scholarly journals Age, sex, race, initial fitness, and response to training: the HERITAGE Family Study

2001 ◽  
Vol 90 (5) ◽  
pp. 1770-1776 ◽  
Author(s):  
James S. Skinner ◽  
Artur Jaskólski ◽  
Anna Jaskólska ◽  
Joanne Krasnoff ◽  
Jacques Gagnon ◽  
...  
Keyword(s):  
Age Groups ◽  
White Men ◽  
Cycle Ergometer ◽  
Men And Women ◽  
Black And White ◽  
Percent Change ◽  
Low Responders ◽  
Before And After ◽  
Blacks And Whites ◽  
Older Subjects

Effects of age, sex, race, and initial fitness on training responses of maximal O2 uptake (V˙o 2 max) are unclear. Data were available on 435 whites and 198 blacks (287 men and 346 women), aged 17–65 yr, before and after standardized cycle ergometer training. Individual responses varied widely, butV˙o 2 max increased significantly for all groups. Responses by men and women and by blacks and whites of all ages varied widely. There was no sex difference for change (Δ) inV˙o 2 max(ml · kg−1 · min−1); women had lower initial values and greater relative (%) increases. Blacks began with lower values but had similar responses. Older subjects had a lower Δ but a similar percent change. BaselineV˙o 2 max correlated nonsignificantly with ΔV˙o 2 max but significantly with percent change. There were high, medium, and low responders in all age groups, both sexes, both races, and all levels of initial fitness. Age, sex, race, and initial fitness have little influence onV˙o 2 max response to standardized training in a large heterogeneous sample of sedentary black and white men and women.

Abstract 15: Trends in Atrial Fibrillation-related Cardiovascular Mortality Rates in The United States: 1999-2017

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Yoshihiro Tanaka ◽  
Nilay Shah ◽  
Rod Passman ◽  
Philip Greenland ◽  
Sadiya Khan
Keyword(s):  
United States ◽  
Atrial Fibrillation ◽  
Black Men ◽  
Cause Of Death ◽  
Age Groups ◽  
White Men ◽  
The United States ◽  
Mortality Rates ◽  
Men And Women ◽  
Black And White

Background: Atrial fibrillation (AF) is the most common sustained arrhythmia in adults and the prevalence is increasing due to the aging of the population and the growing burden of vascular risk factors. Although deaths due to cardiovascular disease (CVD) death have dramatically decreased in recent years, trends in AF-related CVD death has not been previously investigated. Purpose: We sought to quantify trends in AF-related CVD death rates in the United States. Methods: AF-related CVD death was ascertained using the CDC WONDER online database. AF-related CVD deaths were identified by listing CVD (I00-I78) as underlying cause of death and AF (I48) as contributing cause of death among persons aged 35 to 84 years. We calculated age-adjusted mortality rates (AAMR) per 100,000 population, and examined trends over time estimating average annual percent change (AAPC) using Joinpoint Regression Program (National Cancer Institute). Subgroup analyses were performed to compare AAMRs by sex-race (black and white men and women) and across two age groups (younger: 35-64 years, older 65-84 years). Results: A total of 522,104 AF-related CVD deaths were identified between 1999 and 2017. AAMR increased from 16.0 to 22.2 per 100,000 from 1999 to 2017 with an acceleration following an inflection point in 2009. AAPC before 2009 was significantly lower than that after 2009 [0.4% (95% CI, 0.0 - 0.7) vs 3.5% (95% CI, 3.1 - 3.9), p < 0.001). The increase of AAMR was observed across black and white men and women overall and in both age groups (FIGURE), with a more pronounced increase in black men and white men. Black men had the highest AAMR among the younger decedents, whereas white men had the highest AAMR among the older decedents. Conclusion: This study revealed that death rate for AF-related CVD has increased over the last two decades and that there are greater black-white disparities in younger decedents (<65 years). Targeting equitable risk factor reduction that predisposes to AF and CVD mortality is needed to reduce observed health inequities.

scholarly journals Tuskegee and the Health of Black Men*

2017 ◽  
Vol 133 (1) ◽  
pp. 407-455 ◽  
Author(s):  
Marcella Alsan ◽  
Marianne Wanamaker
Keyword(s):  
Life Expectancy ◽  
Black Men ◽  
Medical Profession ◽  
White Men ◽  
Medical Mistrust ◽  
Difference In Differences ◽  
Men And Women ◽  
Demographic Groups ◽  
Black And White ◽  
Before And After

Abstract For 40 years, the Tuskegee Study of Untreated Syphilis in the Negro Male passively monitored hundreds of adult black men with syphilis despite the availability of effective treatment. The study’s methods have become synonymous with exploitation and mistreatment by the medical profession. To identify the study’s effects on the behavior and health of older black men, we use an interacted difference-in-difference-in-differences model, comparing older black men to other demographic groups, before and after the Tuskegee revelation, in varying proximity to the study’s victims. We find that the disclosure of the study in 1972 is correlated with increases in medical mistrust and mortality and decreases in both outpatient and inpatient physician interactions for older black men. Our estimates imply life expectancy at age 45 for black men fell by up to 1.5 years in response to the disclosure, accounting for approximately 35% of the 1980 life expectancy gap between black and white men and 25% of the gap between black men and women.

