scholarly journals An asymmetric outer retinal response to drifting sawtooth gratings

2016 ◽  
Vol 115 (5) ◽  
pp. 2349-2358 ◽  
Author(s):  
Nina Riddell ◽  
Laila Hugrass ◽  
Jude Jayasuriya ◽  
Sheila G. Crewther ◽  
David P. Crewther
Keyword(s):  
Perceptual Experience ◽  
Temporal Frequency ◽  
Luminance Contrast ◽  
Potential Effect ◽  
Sine Wave ◽  
Frame Rate ◽  
Frequency Effects ◽  
Dc Potential ◽  
The Difference ◽  
Retinal Response

Electroretinogram (ERG) studies have demonstrated that the retinal response to temporally modulated fast-ON and fast-OFF sawtooth flicker is asymmetric. The response to spatiotemporal sawtooth stimuli has not yet been investigated. Perceptually, such drifting gratings or diamond plaids shaded in a sawtooth pattern appear brighter when movement produces fast-OFF relative to fast-ON luminance profiles. The neural origins of this illusion remain unclear (although a retinal basis has been suggested). Thus we presented toad eyecups with sequential epochs of sawtooth, sine-wave, and square-wave gratings drifting horizontally across the retina at temporal frequencies of 2.5–20 Hz. All ERGs revealed a sustained direct-current (DC) transtissue potential during drift and a peak at drift offset. The amplitudes of both phenomena increased with temporal frequency. Consistent with the human perceptual experience of sawtooth gratings, the sustained DC potential effect was greater for fast-OFF cf. fast-ON sawtooth. Modeling suggested that the dependence of temporal luminance contrast on stimulus device frame rate contributed to the temporal frequency effects but could not explain the divergence in response amplitudes for the two sawtooth profiles. The difference between fast-ON and fast-OFF sawtooth profiles also remained following pharmacological suppression of postreceptoral activity with tetrodotoxin (TTX), 2-amino-4-phosphonobutric acid (APB), and 2,3 cis-piperidine dicarboxylic acid (PDA). Our results indicate that the DC potential difference originates from asymmetries in the photoreceptoral response to fast-ON and fast-OFF sawtooth profiles, thus pointing to an outer retinal origin for the motion-induced drifting sawtooth brightness illusion.

The Dynamic Response of a Simple Elastic System to Antisymmetric Forcing Functions Characteristic of Airplanes in Unsymmetric Landing Impact

1949 ◽  
Vol 16 (3) ◽  
pp. 310-316
Author(s):  
Joseph B. Woodson
Keyword(s):  
Dynamic Response ◽  
Sine Wave ◽  
Response Curves ◽  
Response Factors ◽  
Natural Period ◽  
Wave Pulse ◽  
Pulse Disturbance ◽  
Landing Impact ◽  
Forcing Functions ◽  
The Difference

Abstract This paper presents an analysis of the dynamic response of an undamped mechanical system with one degree of freedom subjected to disturbances which are described by antisymmetric forcing functions. The analysis was undertaken to throw light on the effect on the vibration of the wings caused by unsymmetric landing impact of an airplane. Two types of disturbances are considered; a full-sine-wave pulse, and a pulse which is the difference between two overlapping half sine waves. The results are presented in the form of dynamic-response curves and dynamic-response-factor curves. The numerically greatest dynamic-response factors, approximately 3.24 and −3.26, resulted for a full-sine-wave pulse disturbance with a ratio of duration of impact to natural period, Ti/T ≅ 1.11. When Ti/T is in the neighborhood of 1, the first positive peak of dynamic response is numerically less than the negative and positive peaks which follow it. For much of the range, the positive and negative dynamic-response factors are numerically approximately equal. The analysis was confined to values of Ti/T between 0.33 and 12. As Ti/T increases without limit, the positive and negative dynamic-response factors tend to 1 and −1, respectively.

scholarly journals Amikacin or Vancomycin Exposure Alters the Postnatal Serum Creatinine Dynamics in ELBW Neonates

