Indexes of body cell mass: nitrogen versus potassium

1983 ◽  
Vol 244 (3) ◽  
pp. E305-E310 ◽  
Author(s):  
S. H. Cohn ◽  
D. Vartsky ◽  
S. Yasumura ◽  
A. N. Vaswani ◽  
K. J. Ellis

In vivo neutron activation has provided investigators with a powerful tool for research on body composition. Total-body nitrogen (TBN), total-body potassium (TBK), and total-body water (TBW) were measured in 133 normal subjects. TBN, measured by neutron activation, is a measure of total-body protein, an index of body cell mass. TBK, also measured by a nuclear reaction, is an index of body cell mass as well as lean body mass. The mass and protein content of two compartments, muscle and nonmuscle lean tissue, were determined from the combined TBN-TBK data by compartmental analysis. In this study, nitrogen was separated into the actively metabolizing body cell mass component and the slowly metabolizing structural component. The TBK, which is 95% intracellular, was found to be more closely related to the actively metabolizing nitrogen than to TBN. The relationship of body cell mass, a concept originally proposed by Moore, to lean body mass, is shown through the relationship of TBN and TBK. The clinical significance of this study, is that TBK is the more sensitive and reliable indicator of changes in body cell mass. Maximum information on body composition, however, is obtained by the measurement of both TBK and TBN.

2003 ◽  
Vol 40 (S1) ◽  
pp. s305-s308 ◽  
Author(s):  
J. Wang ◽  
J. C. Thornton ◽  
S. B. Heymsfield ◽  
R. N. Pierson

1973 ◽  
Vol 142 (1) ◽  
pp. 175-180 ◽  
Author(s):  
H.-P. Sheng ◽  
R. A. Huggins

2017 ◽  
Vol 1 (2) ◽  
pp. 108
Author(s):  
Taufiq Taufiq ◽  
Ari Fahrial Syam ◽  
C Rinaldi Lesmana ◽  
Suhendro Suwarto

Pendahuluan. Bioelectric Impedance Analysis (BIA) mulai banyak digunakan dalam mengevaluasi status nutrisi. Belum ada data penelitian nutrisi di Indonesia yang menggunakan BIA. Penelitian ini dilakukan untuk mengetahui perbedaan rerata hasil pemeriksaan BIA antara status nutrisi baik dan malnutrisi pada penderita penyakit gastrointestinal dan hati yang dirawat inap. Metode. Penelitian potong lintang retrospektif terhadap penderita yang dirawat inap di ruang perawatan interna RSCM periode 1 Juni-31 Desember 2013, untuk mengetahui perbedaan rerata hasil pemeriksaan BIA penderita status nutrisi baik dan malnutrisi pada penyakit gastrointestinal dan hati yang dirawat inap.Hasil. Dari 28 penderita dengan status nutrisi baik, 71,57% laki-laki, dan 21,47% wanita. Dari 28 penderita malnutrisi, 53,60% laki-laki, dan 46,40% wanita. Rerata hasil pemeriksaan BIA antara penderita nutrisi baik dan malnutrisi adalah: lean body mass,  49,5 ± 8,59 v s39,68 ± 6,28kg, p<0,001; body cell mass, 32,19 (20,49-40,95) vs 25,23 (17,83-31,64) kg, p=0,003; total body water, 35,69±1,17 vs 28,58±0,85 kg, p<0,001; dan phase angle 6,18◦(3,73-10,11)◦ vs 3,46◦ (0,40-6,51)◦; , p<0,001. Simpulan. Pada penderita penyakit gastrointestinal dan hati yang dirawat inap dengan status nutrisi baik, memiliki nilai body mass, body cell mass,total body water dan phase angle hasil pemeriksaan BIA yang lebih tinggi dibandingkan dengan penderita malnutrisi. 


2004 ◽  
Vol 286 (1) ◽  
pp. E123-E128 ◽  
Author(s):  
ZiMian Wang ◽  
Marie-Pierre St-Onge ◽  
Beatriz Lecumberri ◽  
F. Xavier Pi-Sunyer ◽  
Stanley Heshka ◽  
...  