Differential Responses of Resistance Arterioles to Elevated Intraluminal Pressure in Blacks and Whites

2021 ◽  
Author(s):  
Ahmad Sabbahi ◽  
Assem Ellythy ◽  
Chueh-Lung Hwang ◽  
Shane A. Phillips
Keyword(s):  
Blood Pressure ◽  
Microvascular Dysfunction ◽  
Normal Pressure ◽  
Intraluminal Pressure ◽  
Internal Diameter ◽  
Mortality And Morbidity ◽  
Black And White ◽  
Average Blood Pressure ◽  
Before And After ◽  
Blacks And Whites

Black Americans have an earlier onset, higher average blood pressure, and higher rates of hypertension-related mortality and morbidity, compared to whites. The racial difference may be related to microvasculature, the major regulatory site of blood pressure. The goal of this study was to compare the response of resistance vessels to high intraluminal pressure between black and white participants. A total of 38 vessels were obtained from human fat samples (21 black, 17 white; mean age 32 ± 12 years and BMI 26.9 ± 4.9; between-group P ≥ 0.05) and included in this study. Internal diameter was measured in response to flow induced by various pressure gradients (Δ10, Δ20, Δ40, Δ60, and Δ100 cmH2O), and flow-induced dilation (FID) was calculated before and after high intraluminal pressure (150 cm H2O). Prior to high intraluminal pressure, FID was not different between blacks and whites (P = 0.112). After exposure to high intraluminal pressure, FID was reduced at every pressure gradient in vessels from blacks (P < 0.001), while FID did not change in white participants except at Δ 100 cmH2O. When incubated with the H2O2 scavenger PEG-catalase, the FID response in vessels from black, but not white, individuals was significantly reduced and the magnitude was higher at normal pressure relative to high pressure. Our findings suggest that vessels from self-identified black individuals are more susceptible to microvascular dysfunction following transient periods of high intraluminal pressure compared to whites and show greater dependence on H2O2 as a main contributor to FID at normal pressures.

Accelerated melanoma mortality rates among middle-aged white males with tumors of all thicknesses.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e21029-e21029
Author(s):  
Juliana Berk-Krauss ◽  
David Polsky ◽  
Jennifer Stein ◽  
Alan Geller
Keyword(s):  
White Women ◽  
Age Groups ◽  
White Men ◽  
Mortality Rates ◽  
Age Group ◽  
Middle Aged ◽  
Mortality Trends ◽  
Men And Women ◽  
And Gender ◽  
Melanoma Mortality

e21029 Background: Effective early detection of melanoma remains one of the most crucial strategies in improving patient prognosis, due to the inverse relationship between primary tumor thickness and survival time. However, recent studies have demonstrated the mortality burden of thin melanomas is at least as severe as that of thicker melanomas. Recognizing specific mortality trends among men and women by age and thickness is essential for establishing targeted melanoma screening efforts. Methods: We evaluated Surveillance, Epidemiology and End Results (SEER) data from 2009-2013. Melanoma thickness was divided into four standard categories: 0.01-1.00mm, 1.01-2.00mm, 2.01-4.00mm and > 4.01 mm. Melanoma mortalities were calculated among white men and women by age and thickness. We used a Bayesian analysis to calculate the probability of an individual dying from a melanoma of a given gender, age, and thickness. We then compared these probabilities between men and women. Results: Among white men, the largest increases in mortality rates occurred in the jump from the 45-49 to 50-54 age group at an increase of 68% for 0.01-1.00mm tumors, and from the 50-54 to 55-59 age group at an increase of 91% for 1.01-2.00mm tumors, 71% 2.01-4.00mm tumors and 80% for > 4.01mm tumors. In white women, mortality rates regardless of thickness increased at a slow incremental pace, across all age groups at an average overall rate of 36%. Mortality rates for white men with < 1mm and 1.01-2mm melanomas were comparable within the age groups less than 64 years, as was the case for white women with tumors of these thicknesses. The probability of a man dying was greater than of a woman for any age or thickness category. Conclusions: Melanoma mortality rate trends are nuanced and can vary significantly by age, thickness, and gender. In white men, mortality rates begin to accelerate sharply around the mid-50s age group. Screening efforts should therefore target detecting melanoma in middle-aged males in the in situ or earliest stage.

