The phosphodiesterases type 5 inhibitor tadalafil reduces the activation of the hypothalamus-pituitary-adrenal axis in men during cycle ergometric exercise

2012 ◽  
Vol 302 (8) ◽  
pp. E972-E978 ◽  
Author(s):  
Luigi Di Luigi ◽  
Paolo Sgrò ◽  
Carlo Baldari ◽  
Maria Chiara Gallotta ◽  
Gian Pietro Emerenziani ◽  
...  
Keyword(s):  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Double Blind ◽  
Phosphodiesterase Type 5 Inhibitors ◽  
Adrenal Axis ◽  
Free Cortisol ◽  
Hypothalamus Pituitary Adrenal Axis ◽  
And Performance ◽  
Pituitary Adrenal Axis

Phosphodiesterase type 5 inhibitors may influence human physiology, health, and performance by also modulating endocrine pathways. We evaluated the effects of a 2-day tadalafil administration on adenohypophyseal and adrenal hormone adaptation to exercise in humans. Fourteen healthy males were included in a double-blind crossover trial. Each volunteer randomly received two tablets of placebo or tadalafil (20 mg/day with a 36-h interval) before a maximal exercise was performed. After a 2-wk washout, the volunteers were crossed over. Blood samples were collected at −30 and −15 min and immediately before exercise, immediately after, and during recovery (+15, +30, +60, and +90 min) for adrenocorticotropin (ACTH), β-endorphin, growth hormone (GH), prolactin, cortisol (C), corticosterone, dehydroepiandrosterone-sulfate (DHEAS), and cortisol binding globulin (CBG) assays. C-to-CBG (free cortisol index, FCI) and DHEAS-to-C ratios were calculated. Exercise intensity, perceived exertion rate, O2 consumption, and CO2 and blood lactate concentration were evaluated. ACTH, GH, C, corticosterone, and CBG absolute concentrations and/or areas under the curve (AUC) increased after exercise after both placebo and tadalafil. Exercise increased DHEAS only after placebo. Compared with placebo, tadalafil administration reduced the ACTH, C, corticosterone, and FCI responses to exercise and was associated with higher β-endorphin AUC and DHEAS-to-C ratio during recovery, without influencing cardiorespiratory and performance parameters. Tadalafil reduced the activation of the hypothalamus-pituitary-adrenal axis during exercise by probably influencing the brain's nitric oxide- and cGMP-mediated pathways. Further studies are necessary to confirm our results and to identify the involved mechanisms, possible health risks, and potential clinical uses.

scholarly journals Does caffeine supplementation alter energy contribution during a work-based ~30 min cycling time-trial?

2020 ◽  
Vol 34 (3) ◽  
pp. 471-481
Author(s):  
Gabriel Barreto ◽  
Rafael Pires da Silva ◽  
Guilherme Yamaguchi ◽  
Luana Farias de Oliveira ◽  
Vitor de Salles Painelli ◽  
...  
Keyword(s):  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Time Trial ◽  
Energy System ◽  
Energy Contribution ◽  
Mean Power ◽  
Double Blind ◽  
Cycling Time Trial ◽  
Cycling Time

Caffeine has been shown to increase anaerobic energy contribution during short-duration cycling time-trials (TT) though no information exists on whether caffeine alters energy contribution during more prolonged, aerobic type TTs. The aim of this study was to determine the effects of caffeine supplementation on longer and predominantly aerobic exercise. Fifteen recreationally-trained male cyclists (age 38±8 y, height 1.76±0.07 m, body mass 72.9±7.7 kg) performed a ~30 min cycling TT following either 6 mg·kg-1BM caffeine (CAF) or placebo (PLA) supplementation, and one control (CON) session without supplementation, in a double- -blind, randomised, counterbalance and cross-over design. Mean power output (MPO) was recorded as the outcome measure. Respiratory values were measured throughout exercise for the determination of energy system contribution. Data were analysed using mixed-models. CAF improved mean MPO compared to CON (P=0.01), and a trend towards an improvement compared to PLA (P=0.07); there was no difference in MPO at any timepoint throughout the exercise between conditions. There was a main effect of Condition (P=0.04) and Time (P<0.0001) on blood lactate concentration, which tended to be higher in CAF vs. both PLA and CON (Condition effect, both P=0.07). Ratings of perceived exertion increased over time (P<0.0001), with no effect of Condition or interaction (both P>0.05). Glycolytic energy contribution was increased in CAF compared to CON and PLA (both P<0.05), but not aerobic or ATP-CP (both P>0.05). CAF improved aerobic TT performance compared to CON, which could be explained by increased glycolytic energy contribution.

