Relationship between ambient temperature and acetylating capacity of human blood

The ability of human blood to acetylate p-aminobenzoic acid, determined in vitro, varied directly with the ambient temperature to which the subject was exposed before the blood was drawn. This was demonstrated by 135 determinations of the acetylating ability of the blood of 49 subjects performed over a period of 3 years, and also in acute experiments in which subjects were exposed to 6 and 37 C for up to 2 hr. Variations in the acetylating ability of blood may reflect the activity of metabolic mechanisms involved in thermal homeostasis. aromatic amines; p-aminobenzoic acid; cold; heat acclimatization; (blood) enzymes; weather; environment Submitted on September 11, 1962

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Fibrinogen-Fibrin-Related Antigen Pattern in Human Blood

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647697 ◽

1974 ◽

Vol 32 (02/03) ◽

pp. 266-276

Author(s):

Carl D. Jacobsen ◽

John C. Hoak ◽

Kenneth K. WU ◽

Glenna L. Fry

Keyword(s):

Human Blood ◽

Plasma Samples

SummaryIn serum from patients with DIC at least 3 different FR-antigenic components could be found. It was difficult to demonstrate these components in the corresponding plasma samples. It is possible that a portion of these antigens formed as a result of in vitro clotting despite the presence of proteolytic inhibitors. These results suggest that the interpretation of “increased split products in serum” may be more complex than current concepts indicate.

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Effect of Aspirin on the Thrombelastogram of Human Blood

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649127 ◽

1973 ◽

Vol 30 (03) ◽

pp. 494-498 ◽

Cited By ~ 1

Author(s):

G de Gaetano ◽

J Vermylen

Keyword(s):

Oral Dose ◽

Single Oral Dose ◽

Platelet Function ◽

Human Blood ◽

Platelet Rich Plasma ◽

Plasma Samples ◽

Release Reaction ◽

Platelet Release

SummaryThrombelastograms of both native blood and re-calcified platelet-rich plasma samples taken from subjects given a single oral dose of aspirin (1 gram) were not significantly different from the pretreatment recordings. Aspirin also did not modify the thrombelastogram when preincubated in vitro with platelet-rich plasma at concentrations inhibiting the platelet “release reaction” by collagen. Thrombelastography therefore cannot evaluate the effect of aspirin on platelet function.

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The Effect of Dipyridamole and RA 233 on Human Platelet Function in Vitro

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648112 ◽

1973 ◽

Vol 29 (03) ◽

pp. 694-700 ◽

Cited By ~ 4

Author(s):

Paul L. Rifkin ◽

Marjorie B. Zucker

Keyword(s):

Mechanism Of Action ◽

Human Blood ◽

Glass Bead ◽

Heart Valves ◽

Human Platelet ◽

Drug Effects ◽

Simple Relation ◽

Prosthetic Heart Valves ◽

Induced Aggregation

SummaryDipyridamole (Persantin) is reported to prolong platelet survival and inhibit embolism in patients with prosthetic heart valves, but its mechanism of action is unknown. Fifty jxM dipyridamole failed to reduce the high percentage of platelets retained when heparinized human blood was passed through a glass bead column, but prolonged the inhibition of retention caused by disturbing blood in vitro. Possibly the prostheses act like disturbance. Although RA 233 was as effective as dipyridamole in inhibiting the return of retention, it was less effective in preventing the uptake of adenosine into erythrocytes, and more active in inhibiting ADP-induced aggregation and release. Thus there is no simple relation between these drug effects.

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Faculty Opinions recommendation of Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.738105264.793575662 ◽

2020 ◽

Author(s):

Dan Rujescu ◽

Matthias Jung

Keyword(s):

Blood Brain Barrier ◽

Human Blood ◽

Pathogenic Mechanism ◽

Brain Barrier ◽

Blood Brain

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Probing glycation potential of dietary sugars in human blood by an integrated in vitro approach

Food Chemistry ◽

10.1016/j.foodchem.2020.128951 ◽

2020 ◽

pp. 128951

Author(s):

Nadezhda Frolova ◽

Alena Soboleva ◽

Viet Duc Nguyen ◽

Ahyoung Kim ◽

Christian Ihling ◽

...

Keyword(s):

Human Blood ◽

Dietary Sugars

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Antioxidant Properties of Ergosterol and Its Role in Yeast Resistance to Oxidation

Antioxidants ◽

10.3390/antiox10071024 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1024

Author(s):

Sebastien Dupont ◽

Paul Fleurat-Lessard ◽

Richtier Gonçalves Cruz ◽

Céline Lafarge ◽

Cédric Grangeteau ◽

...

Keyword(s):

Computational Study ◽

Antioxidant Properties ◽

Beneficial Effects ◽

Tert Butyl Hydroperoxide ◽

Resistance To Oxidation ◽

Specific Accumulation ◽

The Subject

Although the functions and structural roles of sterols have been the subject of numerous studies, the reasons for the diversity of sterols in the different eukaryotic kingdoms remain unclear. It is thought that the specificity of sterols is linked to unidentified supplementary functions that could enable organisms to be better adapted to their environment. Ergosterol is accumulated by late branching fungi that encounter oxidative perturbations in their interfacial habitats. Here, we investigated the antioxidant properties of ergosterol using in vivo, in vitro, and in silico approaches. The results showed that ergosterol is involved in yeast resistance to tert-butyl hydroperoxide and protects lipids against oxidation in liposomes. A computational study based on quantum chemistry revealed that this protection could be related to its antioxidant properties operating through an electron transfer followed by a proton transfer mechanism. This study demonstrates the antioxidant role of ergosterol and proposes knowledge elements to explain the specific accumulation of this sterol in late branching fungi. Ergosterol, as a natural antioxidant molecule, could also play a role in the incompletely understood beneficial effects of some mushrooms on health.

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