2020 ◽  
Author(s):  
Tamara van Donge ◽  
Anne Smits ◽  
John van den Anker ◽  
Karel Allegaert
Keyword(s):  
Serum Creatinine ◽  
Potential Effect ◽  
Mixed Effects ◽  
Treatment Modalities ◽  
Antibiotic Exposure ◽  
Modelling Analysis ◽  
Sensitive Tool ◽  
Elbw Neonates ◽  
The Difference ◽  
The Impact

Background: Disentangling adverse drug reactions from confounders remains a major challenge to assess causality and severity in neonates. Vancomycin and amikacin are perceived as nephrotoxic and often prescribed in neonates. We selected these compounds to assess their impact on creatinine dynamics as sensitive tool to detect a renal impairment signal. Methods: A recently developed dynamical model that characterized serum creatinine concentrations of 217 ELBW neonates (4036 serum creatinine observations) was enhanced with data on individual administration of vancomycin and/or amikacin to identify a potential effect of antibiotic exposure by nonlinear mixed-effects modelling analysis. Results: Of our ELBW patients, 77% were exposed to either vancomycin or amikacin. Antibiotic exposure resulted in transient lower overall creatinine clearance and a modest increase in serum creatinine. Dependency on gestational age was observed in the difference in serum creatinine when exposed to antibiotics during the third week after birth (difference in creatinine for a neonate at 24 weeks gestation decreased with 56% for a 32-week-old neonate). Conclusions: A previously described model on creatinine dynamics was used to explore and quantify the impact amikacin or vancomycin exposure on creatinine dynamics. Such tools can be used to explore minor changes, or compare minor differences between treatment modalities.

scholarly journals Performance Evaluation of Ground AR Anchor with WebXR Device API

2021 ◽  
Vol 11 (17) ◽  
pp. 7877
Author(s):  
Daehyeon Lee ◽  
Woosung Shim ◽  
Munyong Lee ◽  
Seunghyun Lee ◽  
Kye-Dong Jung ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Mixed Reality ◽  
Ground Truth ◽  
Application Programming Interface ◽  
Absolute Error ◽  
Frame Rate ◽  
Difference Image ◽  
Match Rate ◽  
The Difference ◽  
The Web

Recently, the development of 3D graphics technology has led to various technologies being combined with reality, where a new reality is defined or studied; they are typically named by combining the name of the technology with “reality”. Representative “reality” includes Augmented Reality, Virtual Reality, Mixed Reality, and eXtended Reality (XR). In particular, research on XR in the web environment is actively being conducted. The Web eXtended Reality Device Application Programming Interface (WebXR Device API), released in 2018, allows instant deployment of XR services to any XR platform requiring only an active web browser. However, the currently released tentative version has poor stability. Therefore, in this study, the performance evaluation of WebXR Device API is performed using three experiments. A camera trajectory experiment is analyzed using ground truth, we checked the standard deviation between the ground truth and WebXR for the X, Y, and Z axes. The difference image experiment is conducted for the front, left, and right directions, which resulted in a visible difference image for each image of ground truth and WebXR, small mean absolute error, and high match rate. In the experiment for measuring the 3D rendering speed, a frame rate similar to that of real-time is obtained.

Spinal-pelvic orientation: potential effect on the diagnosis of spondyloarthritis

Rheumatology ◽  
2019 ◽  
Vol 59 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Guillermo Carvajal Alegria ◽  
Lucile Deloire ◽  
Marion Herbette ◽  
Florent Garrigues ◽  
Laure Gossec ◽  
...  
Keyword(s):  
Back Pain ◽  
Lumbar Lordosis ◽  
Clinical Presentation ◽  
Imaging Study ◽  
Potential Effect ◽  
Inflammatory Back Pain ◽  
Recent Onset ◽  
Horizontal Angle ◽  
The Difference ◽  
Spine Radiographs

