Exercise and nasal patency

1983 ◽  
Vol 55 (3) ◽  
pp. 860-865 ◽  
Author(s):  
R. D. Forsyth ◽  
P. Cole ◽  
R. J. Shephard
Keyword(s):  
Short Duration ◽  
Healthy Subjects ◽  
Time Course ◽  
Nasal Resistance ◽  
Exercise Recovery ◽  
Nasal Airflow ◽  
Nasal Patency ◽  
Progressive Decrease ◽  
Sudden Decrease

Nasal airflow resistances were studied in 20 healthy subjects at rest, with exercise, and during recovery from exercise. Resistances were first measured under resting conditions. As a basis for comparison 0.1% xylometazoline was applied by insufflation; it reduced nasal resistance by an average of 49%. On a subsequent occasion, the degree and time course of changes in resistance were measured 1) during 5-min exercise bouts at rest 25, 50, and 75% of predicted maximum O2 intake (VO2max), 2) during 5-, 10-, and 15-min exercise bouts at 50% of VO2max, and 3) during recovery from exercise. Resistance decreased with intensity but not duration of exercise; an initial sudden decrease was followed by a more gradual but progressive decrease, which continued for several minutes following vigorous short duration exercise. Thus following 5 min of effort at 75% of VO2max, resistance reached a nadir (46% fall) 5 min after cessation of exercise. Recovery of preexercise values required 5 min after 5 min of exercise at 25% of VO2max and 10 min after 5 min of exercise at 50% of VO2max. Some decrease persisted 15 min after 5 min of exercise at 75% of VO2max.

Obstruction of the nasal valve

1996 ◽  
Vol 110 (3) ◽  
pp. 221-224 ◽  
Author(s):  
Samy Elwany ◽  
Hossam Thabet
Keyword(s):  
Surgical Procedures ◽  
Lateral Cartilage ◽  
Nasal Resistance ◽  
Nasal Airflow ◽  
Nasal Patency ◽  
Nasal Valve ◽  
Nasal Surgery ◽  
History Of ◽  
Upper Lateral Cartilage ◽  
The Mean

AbstractObstruction of the nasal valve is an important cause of chronic nasal obstruction in adults. In a series of 500 patients, obstruction at the level of the nasal valve was diagnosed in 65 of them (13 per cent). The obstruction was unilateral in 57 patients (88 per cent). Forty-seven patients (72 per cent) had history of previous nasal surgery of accidental trauma. Causes of obstruction of the nasal valve included high septal deviations, a weak or deformed upper lateral cartilage, adhesions, and alar collapse. All patients underwent corrective nasal surgery and the surgical procedures were tailored according to the existing pathology. Post-operatively, the mean nasal patency score increased from 2.9 to 8.6, the mean nasal airflow increased from 579.5 to 727 cm/sec (at 150 Pa), and the mean nasal resistance decreased from 0.31 to 0.23 Pa/cm3sec-1.

Peak nasal inspiratory flow – the plateau effect

1995 ◽  
Vol 109 (5) ◽  
pp. 399-402 ◽  
Author(s):  
R. W. Clarke ◽  
A. S. Jones ◽  
H. Richardson
Keyword(s):  
Inspiratory Flow ◽  
Nasal Resistance ◽  
Nasal Patency ◽  
Progressive Decrease ◽  
Respiratory Flow ◽  
Recording Change ◽  
Peak Nasal Inspiratory Flow

AbstractTo study the efficacy of peak nasal inspiration flow (PNIF) as a means of recording change in nasal patency 20 subjects were given increasing doses of intranasal 5tometazo1ine. Nasal resistance (NR) and peak nasal inspiratory flow (PNIF) were measured in the resting stateand after each xylometazoline administration. Successive increases in dose caused a progressive decrease in nasal resistance and an increase in PNIF but the change in peak nasal inspiratory flow (PNIF) was much less. Peak nasal inspiratory flow shows a plateau effect as nasal resistance decreases. The reasons for this plateau are discussed in terms of respiratory flow mechanics

Nasal airflow: resistance and sensation

1989 ◽  
Vol 103 (10) ◽  
pp. 909-911 ◽  
Author(s):  
A. S. Jones ◽  
D. J. Willatt ◽  
L. M. Durham
Keyword(s):  
Objective Measure ◽  
Nasal Resistance ◽  
Nasal Airflow ◽  
Nasal Patency ◽  
Airflow Resistance ◽  
Large Numbers ◽  
Two Parameters

AbstractFor many years nasal resistance to airflow measured by rhinomanometry has been regarded as the objective measure of nasal patency. However, recently it has become apparent that this may not be the case.The present study was designed to affirm or refute this view by using large numbers of subjects and observations.Five hundred estimations of (objective) nasal resistance to airflow and (subjective) nasal sensation of airflow where carried out.No correlation could be demonstrated between these two parameters.It is concluded nasal resistance to airflow and nasal sensation of airflow are two separate modalities which are not directly related. The possible reasons for this finding are discussed with reference to previous work on nasal sensation.

