High-protein nutrition during pregnancy and lactation programs blood pressure, food efficiency, and body weight of the offspring in a sex-dependent manner

2006 ◽  
Vol 291 (4) ◽  
pp. R1025-R1030 ◽  
Author(s):  
C. Thone-Reineke ◽  
P. Kalk ◽  
M. Dorn ◽  
S. Klaus ◽  
K. Simon ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Maternal Diet ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Dependent Manner ◽  
Food Efficiency ◽  
Pregnancy And Lactation ◽  
Fat Pads

Maternal low-protein diet during pregnancy is a risk factor for cardiovascular disease of the offspring in later life. The impact of high-protein diet during pregnancy on the cardiovascular phenotype of the offspring, however, is still unknown. We examined the influence of a high-protein diet during pregnancy and lactation on the renal, hemodynamic, and metabolic phenotype of the F1 generation. Female Wistar rats were either fed a normal protein diet (20% protein: NP) or an isocaloric high-protein diet (40% protein: HP) throughout pregnancy and lactation. At weaning, the offspring were fed with standard diet, and they were allocated according to sex and maternal diet to four groups: normal-protein male (NPm, n = 25), normal-protein female (NPf, n = 19), high-protein male (HPm, n = 24), high-protein female (HPf, n = 29). During the experiment (22 wk), the animals were characterized by repeated measurement of body weight, food intake, blood pressure, glucose tolerance, energy expenditure, and kidney function. At the end of the study period histomorphological analyses of the kidneys and weight measurement of reproductive fat pads were conducted. There were no differences in birth weight between the study groups. No influence of maternal diet on energy expenditure, glucose tolerance, and plasma lipid levels was detected. Blood pressure and glomerulosclerosis were elevated in male offspring only, whereas female offspring were characterized by an increased food efficiency, higher body weight, and increased fat pads. Our study demonstrates that a high-protein diet during pregnancy and lactation in rats programs blood pressure, food efficiency, and body weight of the offspring in a sex-dependent manner.

The effect of plane of nutrition on the body composition of two breeds of wearier sheep fed a high protein diet

1982 ◽  
Vol 98 (2) ◽  
pp. 241-245 ◽  
Author(s):  
T. W. Searle ◽  
N. McC. Graham ◽  
J. B. Donnelly
Keyword(s):  
Body Weight ◽  
Live Weight ◽  
High Protein Diet ◽  
The Body ◽  
High Protein ◽  
The Other ◽  
Protein Diet ◽  
Castrate Male ◽  
Body Component ◽  
The Relationship

SUMMARYCorriedale and Dorset Horn castrate male (wether) lambs reared at pasture were weaned at 19 kg live weight (LW), brought indoors and fed a high protein diet such that half of each group grew at ca. 200 g/day and the other half at ca. 100 g/day. Animals were slaughtered at 25 and 30 kg LW and chemical composition (protein, fat, energy, water and ash) of the body determined. The relationship between each body component and shorn empty-body weight was examined by regression analysis.Within levels of feeding the results were similar in the two breeds. When comparisons were made between feeding levels, the slower-growing animals contained more fat, energy and ash than the faster-growing group, less water, but similar amounts of protein at any given empty-body weight.

Abstract P167: High vs. Standard Protein Diets in Obese Patients with Heart Failure: Effects on Chronic Disease Risks

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Lorraine S Evangelista ◽  
Dawn Lombardo ◽  
Tamara Horwich ◽  
Michele Hamilton ◽  
Gregg C Fonarow
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Chronic Disease ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Obese Patients ◽  
Patients With Heart Failure ◽  
Disease Risks ◽  
Standard Protein

Background: There is controversy over dietary protein’s effect on long-term chronic disease risks in overweight and obese patients with heart failure. The aim of this study was to compare the effects of two calorie-restricted diets differing in protein content on chronic disease risks (e.g., weight, adiposity, glycemic control, lipid profiles, and blood pressure). Methods: A total of 97 overweight and obese (mean body mass index [BMI], 37.0 ± 6.2 kg/m 2 ) patients with heart failure, aged 58.8 ± 9.7 years, 70% males, consumed two diets, each for 12 weeks, in a randomized controlled design. The diets were: (1) a high protein diet (30% protein, 40% carbohydrates, and 30% fat) and (2) a standard protein diet (15% protein, 55% carbohydrates, and 30% fat). Their effects on weight (BMI) visceral fat (i.e. waist circumference), glycemic control (i.e. glycosylated hemoglobin [HgbA1C]), lipid profiles (total cholesterol [TC], low-density lipoprotein [LDL], high-density lipoprotein [HDL], triglycerides [TG]), and blood pressure at the beginning and end of each dietary intervention were analyzed. Results: Both diets were equally effective in promoting weight loss and visceral fat loss and in improving TC, but the high protein diet decreased to a greater extent HgbA1C levels ( P < 0.001) when compared with the standard protein diet. The high protein diet improved significantly TG levels ( P < 0.001) and both systolic and diastolic blood pressures when compared with the standard protein diet ( P < 0.001 and P < 0.001, respectively, see figure). No differences were noted in LDL and HDL levels. Conclusion: Energy restricted diets facilitate weight loss and visceral fat loss and lower TC in overweight and obese patients with heart failure. However, the high protein diet promoted better improvements in TG levels, glycemic control, and blood pressure than the standard protein diet, and may be superior in reducing chronic disease risks and potentially slowing the progression of disease in this population.