Abstract Objective To assess associations of spinal-pelvic orientation with clinical and imaging-study findings suggesting axial SpA (axSpA) in patients with recent-onset inflammatory back pain. Methods Spinal-pelvic orientation was assessed in DESIR cohort patients with recent-onset inflammatory back pain and suspected axSpA, by using lateral lumbar-spine radiographs to categorize sacral horizontal angle (<40° vs ⩾40°), lumbosacral angle (<15° vs ⩾15°) and lumbar lordosis (LL, <50° vs ⩾50°). Associations between these angle groups and variables collected at baseline and 2 years later were assessed using the χ2 test (or Fisher's exact) and the Mann–Whitney test. With Bonferroni’s correction, P < 0.001 indicated significant differences. Results Of 362 patients, 358, 356 and 357 had available sacral horizontal angle, lumbosacral angle and LL values, respectively; means were 39.3°, 14.6° and 53.0°, respectively. The prevalence of sacroiliitis on both radiographs and MRI was higher in the LL < 50° group than in the LL ⩾50° group, but the difference was not statistically significant. Clinical presentation and confidence in a diagnosis of axSpA did not differ across angle groups. No significant differences were identified for degenerative changes according to sacral horizontal angle, lumbosacral angle or LL. Conclusion Spinal-pelvic balance was not statistically associated with the clinical or imaging-study findings suggesting axSpA in patients with recent-onset inflammatory back pain.

Short-Term Memory for Speed

Perception ◽  
1996 ◽  
Vol 25 (1_suppl) ◽  
pp. 156-156
Author(s):  
P Thompson ◽  
R Stone ◽  
E Walton
Keyword(s):  
Spatial Frequency ◽  
Short Term Memory ◽  
Temporal Frequency ◽  
Frequency Discrimination ◽  
Sine Wave ◽  
Short Term ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Speed Discrimination ◽  
Sine Wave Gratings

We have measured the retention of information about stimulus speed in visual short-term memory by measuring speed discrimination in a two-interval forced-choice task. We have also measured such discrimination in conditions where a ‘memory masker’ is presented during the interstimulus interval (ISI) in a fashion analogous to the experiment of Magnussen et al (1991 Vision Research31 1213 – 1219). Magnussen et al found that spatial frequency discrimination was disrupted when the mask had a spatial frequency that differed from the test spatial frequency by an octave or more. We have investigated the speed discrimination of 8 Hz, 1 cycle deg−1 drifting sine-wave gratings with the following drifting masks presented in the ISI: (i) 8 Hz 1 cycle deg−1, same direction as the test; (ii) 8 Hz, 8 cycles deg−1, opposite direction to the test; (iii) 8 Hz, 8 cycles deg−1, same direction as the test; (iv) 24 Hz, 3 cycles deg−1, same direction as the test. These masks were chosen to investigate whether the temporal frequency, the spatial frequency, the speed, or the direction of motion of the mask affected retention. We found that in none of these conditions was the discrimination of the test gratings impaired significantly. This pattern of results is therefore different from that found with spatial frequency discrimination and suggests that, whatever mechanism is responsible for the retention of information about speed, it is different from that responsible for the retention of information about spatial frequency.

Temporal and Spatial Frequency Tuning of the Flicker Motion Aftereffect

Perception ◽  
1996 ◽  
Vol 25 (1_suppl) ◽  
pp. 12-12
Author(s):  
P J Bex ◽  
F A J Verstraten ◽  
I Mareschal
Keyword(s):  
Spatial Frequency ◽  
Frequency Tuning ◽  
Temporal Frequency ◽  
Motion Aftereffect ◽  
Sine Wave ◽  
Test Grating ◽  
Spatial Frequency Tuning ◽  
Spatial Frequencies ◽  
Low Pass ◽  
Sine Wave Gratings

The motion aftereffect (MAE) was used to study the temporal-frequency and spatial-frequency selectivity of the visual system at suprathreshold contrasts. Observers adapted to drifting sine-wave gratings of a range of spatial and temporal frequencies. The magnitude of the MAE induced by the adaptation was measured with counterphasing test gratings of a variety of spatial and temporal frequencies. Independently of the spatial or temporal frequency of the adapting grating, the largest MAE was found with slowly counterphasing test gratings (∼0.125 – 0.25 Hz). For slowly counterphasing test gratings (<∼2 Hz), the largest MAEs were found when the test grating was of similar spatial frequency to that of the adapting grating, even at very low spatial frequencies (0.125 cycle deg−1). However, such narrow spatial frequency tuning was lost when the temporal frequency of the test grating was increased. The data suggest that MAEs are dominated by a single, low-pass temporal-frequency mechanism and by a series of band-pass spatial-frequency mechanisms at low temporal frequencies. At higher test temporal frequencies, the loss of spatial-frequency tuning implicates separate mechanisms with broader spatial frequency tuning.

