Turbulent pressure fluctuations on surface of model vascular stenoses

1991 ◽  
Vol 261 (3) ◽  
pp. H644-H650 ◽  
Author(s):  
H. M. Loree ◽  
R. D. Kamm ◽  
C. M. Atkinson ◽  
R. T. Lee
Keyword(s):  
Peak Pressure ◽  
Plaque Rupture ◽  
Pressure Fluctuations ◽  
Experimental Conditions ◽  
Flow Rates ◽  
Turbulent Pressure ◽  
Stenosis Severity ◽  
Artery Flow ◽  
Diameter Reduction ◽  
Carotid Flow

Turbulence frequently develops when blood passes through a stenosis. To study the hypothesis that turbulence near a plaque surface can cause pressure fluctuations that may promote plaque rupture, models of intravascular stenoses were studied. Experimental conditions simulated peak flow in the coronary and carotid arteries through a stenosis of 80 or 90% diameter reduction and into a region where the plaque had widened distally to a 50-75% stenosis. For symmetric stenoses at carotid artery flow rates, peak pressure fluctuations were observed 1-1.5 upstream diameters distal to the stenosis, but there were no significant turbulent pressure fluctuations at coronary artery flow rates. Stenosis asymmetry strongly increased the intensity of turbulent pressure fluctuations at flows simulating carotid flow and resulted in significant pressure fluctuations for coronary flow conditions. Increasing stenosis severity from 80 to 90% increased the root mean square pressure fluctuations 3.6-fold. These studies predict peak to peak pressure fluctuations of 15 mmHg in a 90% asymmetric coronary stenosis; it is possible that turbulence may play a role in acute damage of atherosclerotic plaques, particularly in asymmetric stenoses.

An anti-settling sample delivery instrument for serial femtosecond crystallography

2012 ◽  
Vol 45 (4) ◽  
pp. 674-678 ◽  
Author(s):  
Lukas Lomb ◽  
Jan Steinbrener ◽  
Sadia Bari ◽  
Daniel Beisel ◽  
Daniel Berndt ◽  
...  
Keyword(s):  
Constant Flow ◽  
Syringe Pump ◽  
Experimental Conditions ◽  
Flow Rates ◽  
X Ray ◽  
Constant Flow Rate ◽  
Significant Impairment ◽  
Working Principle ◽  
After Hours ◽  
Serial Femtosecond Crystallography

Serial femtosecond crystallography (SFX) using X-ray free-electron laser (FEL) sources has the potential to determine the structures of macromolecules beyond the limitation of radiation damage and without the need for crystals of sufficient size for conventional crystallography. In SFX, a liquid microjet is used to inject randomly oriented crystals suspended in their storage solution into the FEL beam. Settling of crystals in the reservoir prior to the injection has been found to complicate the data collection. This article details the development of an anti-settling sample delivery instrument based on a rotating syringe pump, capable of producing flow rates and liquid pressures necessary for the operation of the injector. The device has been used successfully with crystals of different proteins, with crystal sizes smaller than 20 µm. Even after hours of continuous operation, no significant impairment of the experiments due to sample settling was observed. This article describes the working principle of the instrument and sets it in context with regard to the experimental conditions used for SFX. Hit rates for longer measuring periods are compared with and without the instrument operating. Two versions of the instrument have been developed, which both deliver sample at a constant flow rate but which differ in their minimum liquid flow rates and maximum pressures.

The Effect of the Operating Point on the Pressure Fluctuations at the Blade Passage Frequency in the Volute of a Centrifugal Pump

2002 ◽  
Vol 124 (3) ◽  
pp. 784-790 ◽  
Author(s):  
Jorge L. Parrondo-Gayo ◽  
Jose´ Gonza´lez-Pe´rez ◽  
Joaquı´n Ferna´ndez-Francos
Keyword(s):  
Centrifugal Pump ◽  
Pressure Fluctuations ◽  
Fast Response ◽  
Strong Increase ◽  
Flow Rates ◽  
Blade Passage ◽  
Pressure Transducers ◽  
Leading Role ◽  
Dynamic Forces ◽  
Response Pressure

An experimental investigation is presented which analyzes the unsteady pressure distribution existing in the volute of a conventional centrifugal pump with a nondimensional specific speed of 0.48, for flow-rates from 0% to 160% of the best-efficiency point. For that purpose, pressure signals were obtained at 36 different locations along the volute casing by means of fast-response pressure transducers. Particular attention was paid to the pressure fluctuations at the blade passage frequency, regarding both amplitude and phase delay relative to the motion of the blades. Also, the experimental data obtained was used to adjust the parameters of a simple acoustic model for the volute of the pump. The results clearly show the leading role played by the tongue in the impeller-volute interaction and the strong increase in the magnitude of dynamic forces and dipole-like sound generation in off-design conditions.