scholarly journals Complex Interplay Between Determinants of Pacing and Performance During 20-km Cycle Time Trials

2012 ◽  
Vol 7 (2) ◽  
pp. 121-129 ◽  
Author(s):  
Andrew Renfree ◽  
Julia West ◽  
Mark Corbett ◽  
Clare Rhoden ◽  
Alan St Clair Gibson
Keyword(s):  
Negative Affect ◽  
Blood Lactate ◽  
Power Output ◽  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Rating Of Perceived Exertion ◽  
Physiological Status ◽  
Pacing Strategy ◽  
And Performance

Purpose:This study examined the determinants of pacing strategy and performance during self-paced maximal exercise.Methods:Eight well-trained cyclists completed two 20-km time trials. Power output, rating of perceived exertion (RPE), positive and negative affect, and iEMG activity of the active musculature were recorded every 0.5 km, confidence in achieving preexercise goals was assessed every 5 km, and blood lactate and pH were measured postexercise. Differences in all parameters were assessed between fastest (FAST) and slowest (SLOW) trials performed.Results:Mean power output was significantly higher during the initial 90% of FAST, but not the final 10%, and blood lactate concentration was significantly higher and pH significantly lower following FAST. Mean iEMG activity was significantly higher throughout SLOW. Rating of perceived exertion was similar throughout both trials, but participants had significantly more positive affect and less negative affect throughout FAST. Participants grew less confident in their ability to achieve their goals throughout SLOW.Conclusions:The results suggest that affect may be the primary psychological regulator of pacing strategy and that higher levels of positivity and lower levels of negativity may have been associated with a more aggressive strategy during FAST. Although the exact mechanisms through which affect acts to influence performance are unclear, it may determine the degree of physiological disruption that can be tolerated, or be reflective of peripheral physiological status in relation to the still to be completed exercise task.

Does Sodium-Bicarbonate Ingestion Improve Simulated Judo Performance?

2007 ◽  
Vol 17 (2) ◽  
pp. 206-217 ◽  
Author(s):  
Guilherme Giannini Artioli ◽  
Bruno Gualano ◽  
Desiré Ferreira Coelho ◽  
Fabiana Braga Benatti ◽  
Alessandra Whyte Gailey ◽  
...  
Keyword(s):  
Sodium Bicarbonate ◽  
Peak Power ◽  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Crossover Design ◽  
Ratings Of Perceived Exertion ◽  
Mean Power ◽  
Double Blind ◽  
Improved Performance

The aim of the present study was to investigate whether pre exercise sodium-bicarbonate ingestion improves judo-related performance. The study used 2 different protocols to evaluate performance: 3 bouts of a specific judo test (n = 9) and 4 bouts of the Wingate test for upper limbs (n = 14). In both protocols athletes ingested 0.3 g/kg of sodium bicarbonate or placebo 2 h before the tests. Blood samples were collected to determine lactate level, and levels of perceived exertion were measured throughout the trials. The study used a double-blind, counterbalanced, crossover design. Ingestion of sodium bicarbonate improved performance in Bouts 2 and 3 of Protocol 1 (P < 0.05), mean power in Bouts 3 and 4 of Protocol 2 (P < 0.05), and peak power in Bout 4 of Protocol 2 (P < 0.05). Ingestion of bicarbonate increased lactate concentration in Protocol 1 (P < 0.05) but not in Protocol 2. Ratings of perceived exertion did not differ between treatments. In conclusion, sodium bicarbonate improves judo-related performance and increases blood lactate concentration but has no effect on perceived exertion.

scholarly journals Analysis of the ergogenic effect of asynchronous music on physiological, psychophysiological and performance parameters obtained in an incremental runing test

