scholarly journals Aerosol dispersion in human lung: comparison between numerical simulations and experiments for bolus tests

1997 ◽  
Vol 83 (3) ◽  
pp. 966-974 ◽  
Author(s):  
Chantal Darquenne ◽  
Peter Brand ◽  
Joachim Heyder ◽  
Manuel Paiva
Keyword(s):  
Numerical Simulations ◽  
Flow Rate ◽  
Human Lung ◽  
Half Width ◽  
Constant Flow Rate ◽  
Mode Shift ◽  
Convective Mixing ◽  
Apparent Diffusion ◽  
Aerosol Dispersion ◽  
Good Agreement

Darquenne, Chantal, Peter Brand, Joachim Heyder, and Manuel Paiva. Aerosol dispersion in human lung: comparison between numerical simulations and experiments for bolus tests. J. Appl. Physiol. 83(3): 966–974, 1997.—Bolus inhalations of 0.87-μm-diameter particles were administered to 10 healthy subjects, and data were compared with numerical simulations based on a one-dimensional model of aerosol transport and deposition in the human lung ( J. Appl. Physiol. 77: 2889–2898, 1994). Aerosol boluses were inhaled at a constant flow rate into various volumetric lung depths up to 1,500 ml. Parameters such as bolus half-width, mode shift, skewness, and deposition were used to characterize the bolus and to display convective mixing. The simulations described the experimental results reasonably well. The sensitivity of the simulations to different parameters was tested. Simulated half-width appeared to be insensitive to altered values of the deposition term, whereas it was greatly affected by modified values of the apparent diffusion in the alveolar zone of the lung. Finally, further simulations were compared in experiments with a fixed penetration volume and various flow rates. Comparison showed good agreement, which may be explained by the fact that half-width, mode shift, and skewness were little affected by the flow rate.

scholarly journals Effect of gravity on aerosol dispersion and deposition in the human lung after periods of breath holding

2000 ◽  
Vol 89 (5) ◽  
pp. 1787-1792 ◽  
Author(s):  
Chantal Darquenne ◽  
Manuel Paiva ◽  
G. Kim Prisk
Keyword(s):  
Flow Rate ◽  
Turbulent Mixing ◽  
Direct Evidence ◽  
Human Lung ◽  
Hold Time ◽  
Aerosol Deposition ◽  
Breath Holding ◽  
Breath Hold ◽  
Constant Flow Rate ◽  
Aerosol Dispersion

To determine the extent of the role that gravity plays in dispersion and deposition during breath holds, we performed aerosol bolus inhalations of 1-μm-diameter particles followed by breath holds of various lengths on four subjects on the ground (1G) and during short periods of microgravity (μG). Boluses of ∼70 ml were inhaled to penetration volumes (Vp) of 150 and 500 ml, at a constant flow rate of ∼0.45 l/s. Aerosol concentration and flow rate were continuously measured at the mouth. Aerosol deposition and dispersion were calculated from these data. Deposition was independent of breath-hold time at both Vp in μG, whereas, in 1G, deposition increased with increasing breath hold time. At Vp = 150 ml, dispersion was similar at both gravity levels and increased with breath hold time. At Vp = 500 ml, dispersion in 1G was always significantly higher than in μG. The data provide direct evidence that gravitational sedimentation is the main mechanism of deposition and dispersion during breath holds. The data also suggest that cardiogenic mixing and turbulent mixing contribute to deposition and dispersion at shallow Vp.

Effect of microgravity and hypergravity on deposition of 0.5- to 3-μm-diameter aerosol in the human lung

1997 ◽  
Vol 83 (6) ◽  
pp. 2029-2036 ◽  
Author(s):  
Chantal Darquenne ◽  
Manuel Paiva ◽  
John B. West ◽  
G. Kim Prisk
Keyword(s):  
Particle Size ◽  
Tidal Volume ◽  
Flow Rate ◽  
Human Lung ◽  
Constant Flow ◽  
Parabolic Flights ◽  
Constant Flow Rate ◽  
Numerical Predictions ◽  
Model Predictions ◽  
Good Agreement

Darquenne, Chantal, Manuel Paiva, John B. West, and G. Kim Prisk. Effect of microgravity and hypergravity on deposition of 0.5- to 3-μm-diameter aerosol in the human lung. J. Appl. Physiol. 83(6): 2029–2036, 1997.—We measured intrapulmonary deposition of 0.5-, 1-, 2-, and 3-μm-diameter particles in four subjects on the ground (1 G) and during parabolic flights both in microgravity (μG) and at ∼1.6 G. Subjects breathed aerosols at a constant flow rate (0.4 l/s) and tidal volume (0.75 liter). At 1 G and ∼1.6 G, deposition increased with increasing particle size. In μG, differences in deposition as a function of particle size were almost abolished. Deposition was a nearly linear function of the G level for 2- and 3-μm-diameter particles, whereas for 0.5- and 1.0-μm-diameter particles, deposition increased less between μG and 1 G than between 1 G and ∼1.6 G. Comparison with numerical predictions showed good agreement for 1-, 2-, and 3-μm-diameter particles at 1 and ∼1.6 G, whereas the model consistently underestimated deposition in μG. The higher deposition observed in μG compared with model predictions might be explained by a larger deposition by diffusion because of a higher alveolar concentration of aerosol in μG and to the nonreversibility of the flow, causing additional mixing of the aerosols.

