scholarly journals A Case-Control Study of the Role of Cold Symptoms and other Historical Triggering Factors in Asthma Exacerbations

2000 ◽  
Vol 7 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Susan M Tarlo ◽  
Irvin Broder ◽  
Paul Corey ◽  
Moira Chan-Yeung ◽  
Alexander Ferguson ◽  
...  

BACKGROUND:Asthma exacerbations can be provoked by many triggers such as allergens, respiratory irritants and viral infections. The relative importance of these has not been prospectively documented in a case-control study.OBJECTIVE:To assess the relative importance of colds and other nonclimatic historical triggers of asthma exacerbations.METHODS:One hundred and nineteen adults and children with asthma in two Canadian cities participated in a one-year study of the role of exacerbating factors in asthma. Among these, 36 pairs (21 adult, 15 children) completed the case-control study. Patients were considered cases if they developed an acute asthma exacerbation and notified the centre within 24 h to allow the completion of a questionnaire and viral studies (cultures of nasopharyngeal swabs and serology). Control people with asthma were matched for sex, age and area of residence, had no exacerbation during the preceding four weeks and participated within 48 h of the case patients.RESULTS:Case patients versus control patients had a mean age of 22 years versus 20 years, 50% versus 55% were male, and 92% versus 86% had at least one positive aeroallergen skin test. Cases were more likely to have taken regular inhaled steroids (63% versus 33%, P<0.002). Cases were more likely to report the following within the previous week: fever (P<0.001), sore throat (P<0.001), increase in nasal symptoms (P<0.01), increased dust exposure (P<0.05), exposure to others with a cold (P<0.001) and, over the previous year, increased passive smoke exposure (P<0.05). Viral cultures and paired serology were negative.CONCLUSIONS:Symptomatic colds were the most common trigger of asthma exacerbations in the winter and spring, while a transient increase in dust exposure was also identified as a significant trigger. The association with chronic, passive smoke exposure and the use of inhaled costicosteroid medications likely reflected less stable pre-study asthma in those with exacerbations.

1993 ◽  
Vol 22 (5) ◽  
pp. 804-808 ◽  
Author(s):  
ROSS C BROWNSON ◽  
MICHAEL C R ALAVANJA ◽  
EDWARD T HOCK

2012 ◽  
Vol 8 (4S_Part_9) ◽  
pp. P341-P341
Author(s):  
Martha Dlugaj ◽  
Christoph Mönninghoff ◽  
Hans-Jürgen Huppertz ◽  
Isabel Wanke ◽  
Daniel Jokisch ◽  
...  

1998 ◽  
Vol 106 ◽  
pp. 887 ◽  
Author(s):  
Susan Preston-Martin ◽  
Janice M. Pogoda ◽  
Beth A. Mueller ◽  
Flora Lubin ◽  
Baruch Modan ◽  
...  

2021 ◽  
pp. FSO745
Author(s):  
Octavian Sabin Tătaru ◽  
Orsolya Martha ◽  
Felice Crocetto ◽  
Biagio Barone ◽  
Septimiu Voidazan ◽  
...  

Aim: This study aims to investigate any modification of serological FSCN1 in prostate cancer patients compared with patients without neoplasia. Material & methods: Clinical data and blood specimens from patients with and without prostate cancer were obtained. A quantitative sandwich ELISA method was used to determine serological values of FSCN1. Results: Although serum values of FSCN1 were dissimilar in the two cohorts of patients (6.90 vs 7.33 ng/ml), the difference was not statistically significant (p = 0.20). Serum values of FSCN1 stratified for Gleason score groups were not significantly distinguishable (p = 0.65). A negative correlation (rho = -0.331; p = 0.009) was reported between FSCN1 and age. Conclusion: Further studies are required to evaluate a possible diagnostic role of FSCN1 in prostate cancer.


2020 ◽  
Vol 15 (2) ◽  
pp. 207
Author(s):  
Nurjaya Nurjaya ◽  
Djuhadiah Saadong ◽  
Subriah Subriah

