Microgravity and Space Medicine

This Special Issue (SI), “Microgravity and Space Medicine”, covers research articles and reviews focusing on gravitational biology, cancer research and space medicine. It includes publications investigating the effects of altered gravity conditions on mammalian cells and humans during real microgravity (r-μg) on the International Space Station (ISS) and parabolic flights (PFs) [...]

Probing regolith-covered surfaces in low gravity

The surfaces of many planetary bodies, including asteroids, moons, and planets, are composed of rubble-like grains held together by varying levels of gravitational attraction and cohesive forces. Future instrumentation for operation on, and interacting with, such surfaces will require efficient and effective design principles and methods of testing. Here we present results from the EMPANADA experiment (Ejecta-Minimizing Protocols for Applications Needing Anchoring or Digging on Asteroids) which flew on several reduced gravity parabolic flights. EMPANADA studies the effects of the insertion of a flexible probe into a granular medium as a function of ambient gravity. This is done for an idealized 2D system as well as a more realistic 3D sample. To quantify the dynamics inside the 2D granular material we employ photoelasticity to identify the grain-scale forces throughout the system, while in 3D experiments we use simulated regolith. Experiments were conducted at three different levels of gravity: martian, lunar, and microgravity. In this work, we demonstrate that the photoelastic technique provides results that complement traditional load cell measurements in the 2D sample, and show that the idealized system exhibits similar behaviour to the more realistic 3D sample. We note that the presence of discrete, stick-slip failure events depends on the gravitational acceleration.

Dynamics of Single Hydrogen Bubbles at Pt Microelectrodes in Microgravity

The dynamics of single hydrogen bubbles electrogenerated in acidic electrolytes at a Pt microelectrode under potentiostatic conditions is investigated in microgravity during parabolic flights. Three bubble evolution scenarios have been...

Shared Metabolic Remodeling Processes Characterize the Transcriptome of Arabidopsis thaliana within Various Suborbital Flight Environments

The increasing availability of flights on suborbital rockets creates new avenues for the study of spaceflight effects on biological systems, particularly of the transitions between hypergravity and microgravity. This paper presents an initial comparison of the responses of Arabidopsis thaliana to suborbital and atmospheric parabolic flights as an important step toward characterizing these emerging suborbital platforms and their effects on biology. Transcriptomic profiling of the response of the Arabidopsis ecotype Wassilewskija (WS) to the aggregate suborbital spaceflight experiences in Blue Origin New Shepard and Virgin Galactic SpaceShipTwo revealed that the transcriptomic load induced by flight differed between the two flights, yet was biologically related to traditional parabolic flight responses. The sku5 skewing mutant and 14-3-3κ:GFP regulatory protein overexpression lines, flown in the Blue Origin and parabolic flights, respectively, each showed altered intra-platform responses compared to WS. An additional parabolic flight using the F-104 Starfighter showed that the response of 14-3-3κ:GFP to flight was modulated in a similar manner to the WS line. Despite the differing genotypes, experimental workflows, flight profiles, and platforms, differential gene expression linked to remodeling of central metabolic processes was commonly observed in the flight responses. However, the timing and directionality of differentially expressed genes involved in the conserved processes differed among the platforms. The processes included carbon and nitrogen metabolism, branched-chain amino acid degradation, and hypoxic responses. The data presented herein highlight the potential for various suborbital platforms to contribute insights into biological responses to spaceflight, and further suggest that in-flight fixation during suborbital experiments will enhance insights into responses during each phase of flight.

Cluster dynamics in dense granular gases of rod-like particles

Granular gases are interesting multiparticle systems which, irrespective of the apparent simplicity of particle interactions, exhibit a rich scenario of so far only little understood features. We have numerically investigated a dense granular gas composed of frictional spherocylinders which are excited mechanically by lateral vibrating container walls. This study was stimulated by experiments in microgravity on parabolic flights. The formation of spatial inhomogeneities (clusters) was observed in a region near the corners of the container, about halfway from the excitation plates. The particles in the clusters show a tendency to align parallel to the container walls, seemingly increasing the stabilizing effect of friction. The simulation results provide hints that the phase difference of the vibrations of the two excitation walls might affect the cluster dynamics.

Experimental Characterization of Weightlessness During Glider Parabolic Flights

Access to earthbound weightlessness is critical to many branches of applied sciences. Besides, several space systems require microgravity testing before their launch. Existing solutions (drop towers, parabolic flights, sounding rockets) offer variable durations and qualities of microgravity environment, but their cost and lead times make them unpractical for small actors such as universities or start-up companies. This leads to a growing interest for alternative microgravity platforms. Here, we study the use of gliders to perform parabolic flights at a lower cost, and we propose a systematic quantification of glider’s 0-g flight capabilities. Results of our flight test campaign show that gliders offer up to 5.5s of weightlessness, with excursions below 0.1g, and a satisfactory level of repeatability. Besides, the recordings do not suffer from the increased level of vibrations generated by piston engines, typical of light-aircraft-based alternatives. Operational considerations associated with glider parabolic flights are also discussed. Finally, we conclude that a microgravity platform based on gliders would be suitable especially for compact experiments and equipment in order to support accelerated design and development, or to produce preliminary experimental results.