Aerosol bolus dispersion and convective mixing in human and dog lungs and physical models

1992 ◽  
Vol 73 (3) ◽  
pp. 862-873 ◽  
Author(s):  
F. S. Rosenthal ◽  
J. D. Blanchard ◽  
P. J. Anderson
Keyword(s):  
Flow Rate ◽  
Vital Capacity ◽  
Human Subjects ◽  
Packed Bed ◽  
Physical Models ◽  
Straight Tube ◽  
Particle Mobility ◽  
Convective Mixing ◽  
Artificial Larynx ◽  
Aerosol Dispersion

The dispersion of aerosol boluses in the lung is a probe for convective mixing and has been proposed as a marker for abnormal lung function. To better understand the factors underlying this phenomenon, aerosol dispersion was compared in human subjects, dogs, and various physical models. In all systems, dispersion increased with the volumetric penetration of the aerosol bolus. The rate of this increase was 83% greater in humans compared with dogs. Dispersion in dogs was close to that in a packed bed with beads of 2.5 mm. Aerosol dispersion decreased with increasing flow rate in human subjects. An artificial larynx inserted into the straight tube caused a 33% increase in dispersion. In humans, aerosol dispersion was significantly correlated with forced expired flow between 25 and 75% of vital capacity. A 2-s pause between inspiration and expiration increased dispersion 23–58% in three isolated dog lungs but did not affect dispersion in the packed bed. The data suggest that lung geometry, flow rate, particle mobility, and the larynx all significantly affect aerosol dispersion by influencing the reversibility of aerosol transport between inspiration and expiration.

scholarly journals EFFECT OF TUBE PITCH ON HEAR TRANSFER IN SPRINKLED TUBE BUNDLE

2015 ◽  
Vol 55 (5) ◽  
pp. 329 ◽  
Author(s):  
Petr Kracík ◽  
Jiří Pospíšil
Keyword(s):  
Flow Rate ◽  
Tube Bundle ◽  
Thin Liquid Film ◽  
Thermal Conditions ◽  
Tube Length ◽  
Falling Film ◽  
Constant Flow Rate ◽  
Physical Conditions ◽  
The Individual ◽  
Tube Pitch

Water flowing on a sprinkled tube bundle forms three basic modes: the Droplet mode (the liquid drips from one tube to another), the Jet mode (with an increasing flow rate, the droplets merge into a column) and the Membrane (Sheet) mode (with a further increase in the flow rate of the falling film liquid, the columns merge and create sheets between the tubes. With a sufficient flow rate, the sheets merge at this stage, and the tube bundle is completely covered by a thin liquid film). There are several factors influencing both the individual modes and the heat transfer. Beside the above-mentioned falling film liquid flow rate, these are for instance the tube diameters, the tube pitches in the tube bundle, or the physical conditions of the falling film liquid. This paper presents a summary of data measured at atmospheric pressure, with a tube bundle consisting of copper tubes of 12 millimetres in diameter, and with a studied tube length of one meter. The tubes are situated horizontally one above another at a pitch of 15 to 30 mm, and there is a distribution tube placed above them with water flowing through apertures of 1.0mm in diameter at a 9.2mm span. Two thermal conditions have been tested with all pitches: 15 °C to 40 °C and 15 °C to 45 °C. The temperature of the falling film liquid, which was heated during the flow through the exchanger, was 15 °C at the distribution tube input. The temperature of the heating liquid at the exchanger input, which had a constant flow rate of approx. 7.2. litres per minute, was 40 °C, or alternatively 45 °C.

scholarly journals Quantitative Monitoring of Dynamic Blood Flows Using Coflowing Laminar Streams in a Sensorless Approach

2021 ◽  
Vol 11 (16) ◽  
pp. 7260
Author(s):  
Yang Jun Kang
Keyword(s):  
Blood Flow ◽  
Flow Rate ◽  
Blood Viscosity ◽  
Measurement Errors ◽  
Present Method ◽  
Test Fluid ◽  
Constant Flow Rate ◽  
Rbc Aggregation ◽  
Sinusoidal Flow ◽  
Analytical Expressions

Determination of blood viscosity requires consistent measurement of blood flow rates, which leads to measurement errors and presents several issues when there are continuous changes in hematocrit changes. Instead of blood viscosity, a coflowing channel as a pressure sensor is adopted to quantify the dynamic flow of blood. Information on blood (i.e., hematocrit, flow rate, and viscosity) is not provided in advance. Using a discrete circuit model for the coflowing streams, the analytical expressions for four properties (i.e., pressure, shear stress, and two types of work) are then derived to quantify the flow of the test fluid. The analytical expressions are validated through numerical simulations. To demonstrate the method, the four properties are obtained using the present method by varying the flow patterns (i.e., constant flow rate or sinusoidal flow rate) as well as test fluids (i.e., glycerin solutions and blood). Thereafter, the present method is applied to quantify the dynamic flows of RBC aggregation-enhanced blood with a peristaltic pump, where any information regarding the blood is not specific. The experimental results indicate that the present method can quantify dynamic blood flow consistently, where hematocrit changes continuously over time.