Experimental Investigation of Pressure Fluctuations on Inner Wall of a Centrifugal Pump

2019 ◽  
Vol 36 (4) ◽  
pp. 401-410 ◽  
Author(s):  
Xiao-Qi Jia ◽  
Bao-Ling Cui ◽  
Zu-Chao Zhu ◽  
Yu-Liang Zhang
Keyword(s):  
Centrifugal Pump ◽  
Flow Rate ◽  
Pressure Fluctuation ◽  
Pressure Fluctuations ◽  
High Flow ◽  
Low Flow ◽  
Centrifugal Pumps ◽  
Flow Rates ◽  
Pressure Distributions ◽  
Blade Passing Frequency

Abstract Affected by rotor–stator interaction and unstable inner flow, asymmetric pressure distributions and pressure fluctuations cannot be avoided in centrifugal pumps. To study the pressure distributions on volute and front casing walls, dynamic pressure tests are carried out on a centrifugal pump. Frequency spectrum analysis of pressure fluctuation is presented based on Fast Fourier transform and steady pressure distribution is obtained based on time-average method. The results show that amplitudes of pressure fluctuation and blade-passing frequency are sensitive to the flow rate. At low flow rates, high-pressure region and large pressure gradients near the volute tongue are observed, and the main factors contributing to the pressure fluctuation are fluctuations in blade-passing frequency and high-frequency fluctuations. By contrast, at high flow rates, fluctuations of rotating-frequency and low frequencies are the main contributors to pressure fluctuation. Moreover, at low flow rates, pressure near volute tongue increases rapidly at first and thereafter increases slowly, whereas at high flow rates, pressure decreases sharply. Asymmetries are observed in the pressure distributions on both volute and front casing walls. With increasing of flow rate, both asymmetries in the pressure distributions and magnitude of the pressure decrease.

Accounting for sensor calibration, concentration heterogeneity, measurement and sampling uncertainties in monitoring urban drainage systems

2003 ◽  
Vol 47 (2) ◽  
pp. 95-102 ◽  
Author(s):  
J.-L. Bertrand-Krajewski ◽  
J.-P. Bardin ◽  
M. Mourad ◽  
Y. Béranger
Keyword(s):  
Performance Indicator ◽  
Sensor Calibration ◽  
Urban Drainage ◽  
Experimental Conditions ◽  
Flow Rates ◽  
Rainfall Events ◽  
Drainage Systems ◽  
Methods And Techniques ◽  
Urban Drainage Systems ◽  
Online Measurements

Assessing the functioning and the performance of urban drainage systems on both rainfall event and yearly time scales is usually based on online measurements of flow rates and on samples of influent and effluent for some rainfall events per year. In order to draw pertinent scientific and operational conclusions from the measurement results, it is absolutely necessary to use appropriate methods and techniques in order to i) calibrate sensors and analytical methods, ii) validate raw data, iii) evaluate measurement uncertainties, iv) evaluate the number of rainfall events to sample per year in order to determine performance indicator with a given uncertainty. Based on previous work, the paper gives a synthetic review of required methods and techniques, and illustrates their application to storage and settling tanks. Experiments show that, despite controlled and careful experimental conditions, relative uncertainties are about 20% for flow rates in sewer pipes, 6-10% for volumes, 25-35% for TSS concentrations and loads, and 18-276% for TSS removal rates. In order to evaluate the annual pollutant interception efficiency of storage and settling tanks with a given uncertainty, efforts should first be devoted to decrease the sampling uncertainty by increasing the number of sampled events.

Effects of short blades on performance and inner flow characteristics of a low-specific-speed centrifugal pump

2017 ◽  
Vol 231 (4) ◽  
pp. 290-302 ◽  
Author(s):  
Can Kang ◽  
Ning Mao ◽  
Chen Pan ◽  
Yang Zhu ◽  
Bing Li
Keyword(s):  
Centrifugal Pump ◽  
Flow Rate ◽  
Pressure Fluctuations ◽  
Flow Characteristics ◽  
Low Flow ◽  
Back Surface ◽  
Flow Rates ◽  
Pump Operation ◽  
Low Specific Speed ◽  
Specific Speed

A low-specific-speed centrifugal pump equipped with long and short blades is studied. Emphasis is placed on the pump performance and inner flow characteristics at low flow rates. Each short blade is intentionally shifted towards the back surface of the neighboring long blade, and the outlet parts of the short blades are uniformly shortened. Unsteady numerical simulation is conducted to disclose inner flow patterns associated with the modified design. Thereby, a comparison is enabled between the two schemes featured by different short blades. Both practical operation data and numerical results support that the deviation and cutting of the short blades can eliminate the positive slope of pump head curve at low flow rates. Therefore, the modification of short blades improves the pump operation stability. Due to the shortening of the outlet parts of the short blades, velocity distributions between impeller outlet and radial diffuser inlet exhibit explicitly altered circumferential flow periodicity. Pressure fluctuations in the radial diffuser are complex in terms of diversified periodicity and amplitudes. Flow rate influences pressure fluctuations in the radial diffuser considerably. As flow rate decreases, the regularity of the orbit of hydraulic loads exerted upon the impeller collapses while hydraulic loads exerted upon the short blades remain circumferentially periodic.

scholarly journals The Effect of Variable Geometry on the Operating Range and Surge Margin of a Centrifugal Compressor

1976 ◽  
Author(s):  
A. Whitfield ◽  
F. J. Wallace ◽  
R. C. Atkey
Keyword(s):  
Centrifugal Compressor ◽  
Peak Pressure ◽  
Pressure Ratio ◽  
Variable Geometry ◽  
Vaneless Diffuser ◽  
Flow Rates ◽  
Lower Flow ◽  
Operating Range ◽  
Surge Margin ◽  
Isentropic Efficiency

Two variable geometry techniques have been applied to a small turbocharger compressor, with the objective of trying to move the peak pressure ratio operating point to lower flow rates, thereby yielding a broad flow range map. Variable prewhirl guide vanes and variable vaneless diffuser passage height have been studied separately. The results obtained with both techniques are compared and the relative merits and demerits with respect to improved flow range and isentropic efficiency penalties are considered.

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