Recovery of subjective visual horizontal after unilateral vestibular deafferentation by intratympanic instillation of gentamicin

2006 ◽  
Vol 16 (1-2) ◽  
pp. 69-73 ◽  
Author(s):  
Yoshinari Takai ◽  
Toshihisa Murofushi ◽  
Munetaka Ushio ◽  
Shinichi Iwasaki
Keyword(s):  
Healthy Subjects ◽  
Time Course ◽  
Early Stage ◽  
Ccd Camera ◽  
The Other ◽  
Spontaneous Nystagmus ◽  
Vestibular Evoked Myogenic Potentials ◽  
Normal Range ◽  
Intratympanic Gentamicin ◽  
Unilateral Vestibular Deafferentation

The time course of the recovery of subjective visual horizontal (SVH) after unilateral vestibular deafferentation by intratympanic instillation of gentamicin was studied. Six patients who underwent intratympanic gentamicin instillation therapy for Meniere's disease (1 man and 5 women, 32 to 69 years of age) were enrolled in this study. For comparison, SVH in 23 healthy subjects (12 men and 11 woman, 23 to 48 years of age) was also measured. The mean ± SD of SVH in healthy subjects was 0.0 ± 1.1 deg. All of the 6 patients showed significantly deviated SVH toward the injected side-down at the early stage after the therapy. Although one patient showed recovery of SVH to the normal range 25 days after the injection, the other patients required more time for recovery. Three patients did not show recovery to the normal range after 1 year. On the other hand, spontaneous nystagmus observed using an infrared CCD camera in total dark disappeared after 35 days (median). Patients who had normal vestibular evoked myogenic potentials before the therapy showed a tendency of delay of recovery of SVH. The reasons why the recovery of SVH took longer than the disappearance of spontaneous nystagmus are discussed in this report.

Effect of physical training on exercise-induced sweating in women

1981 ◽  
Vol 51 (6) ◽  
pp. 1526-1532 ◽  
Author(s):  
T. Araki ◽  
K. Matsushita ◽  
K. Umeno ◽  
A. Tsujino ◽  
Y. Toda
Keyword(s):  
Physical Training ◽  
Time Course ◽  
Sweat Rate ◽  
Work Load ◽  
Young Female ◽  
Bicycle Ergometer ◽  
Progressive Decrease ◽  
Trained Group ◽  
Hot Environment ◽  
Exercise Induced

The effect of physical training on the time course of sweat rate in women has been examined. Physically untrained and trained young female subjects pedaled a bicycle ergometer at work rates of 483 and 981 kgm.min-1, for 2 h in summer and winter in an ambient environment of 30 degrees C db and 60% rh. The trained women also worked at 1,070 kgm.min-1 and the untrained at 391 kgm.min-1. Rectal temperature was measured, and capsule sweat samples were collected from the back every 5 min. Sweating was initiated more rapidly in the trained group than in the untrained group. The trained group working at a load of 981 kgm.min-1 exhibited a progressive decrease in sweat rate. This was not observed at a work load of 483 kgm.min-1. Hidromeiosis was rarely seen in the untrained group. However, in the untrained women who underwent 60 days of physical training, initiation of sweating occurred more quickly and hidromeiosis was observed. It was concluded that previous physical training improved women's capacity for useful sweating during exercise in a hot environment.

scholarly journals Differential uptake of three clinically relevant allergens by human plasmacytoid dendritic cells

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Noelle Zurmühl ◽  
Anna Schmitt ◽  
Ulrike Formentini ◽  
Johannes Weiss ◽  
Heike Appel ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Healthy Subjects ◽  
Time Course ◽  
In Vitro Study ◽  
Allergic Diseases ◽  
Plasmacytoid Dendritic Cells ◽  
Antigen Uptake ◽  
Der P 1 ◽  
The Impact

