Adiposity-independent sympathetic activity in black men

Obesity is thought to lead to sympathetic overactivity as a compensatory adjustment to weight gain. However, most of the experimental support for the hypothesis has been derived from white cohorts. Our previous study in blacks indicated that sympathetic nerve activity (SNA) is closely correlated with body mass index only in women, whereas, in black men, SNA is elevated and dissociated from adiposity (Abate et al., Hypertension 38: 379–383, 2001). To further determine whether total and regional adiposity are determinants of SNA in blacks, we performed a prospective weight loss study in 12 normotensive obese black men and 9 obese black women. SNA, body mass index, and abdominal fat mass were measured before and 16 wk after hypocaloric diet. The major new findings are that, in obese black men, the dietary-induced weight loss of 11.3 ± 0.8 kg resulted in reduction in plasma leptin, insulin, and visceral abdominal fat but had no effect on SNA (from baseline of 26 ± 4 to 28 ± 3 bursts/min, P = not significant). In contrast, in black women, weight loss of 8.0 ± 0.9 kg caused similar reductions in plasma leptin, insulin, and visceral abdominal fat and led to a reduction in SNA by 40% (from baseline of 22 ± 2 to 13 ± 3 bursts/min, P < 0.05). In conclusion, these new data from this prospective study provide strong support for a major adiposity-independent sympathetic activity in black men and adiposity-related sympathetic activity in black women.

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Lifestyle-intervention-induced reduction of abdominal fat is reflected by a decreased circulating glycerol level and an increased HDL diameter

10.1101/718023 ◽

2019 ◽

Author(s):

Marian Beekman ◽

Bianca A.M. Schutte ◽

Erik B. van den Akker ◽

Raymond Noordam ◽

Petra Dibbets-Schneider ◽

...

Keyword(s):

Body Mass Index ◽

Weight Loss ◽

Lifestyle Intervention ◽

Body Mass ◽

Fat Mass ◽

Disease Risk ◽

Abdominal Fat ◽

Cardiometabolic Disease ◽

General Weight ◽

Metabolic Biomarkers

SCOPEAbdominal obesity is one of the main modifiable risk factors of age-related cardiometabolic disease. Cardiometabolic disease risk and its associated high abdominal fat mass, high cholesterol and glucose concentrations can be reduced by a healthier lifestyle. Hence, our aim is to understand the relation between lifestyle-induced changes in body composition, and specifically abdominal fat, and accompanying changes in circulating metabolic biomarkers.Methods and resultsWe used the data from the Growing Old Together (GOTO) study, in which 164 older adults (mean age 63 years, BMI 23-35 kg/m2) changed their lifestyle during 13 weeks by 12.5% caloric restriction plus 12.5% increase in energy expenditure. We show that levels of circulating metabolic biomarkers, even after adjustment for body mass index, specifically associate with abdominal fat mass. Next, we show that the applied lifestyle intervention mainly reduces abdominal fat mass (−2.6%, SD=3.0) and that this reduction, when adjusted for general weight loss, is highly associated with decreased circulating glycerol concentrations and increased HDL diameter.ConclusionsThe lifestyle-induced reduction of abdominal fat mass is particularly associated, independent of body mass index or general weight loss, with associated with decreased circulating glycerol concentrations and increased HDL diameter.

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Influence of gender, age, body mass index, abdominal fat and serum levels on growth hormone (GH) responses to GH-releasing hormone plus arginine and insulin tolerance tests

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2007-990430 ◽

2007 ◽

Vol 115 (08) ◽

Author(s):

E Fedeler ◽

E Spilcke-Liss ◽

MM Lerch ◽

N Friedrich ◽

H Wallaschofski

Keyword(s):

Body Mass Index ◽

Growth Hormone ◽

Body Mass ◽

Serum Levels ◽

Abdominal Fat ◽

Releasing Hormone ◽

Insulin Tolerance

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Triple-negative breast cancers are increased in black women regardless of age or body mass index

Breast Cancer Research ◽

10.1186/bcr2242 ◽

2009 ◽

Vol 11 (2) ◽

Cited By ~ 144

Author(s):

Lesley A Stead ◽

Timothy L Lash ◽

Jerome E Sobieraj ◽

Dorcas D Chi ◽

Jennifer L Westrup ◽

...

Keyword(s):

Body Mass Index ◽

Black Women ◽

Body Mass ◽

Triple Negative ◽

Breast Cancers

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Waist Circumference Adjusted for Body Mass Index and Intra-Abdominal Fat Mass

PLoS ONE ◽

10.1371/journal.pone.0032213 ◽

2012 ◽

Vol 7 (2) ◽

pp. e32213 ◽

Cited By ~ 14

Author(s):

Tina Landsvig Berentzen ◽

Lars Ängquist ◽

Anna Kotronen ◽

Ronald Borra ◽

Hannele Yki-Järvinen ◽

...

Keyword(s):

Body Mass Index ◽

Waist Circumference ◽

Body Mass ◽

Fat Mass ◽

Abdominal Fat

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Disentangling the obesity paradox in upper gastrointestinal cancers: Weight loss matters more than body mass index

Cancer Epidemiology ◽

10.1016/j.canep.2021.101912 ◽

2021 ◽

Vol 72 ◽

pp. 101912

Author(s):

Shria Kumar ◽

Nadim Mahmud ◽

David S. Goldberg ◽

Jashodeep Datta ◽

David E. Kaplan

Keyword(s):

Body Mass Index ◽

Weight Loss ◽

Body Mass ◽

Obesity Paradox ◽

Gastrointestinal Cancers ◽

Upper Gastrointestinal

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Enrolling Caregivers in Obesity Interventions to Improve Obesity-Related Outcomes in Children

Western Journal of Nursing Research ◽

10.1177/01939459211037057 ◽

2021 ◽

pp. 019394592110370

Author(s):

Hannah Bessette ◽

MinKyoung Song ◽

Karen S. Lyons ◽

Sydnee Stoyles ◽

Christopher S. Lee ◽

...