Stereoscopic Transparency and Segregation in Depth

Perception ◽  
1996 ◽  
Vol 25 (1_suppl) ◽  
pp. 90-90
Author(s):  
M J M Lankheet ◽  
M Palmen
Keyword(s):  
Temporal Integration ◽  
Frame Rate ◽  
Single Plane ◽  
Television Monitor ◽  
Depth Discontinuities ◽  
Sinusoidal Gratings ◽  
Random Dot Stereograms ◽  
Motion Contrast ◽  
The Difference ◽  
Method Of Constant Stimuli

We previously described the spatiotemporal requirements for binocular correlation in stereopsis using sinusoidal gratings-in-depth (Lankheet and Lennie, 1996 Vision Research36 527 – 538). The use of smooth sinusoidal surfaces emphasised the effects of spatial and temporal integration. Binocular correlation, however, depends not only on integration, but also on segregation at depth discontinuities. In the present experiments we therefore investigated segregation-in-depth, using random dot stereograms that depicted two transparent frontoparallel planes positioned symmetrically on either side of a binocular fixation point. Sensitivity for segregating the two planes was established by adding Gaussian distributed disparity noise to the disparities specifying the planes, and finding the noise amplitude that rendered transparency just detectable. The stimuli consisted of dynamic random-dot displays (dot lifetime 4 frames, at a frame rate of 67 Hz), generated in real time by a Macintosh computer, displayed on a television monitor, and viewed through a stereoscope. We used a method of constant stimuli and a 2AFC procedure. Two transparent planes were presented in one interval, and a single plane, with Gaussian distributed disparity values spanning the same range, was presented in the other. Segregation of stationary patterns was optimal for disparity differences of about ±9 min arc. Differences smaller than ±3 min arc and larger than about ±18 min arc could not be resolved. Motion contrast between the two patterns greatly facilitated segregation in depth. The facilitating effect increased with the difference in motion directions. The optimal speed varied with the difference in disparity.

Effects of Continuous Strain Rate Changing on Environmental Fatigue for Stainless Steels in PWR Environment

2010 ◽  
Author(s):  
Yuichiro Nomura ◽  
Seiji Asada ◽  
Takao Nakamura ◽  
Masakazu Tanaka
Keyword(s):  
Fatigue Life ◽  
Strain Rate ◽  
Water Environment ◽  
Sine Wave ◽  
Fatigue Tests ◽  
Integral Model ◽  
Strain Rates ◽  
Test Results ◽  
Approach Method ◽  
The Difference

The strain rates in actual transients of operating plants are not constant and changing momentarily. A large number of fatigue tests under stepwise strain rate changing conditions were performed to develop a method for evaluating fatigue life under varying strain rate conditions. Based on these test results, a strain base integral model known as the named the modified rate approach method was developed and verified. However it was reported recently that in the case of sine wave fatigue tests in BWR environment, the fatigue life was two to six times longer than the fatigue life predicted by the modified rate approach method. For this paper, in order to confirm whether the same tendency is observed in PWR environment, fatigue tests of sine wave were performed of SS316 in simulated PWR water environment. As the result, the difference of fatigue life by sine wave test reported in BWR environment was not observed between experimental and predicted life in PWR environment and the modified rate approach method was applicable under continuous strain rate changing condition.

scholarly journals Temporal Frequency and Velocity-Like Tuning in the Pigeon Accessory Optic System