Abstract Background Human plasmacytoid dendritic cells (pDC) have a dual role as interferon-producing and antigen-presenting cells. Their relevance for allergic diseases is controversial. and the impact of pDC on allergic immune responses is poorly understood. Methods This in vitro study on human pDC isolated from peripheral blood was designed to compare side by side the uptake of three clinically relevant representative allergens: fluorochrome-labeled house dust mite Der p 1, Bee venom extract from Apis mellifera (Api) and the food allergen OVA analyzed flow cytometry and confocal microscopy. Results We found that the internalization and its regulation by TLR9 ligation was significantly different between allergens in terms of time course and strength of uptake. Api and OVA uptake in pDC of healthy subjects was faster and reached higher levels than Der p 1 uptake. CpG ODN 2006 suppressed OVA uptake and to a lesser extent Der p 1, while Api internalization was not affected. All allergens colocalized with LAMP1 and EEA1, with Api being internalized particularly fast and reaching highest intracellular levels in pDC. Of note, we could not determine any specific differences in antigen uptake in allergic compared with healthy subjects. Conclusions To our knowledge this is the first study that directly compares uptake regulation of clinically relevant inhalative, injective and food allergens in pDC. Our findings may help to explain differences in the onset and severity of allergic reactions as well as in the efficiency of AIT.

scholarly journals Primary school children often underestimate their nasal obstruction

2016 ◽  
Vol 54 (2) ◽  
pp. 164-169
Author(s):  
Francesca Occasi ◽  
Marzia Duse ◽  
Tommaso Vittori ◽  
Anna Rugiano ◽  
Giancarlo Tancredi ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Secondary School ◽  
Primary School ◽  
Nasal Obstruction ◽  
School Children ◽  
Primary School Children ◽  
Nasal Resistance ◽  
Nasal Patency ◽  
School Aged Children ◽  
Subjective Sensation

Background: No consensus has ever been reached about the correlation between nasal resistance and the subjective sensation of nasal patency. The aim of the present study was to better de ne whether primary school and secondary school aged children correctly estimate their nasal obstruction. Materials and methods: Two hundred eighty four children (168 males and 116 female) aged between 6 and 14 years (9.5+2.9 years) affected by Pediatric Allergic Rhinitis underwent Rhinomanometry and they were considered as correctly estimating their nasal obstruction when the grade of nasal patency corresponded to the severity of the NOSE score, overestimating when the grade of nasal patency was <1 when compared to the severity of the score, underestimating when the grade of nasal patency was >1 when compared to the severity of the score. Results: Correlation between NOSE score and nasal patency was statistically significant (r -0.74; p<0.001). Children between 6 and 9 years of age underestimate (43.7%) and children >12 overestimate (34.7%) their symptoms more frequently than children among other age ranges (p<0.001). Conclusion: Although NOSE score approximately allow to quantify nasal obstruction, in children, especially between 6 and 9 years of age, an objective measurement of nasal patency should be performed to better define the therapeutic approach.

scholarly journals Changes in Nitric Oxide Releases of the Contralateral Acupoint during and after Laser Acupuncture at Bilateral Same-Name Acupoints in Human

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Wan-Ling Jiang ◽  
Hua-Jiang Wei ◽  
Zhou-Yi Guo ◽  
Yi-Rong Ni ◽  
Hong-Qin Yang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Healthy Subjects ◽  
Vessel Wall ◽  
Time Course ◽  
Contralateral Side ◽  
Control Area ◽  
Laser Acupuncture ◽  
Blinded Fashion ◽  
No Release ◽  
No Releases

Objective.The purpose of the study was to examine the effects of laser acupuncture (LA) at right Neiguan (RPC6)/left Neiguan (LPC6) acupoints on the releases of nitric oxide (NO) in the treated and contralateral/nontreated PC6, compared to the nonacupoint control area.Methods. 24 mW LA at RPC6, LPC6, and nonacupoint in 22 healthy subjects for 40 min: sterilized dialysis tube was taped to the nontreated PC6/nonacupoint during the treatment and immediately taped to the treated and nontreated PC6/nonacupoint after LA removal. NO-scavenging compound was injected into the tube for 40 min to absorb the molecular which was tested by spectrophotometry in a blinded fashion.Results. LA-induced NO releases over PC6 acupoints for the nontreated and treated sides all significantly increased after LA removal, but for the nontreated acupoints they did not change during LA stimulation. LA at RPC6 induced the more release of the NO at contralateral side than stimulating LPC6, but not on nonacupoints. The results suggest that LA-induced NO release over contralateral acupoint and NO release resulting from the lateralized specificity all are different and specific to the acupoint within different time course.Conclusions. LA-evoked NO release over acupoints could improve the neurogenic, endothelial activity of the vessel wall to further facilitate microcirculation.

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