Expression of Three Cell Adhesion Molecules in Bladder Carcinomas: Correlation with Pathological Features
Recently, independent studies have shown that the expression of two integrin chains,β4 andα2, plus the epithelial cadherin are related to tumour progression in human bladder carcinomas. For the first time, we compare the expression of these three cell adhesion molecules using immunohistochemical analysis of consecutive cryosections from a series of 50 bladder tumours. E‐cadherin,β4, andα2 were strongly expressed in normal urothelium. A majority of non‐invasive bladder cancers stained positively for E‐cadherin (62%), whereas only 29% expressed normal positivity forα2, and only 35% forβ4. However, most invasive tumours presented an aberrant expression ofα2 (81%),β4 (100%), and E‐cadherin (75%). We studied the correlation of immunoreactivity with histological grade and stage. Theα2 pattern was not correlated with stage and grade. In contrast, loss of normalβ4 expression was significantly related to increasing tumour grade and deep invasion with a higher correlation for grade. Finally, E‐cadherin expression was highly correlated with stage, but not with grade. Thus our results indicate that, although many invasive bladder tumours presented a disorder in expression of the two integrinsα2 andβ4, E‐cadherin appeared to be a better marker of invasiveness in bladder carcinomas.