interconnection of applied cultural studies and culture management, develop methodological basis for analysis of efficiency of their integration, define viability of realizing cultural practices in the context of applied cultural studies branch. The methodology. By analyzing and synthesizing the scientific knowledge, a flexible methodological system is created, which enables analyzing the present and predicting the future, and create, not only in theory, but in practice, the culture­creation technologies, thus setting the vector for culture development. The leading methods of research are analysis of scientific facts, juxtaposition of theoretical positions, generalization and synthesis of methodological basis for defining leading scientific approaches to researching applied cultural studies and culture management. The results. Utilization of developed methodology enables examination of applied cultural studies as a mechanism of culture creativity, and culture management as a tool of scientifically justified regulation of this process. Thanks to applied cultural studies, management gains deep meanings, and not only rational management and realization of its own functions, and applied cultural studies is manifested in practice and transforms into a technological plane the meanings and concepts of contemporary culture model. The topicality. It was defined that gnoseological, worldview, logic­gnoseological, scientific content­related, technological and scientific­methodological levels of methodology allows to create the applied cultural studies and culture management analysis model in a substantial interconnection. Justification was provided for some scientific approaches, which are taken as the baseline of methodological analysis of integrating applied cultural studies branch and management in the sociocultural field. The practical significance. According to the results of the study, applied cultural studies have a broad social mission, which manifests itself in creation of advantageous environment of interaction in the object field of culture, constructing mechanisms of implementing innovations in the sociocultural field, and developing future cultural practices models, which will eventually promote establishment of its new formats. In order to achieve this task, culture management implements social marketing, innovative and investment varieties of management technologies, branding, purposeful communication and human resource management, etc., which opens new perspectives of diversifying research of culture management in the context of applied cultural studies.

Peculiarities of purpose in providing the information stability of surveillance radar sensing modes in the process of their radio electronic suppression

It is possible to look at the special features of the goal setting while ensuring information stability of radar sounding modes when they are suppressed by the active interferences and interfering information influences. Overcoming the complexity of goal-setting processes, the validity and prompt decision-making with a shortage of time for its adoption is associated with insuring the consistency of goal-setting the levels of their intellectualization and formalization. This will contribute to imparting the desired properties, synthesized during the conflict, to the multipurpose strategies and the situational law of the control of the REP processes and the coordination of actions. An increase in the level of intellectualization of goal-setting processes is ensured by: decomposition of the general goal-setting problem into separate, simpler subtasks with effective solutions, implemented in the corresponding subsystems of the ACSstab (or basic associations of its functional elements) at stages of information support, preparation, adoption and implementation of the decision at the stages of hierarchical levels of management; cognitive analysis of goals and reflexive synthesis of goal-setting processes using the capabilities of a specialized intelligent decision support system to enhance the creative-reflexive abilities of the subject of management and increase the level of his professional competencies; combining the universality of the stages of rational management of the synthesis of the strategy for managing the REP processes with the specifics of conflict situations, subjectivity, cognition and reflexivity nature of intellectual control. Methods and means of partial formalization of goal-setting processes are presented, when the structuring of the main goal is carried out taking into account belonging to the strategies of internal and external control of the REP, the decomposition of the two-sided dynamic model of the conflict between the systems of the RES complex and the radar, the hierarchy of management levels, various approaches applied to goal-setting in a crisis management, as well as methods of justifying goals, resource costs and control of achieving the goals. These features can significantly reduce the degree of subjectivity of management for goal-setting and achieve their validity, completeness, consistency.

Genetic Diversity of Peach Cultivars from the Collection of the Nikita Botanical Garden Based on SSR Markers

The Nikita Botanical Garden (NBG) has a unique Prunus L. collection (peach, apricot, plum, cherry) comprising more than 3000 accessions. NBG is also a breeding center for stone fruits, including peach (Prunus persica (L.) Batsch). In the present study a set of 85 peach cultivars bred in NBG, Europe, and North America was analyzed using 12 SSR markers to assess their genetic diversity and relatedness. The detected polymorphism level was comparable to the previous estimates of genetic variability in peach cultivars. The average number of alleles per locus was 5.67, PIC value averaged 0.49, expected, and observed heterozygosity averaged 0.52 and 0.31, respectively. Among the detected alleles, 19 (27.94%) were rare and 12 (17.65%) were unique. All studied accessions except two could be identified with the used marker set. Cluster analysis revealed some groups according to the cultivars’ pedigrees. No clear differentiation of the studied sample according to geographic origin or fruit characteristics of peach cultivars was revealed. The results provide valuable information for identification and rational management of the material preserved in the NBG peach collection.

DEVELOPMENT OF METHODOLOGICAL TOOLS FOR INTERNAL CONTROL OF RESERVE MOVEMENT

One of the factors for the effective development of enterprises is the rational management of stocks, the state of which affects its production and financial activities. For the rational management of stocks, their effective control should be organized, taking into account the specifics, scale and features of production technology. The purpose of the research is to improve the methodological support of internal control over the movement of stocks. In the course of the study, the main stages of internal control of the movement and the efficiency of using stocks, consisting in planning and carrying out control measures, were considered. In order to comply with the principles of rationality, priority and consistency in the conduct of internal control, it was proposed to use the working document “The program for internal control of the movement and efficiency of inventory use”. Checking the correctness of the estimate of stocks when they are received, procured, or purchased is possible using the internal control working document “Checking the correctness of stock estimates”. It makes it possible to identify errors in the assessment of stocks and the formation of their actual cost, which affects production costs and the final financial result. For the analysis of the movement of stocks, we can recommend the internal control working paper “Analysis of the movement of stocks”. It allows you to control the compliance of the actual size of stocks of the most important types of raw materials and materials with the normative ones. By comparing the incoming and outgoing stocks on the basis of this document, it is possible to identify excessive and unclaimed material resources in the production and financial activities of the enterprise, to establish stocks for which there is a shortage, to prevent a decrease in the quality of products, a decrease in production volumes, a decrease in profits