ABSTRAK Latar Belakang :  IMD sangat bermanfaat bukan hanya bagi bayi yang baru lahir tetapi juga bagi ibu yang melakukan IMD. Jika bayi berada dalam dekapan ibu, maka bayi tersebut dengan sendirinya merangkak ke payudara ibu dan akan mulai menghisap puting susu ibunya. Data menunjukkan bahwa di Indonesia, persentase pemberian Air Susu Ibu (ASI) dalam 1 jam pertama setelah bayi dilahirkan masih rendah yaitu sebesar 38%. Angka tersebut masih jauh tertinggal bila dibandingkan dengan negara-negara berkembang lainnya seperti Oman (85%), Srilangka (75%), Filipina (54%), dan Turki (54%)(SDKI 2017). Oleh karena itu tujuan dari penelitian ini adalah untuk Mengetahui faktor yang mempengaruhi penerapan inisiasi menyusu dini di wilayah kerja Puskesmas Jumpandang Baru Makassar tahun 2018..Jenis penelitian ini: Penelitian ini menggunakan desain case control study. Populasi pada penelitian ini adalah semua ibu yang melahirkan di Wilayah kerja Puskesmas Jumpandang Baru. Pengambilan sampel dilakukan dengan Consecutive Sampling yaitu dengan perbandingan 1 : 2 yang dibutuhkan adalah 30 kasus dan 60 kontrol.. Pengumpulan data dilakukan menggunakan lembaran kuesioner. Data dianalisis secara univariat, bivariat dan multivariat dengan menggunakan uji Regresi Berganda LogistikHasil penelitian : Ada pengaruh pengetahuan ( OR = 5,5), peran bidan/penolong persalinan (OR = 12,571), dukungan dari suami ( OR = 3,3) terhadap penerapan inisiasi menyusu dini dan Hasil uji multivariat menunjukkan bahwa variabel peran bidan/penolong persalinan merupakan faktor yang paling berpengaruh terhadap penerapan inisiasi menyusu dini dengan nilai Wald sebesar 13 dan signifikansi sebesar 0,010.Kesimpulan : Terdapat pengaruh pengetahuan, peran bidan/penolong persalinan , dukungan dari suami terhadap penerapan inisiasi menyusu dini, dan variable peran bidan/penolong persalinan yang paling berpengaruh terhadap penerapan inisiasi menyusu dini. Kata Kunci: Penerapan Inisiasi Menyusu DiniABSTRACT Background: IMD is very beneficial not only for newborns but also for mothers who do IMD. If the baby is in the mother's arms, the baby naturally crawls into the mother's breast and will start sucking her mother's nipples. Data shows that in Indonesia, the percentage of breastfeeding in the first 1 hour after the baby is born is still low at 38%. This figure is far behind when compared to other developing countries such as Oman (85%), Sri Lanka (75%), the Philippines (54%), and Turkey (54%) (IDHS 2017) . Therefore the purpose of the research This is to find out the factors that influence the application of early breastfeeding initiation in the working area of the Jumpandang Baru Makassar Health Center in 2018 ..Type of research: This study uses a case control study design. The population in this study were all mothers who gave birth in the Working Area of the Jumpandang Baru Health Center. Sampling was done by Consecutive Sampling, which is a ratio of 1: 2. It takes 30 cases and 60 controls. Data collection is done using a questionnaire sheet. Data were analyzed by univariate, bivariate and multivariate using the Multiple Logistic Regression testResults: There was influence of knowledge (OR = 5,5), role of midwife / birth attendant (OR = 13), support from husband (OR = 3,3) on the application of early breastfeeding initiation and multivariate test results showed that the role of midwives / birth attendants was a factor the most influential on the application of early breastfeeding initiation with a Wald value of 12,956 and a significance of 0.010.Conclusion: There is an influence of knowledge, the role of midwives / birth attendants, support from husbands on the application of early breastfeeding initiation, and the role variables of midwives / birth attendants who most influence the application of early breastfeeding initiation. Keywords: Application of Early Breastfeeding Initiation 


2021 ◽  
Author(s):  
Yaa-Hui Dong ◽  
Jo-Hsuan Wu ◽  
Jiun-Ling Wang ◽  
Ho-Min Chen ◽  
James L. Caffrey ◽  
...  

Abstract Purpose Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may modulate ACE2 level and the risk of viral infections. However, studies of the risk of the severity of influenza associated with ACEIs or ARBs in the real-world settings were limited and the findings are conflicting. Methods This case-control study evaluated the risk of developing severe influenza disease associated with ACEIs and ARBs in hypertension patients hospitalized for influenza from a population-based Taiwanese database. Logistic regression models were conducted to estimate ORs and 95% CIs associated with ACEIs or ARBs within 30 days before hospitalization. Results We included 1,369 cases (severe influenza patients) and 4,107 matched controls (non-severe influenza patients). ORs for any use of ACEIs and ARBs were 1.15 (95% CI, 0.93–1.42) and 0.97 (0.84–1.12) versus nonuse. Similarly, no significant association was observed for monotherapy with ACEIs (1.47; 0.95–2.29) or ARBs (0·76; 0.53–1.10) versus nonuse. Combination therapy between calcium channel blockers (CCBs) and either ACEIs (1.57; 0.91–2.70) or ARBs (1.23; 0·93-1.62) were not significantly different from CCBs alone. Conclusions Our findings did not suggest an association between ACEIs and/or ARBs and the severity of influenza. Stable patients should maintain their anti-hypertensive regimens in the influenza epidemic era.


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