Investigation of Quench-16 Experiment With MELCOR Computer Code

2014 ◽  
Author(s):  
Petya Vryashkova ◽  
Pavlin Groudev ◽  
Antoaneta Stefanova
Keyword(s):  
Experimental Data ◽  
Flow Rate ◽  
Initial Temperature ◽  
Computer Code ◽  
Air Flow Rate ◽  
Fuel Rod ◽  
Fuel Bundle ◽  
Oxygen Starvation ◽  
Air Ingress ◽  
Good Agreement

This paper presents a comparison of MELCOR calculated results with experimental data for the QUENCH-16 experiment. The analysis for the air ingress experiment QUENCH-16 has been performed by INRNE. The calculations have been performed with MELCOR code. The QUENCH-16 experiment has been performed on 27-th of July 2011 in the frame of the EC-supported LACOMECO program. The experiments have focused on air ingress investigation into an overheated core following earlier partial oxidation in steam. QUENCH-16 has been performed with limited pre-oxidation and low air flow rate. One of the main objectives of QUENCH-16 was to examine the interaction between nitrogen and oxidized cladding during a prolonged period of oxygen starvation. The bundle is made from 20 heated fuel rod simulators arranged in two concentric rings and one unheated central fuel rod simulator, each about 2.5 m long. The tungsten heaters were surrounded by annular ZrO2 pellets to simulate the UO2 fuel. The geometry and most other bundle components are prototypical for Western-type PWRs. To improve the obtained results it has been made a series of calculations to select an appropriate initial temperature of the oxidation of the fuel bundle and modified correlation oxidation of Zircaloy with MELCOR computer code. The compared results have shown good agreement of calculated hydrogen and oxygen starvation in comparison with test data.

The penetration and ricochet of ogive-nosed rigid projectiles obliquely impacting metallic targets

2021 ◽  
pp. 204141962110377
Author(s):  
Yaniv Vayig ◽  
Zvi Rosenberg
Keyword(s):  
Experimental Data ◽  
Numerical Simulations ◽  
Dynamic Pressure ◽  
Oblique Impacts ◽  
Simulation Results ◽  
The Impact ◽  
Penetration Depths ◽  
Resistance To Penetration ◽  
Good Agreement

A large number of 3D numerical simulations were performed in order to follow the trajectory changes of rigid CRH3 ogive-nosed projectiles, impacting semi-infinite metallic targets at various obliquities. These trajectory changes are shown to be related to the threshold ricochet angles of the projectile/target pairs. These threshold angles are the impact obliquities where the projectiles end up moving in a path parallel to the target’s face. They were found to depend on a non-dimensional entity which is equal to the ratio between the target’s resistance to penetration and the dynamic pressure exerted by the projectile upon impact. Good agreement was obtained by comparing simulation results for these trajectory changes with experimental data from several published works. In addition, numerically-based relations were derived for the penetration depths of these ogive-nosed projectiles at oblique impacts, which are shown to agree with the simulation results.

HPLC METHOD DEVELOPMENT FOR ESTIMATION OF RAMELTEON IN TABLET DOSAGE FORM

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (06) ◽  
pp. 20-23
Author(s):  
S Sahoo ◽  
◽  
P. K. Panda ◽  
S. K. Mishra
Keyword(s):  
Flow Rate ◽  
Dosage Form ◽  
Method Development ◽  
Hplc Method ◽  
Reverse Phase Hplc ◽  
Ich Guidelines ◽  
Hplc Method Development ◽  
Tablet Dosage ◽  
Good Agreement

A simple, fast, accurate and precise reverse phase HPLC method is developed and described for the determination of ramelteon in tablet dosage form. Chromatography was carried on an ODS column using a mixture of acetonitrile and phosphate buffer pH 7.0 (35:65 V/V) as the mobile phase at a flow rate of 1.0 mL/min with detection at 286 nm. The retention time of the drug was 7.7 min. The procedure was validated for linearity, precision, accuracy, and robustness. The developed method was validated for linearity from 50 to 150% which shows the method is quite linear with a correlation coefficient of 0.999, for precision which includes system precision, method precision, intraday and by another analyst on another day, and accuracy. The %RSD for system precision was observed to be 1.1, whereas the method precision was observed to be 0.2. The % recovery from ‘accuracy’ studies yielded the recovery of 99.7-101.5% which indicates the capability of the method, and finally for robustness that includes studies w.r.t. change in flow rate, the percentage of organic modifier and pH. As per ICH guidelines, method validation results are in good agreement. The proposed method was simple, sensitive, precise and accurate.

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