Nephron number and blood pressure in rat offspring with maternal high-protein diet

2002 ◽  
Vol 17 (12) ◽  
pp. 1000-1004 ◽  
Author(s):  
Monika Zimanyi ◽  
John Bertram ◽  
Jane Black
Keyword(s):  
Blood Pressure ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Nephron Number ◽  
Rat Offspring

Dietetic Treatment of Diabetes Mellitus with Special Reference to High Blood-Pressure

1938 ◽  
Vol 31 (10) ◽  
pp. 1183-1204
Author(s):  
Dennis Embleton
Keyword(s):  
Blood Pressure ◽  
High Protein Diet ◽  
Normal Glucose Tolerance ◽  
High Protein ◽  
Protein Diet ◽  
Normal Glucose ◽  
Glucose Tolerance Curve ◽  
Treatment Of Diabetes ◽  
Tolerance Curve ◽  
Carbohydrate Intolerance

The error in a diabetic is essentially a carbohydrate intolerance, and correction of this defect should be aimed at in treatment. Dietetic treatment of diabetes is more readily studied in early cases or cases in the pre-diabetic state, before arterial degeneration and other catastrophes have become manifest. It is suggested that such a condition exists in obese subjects with a carbohydrate intolerance. A high protein diet based on a study of these cases is brought forward. This diet has been shown to operate favourably in diabetic states. Many cases of reasonable severity can be brought to develop a normal or nearly normal glucose tolerance curve and retain this state over a period of years. Cases in this state are better able to resist concomitant infections without deterioration of their tolerance than cases imperfectly balanced with insulin. The high protein diet can be used in cases of hyperpiesia in the absence of gross kidney damage. These cases show a steady and lasting drop in blood-pressure without the necessity of employing rest. The value of the pure fruit diet in increasing tolerance of certain diabetics to carbohydrate is demonstrated. The indiscriminate use of insulin in hyperglycæmic states is deprecated on the grounds that it is frequently unnecessary, and though it may balance it does not necessarily rectify the main deficiency of carbohydrate intolerance. By the use of this simple high protein diet, where no weighing, &c., is required, a large number of diabetics at present on insulin could be readily dealt with, a return to a normal or nearly normal glucose tolerance curve being obtained and maintained.

scholarly journals THE EFFECT OF HIGH PROTEIN DIETS ON EXPERIMENTAL RENAL HYPERTENSION

1941 ◽  
Vol 74 (6) ◽  
pp. 591-600 ◽  
Author(s):  
H. Philipsborn ◽  
L. N. Katz ◽  
S. Rodbard
Keyword(s):  
Blood Pressure ◽  
Renal Hypertension ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Low Protein ◽  
Experimental Renal Hypertension ◽  
High Protein Diets ◽  
Protein Diets

The effect of high and low protein diets were studied on fourteen dogs in twenty-four different experiments. In only two of these animals, both with moderate renal excretory failure, was a reversible rise in blood pressure elicited by a high protein diet. The possible mechanisms involved in meeting an increased excretory load are discussed.

scholarly journals Effect of resistance training exercise combined with high protein diet on body weight and muscle mass in underweight adolescent males

2021 ◽  
Vol 27 (1) ◽  
pp. 041-052
Author(s):  
Wittawas Sajjapong ◽  
◽  
Preeya Leelahagul ◽  
Sitha Pongphibool ◽  
Narupon Thongsuk ◽  
...  
Keyword(s):  
Body Weight ◽  
Resistance Training ◽  
Protein Intake ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Protein Supplements ◽  
High Protein Intake ◽  
Training Exercise ◽  
Resistance Training Exercise

Introduction: Many underweight males take commercial protein supplements to increase their body weight and build muscle. Nonetheless, commercial protein supplements may cause adverse effects. This study aimed to determine the effects of resistance training exercise combined with a high protein diet on body weight and muscle mass in underweight adolescent males. Methods: A repeated measures design study was conducted on nine males aged 12-15 years with low body weight. Energy and protein requirements were calculated, and energy and protein consumptions were measured for each meal during the high protein diet without exercise (HP) period and the high protein diet with resistance exercise (HPE) period. Subjects engaged in three resistance training sessions each week during HP-E period, for eight weeks. Dietary intake, body composition, blood biochemistry, physical fitness, and self-esteem were assessed. Results: In HP-E period, resistance training exercise combined with a high protein intake (2.14 g/kg/d) increased body weight and lean tissue mass (LTM) by 0.5 kg and 0.5 kg, respectively. Resistance training during HP-E period increased arm, leg, and trunk muscle strength by 20.2%, 7.2%, and 14.5%, respectively, more than high protein diet alone during HP period. High protein intake in HP-E period did not affect blood urea nitrogen (BUN) and creatinine levels (11.0 mg/dL and 0.70 mg/dL, respectively). Conclusion: Eight weeks of resistance training combined with a high protein diet increased body weight and LTM without adverse effects. In particular, resistance exercise predominantly increased muscle strength. Kidney function was not affected by high protein consumption throughout this study.

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