Abstract MP73: Years of Potential Life Lost Due to Premature Cardiometabolic Mortality in The United States, 1999-2017

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Nilay S Shah ◽  
Donald M Lloyd-jones ◽  
Kiarri N Kershaw ◽  
Mercedes R Carnethon ◽  
Sadiya S Khan
Keyword(s):  
Black Men ◽  
White Women ◽  
Age Of Onset ◽  
Financial Burden ◽  
The United States ◽  
Cardiometabolic Health ◽  
Annual Percent Change ◽  
Men And Women ◽  
Black And White ◽  
Before And After

Introduction: Age of onset for heart disease (HD), cerebrovascular disease (CBD), and diabetes (DM) has shifted earlier, with increases in avoidable cardiometabolic deaths. We quantified total and trends in years of potential life lost (YPLL) before the age of 65 from HD, CBD, and DM, to describe population burden of premature preventable cardiometabolic mortality. Hypothesis: YPLL from premature cardiometabolic deaths in the U.S. have increased and are highest in black adults. Methods: Death certificates from the CDC’s Wide-Ranging Online Database for Epidemiologic Research (WONDER) were used to quantify mean age at death and proportion of deaths that were premature (<65 years) from HD, CBD, and DM as underlying cause of death. We then calculated age standardized premature YPLL (before age 65) per 100,000 people and mean annual percent change (APC) in YPLL, overall and in black and white women and men, before and after the previously published inflection in cardiometabolic death rates in 2011. Results: Between 1999-2017, 19% of HD deaths, 14% of CBD deaths, and 27% of DM deaths were premature. Overall, premature YPLL from HD decreased between 1999-2011 from 512 to 416 per 100,000 (APC -1.7%/year, 95% CI [-2.0, -1.5]), then remained unchanged from 2011-2017. For CBD, premature YPLL decreased 1.8%/year (-2.2, -1.5) to 70 per 100,000 in 2011, but remained unchanged through 2017. Premature YPLL from DM remained unchanged at 71 per 100,000 from 1999-2011, then increased 2.5%/year (1.8, 3.1) to 81 per 100,000 in 2017. Premature YPLL were higher in black men and women compared with white men and women, respectively (FIGURE). Conclusions: Premature YPLL from cardiometabolic causes plateaued or increased after 2011. Disparities in YPLL have persisted in the past decade with nearly half of cardiometabolic deaths in black men occurring before age 65. Equitable promotion of cardiometabolic health early in the lifespan may reduce population, health system, and financial burden of premature cardiometabolic mortality.

Stomach Cancer Risk Among Black and White Men and Women

1995 ◽  
Vol 37 (10) ◽  
pp. 1218-1223 ◽  
Author(s):  
Patricia Brissette Burns ◽  
G. Marie Swanson
Keyword(s):  
Cancer Risk ◽  
Stomach Cancer ◽  
White Men ◽  
Men And Women ◽  
Black And White

scholarly journals Serum γ-Glutamyltransferase Was Differently Associated with Microalbuminuria by Status of Hypertension or Diabetes: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

2005 ◽  
Vol 51 (7) ◽  
pp. 1185-1191 ◽  
Author(s):  
Duk-Hee Lee ◽  
David R Jacobs ◽  
Myron Gross ◽  
Michael Steffes
Keyword(s):  
Dose Response ◽  
White Men ◽  
Vulnerable Groups ◽  
Quadratic Term ◽  
Short Term ◽  
Men And Women ◽  
Black And White ◽  
The Status ◽  
Incidence Risk

Abstract Background: We hypothesized that serum γ-glutamyltransferase (GGT) would positively predict the risk of microalbuminuria, a frequent consequence of both diabetes and hypertension, because serum GGT predicted diabetes and hypertension in dose–response relationships. Methods: In this prospective study, 2478 black and white men and women without microalbuminuria at year 10 provided urine samples 5 years later. Year 10 GGT cutpoints were 12, 18, and 29 U/L. Results: The incidence of microalbuminuria across year 10 GGT categories was U-shaped. Adjusted odds ratios across quartiles of serum GGT were 1.0, 0.39, 0.54, and 0.94 (P &lt;0.01 for quadratic term), but the shape of association depended on the status of hypertension or diabetes (P &lt;0.01 for interaction). Among individuals who ever had hypertension or diabetes, year 10 serum GGT showed a clear positive dose–response association with incident microalbuminuria (P &lt;0.01 for trend), whereas among individuals with neither hypertension nor diabetes during the study, year 10 GGT showed a U-shaped association with it (P = 0.01 for quadratic term). When the long-term risk was evaluated in 3895 participants based on serum GGT at year 0 and prevalence of microalbuminuria at year 10 or year 15, the trends were similar but weaker than those of short-term incidence risk. Conclusions: Serum GGT within the physiologic range predicted microalbuminuria among patients with hypertension or diabetes and may act as a predictor of microvascular and/or renal complications in these vulnerable groups. GGT showed a U-shaped association with microalbuminuria among persons who did not develop either hypertension or diabetes.

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