Myocardial T1 Mapping: Techniques and Potential Applications

Abstract Funding Acknowledgements Type of funding sources: None. Background. Recent studies revealed the ability of MRI T1 mapping to characterize myocardial involvement in both idiopathic inflammatory myopathy (IIM) and acute viral myocarditis (AVM), as compared to healthy controls. However, neither myocardial T1 nor T2 maps were able to discriminate between IIM and AVM patients, when considering conventional myocardial mean values and derived indices such as lambda and extracellular volume. Purpose. To investigate the ability of T1 mapping-derived texture analysis to differentiate IIM from AVM. Methods. Forty patients, 20 with IIM (51 ± 17 years, 9 men) and 20 with AVM (34 ± 13 years, 16 men) underwent 1.5T MRI T1 mapping using a modified Look-Locker inversion-recovery sequence before and 15 minutes after injection of a gadolinium contrast agent. After manual delineation of endocardial and epicardial borders and co-registration of all inversion time images, native and post-contrast T1 maps were estimated. Myocardial texture analysis was performed on native T1 maps. Textural features such as: autocorrelation, contrast, dissimilarity, energy and sum entropy were used to build a least squares-based linear regression model. Finally, receiver operating characteristic (ROC) analysis was used to investigate the ability of such texture features score to classify IIM vs. AVM patients, compared to the performance of mean myocardial T1. A Wilcoxon rank-sum test was also used to test difference significance between groups. Results. Both native and post-contrast mean myocardial T1 values were comparable between IIM (native: 1022 ± 43 ms; post-contrast: 319 ± 44 ms) and AVM (1056 ± 59 ms, p = 0.07; 318 ± 35 ms, p = 0.90, respectively) groups. Results of ROC analyses are provided in the Table, indicating that a better discrimination between IIM and AVM patients was obtained when using texture features, with higher AUC and accuracy than mean T1 values (Figure). Conclusion. Texture analysis derived from MRI T1 maps without contrast agent injection was able to discriminate between IIM and AVM with higher accuracy, sensitivity and specificity than conventional T1 indices. Such analysis could provide a useful myocardial signature to help diagnose and manage cardiac alterations associated with IIM in patients presenting with myocarditis and primarily suspected of AVM. Table Area under curve (AUC) Accuracy Sensitivity Specificity Native T1 0.67 0.70 0.65 0.75 Post-contrast T1 0.49 0.60 0.25 0.95 Texture features score 0.85 0.82 0.90 0.75 ROC analyses for classification between IIM and AVM patients Abstract Figure

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Evaluation of malignant effusions using MR-based T1 mapping

Scientific Reports ◽

10.1038/s41598-021-86632-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

D. Kuetting ◽

J. Luetkens ◽

A. Faron ◽

A. Isaak ◽

U. Attenberger ◽

...

Keyword(s):

T1 Mapping ◽

Ex Vivo ◽

Diagnostic Yield ◽

Spin Echo ◽

Relaxation Times ◽

Inversion Recovery ◽

Malignant Effusions ◽

Mapping Techniques ◽

Set Up ◽

Post Hoc

AbstractOur aim was to investigate the diagnostic yield of rapid T1-mapping for the differentiation of malignant and non-malignant effusions in an ex-vivo set up. T1-mapping was performed with a fast modified Look-Locker inversion-recovery (MOLLI) acquisition and a combined turbo spin-echo and inversion-recovery sequence (TMIX) as reference. A total of 13 titrated albumin-solutions as well as 48 samples (29 ascites/pleural effusions from patients with malignancy; 19 from patients without malignancy) were examined. Samples were classified as malignant-positive histology, malignant-negative histology and non-malignant negative histology. In phantom analysis both mapping techniques correlated with albumin-content (MOLLI: r = − 0.97, TMIX: r = − 0.98). MOLLI T1 relaxation times were shorter in malignancy-positive histology fluids (2237 ± 137 ms) than in malignancy-negative histology fluids (2423 ± 357 ms) as well as than in non-malignant-negative histology fluids (2651 ± 139 ms); post hoc test for all intergroup comparisons: < 0.05. ROC analysis for differentiation between malignant and non-malignant effusions (malignant positive histology vs. all other) showed an (AUC) of 0.89 (95% CI 0.77–0.96). T1 mapping allows for non-invasive differentiation of malignant and non-malignant effusions in an ex-vivo set up.