Keyword(s):

Physical Activity ◽

Body Mass Index ◽

Weight Loss ◽

Linear Regression ◽

Body Mass ◽

Sedentary Time ◽

Vigorous Physical Activity ◽

Weight Loss Program ◽

Weight Loss Programs ◽

Obesity Interventions

In this study, we assessed the influences of change in moderate-to-vigorous physical activity (MVPA)/sedentary time (ST) of caregivers participating in a commercial weight-loss program on their children’s change in MVPA/ST. Data from 29 caregivers and their children were collected over 8 weeks. We used multivariable linear regression to assess associations of changes in caregiver’s percent of time spent in MVPA/ST and changes in their child’s percent of time spent in MVPA/ST. For caregivers that decreased body mass index (BMI) over 8 weeks, changes in caregivers’ MVPA was strongly associated with the change in children’s MVPA (β = 2.61 [95% CI: 0.45, 4.77]) compared to caregivers who maintained/increased BMI (β = 0.24 [–2.16, 2.64]). Changes in caregivers’ ST was strongly associated with changes in children’s ST (β = 2.42 [1.02, 3.81]) compared to caregivers who maintained/increased BMI (β = 0.35 [–0.45, 1.14]). Findings reinforce encouraging caregivers to enroll in weight-loss programs for the benefit of their children as well as for themselves.

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The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

Cancers ◽

10.3390/cancers13133245 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3245

Author(s):

Emma C. Atakpa ◽

Adam R. Brentnall ◽

Susan Astley ◽

Jack Cuzick ◽

D. Gareth Evans ◽

...

Keyword(s):

Body Mass Index ◽

Weight Loss ◽

Body Mass ◽

Breast Density ◽

Small Sample ◽

Weight Loss Intervention ◽

Short Term ◽

Dense Area ◽

Short Term Change ◽

Term Change

We evaluated the association between short-term change in body mass index (BMI) and breast density during a 1 year weight-loss intervention (Manchester, UK). We included 65 premenopausal women (35–45 years, ≥7 kg adult weight gain, family history of breast cancer). BMI and breast density (semi-automated area-based, automated volume-based) were measured at baseline, 1 year, and 2 years after study entry (1 year post intervention). Cross-sectional (between-women) and short-term change (within-women) associations between BMI and breast density were measured using repeated-measures correlation coefficients and multivariable linear mixed models. BMI was positively correlated with dense volume between-women (r = 0.41, 95%CI: 0.17, 0.61), but less so within-women (r = 0.08, 95%CI: −0.16, 0.28). There was little association with dense area (between-women r = −0.12, 95%CI: −0.38, 0.16; within-women r = 0.01, 95%CI: −0.24, 0.25). BMI and breast fat were positively correlated (volume: between r = 0.77, 95%CI: 0.69, 0.84, within r = 0.58, 95%CI: 0.36, 0.75; area: between r = 0.74, 95%CI: 0.63, 0.82, within r = 0.45, 95%CI: 0.23, 0.63). Multivariable models reported similar associations. Exploratory analysis suggested associations between BMI gain from 20 years and density measures (standard deviation change per +5 kg/m2 BMI: dense area: +0.61 (95%CI: 0.12, 1.09); fat volume: −0.31 (95%CI: −0.62, 0.00)). Short-term BMI change is likely to be positively associated with breast fat, but we found little association with dense tissue, although power was limited by small sample size.

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Five-year Outcomes of Sleeve Gastrectomy: A Prospective Multicenter study

The American Surgeon ◽

10.1177/0003134821991984 ◽

2021 ◽

pp. 000313482199198

Author(s):

Imad El Moussaoui ◽

Etienne Van Vyve ◽

Hubert Johanet ◽

André Dabrowski ◽

Arnaud Piquard ◽

...

Keyword(s):

Body Mass Index ◽

Weight Loss ◽

Sleeve Gastrectomy ◽

Body Mass ◽

Excess Weight Loss ◽

Prospective Multicenter Study ◽

Weight Loss Failure ◽

Obstructive Sleep ◽

The Mean ◽

Predictors Of Weight Loss

Background Sleeve gastrectomy (SG) is the most frequently performed bariatric procedure in the world. Our purpose was to evaluate the percentage of excess weight loss (%EWL), resolution of obesity-related comorbidities after SG, and identify predictive factors of weight loss failure. Methods A prospective cohort study of adults who underwent SG during 2014 in 7 Belgian-French centers. Their demographic, preoperative, and postoperative data were prospectively collected and analyzed statistically. Results Overall, 529 patients underwent SG, with a mean preoperative weight and body mass index (BMI) of 118.9 ± 19.9 kg and 42.9 ± 5.5 kg/m2, respectively. Body mass index significantly decreased to 32.2 kg/m2 at 5 years ( P < .001). The mean %EWL was 63.6% at 5 years. A significant reduction in dyslipidemia (28.0%-18.2%), obstructive sleep apnea (OSAS) (34.6%-25.1%), and arterial hypertension (HTN) (30.4%-21.5%) was observed after 5 years, but not for diabetes and gastroesophageal reflux disease (GERD). At multivariate analysis, age >50 years old, BMI >50 kg/m2, and previous laparoscopic adjustable gastric banding (LAGB) remained independent predictors of weight loss failure. Conclusions Five years after SG, weight loss was satisfactory; the reduction of comorbidities was significant for dyslipidemia, OSAS, and HTN, but not diabetes and GERD. Age >50 years old, BMI >50 kg/m2, and previous LAGB were independent predictors of weight loss failure.

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