Temporal Dynamics of Acoustic Stimuli Enhance Amplitude Tuning of Inferior Colliculus Neurons

2000 ◽  
Vol 83 (1) ◽  
pp. 128-138 ◽  
Author(s):  
Alexander V. Galazyuk ◽  
Daniel Llano ◽  
Albert S. Feng
Keyword(s):  
Inferior Colliculus ◽  
Real World ◽  
Temporal Dynamics ◽  
Small Population ◽  
Behavioral Context ◽  
Response Properties ◽  
Pulse Trains ◽  
Rate Level ◽  
Rate Dependent ◽  
Level Function

Sounds in real-world situations seldom occur in isolation. In spite of this, most studies in the auditory system have employed sounds that serve to isolate physiological responses, namely, at low rates of stimulation. It is unclear, however, whether the basic response properties of a neuron derived thereof, such as its amplitude and frequency selectivities, are applicable to real-world situations where sounds occur in rapid succession. In the present study, we investigated one of the basic response properties of neurons in the bat inferior colliculus (IC), i.e., the rate-level function, to tone pulses in three different configurations: individual tone pulses of constant amplitude at different rates of stimulation, random-amplitude pulse trains, and dynamic-amplitude-modulated pulse trains the temporal pattern of which was similar to what bats encounter in a behavioral context. We reported that for the majority of IC neurons, amplitude selectivity to tone pulses was dependent on the rate of stimulation. In general, the selectivity was greater at high rates or in a behavioral context than at low rates. For a small population of IC neurons, however, the rate of stimulation had little or no effect on their rate-level functions. Thus for IC neurons, responses to sounds presented at low rates may or may not be used to predict the responses to the same stimuli presented at high rates or in a behavioral context. The possible neural mechanisms underlying the rate-dependent effects are discussed.

Plasticity of response properties of inferior colliculus neurons following acute cochlear damage

1996 ◽  
Vol 75 (1) ◽  
pp. 171-183 ◽  
Author(s):  
J. Wang ◽  
R. J. Salvi ◽  
N. Powers
Keyword(s):  
Inferior Colliculus ◽  
Discharge Rate ◽  
Excitatory Response ◽  
Response Properties ◽  
Tuning Curves ◽  
Rate Level ◽  
Discharge Rates ◽  
Inhibitory Circuit ◽  
Threshold Tuning ◽  
High Sound

1. The discharge patterns of 40 neurons in the central nucleus of the inferior colliculus (ICC) of the chinchilla were evaluated before and after acute cochlea trauma from intense tone exposure. Single-unit recordings were obtained from neurons in the ICC contralateral to the sound-stimulated ear. Cochlear trauma was induced with a short-duration (15-25 min), high-intensity pure tone (95-115 dB SPL) at a frequency above the neuron's characteristic frequency (CF). The aim of the traumatizing exposure was to damage the peripheral sensory receptors associated with frequencies above the neuron's CF. The damage was expected to attenuate inputs to the neural circuits responsible for activating the inhibitory sidebands above CF. 2. Three types of frequency-threshold tuning curves were observed before the exposure: 1) open V tuning curves (55%) that became wider as sound intensity increased; 2) level-tolerant tuning curves (37.5%) that maintained a very narrow bandwidth even at high sound intensities; and 3) upper-threshold tuning curves (7.5%) in which excitatory responses were elicited at low and moderate intensities, but not at high intensities. The traumatizing exposure caused a dramatic widening of level-tolerant (80% of sample) and upper-threshold tuning curves (100% of sample) at high sound intensities but caused almost no change in the low-threshold tip of the tuning curves. By contrast, tuning curves with an open V configuration were generally unaffected (approximately 90% of sample) by the traumatizing exposure. 3. Discharge rate-level functions in the ICC were of two general types: 1) strongly nonmonotonic (60%) or 2) saturating, monotonic (40%). The traumatizing exposure caused a significant increase in the suprathreshold discharge rates in 70% of all neurons studied. Among the neurons with strongly nonmonotonic discharge rate-level functions, 93% showed a significant increase in discharge rate. 4. The poststimulus time histograms (PSTH) to tone bursts were of three main types: 1) onset, 2) pauser, and 3) sustained responders. The traumatizing exposure had almost no effect on the PSTH of onset or sustained responders. However, pause PSTH frequently (75%) showed a significant decrease in the pause duration and an increase in the sustained discharge rate following the pause after the exposure. 5. The results suggest that the response properties of neurons with extremely narrow tuning curves and nonmonotonic discharge rate-level functions are shaped by an inhibitory circuit that is activated by frequencies above the high-frequency flank of the tuning curve. This inhibitory circuit modifies the excitatory response in the following ways: 1) it narrows the excitatory response area at suprathreshold intensities particularly at frequencies below CF, 2) it alters the shape of the discharge rate-level function by suppressing the discharge rates at suprathreshold intensities, and 3) it modifies the temporal discharge pattern of the pause PSTH by suppressing neural activity that occurs after the onset response. The effects of these inhibitory inputs can be reduced (disinhibition) by damaging the sensory cells in the inner ear that activate this circuit. The exact locus of the inhibitory circuit(s) is unknown but may involve inhibitory inputs located at the level of the cochlear nucleus and/or at levels up to the inferior colliculus.