2019 ◽  
Author(s):  
Felipe Marroni Rasteiro ◽  
Fulvia de Barros Manchado Gobatto ◽  
Leonardo Henrique Dalcheco Messias ◽  
João Pedro da Cruz ◽  
Rafael Lucas Cetein ◽  
...  
Keyword(s):  
Anaerobic Threshold ◽  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Physiological Parameters ◽  
Ergogenic Effect ◽  
Time To Exhaustion ◽  
Threshold Intensity ◽  
Perceived Effort ◽  
And Performance

Ten healthy male individuals were randomly evaluated in two exercise sessions (with or without music during the tests). They were submited to an incremental running test (3-min stages; initial intensity equal to 7 km.h-1 and 1 km.h-1 increments; treadmill inclination equal to 1%). The music´s motivation were adressed by the Brunel Rating Music Inventory- 2, considering the most motivation on top of the playlist, and then yours subsequents. Anaerobic threshold intensity (iAnT), blood lactate concentration ([Lac]iAnT) and heart rate (HRiAnT) at anaerobic threshold intensity were considered as physiological parameters. Psychophysiological scales such as Perceived Exertion (PSEBorg), Perceived Effort (PSEFoster) and Estimation of Time Limit (ETL) were used for psychophysiological analyses. Time to exhaustion (T.T) was considered as performance parameter. No differences were found between iAnT (p=0.248), [Lac]iAnT (p=0.786), HRiAnT (p=1.000) an T.T (p=0.055). However, 70% of the sample presented better performance with asynchronous music was inserted (p=0.003). Significant differences were visualized for PSEBorg (AM= ;WM= ;0,042) and ETL (AM= ;WM= ;p=0.015). In sumary, for 70% of the evaluated sample asynchronous music exerted ergogenic effect on the physical performance in an incremental running protocol attenuating the psychophysiological responses without changing physiological parameters.

Impact of sodium citrate ingestion during recovery after dehydrating exercise on rehydration and subsequent 40-km cycling time-trial performance in the heat

2018 ◽  
Vol 43 (6) ◽  
pp. 571-579 ◽  
Author(s):  
Silva Suvi ◽  
Martin Mooses ◽  
Saima Timpmann ◽  
Luule Medijainen ◽  
Daria Narõškina ◽  
...  
Keyword(s):  
Water Intake ◽  
Perceived Exertion ◽  
Sodium Citrate ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Time Trial ◽  
Cycling Performance ◽  
Double Blind ◽  
Warm Environment ◽  
The Impact

The purpose of this study was to assess the impact of sodium citrate (CIT) ingestion (600 mg·kg−1) during recovery from dehydrating cycling exercise (DE) on subsequent 40-km cycling performance in a warm environment (32 °C). Twenty male nonheat-acclimated endurance athletes exercised in the heat until 4% body mass (BM) loss occurred. After 16 h recovery with consumption of water ad libitum and prescribed diet (evening meal 20 kcal·kg−1, breakfast 12 kcal·kg−1) supplemented in a double-blind, randomized, crossover manner with CIT or placebo (PLC), they performed 40-km time-trial (TT) on a cycle ergometer in a warm environment. During recovery greater increases in BM and plasma volume (PV) concomitant with greater water intake and retention occurred in the CIT trial compared with the PLC trial (p < 0.0001). During TT there was greater water intake and smaller BM loss in the CIT trial than in the PLC trial (p < 0.05) with no between-trial differences (p > 0.05) in sweat loss, PV decrement, ratings of perceived exertion, or TT time (CIT 68.10 ± 3.28 min, PLC 68.11 ± 2.87 min). At the end of TT blood lactate concentration was higher (7.58 ± 2.44 mmol·L−1 vs 5.58 ± 1.32 mmol·L−1; p = 0.0002) and rectal temperature lower (39.54 ± 0.50 °C vs 39.65 ± 0.52 °C; p = 0.033) in the CIT trial than in the PLC trial. Compared with pre-DE time point, PV had decreased to a lower level in the PLC trial than in the CIT trial (p = 0.0001). In conclusion, CIT enhances rehydration after exercise-induced dehydration but has no impact on subsequent 40-km cycling TT performance in a warm uncompensable environment.

scholarly journals Does caffeine supplementation alter energy contribution during a work-based ~30 min cycling time-trial?

