Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function

2021 ◽  
Vol 321 (4) ◽  
pp. H667-H683
Author(s):  
Ashlyn C. Harmon ◽  
Alexandra Noël ◽  
Balamurugan Subramanian ◽  
Zakia Perveen ◽  
Merilyn H. Jennings ◽  
...  
Keyword(s):  
Organic Matter ◽  
Free Radicals ◽  
Particulate Matter ◽  
Healthy Adult ◽  
Vascular Dysfunction ◽  
Pulmonary Inflammation ◽  
Cardiovascular Dysfunction ◽  
Adult Mice ◽  
Vascular Responsiveness ◽  
Direct Target

Particulate matter (PM) resulting from the combustion of organic matter is known to contribute to cardiopulmonary disease. Despite hypotheses that cardiovascular dysfunction occurring after PM exposures is secondary to lung or systemic inflammation, these studies investigating exposures to PM-containing environmentally persistent free radicals (EPFRs) demonstrate that cardiovascular dysfunction precedes pulmonary inflammation. The cardiopulmonary health consequences of EPFRs have yet to be thoroughly evaluated, especially in healthy, adult mice. Our data suggest the vasculature as a direct target of PM exposure, and our studies aimed to elucidate the mechanisms contributing to EPFR-induced vascular dysfunction.

Abstract 17375: In Utero Particulate Matter Exposure Produces Heart Failure and Electrical Remodeling at Adulthood

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Victor P Long ◽  
Vineeta Tanwar ◽  
Matthew W Gorr ◽  
Stephen H Baine ◽  
Ingrid M Bonilla ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Cardiac Dysfunction ◽  
Systolic Function ◽  
In Utero ◽  
In Utero Exposure ◽  
Electrical Remodeling ◽  
Morphological Alterations ◽  
Adult Mice ◽  
Significant Prolongation ◽  
Electrophysiological Recordings

Introduction: In utero exposure to particulate matter through perinatal development has been demonstrated to produce cardiac dysfunction during adulthood. It is unknown what effect exposure to air pollution during the in utero period alone has on cardiac dysfunction and electrical remodeling in adulthood. We tested the hypothesis that adult mice exposed to concentrated particulate matter in utero would demonstrate global cardiac dysfunction as well as cellular electrical remodeling at adulthood. Methods: Female FVB mice were exposed either to filtered air (FA) or particulate matter with diameter less than 2.5 μm (PM2.5) at a concentration of ~ 51.69 μg/m3 for 6 h/day, 7 days/wk (consistent with exposure in a large metropolitan city) beginning at plug formation throughout pregnancy. Cardiac function was assessed via ECHO in male offspring at 12 wks of age, followed by sacrifice and isolation of ventricular cardiomyocytes from both groups of mice for electrophysiological recordings. Results: ECHO identified increased LVESd (2.25 ± 0.20 FA, 2.61 ± 0.35 PM2.5, P=0.0001) and LVEDd (3.89 ± 0.03 FA, 3.99 ± 0.038 PM2.5, P=0.04) dimensions and reduced PWTs (1.40 ± 0.05 FA, 1.26 ± 0.04 PM2.5, P=0.04) in mice exposed in utero to PM2.5. Morphological alterations were associated with lower systolic function as indicated by reduced fractional shortening% (43.6 ± 2.1 FA, 33.2 ± 1.6 PM2.5, P=0.0009) in PM2.5 exposed mice compared to FA controls. Electrophysiological recordings revealed significant prolongation of the action potential at 90% repolarization (APD90) in PM2.5 exposed mice compared to FA. (FIGURE) Conclusions: In utero exposure to relevant levels of particulate matter results in dilated cardiomyopathy and electrical remodeling. Future studies are warranted to determine the causes of, and the exposure thresholds resulting in this adverse cardiac remodeling.

