Gamma irradiation on rat whole blood cholinesterase

1959 ◽  
Vol 196 (5) ◽  
pp. 949-950 ◽  
Author(s):  
Martin W. Williams
Keyword(s):  
Gamma Irradiation ◽  
Gamma Rays ◽  
Whole Blood ◽  
Cholinesterase Activity ◽  
Whole Body

Rat whole blood cholinesterase levels were followed electrometrically for 10 days following whole-body irradiation with 300 and 600 r gamma rays from a Co60 source. Cholinesterase activity was significantly depressed in both groups after the 3rd day, reaching its lowest observed levels on the 10th day. The toxicity of acetylcholine bromide was significantly greater to mice 9 days after 300 r of whole-body gamma irradiation than in nonirradiated controls as indicated by the intraperitoneal ld50 which was 294 mg/kg prior to, and 235 mg/kg after, irradiation.

Effect of Gamma-Irradiation on Prenatal Development of the Nasal Septal Cartilage in CD-1 Mice

1994 ◽  
Vol 31 (3) ◽  
pp. 167-172 ◽  
Author(s):  
A. Yousef M. Saad
Keyword(s):  
Gamma Irradiation ◽  
Gamma Rays ◽  
Nasal Septum ◽  
Prenatal Development ◽  
Septal Cartilage ◽  
Whole Body ◽  
Maturation Process ◽  
Head Height ◽  
Mouse Fetuses ◽  
Nasal Septal Cartilage

The effects of gamma-rays on nasal septum development in CD-1 mouse fetuses subsequent to irradiation of their mothers were studied. Pregnant CD-1 mice exposed to 400 rads of whole body gamma-irradiation 12 days after gestation were sacrificed on day 18, post coltum. The fetuses were removed via laparotomy and analyzed. Data on head dimensions, including head height, width, and circumference were recorded. Fetal heads were then routinely prepared for histologic examination of the developing nasal septal cartilage. Analysis of data revealed significant reduction in litter size (p < .0025) and head measurements (p < .0005) of irradiated animals. Histologically, the nasal septa of Irradiated fetuses had retarded growth, were less differentiated, and smaller than those of control mice. Results suggest that gamma-irradiation has detrimental effects on litter and head sizes and may interfere with the cellular maturation process of nasal septal cartilage as well as other structures.

Effects of Carbamates on Whole Blood Cholinesterase Activity: Chemical Protection Against Soman

1980 ◽  
Vol 3 (3) ◽  
pp. 319-332 ◽  
Author(s):  
William C. Heyl ◽  
Larrel W. Harris ◽  
David L. Stitcher
Keyword(s):  
Whole Blood ◽  
Cholinesterase Activity ◽  
Chemical Protection

scholarly journals Chronic Gamma Irradiation Changes Phenotype and Gene Expression Partially Transmitted to Next-Generation Tomato Seedlings

Agronomy ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1638
Author(s):  
Seong-Min Kim ◽  
Yeong Deuk Jo ◽  
Jae-In Chun ◽  
Jin-Baek Kim ◽  
Jin-Ho Kang
Keyword(s):  
Gene Expression ◽  
Gamma Irradiation ◽  
Gamma Rays ◽  
Mutation Breeding ◽  
Fruit Shape ◽  
Leaf Length ◽  
Trichome Density ◽  
Next Generation ◽  
Seed Number ◽  
And Control

Compared to the studies on acute irradiation of seeds, fewer studies have reported on the chronic irradiation of seedlings, especially in fruit-bearing vegetables. We examined the effects of chronic gamma irradiation on tomato (Solanum lycopersicum ‘Micro-Tom’) seedlings exposed to gamma rays (50, 100, 150, and 200 Gy) for 4 weeks. As the total dose of gamma rays increased, leaf length, trichome density, and seed number were reduced in the irradiated seedlings (M1). Additionally, a change in fruit shape was observed. Chronic gamma irradiation reduced the expression of two trichome-related genes and affected the expression levels of 11 reactive oxygen species (ROS)-related genes. We examined the transmittance of these effects using M2 plants. The trichome density and fruit shape were similar between M2 and control plants; however, a reduction in leaf length and seed number was detected in M2 plants. Interestingly, changes in the expression of four ROS-related genes (ZAT10, Mn-SOD, POD3, and RBOH1) found in M1 were detected in M2 plants. Thus, the changes in phenotype and gene expression induced by chronic gamma irradiation were transmitted to the next generation. Additionally, we found novel mutants from M2 plants, suggesting that chronic gamma irradiation may be considered in tomato mutation breeding.

scholarly journals Lactoferrin beneficially influences the recovery of physiological and behavioral indexes in mice exposed to acute gamma-irradiation