GABAergic circuits sharpen tuning curves and modify response properties in the mustache bat inferior colliculus

1992 ◽  
Vol 68 (5) ◽  
pp. 1760-1774 ◽  
Author(s):  
L. Yang ◽  
G. D. Pollak ◽  
C. Resler
Keyword(s):  
Inferior Colliculus ◽  
Frequency Tuning ◽  
Tuning Curve ◽  
Sound Level ◽  
Response Properties ◽  
Tuning Curves ◽  
Rate Level ◽  
Wide Range ◽  
Discharge Patterns ◽  
Threshold Tuning

1. The influence of bicuculline on the tuning curves of 65 neurons in the inferior colliculus of the mustache bat was investigated. Single units were recorded with multibarrel electrodes where one barrel contained bicuculline, an antagonist specific for gamma-amino-butyric acid (GABA)A receptors. Fifty-nine tuning curves were recorded from units that were sharply tuned to 60 kHz, the dominant frequency of the bat's orientation call, but six tuning curves were also recorded from units tuned to lower frequencies and whose tuning curves were broader than the 60 kHz cells. Tuning curves were constructed from peristimulus time (PST) histograms obtained over a wide range of frequency-intensity combinations. Thus tuning curves, PST histograms evoked by frequencies within the tuning curve, and rate-level functions at the best frequency were obtained before iontophoresis of bicuculline and compared with the tuning curves and response properties obtained during the administration of bicuculline. 2. Three general types of tuning curves were obtained: 1) open tuning curves that broadened on both the high- and low-frequency sides with increasing sound level; 2) level-tolerant tuning curves in which the width of the tuning curve remained uniformly narrow with increasing sound level; and 3) upper-threshold tuning curves, which did not discharge to high-intensity tone bursts at the best frequency, thereby creating closed or folded tuning curves. 3. One major finding is that GABAergic inhibition plays an important role in sharpening frequency tuning properties of many neurons in the mustache bat inferior colliculus. In response to blocking GABAergic inputs with bicuculline, the tuning curves broadened in 42% of the neurons that were sharply tuned to 60 kHz. The degree of change in most units varied with sound level: tuning curves were least affected, or not affected at all, within 10 dB of threshold and showed progressively greater changes at higher sound levels. These effects were seen in units that had open, level-tolerant, and upper-threshold tuning curves. 4. A second key result is that bicuculline affected rate-level functions and/or temporal discharge patterns in many units. Bicuculline transformed the rate-level functions of 13 cells that originally had nonmonotonic rate level functions, from strongly nonmonotonic into weakly nonmonotonic or monotonic functions. It also changed the temporal discharge patterns in 22 cells, and the changes were often frequency specific.(ABSTRACT TRUNCATED AT 400 WORDS)

Temporal dynamics of real-world emotion are more strongly linked to prediction error than outcome.

2020 ◽  
Vol 149 (9) ◽  
pp. 1755-1766 ◽  
Author(s):  
William J. Villano ◽  
A. Ross Otto ◽  
C. E. Chiemeka Ezie ◽  
Roderick Gillis ◽  
Aaron S. Heller
Keyword(s):  
Real World ◽  
Prediction Error ◽  
Temporal Dynamics

Brief exposure of juvenile rats to noise impairs the development of the response properties of inferior colliculus neurons

2009 ◽  
Vol 29 (9) ◽  
pp. 1921-1930 ◽  
Author(s):  
Jolana Grécová ◽  
Zbyněk Bureš ◽  
Jiří Popelář ◽  
Daniel Šuta ◽  
Josef Syka
Keyword(s):  
Inferior Colliculus ◽  
Juvenile Rats ◽  
Response Properties

Response properties of neurons in the core of the central nucleus of the inferior colliculus of the barn owl