2020 ◽  
Vol 34 (3) ◽  
pp. 471-481
Author(s):  
Gabriel Barreto ◽  
Rafael Pires da Silva ◽  
Guilherme Yamaguchi ◽  
Luana Farias de Oliveira ◽  
Vitor de Salles Painelli ◽  
...  
Keyword(s):  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Time Trial ◽  
Energy System ◽  
Energy Contribution ◽  
Mean Power ◽  
Double Blind ◽  
Cycling Time Trial ◽  
Cycling Time

Caffeine has been shown to increase anaerobic energy contribution during short-duration cycling time-trials (TT) though no information exists on whether caffeine alters energy contribution during more prolonged, aerobic type TTs. The aim of this study was to determine the effects of caffeine supplementation on longer and predominantly aerobic exercise. Fifteen recreationally-trained male cyclists (age 38±8 y, height 1.76±0.07 m, body mass 72.9±7.7 kg) performed a ~30 min cycling TT following either 6 mg·kg-1BM caffeine (CAF) or placebo (PLA) supplementation, and one control (CON) session without supplementation, in a double- -blind, randomised, counterbalance and cross-over design. Mean power output (MPO) was recorded as the outcome measure. Respiratory values were measured throughout exercise for the determination of energy system contribution. Data were analysed using mixed-models. CAF improved mean MPO compared to CON (P=0.01), and a trend towards an improvement compared to PLA (P=0.07); there was no difference in MPO at any timepoint throughout the exercise between conditions. There was a main effect of Condition (P=0.04) and Time (P<0.0001) on blood lactate concentration, which tended to be higher in CAF vs. both PLA and CON (Condition effect, both P=0.07). Ratings of perceived exertion increased over time (P<0.0001), with no effect of Condition or interaction (both P>0.05). Glycolytic energy contribution was increased in CAF compared to CON and PLA (both P<0.05), but not aerobic or ATP-CP (both P>0.05). CAF improved aerobic TT performance compared to CON, which could be explained by increased glycolytic energy contribution.

Induced Alkalosis and Caffeine Supplementation: Effects on 2,000-m Rowing Performance

2011 ◽  
Vol 21 (5) ◽  
pp. 357-364 ◽  
Author(s):  
Amelia J. Carr ◽  
Christopher J. Gore ◽  
Brian Dawson
Keyword(s):  
Sodium Bicarbonate ◽  
Perceived Exertion ◽  
Lactate Concentration ◽  
Gastrointestinal Symptoms ◽  
Blood Lactate Concentration ◽  
Rating Of Perceived Exertion ◽  
Urine Ph ◽  
Double Blind ◽  
Rowing Performance ◽  
Induced Alkalosis

Introduction:The purpose of this investigation was to determine the effect of ingested caffeine, sodium bicarbonate, and their combination on 2,000-m rowing performance, as well as on induced alkalosis (blood and urine pH and blood bicarbonate concentration [HCO3−]), blood lactate concentration ([La−]), gastrointestinal symptoms, and rating of perceived exertion (RPE).Methods:In a double-blind, crossover study, 8 well-trained rowers performed 2 baseline tests and 4 × 2,000-m rowing-ergometer tests after ingesting 6 mg/kg caffeine, 0.3 g/kg body mass (BM) sodium bicarbonate, both supplements combined, or a placebo. Capillary blood samples were collected at preingestion, pretest, and posttest time points. Pairwise comparisons were made between protocols, and differences were interpreted in relation to the likelihood of exceeding the smallestworthwhile- change thresholds for each variable. A likelihood of >75% was considered a substantial change.Results:Caffeine supplementation elicited a substantial improvement in 2,000-m mean power, with mean (± SD) values of 354 ± 67 W vs. placebo with 346 ± 61 W. Pretest [HCO3−] reached 29.2 ± 2.9 mmol/L with caffeine + bicarbonate and 29.1 ± 1.9 mmol/L with bicarbonate. There were substantial increases in pretest [HCO3−] and pH and posttest urine pH after bicarbonate and caffeine + bicarbonate supplementation compared with placebo, but unclear performance effects.Conclusions:Rowers’ performance in 2,000-m efforts can improve by ~2% with 6 mg/kg BM caffeine supplementation. When caffeine is combined with sodium bicarbonate, gastrointestinal symptoms may prevent performance enhancement, so further investigation of ingestion protocols that minimize side effects is required.