2003 ◽  
Vol 90 (3) ◽  
pp. 1829-1841 ◽  
Author(s):  
Nathan A. Crowder ◽  
Michael R.W. Dawson ◽  
Douglas R.W. Wylie
Keyword(s):  
Motion Detection ◽  
Temporal Frequency ◽  
Sine Wave ◽  
Direction Selectivity ◽  
Large Field ◽  
Apparent Velocity ◽  
Correlation Model ◽  
Optic System ◽  
Accessory Optic System ◽  
Optokinetic Response

Neurons in the accessory optic system (AOS) and pretectum are involved in the analysis of optic flow and the generation of the optokinetic response. Previous studies found that neurons in the pretectum and AOS exhibit direction selectivity in response to large-field motion and are tuned in the spatiotemporal domain. Furthermore, it has been emphasized that pretectal and AOS neurons are tuned to a particular temporal frequency, consistent with the “correlation” model of motion detection. We examined the responses of neurons in the nucleus of the basal optic root (nBOR) of the AOS in pigeons to large-field drifting sine wave gratings of varying spatial (SF) and temporal frequencies (TF). nBOR neurons clustered into two categories: “Fast” neurons preferred low SFs and high TFs, and “Slow” neurons preferred high SFs and low TFs. The fast neurons were tuned for TF, but the slow nBOR neurons had spatiotemporally oriented peaks that suggested velocity tuning (TF/SF). However, the peak response was not independent of SF; thus we refer to the tuning as “apparent velocity tuning” or “velocity-like tuning.” Some neurons showed peaks in both the fast and slow regions. These neurons were TF-tuned at low SFs, and showed velocity-like tuning at high SFs. We used computer simulations of the response of an elaborated Reichardt detector to show that both the TF-tuning and velocity-like tuning shown by the fast and slow neurons, respectively, may be explained by modified versions of the correlation model of motion detection.

scholarly journals Spatiotemporal Properties of Fast and Slow Neurons in the Pretectal Nucleus Lentiformis Mesencephali in Pigeons

2000 ◽  
Vol 84 (5) ◽  
pp. 2529-2540 ◽  
Author(s):  
Douglas R. W. Wylie ◽  
Nathan A. Crowder
Keyword(s):  
Temporal Frequency ◽  
Receptive Fields ◽  
Sine Wave ◽  
Accessory Optic System ◽  
Stimulus Velocity ◽  
Preferred Direction ◽  
Pretectal Nucleus ◽  
Contralateral Eye ◽  
Sine Wave Gratings ◽  
Self Motion

Neurons in the pretectal nucleus lentiformis mesencephali (LM) are involved in the analysis of optic flow that results from self-motion. Previous studies have shown that LM neurons have large receptive fields in the contralateral eye, are excited in response to largefield stimuli moving in a particular (preferred) direction, and are inhibited in response to motion in the opposite (anti-preferred) direction. We investigated the responses of LM neurons to sine wave gratings of varying spatial and temporal frequency drifting in the preferred and anti-preferred directions. The LM neurons fell into two categories. “Fast” neurons were maximally excited by gratings of low spatial [0.03–0.25 cycles/° (cpd)] and mid-high temporal frequencies (0.5–16 Hz). “Slow” neurons were maximally excited by gratings of high spatial (0.35–2 cpd) and low-mid temporal frequencies (0.125–2 Hz). Of the slow neurons, all but one preferred forward (temporal to nasal) motion. The fast group included neurons that preferred forward, backward, upward, and downward motion. For most cells (81%), the spatial and temporal frequency that elicited maximal excitation to motion in the preferred direction did not coincide with the spatial and temporal frequency that elicited maximal inhibition to gratings moving in the anti-preferred direction. With respect to motion in the anti-preferred direction, a substantial proportion of the LM neurons (32%) showed bi-directional responses. That is, the spatiotemporal plots contained domains of excitation in addition to the region of inhibition. Neurons tuned to stimulus velocity across different spatial frequency were rare (5%), but some neurons (39%) were tuned to temporal frequency. These results are discussed in relation to previous studies of the responses of neurons in the accessory optic system and pretectum to drifting gratings and other largefield stimuli.

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