Abstract P391: Inhalation Of Airborne Particulate Matter Alters Cardiovascular Function Of Alzheimer-prone Mice

2021 ◽  
Vol 129 (Suppl_1) ◽  
Author(s):  
Devin R O'Piela ◽  
Ty A Saldana ◽  
David M Aslaner ◽  
Matthew W Gorr ◽  
Amy R Mackos ◽  
...  
Keyword(s):  
Heart Failure ◽  
Air Pollution ◽  
Risk Factor ◽  
Particulate Matter ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Airborne Particulate Matter ◽  
Transgenic Mouse Model ◽  
Cardiovascular Dysfunction ◽  
Airborne Particulate

Air pollution has detrimental effects on cardiovascular and lung function, and the extent of its pathological consequences continues to be uncovered. Recently, air pollution has been implicated in the development of Alzheimer Disease (AD) progression. AD and heart failure are common co-morbidities, giving reason to believe that cardiovascular dysfunction may contribute to AD. A known contributor to cardiovascular dysfunction-particulate matter (PM 2.5 , < 2.5 μm diameter)—is a critical component of air pollution and is considered a risk factor for heart failure and AD development. This co-morbidity pattern and shared environmental risk factor prompted the hypothesis that PM 2.5 contributes to cardiovascular dysfunction in a transgenic mouse model of AD. We tested our hypothesis by subjecting 6-month-old transgenic (APP) and non-carrier wildtype (WT) male mice to filtered air (FA) or PM 2.5 for 5 days/week, 6 hours/day for 3 months (n = 34). Following exposure, echocardiography, pressure-volume (PV) loops, and respiratory mechanics were performed to detect cardiac and pulmonary changes associated with genotype and exposure conditions among the 3-month group. Echocardiography revealed left ventricular anterior wall thickness in systole was significantly elevated among PM-exposed APP mice compared to FA-exposed APP controls. PV data demonstrated significant reduced end-systolic elastance in PM-exposed mice compared to FA-exposed mice in both WT and APP mouse models, demonstrating impaired contractility. PV loops also showed that the time constant of isovolumetric relaxation was increased in PM-exposed compared to FA-exposed WT mice. APP mice experienced higher lung resistance and central airway resistance with an increasing dose of methacholine. Taken together, these findings indicate airborne particulate matter exposure causes cardiac and pulmonary dysfunction in a transgenic mouse model of AD.

Airborne particulate matter from livestock production systems: A review of an air pollution problem

2010 ◽  
Vol 158 (1) ◽  
pp. 1-17 ◽  
Author(s):  
María Cambra-López ◽  
André J.A. Aarnink ◽  
Yang Zhao ◽  
Salvador Calvet ◽  
Antonio G. Torres
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Production Systems ◽  
Airborne Particulate Matter ◽  
Livestock Production ◽  
Airborne Particulate ◽  
Pollution Problem

scholarly journals Cardiomyocyte-specific overexpression of oestrogen receptor β improves survival and cardiac function after myocardial infarction in female and male mice

2016 ◽  
Vol 130 (5) ◽  
pp. 365-376 ◽  
Author(s):  
Iris Schuster ◽  
Shokoufeh Mahmoodzadeh ◽  
Elke Dworatzek ◽  
Frédéric Jaisser ◽  
Smail Messaoudi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Mouse Model ◽  
Cardiac Function ◽  
Transgenic Mouse ◽  
Oestrogen Receptor ◽  
Transgenic Mouse Model ◽  
Male Mice ◽  
Specific Effects

The study provides new insights into cardiomyocyte-specific effects of ERβ in the setting of chronic MI using a transgenic mouse model. ERβ-overexpressing mice of both sexes showed improved survival, less maladaptive LV remodelling, better cardiac function and less heart failure development.

scholarly journals Exposure to Airborne Particulate Matter: An Additional Risk Factor for Metabolic Syndrome in Saudi Arabia

2015 ◽  
Vol 26 (2) ◽  
pp. 63-73
Author(s):  
Mansour A. Alghamdi Mansour A. Alghamdi
Keyword(s):  
Metabolic Syndrome ◽  
Saudi Arabia ◽  
Risk Factor ◽  
Particulate Matter ◽  
Elemental Composition ◽  
Life Style ◽  
Airborne Particulate Matter ◽  
Additional Risk Factor ◽  
Airborne Particulate ◽  
Additional Risk

. Metabolic syndrome is a serious problem in Saudi Arabia. It has been attributed mainly to life style. Exposure to airborne particulate matter is a subject of concern in Jeddah. The present study aimed to find a possible association of metabolic syndrome prevalence with levels of particulate matter and their elemental constituents. The study was conducted in two districts of Jeddah, Al Nuzlah and Al Rehab. PM10 and PM2.5 were measured in each district as well as their elemental composition. Metabolic syndrome was defined by the presence of three components: hyperglycemia, hypertension and obesity. Al Nuzlah district showed higher prevalence of metabolic syndrome, together with higher levels of PM2.5, nickel and cadmium. It can be concluded that exposure to particulate matter may be considered as an additional risk factor for metabolic syndrome.

scholarly journals Spatial Extent and Distribution of Ambient Airborne Particulate Matter (PM2.5) in Selected Land Use Sites in Nairobi, Kenya