Existing models to estimate the metabolically active body cell mass (BCM) component in vivo remain incompletely developed. The classic Moore model is based on an assumed BCM potassium content of 120 mmol/kg. Our objectives were to develop an improved total body potassium (TBK)-independent BCM prediction model on the basis of an earlier model (Cohn SH, Vaswani AN, Yasumura S, Yuen K, and Ellis KJ. J Lab Clin Med 105: 305-311, 1985), to apply this improved model in subjects to explore the sex and age dependence of the TBK/BCM ratio, to develop a new TBK/BCM model on the basis of physiological associations between TBK and total body water (TBW) at the cellular level of body composition, and to fit this new model with available reference data. Subjects were 112 healthy adults who had the following components measured: TBW by 2H2O or 3H2O, extracellular water by NaBr, total body nitrogen by in vivo neutron activation, bone mineral by dual-energy X-ray absorptiometry, and TBK by whole body counting. Human reference data were collected from earlier published reports. The improved Cohn model-derived TBK/BCM ratio was (mean ± SD) 109.0 ± 10.9 mmol/kg and was not significantly related to sex and age. A simplified version of the new TBK-TBW model provided a TBK/BCM ratio almost identical (109.1 mmol/kg) to that derived by the improved Cohn model. The TBK-BCM prediction formula derived from the improved and new models [BCM (kg) = 1/109 × TBK (mmol); or BCM = 0.0092 × TBK] gives BCM estimates ∼11% higher than the classic Moore model (BCM = 0.0083 × TBK) formulated on rough tissue composition estimates. The present analyses provide a physiologically based, improved, and validated TBK-BCM prediction formula that should prove useful in body composition and metabolism research.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Till Ittermann ◽  
Marcello R. P. Markus ◽  
Martin Bahls ◽  
Stephan B. Felix ◽  
Antje Steveling ◽  
...  

AbstractPrevious studies on the association between thyroid function and body composition are conflicting and showed strong differences across age groups. Our aim was to clarify age-specific associations of serum thyroid-stimulating hormone (TSH) levels with markers of body composition including body mass index (BMI), waist circumference, fat mass (FM), fat-free mass (FFM) and body cell mass (BCM). We used data from two independent population-based cohorts within the framework of the Study of Health in Pomerania. The study population included 5656 individuals aged 20 to 90 years. Markers of body composition were measured by bioelectrical impedance analysis. Serum TSH levels were significantly positively associated with BMI (β = 0.16; 95% confidence interval [CI]: 0.06 to 0.27), waist circumference (β = 0.35; 95% CI: 0.08 to 0.62) and FM (β = 0.32; 95% CI: 0.12 to 0.52), but not with FFM and BCM. Interaction analysis revealed positive associations of serum TSH levels with BMI, waist circumference, FM, FFM and BCM in individuals older than 60 years, while no such associations were observed in younger individuals. We demonstrated that lower serum TSH levels were accompanied with lower values of BMI, waist circumference, FM, FFM, and BCM in the elderly, while no such associations were observed in younger individuals.


2018 ◽  
Vol 64 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Ana Paula Signori Urbano ◽  
Ligia Yukie Sassaki ◽  
Mariana de Souza Dorna ◽  
Paula Torres Presti ◽  
Maria Antonieta de Barros Leite Carvalhaes ◽  
...  

Summary Objective: The aim of our study was to assess body composition status and its association with inflammatory profile and extent of intestinal damage in ulcerative colitis patients during clinical remission. Method: This is a cross-sectional study in which body composition data (phase angle [PhA], fat mass [FM], triceps skin fold thickness [TSFt], mid-arm circumference [MAC], mid-arm muscle circumference [MAMC], adductor pollicis muscle thickness [APMt]), inflammatory profile (C-reactive protein [CRP], a1-acid glycoprotein, erythrocyte sedimentation rate [ESR]) and disease extent were recorded. Results: The mean age of the 59 patients was 48.1 years; 53.3% were women. Most patients were in clinical remission (94.9%) and 3.4% was malnourished according to body mass index. PhA was inversely correlated with inflammatory markers such as CRP (R=-0.59; p<0.001) and ESR (R=-0.46; p<0.001) and directly correlated with lean mass: MAMC (R=0.31; p=0.01) and APMt (R=0.47; p<0.001). Lean mass was inversely correlated with non-specific inflammation marker (APMt vs. ESR) and directly correlated with hemoglobin values (MAMC vs. hemoglobin). Logistic regression analysis revealed that body cell mass was associated with disease extent (OR 0.92; 95CI 0.87-0.97; p<0.01). Conclusion: PhA was inversely correlated with inflammatory markers and directly correlated with lean mass. Acute inflammatory markers were correlated with disease extent. Body cell mass was associated with disease extent.


2004 ◽  
Vol 52 (6) ◽  
pp. 886-891 ◽  
Author(s):  
Stefano Volpato ◽  
Franco Romagnoni ◽  
Lucia Soattin ◽  
Alessandro Blè ◽  
Vincenzo Leoci ◽  
...  

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