Abstract P391: Inhalation Of Airborne Particulate Matter Alters Cardiovascular Function Of Alzheimer-prone Mice

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
Devin R O'Piela ◽  
Ty A Saldana ◽  
David M Aslaner ◽  
Matthew W Gorr ◽  
Amy R Mackos ◽  
...  
Keyword(s):  
Heart Failure ◽  
Air Pollution ◽  
Risk Factor ◽  
Particulate Matter ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Airborne Particulate Matter ◽  
Transgenic Mouse Model ◽  
Cardiovascular Dysfunction ◽  
Airborne Particulate

Air pollution has detrimental effects on cardiovascular and lung function, and the extent of its pathological consequences continues to be uncovered. Recently, air pollution has been implicated in the development of Alzheimer Disease (AD) progression. AD and heart failure are common co-morbidities, giving reason to believe that cardiovascular dysfunction may contribute to AD. A known contributor to cardiovascular dysfunction-particulate matter (PM 2.5 , < 2.5 μm diameter)—is a critical component of air pollution and is considered a risk factor for heart failure and AD development. This co-morbidity pattern and shared environmental risk factor prompted the hypothesis that PM 2.5 contributes to cardiovascular dysfunction in a transgenic mouse model of AD. We tested our hypothesis by subjecting 6-month-old transgenic (APP) and non-carrier wildtype (WT) male mice to filtered air (FA) or PM 2.5 for 5 days/week, 6 hours/day for 3 months (n = 34). Following exposure, echocardiography, pressure-volume (PV) loops, and respiratory mechanics were performed to detect cardiac and pulmonary changes associated with genotype and exposure conditions among the 3-month group. Echocardiography revealed left ventricular anterior wall thickness in systole was significantly elevated among PM-exposed APP mice compared to FA-exposed APP controls. PV data demonstrated significant reduced end-systolic elastance in PM-exposed mice compared to FA-exposed mice in both WT and APP mouse models, demonstrating impaired contractility. PV loops also showed that the time constant of isovolumetric relaxation was increased in PM-exposed compared to FA-exposed WT mice. APP mice experienced higher lung resistance and central airway resistance with an increasing dose of methacholine. Taken together, these findings indicate airborne particulate matter exposure causes cardiac and pulmonary dysfunction in a transgenic mouse model of AD.

scholarly journals The Paths of the Suspended Particulate Inorganic and Organic Matter in a Small Urban Estuary: The Aarhus Harbour Estuary

1986 ◽  
Vol 17 (1) ◽  
pp. 31-46 ◽  
Author(s):  
K. B. Kronvang ◽  
C. Christiansen
Keyword(s):  
Organic Matter ◽  
Particulate Matter ◽  
Organic Content ◽  
Temporal And Spatial Distribution ◽  
Urban Estuary ◽  
Inorganic Matter ◽  
Organic Sediment ◽  
Suspended Particulate ◽  
Good Agreement ◽  
Inorganic And Organic

The nverine supply of suspended inorganic and organic sediment, its temporal and spatial distribution and its exchange with the bay, were estimated for an urban estuary (Aarhus Harbour Estuary, Denmark) during 1983-84. The river supplies high levels of particulate matter to the estuary. Export from the estuary averages one fifth of the river introduced particulate matter resulting in the accumulation of terrigenous material in the estuary. River discharge determines whether the high depletion of particulate matter in the upper estuary follows an exponential(flocculation) or a lineary curve (dilution). Preferential deposition of organic as opposed to inorganic matter in the upper estuary depletes the particulate matter of organic matter and associated pollutants. The estuary is divided into three depositional zones identified on the basis of sediment activity, grain-size and organic content. A sediment budget is precented for the estuary. Good agreement is shown between the actually dredged sediment quantity and the mass to sedimentation from the budget.

Nanoparticle stability in lake water shaped by natural organic matter properties and presence of particulate matter

2019 ◽  
Vol 656 ◽  
pp. 338-346 ◽  
Author(s):  
Danielle L. Slomberg ◽  
Patrick Ollivier ◽  
Hélène Miche ◽  
Bernard Angeletti ◽  
Auguste Bruchet ◽  
...  
Keyword(s):  
Organic Matter ◽  
Particulate Matter ◽  
Natural Organic Matter ◽  
Lake Water ◽  
Nanoparticle Stability
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