2020 ◽  
pp. 29-33 ◽  
Author(s):  
М.Ю. Копаева ◽  
И.Б. Алчинова ◽  
М.В. Нестеренко ◽  
А.Б. Черепов ◽  
И.Ю. Зарайская ◽  
...  
Keyword(s):  
Body Weight ◽  
Survival Rate ◽  
Gamma Irradiation ◽  
Life Span ◽  
Open Field Test ◽  
Whole Body ◽  
Sublethal Dose ◽  
Male Mice ◽  
Research Activity ◽  
Compensatory Effect

Целью настоящей работы стало исследование эффектов лактоферрина (Лф) человека у мышей после острого гамма-облучения в сублетальной дозе. Методы. Исследование было проведено на 2-2,5-месячных самцах мышей линии C57Bl/6. Животные из экспериментальных групп были подвергнуты общему воздействию гамма-излучения в дозе 7,5 Гр. Сразу после облучения и повторно через 24 часа после него часть животных получила инъекцию Лф (внутрибрюшинно, 4 мг на животное). Было изучено влияние Лф на выживаемость и среднюю продолжительность жизни мышей. Для оценки общей двигательной и исследовательской активности использовали тест «Открытое поле». Результаты. Введение Лф позволило увеличить выживаемость и среднюю продолжительность жизни облученных мышей в течение эксперимента. Происходила более быстрая нормализация динамики изменения массы тела. Кроме того, Лф оказал компенсаторное действие на исследовательскую активность облученных животных. The aim of this study was to investigate effects of human lactoferrin (Lf) in mice exposed to acute gamma-irradiation at a sublethal dose. Methods. C57Вl/6 2-2.5-month-old male mice were used for the experiments. Animals from experimental groups were exposed to whole-body gamma-radiation at a dose of 7.5 Gy. Some animals received an intraperitoneal injection of Lf (4 mg per animal) immediately and then at 24 hours after the irradiation. The effect of Lf on survival rate and life span was studied. The open field test was used to assess locomotor and research activity. Results. The Lf administration increased the survival rate and life span of irradiated mice during the experiment. The dynamics of body weight normalized faster. In addition, Lf exerted a compensatory effect on the research activity of irradiated animals.

scholarly journals Study on the immuno stimulation of radiation degraded β-glucan in swiss mice

2015 ◽  
Vol 5 (4) ◽  
pp. 9-15
Author(s):  
Thanh Long Nguyen ◽  
Quang Luan Le
Keyword(s):  
Cell Wall ◽  
Immune System ◽  
Gamma Irradiation ◽  
Gamma Rays ◽  
Irradiation Dose ◽  
Functional Foods ◽  
Water Soluble ◽  
Molecular Weights ◽  
Swiss Mice ◽  
Stimulation Of

The mixtures β-glucan extracted from the yeast cell wall were irradiated under gamma rays from a Co-60 source at doses of 100, 200 and 300 kGy in order to prepare water-soluble β-glucan. Yields of the water soluble β-glucan produced are 25.9, 49.1, 66.71%, and their molecular weights (Mw) are 30.5, 24.9 and 10.8 kDa, respectively. There are no any new peak in the IR spectra of the irradiated β-glucan samples, but the intensity ratio between the peaks at wavenumber of 1156 cm-1 (assigned to C-O-C bond) and of 1040 cm-1 (assigned to C-C bond) in glycosidic linkages was reduced with irradiation dose. These results revealed that gamma irradiation did not cause any change in the β-glucan structure except the scissions of glycosidic linkages. In this study, immuno stimulation of the irradiated b-glucan was also investigated for the Swiss mice. After 28 days supplying with the irradiated b-glucan, not only cellular indexes (white blood cell, neutrophils and lymphocytes counts), but also humoral  immunity indexes (IgA and IgM) of the mice significantly increased and the highest effects was obtained for the mice supplied with the oligoβ-glucan prepared by gamma irradiation at 200 kGy. Thus, the water soluble oligoβ-glucan with Mw ~ 24.9 kDa prepared by gamma radiation much stimulated the natural immune system (non-specific immunity) in mice including both the cellular and humoral immunities. Particularly, the irradiated b-glucan is a very promising product for preparation of functional foods aiming at cancer prevention.

scholarly journals Effect of Clodronate Alone or In Combination with Vitamin E on Demineralization Induced By Whole Body Gamma Irradiation in Rats

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Heba Gheita ◽  
Walaa Elsabbagh ◽  
Rania Abdelsalam ◽  
Amina Attia ◽  
Mona El-Ghazaly
Keyword(s):  
Vitamin E ◽  
Gamma Irradiation ◽  
Whole Body

Tissue–air ratios for whole body irradiation with cobalt 60 gamma rays

1978 ◽  
Vol 51 (606) ◽  
pp. 460-462 ◽  
Author(s):  
E. Hochhäauser ◽  
O. A. Balk
Keyword(s):  
Gamma Rays ◽  
Whole Body
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