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Imaging sequence for joint myocardial T1 mapping and fat/water separation

Magnetic Resonance in Medicine ◽

10.1002/mrm.27390 ◽

2018 ◽

Vol 81 (1) ◽

pp. 486-494 ◽

Cited By ~ 4

Author(s):

Maryam Nezafat ◽

Shiro Nakamori ◽

Tamer A. Basha ◽

Ahmed S. Fahmy ◽

Thomas Hauser ◽

...

Keyword(s):

T1 Mapping ◽

Water Separation ◽

Imaging Sequence ◽

Myocardial T1

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Relation of intestinal microbiota composition to extracellular matrix volume assessed by myocardial T1 mapping in patients with chronic heart failure and preserved left ventricular ejection fraction

Profilakticheskaya meditsina ◽

10.17116/profmed20212411128 ◽

2021 ◽

Vol 24 (11) ◽

pp. 28

Author(s):

A.N. Kaburova ◽

O.M. Drapkina ◽

S.M. Yudin ◽

S.N. Koretsky ◽

V.V. Makarov ◽

...

Keyword(s):

Heart Failure ◽

Extracellular Matrix ◽

Chronic Heart Failure ◽

T1 Mapping ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Microbiota Composition ◽

Ventricular Ejection Fraction ◽

Matrix Volume ◽

Myocardial T1

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Comparison of myocardial T1 mapping during breath-holding and free-breathing

Cardiology in the Young ◽

10.1017/s1047951121003292 ◽

2021 ◽

pp. 1-5

Author(s):

Hideharu Oka ◽

Kouichi Nakau ◽

Sadahiro Nakagawa ◽

Yuki Kobayashi ◽

Rina Imanishi ◽

...

Keyword(s):

Cross Sections ◽

T1 Mapping ◽

Free Breathing ◽

Breath Holding ◽

Basal Region ◽

Analysis Method ◽

Imaging Analysis ◽

Myocardial T1 ◽

The Mean ◽

Almost All

Abstract Background: T1 mapping is a recently developed imaging analysis method that allows quantitative assessment of myocardial T1 values obtained using MRI. In children, MRI is performed under free-breathing. Thus, it is important to know the changes in T1 values between free-breathing and breath-holding. This study aimed to compare the myocardial T1 mapping during breath-holding and free-breathing. Methods: Thirteen patients and eight healthy volunteers underwent cardiac MRI, and T1 values obtained during breath-holding and free-breathing were examined and compared. Statistical differences were determined using the paired t-test. Results: The mean T1 values during breath-holding were 1211.1 ± 39.0 ms, 1209.7 ± 37.4 ms, and 1228.9 ± 52.5 ms in the basal, mid, and apical regions, respectively, while the mean T1 values during free-breathing were 1165.1 ± 69.0 ms, 1103.7 ± 55.8 ms, and 1112.0 ± 81.5 ms in the basal, mid, and apical regions, respectively. The T1 values were lower during free-breathing than during breath-holding in almost all segments (basal: p = 0.008, mid: p < 0.001, apical: p < 0.001). The mean T1 values in each cross section were 3.1, 7.8, and 7.7% lower during free-breathing than during breath-holding in the basal, mid, and apical regions, respectively. Conclusions: We found that myocardial T1 values during free-breathing were about 3–8% lower in all cross sections than those during breath-holding. In free-breathing, it may be difficult to assess myocardial T1 values, except in the basal region, because of underestimation; thus, the findings should be interpreted with caution, especially in children.

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