scholarly journals Quantification of Training and Competition Loads in Endurance Sports: Methods and Applications

2017 ◽  
Vol 12 (s2) ◽  
pp. S2-9-S2-17 ◽  
Author(s):  
Iñigo Mujika
Keyword(s):  
Perceived Exertion ◽  
Training Programs ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Rating Of Perceived Exertion ◽  
Stress Recovery ◽  
Endurance Sports ◽  
Biological Stress ◽  
Technological Advances ◽  
And Performance

Training quantification is basic to evaluate an endurance athlete’s responses to training loads, ensure adequate stress/recovery balance, and determine the relationship between training and performance. Quantifying both external and internal workload is important, because external workload does not measure the biological stress imposed by the exercise sessions. Generally used quantification methods include retrospective questionnaires, diaries, direct observation, and physiological monitoring, often based on the measurement of oxygen uptake, heart rate, and blood lactate concentration. Other methods in use in endurance sports include speed measurement and the measurement of power output, made possible by recent technological advances such as power meters in cycling and triathlon. Among subjective methods of quantification, rating of perceived exertion stands out because of its wide use. Concurrent assessments of the various quantification methods allow researchers and practitioners to evaluate stress/recovery balance, adjust individual training programs, and determine the relationships between external load, internal load, and athletes’ performance. This brief review summarizes the most relevant external- and internal-workload-quantification methods in endurance sports and provides practical examples of their implementation to adjust the training programs of elite athletes in accordance with their individualized stress/recovery balance.

The Influence of Caffeine and Carbohydrate Coingestion on Simulated Soccer Performance

2010 ◽  
Vol 20 (3) ◽  
pp. 191-197 ◽  
Author(s):  
Nicholas Gant ◽  
Ajmol Ali ◽  
Andrew Foskett
Keyword(s):  
Heart Rate ◽  
Body Mass ◽  
Electrolyte Solution ◽  
Perceived Exertion ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Performance Outcomes ◽  
Rating Of Perceived Exertion ◽  
Subjective Experiences ◽  
And Performance

Carbohydrate and caffeine are known to independently improve certain aspects of athletic performance. However, less is understood about physiological and performance outcomes when these compounds are coingested in a rehydration and carbohydrate-replacement strategy. The aim of this study was to examine the influence of adding a moderate dose of caffeine to a carbohydrate solution during prolonged soccer activity. Fifteen male soccer players performed two 90-min intermittent shuttle-running trials. They ingested a carbohydrate-electrolyte solution (CON) providing a total of 1.8 g/kg body mass (BM) of carbohydrate or a similar solution with added caffeine (CAF; 3.7 mg/kg BM). Solutions were ingested 1 hr before exercise and every 15 min during the protocol. Soccer passing skill and countermovement-jump height (CMJ) were quantified before exercise and regularly during exercise. Sprinting performance, heart rate, blood lactate concentration (La) and the subjective experiences of participants were measured routinely. Mean 15-m sprint time was faster during CAF (p = .04); over the final 15 min of exercise mean sprint times were CAF 2.48 ± 0.15 s vs. CON 2.59 ± 0.2 s. Explosive leg power (CMJ) was improved during CAF (52.9 ± 5.8 vs. CON 51.7 ± 5.7 cm, p = .03). Heart rate was elevated throughout CAF, and ratings of pleasure were significantly enhanced. There were no significant differences in passing skill, rating of perceived exertion, La, or body-mass losses between trials. The addition of caffeine to the carbohydrate-electrolyte solution improved sprinting performance, countermovement jumping, and the subjective experiences of players. Caffeine appeared to offset the fatigue-induced decline in self-selected components of performance.

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