2002 ◽  
Vol 15 (8) ◽  
pp. 1343-1352 ◽  
Author(s):  
Hermann Wagner ◽  
James A. Mazer ◽  
Mark Von Campenhausen
Keyword(s):  
Inferior Colliculus ◽  
Barn Owl ◽  
Central Nucleus ◽  
Response Properties ◽  
The Core

scholarly journals Nonlinear visuoauditory integration in the mouse superior colliculus

2021 ◽  
Author(s):  
Shinya Ito ◽  
Yufei Si ◽  
Alan M. Litke ◽  
David A. Feldheim
Keyword(s):  
Superior Colliculus ◽  
Sensory Integration ◽  
Large Scale ◽  
Temporal Dynamics ◽  
Critical Role ◽  
Sensory Information ◽  
Population Level ◽  
Object Identification ◽  
Response Properties ◽  
The Individual

AbstractSensory information from different modalities is processed in parallel, and then integrated in associative brain areas to improve object identification and the interpretation of sensory experiences. The Superior Colliculus (SC) is a midbrain structure that plays a critical role in integrating visual, auditory, and somatosensory input to assess saliency and promote action. Although the response properties of the individual SC neurons to visuoauditory stimuli have been characterized, little is known about the spatial and temporal dynamics of the integration at the population level. Here we recorded the response properties of SC neurons to spatially restricted visual and auditory stimuli using large-scale electrophysiology. We then created a general, population-level model that explains the spatial, temporal, and intensity requirements of stimuli needed for sensory integration. We found that the mouse SC contains topographically organized visual and auditory neurons that exhibit nonlinear multisensory integration. We show that nonlinear integration depends on properties of auditory but not visual stimuli. We also find that a heuristically derived nonlinear modulation function reveals conditions required for sensory integration that are consistent with previously proposed models of sensory integration such as spatial matching and the principle of inverse effectiveness.

scholarly journals State Variable Effects in Graphical Event Models

2020 ◽  
Author(s):  
Debarun Bhattacharjya ◽  
Dharmashankar Subramanian ◽  
Tian Gao
Keyword(s):  
Real World ◽  
Continuous Time ◽  
Point Processes ◽  
Temporal Dynamics ◽  
Search Algorithm ◽  
State Variables ◽  
Discrete State ◽  
State Variable ◽  
Event Models ◽  
Real World Datasets

Many real-world domains involve co-evolving relationships between events, such as meals and exercise, and time-varying random variables, such as a patient's blood glucose levels. In this paper, we propose a general framework for modeling joint temporal dynamics involving continuous time transitions of discrete state variables and irregular arrivals of events over the timeline. We show how conditional Markov processes (as represented by continuous time Bayesian networks) and multivariate point processes (as represented by graphical event models) are among various processes that are covered by the framework. We introduce and compare two simple and interpretable yet practical joint models within the framework with relevant baselines on simulated and real-world datasets, using a graph search algorithm for learning. The experiments highlight the importance of jointly modeling event arrivals and state variable transitions to better fit joint temporal datasets, and the framework opens up possibilities for models involving even more complex dynamics whenever suitable.

scholarly journals Joint Modeling of Local and Global Temporal Dynamics for Multivariate Time Series Forecasting with Missing Values

2020 ◽  
Vol 34 (04) ◽  
pp. 5956-5963
Author(s):  
Xianfeng Tang ◽  
Huaxiu Yao ◽  
Yiwei Sun ◽  
Charu Aggarwal ◽  
Prasenjit Mitra ◽  
...  
Keyword(s):  
Time Series ◽  
Real World ◽  
Missing Values ◽  
Temporal Dynamics ◽  
Multivariate Time Series ◽  
Temporal Distribution ◽  
Joint Modeling ◽  
Adversarial Training ◽  
Global Patterns ◽  
Real World Datasets

Multivariate time series (MTS) forecasting is widely used in various domains, such as meteorology and traffic. Due to limitations on data collection, transmission, and storage, real-world MTS data usually contains missing values, making it infeasible to apply existing MTS forecasting models such as linear regression and recurrent neural networks. Though many efforts have been devoted to this problem, most of them solely rely on local dependencies for imputing missing values, which ignores global temporal dynamics. Local dependencies/patterns would become less useful when the missing ratio is high, or the data have consecutive missing values; while exploring global patterns can alleviate such problem. Thus, jointly modeling local and global temporal dynamics is very promising for MTS forecasting with missing values. However, work in this direction is rather limited. Therefore, we study a novel problem of MTS forecasting with missing values by jointly exploring local and global temporal dynamics. We propose a new framework øurs, which leverages memory network to explore global patterns given estimations from local perspectives. We further introduce adversarial training to enhance the modeling of global temporal distribution. Experimental results on real-world datasets show the effectiveness of øurs for MTS forecasting with missing values and its robustness under various missing ratios.