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Caroline Kiai ◽  
Christopher Kanali ◽  
Joseph Sang ◽  
Michael Gatari
Keyword(s):  
Land Use ◽  
Air Pollution ◽  
Particulate Matter ◽  
Air Quality ◽  
Low Cost ◽  
Airborne Particulate Matter ◽  
Spatial Extent ◽  
Airborne Particulate ◽  
Concentration Levels ◽  
Pm2.5 Concentration

Air pollution is one of the most important environmental and public health concerns worldwide. Urban air pollution has been increasing since the industrial revolution due to rapid industrialization, mushrooming of cities, and greater dependence on fossil fuels in urban centers. Particulate matter (PM) is considered to be one of the main aerosol pollutants that causes a significant adverse impact on human health. Low-cost air quality sensors have attracted attention recently to curb the lack of air quality data which is essential in assessing the health impacts of air pollutants and evaluating land use policies. This is mainly due to their lower cost in comparison to the conventional methods. The aim of this study was to assess the spatial extent and distribution of ambient airborne particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) in Nairobi City County. Seven sites were selected for monitoring based on the land use type: high- and low-density residential, industrial, agricultural, commercial, road transport, and forest reserve areas. Calibrated low-cost sensors and cyclone samplers were used to monitor PM2.5 concentration levels and gravimetric measurements for elemental composition of PM2.5, respectively. The sensor percentage accuracy for calibration ranged from 81.47% to 98.60%. The highest 24-hour average concentration of PM2.5 was observed in Viwandani, an industrial area (111.87 μg/m³), and the lowest concentration at Karura (21.25 μg/m³), a forested area. The results showed a daily variation in PM2.5 concentration levels with the peaks occurring in the morning and the evening due to variation in anthropogenic activities and the depth of the atmospheric boundary layer. Therefore, the study suggests that residents in different selected land use sites are exposed to varying levels of PM2.5 pollution on a regular basis, hence increasing the potential of causing long-term health effects.

scholarly journals A Transgenic Mouse Model of Heart Failure Using Inducible Gαq

2005 ◽  
Vol 280 (48) ◽  
pp. 40337-40346 ◽  
Author(s):  
Gaofeng Fan ◽  
Ya-Ping Jiang ◽  
Zhongju Lu ◽  
Dwight W. Martin ◽  
Damon J. Kelly ◽  
...  
Keyword(s):  
Heart Failure ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model

scholarly journals The Impact of Ambient Fine Particulate Matter on Consumer Expenditures

2020 ◽  
Vol 12 (5) ◽  
pp. 1855
Author(s):  
Hojin Jung
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Power Plants ◽  
Airborne Particulate Matter ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Significant Heterogeneity ◽  
Airborne Particulate ◽  
Consumer Expenditures ◽  
The Impact

Airborne particulate matter suspended from industrial facilities, power plants, and automobiles is detrimental to health. Growing concerns about the increasing level of airborne particulate matter have led many industrialized nations to advocate for the transformation of the energy market and investment in sustainable energy products. At the other end, consumers have made individual adjustments and attempted to reduce the exposure to the particulate matter. In this paper, we focus on the effect of ambient air pollution on consumer expenditures based on scanner panel data on consumers’ debit and credit card transactions. A series of empirical analyses found robust evidence that the increased level of particulate matter led to considerable disruption in total consumer expenditures with significant heterogeneity across categories. Our findings suggest that consumers alter their spending behaviors in an attempt to reduce the risk of exposures to particulate matter. Such an estimated effect of air pollution is qualitatively different from those of other macroeconomic factors and provides important guidance for policy interventions and practical decisions aimed at sustaining economic growth.

scholarly journals Variations in Reactive Oxygen Species Generation by Urban Airborne Particulate Matter in Lung Epithelial Cells—Impact of Inorganic Fraction

2020 ◽  
Vol 8 ◽  
Author(s):  
Olga Mazuryk ◽  
Grazyna Stochel ◽  
Małgorzata Brindell
Keyword(s):  
Reactive Oxygen Species ◽  
Air Pollution ◽  
Particulate Matter ◽  
Epithelial Cells ◽  
A549 Cells ◽  
Reactive Oxygen ◽  
Airborne Particulate Matter ◽  
Oxygen Species ◽  
Airborne Particulate ◽  
Inorganic Fraction

Air pollution is associated with numerous negative effects on human health. The toxicity of organic components of air pollution is well-recognized, while the impact of their inorganic counterparts in the overall toxicity is still a matter of various discussions. The influence of airborne particulate matter (PM) and their inorganic components on biological function of human alveolar-like epithelial cells (A549) was investigated in vitro. A novel treatment protocol based on covering culture plates with PM allowed increasing the studied pollutant concentrations and prolonging their incubation time without cell exposure on physical suffocation and mechanical disturbance. PM decreased the viability of A549 cells and disrupted their mitochondrial membrane potential and calcium homeostasis. For the first time, the difference in the reactive oxygen species (ROS) profiles generated by organic and inorganic counterparts of PM was shown. Singlet oxygen generation was observed only after treatment of cells with inorganic fraction of PM, while hydrogen peroxide, hydroxyl radical, and superoxide anion radical were induced after exposure of A549 cells to both PM and their inorganic fraction.

Sign in / Sign up

Export Citation Format

Share Document