Excitation Properties of Computational Models of Unmyelinated Peripheral Axons
Biophysically-based computational models of nerve fibers are important tools for designing electrical stimulation therapies, investigating drugs that affect ion channels, and studying diseases that affect neurons. Although peripheral nerves are primarily composed of unmyelinated axons (i.e., C-fibers), most modeling efforts focused on myelinated axons. We implemented the single-compartment model of vagal afferents from Schild et al. 1994 and extended the model into a multi-compartment axon, presenting the first cable model of a C-fiber vagal afferent. We also implemented the updated parameters from Schild and Kunze 1997. We compared the responses of these novel models to three published models of unmyelinated axons (Rattay and Aberham 1993; Sundt et al. 2015; Tigerholm et al. 2014) and to experimental data from single fiber recordings. Comparing Schild et al. 1994 and 1997 revealed that differences in rest potential and action potential shape were driven by changes in maximum conductances rather than changes in sodium channel dynamics. Comparing the five model axons, the conduction speeds and strength-duration responses were largely within expected ranges, but none of the models captured the experimental threshold recovery cycle-including a complete absence of late subnormality in the models-and their action potential shapes varied dramatically. The Tigerholm et al. 2014 model best reproduced the experimental data, but these modeling efforts make clear that additional data are needed to parameterize and validate future models of autonomic C-fibers.