scholarly journals Effect of current focusing on the sensitivity of inferior colliculus neurons to amplitude-modulated stimulation

2016 ◽  
Vol 116 (3) ◽  
pp. 1104-1116 ◽  
Author(s):  
Shefin S. George ◽  
Mohit N. Shivdasani ◽  
James B. Fallon
Keyword(s):  
Inferior Colliculus ◽  
Cochlear Implants ◽  
Modulation Depth ◽  
Neural Activation ◽  
Detection Thresholds ◽  
P Values ◽  
Pulse Trains ◽  
Spectral Cues ◽  
Current Focusing ◽  
Channel Interactions

In multichannel cochlear implants (CIs), current is delivered to specific electrodes along the cochlea in the form of amplitude-modulated pulse trains, to convey temporal and spectral cues. Our previous studies have shown that focused multipolar (FMP) and tripolar (TP) stimulation produce more restricted neural activation and reduced channel interactions in the inferior colliculus (IC) compared with traditional monopolar (MP) stimulation, suggesting that focusing of stimulation could produce better transmission of spectral information. The present study explored the capability of IC neurons to detect modulated CI stimulation with FMP and TP stimulation compared with MP stimulation. The study examined multiunit responses of IC neurons in acutely deafened guinea pigs by systematically varying the stimulation configuration, modulation depth, and stimulation level. Stimuli were sinusoidal amplitude-modulated pulse trains (carrier rate of 120 pulses/s). Modulation sensitivity was quantified by measuring modulation detection thresholds (MDTs), defined as the lowest modulation depth required to differentiate the response of a modulated stimulus from an unmodulated one. Whereas MP stimulation showed significantly lower MDTs than FMP and TP stimulation ( P values <0.05) at stimulation ≤2 dB above threshold, all stimulation configurations were found to have similar modulation sensitivities at 4 dB above threshold. There was no difference found in modulation sensitivity between FMP and TP stimulation. The present study demonstrates that current focusing techniques such as FMP and TP can adequately convey amplitude modulation and are comparable to MP stimulation, especially at higher stimulation levels, although there may be some trade-off between spectral and temporal fidelity with current focusing stimulation.

Effect of tone-pulse rise time on rate-level functions of cat auditory cortex neurons: excitatory and inhibitory processes shaping responses to tone onset

1988 ◽  
Vol 59 (5) ◽  
pp. 1524-1539 ◽  
Author(s):  
D. P. Phillips
Keyword(s):  
Auditory Cortex ◽  
Rise Time ◽  
Cortical Neurons ◽  
Tone Onset ◽  
Tone Frequency ◽  
Pulse Envelope ◽  
Pulse Rise Time ◽  
Rate Level ◽  
Tone Pulse ◽  
Level Function

1. The responses of cat auditory cortex neurons are largely dominated by transient stimulus events, including tone-pulse onset. In addition, these neurons often receive sensitive inhibitory inputs in tone frequency-intensity domains flanking the excitatory one centered at characteristic frequency (CF). These observations suggest that auditory cortex neurons might be sensitive to the spectral splatter that occurs at tone onset due to the tone-pulse envelope shape. 2. To investigate this hypothesis, single neurons in the primary auditory cortex of anesthetized cats were studied for the form of their spike-rate versus tone-level functions using CF tone pulses of different rise times. Stimuli were presented to the contralateral ear using a calibrated, sealed stimulus delivery system. 3. Some neurons with monotonic rate-level functions for conventional (5-10 ms) rise-time tones were relatively insensitive to variations in tone-pulse rise time. Other monotonic neurons showed rate-level functions that became increasingly bell shaped for shorter rise-time stimuli. All neurons with bell-shaped, nonmonotonic rate-level functions for conventional rise-time tones became increasingly nonmonotonic for shorter rise-time signals. In the same neurons, lengthening of tone rise times typically reduced the slope of the high-intensity, descending limb of the rate-level function, in some cases to zero. 4. This pattern of rise-time effects is consistent with previous evidence on the association between rate-level function shape and the presence of inhibitory tone response areas flanking the excitatory one at CF. The present data suggest that cortical neurons are sensitive to the gross shape of the short-term stimulus spectrum at tone onset, and that for many neurons, the nonmonotonic form of CF tone rate level functions may be configured as much by the rate of tone onset as by the plateau amplitude of a tone pulse.

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