scholarly journals Nanotechnology: Emerging Developments and Early Detection of Cancer. A Two-Day Workshop Sponsored by the National Cancer Institute and the National Institute of Standards and Technology, August 30–31 2001, on the National Institute of Standards and Technology Campus, Gaithersburg, MD, USA

2002 ◽  
Vol 18 (4) ◽  
pp. 153-158 ◽  
Author(s):  
Steven J. Zullo ◽  
Sudhir Srivastava ◽  
J. Patrick Looney ◽  
Peter E. Barker

A recent meeting jointly sponsored by the National Cancer Institute (NCI) and National Institute of Standards and Technology (NIST) brought together researchers active in nanotechnology and cancer molecular biology to discuss and evaluate the interface between disciplines. Emerging areas where nanotechnologies may impact cancer prevention and early cancer detection were elaborated by key researchers who catalyzed interdisciplinary dialogue aimed at fostering cross-discipline communications and future collaboration.

2006 ◽  
Vol 52 (9) ◽  
pp. 1669-1674 ◽  
Author(s):  
Peter E Barker ◽  
Paul D Wagner ◽  
Stephen E Stein ◽  
David M Bunk ◽  
Sudhir Srivastava ◽  
...  

Abstract NIST and the National Cancer Institute cosponsored a workshop on August 18–19, 2005, to examine needs for reference materials for early cancer detection. This meeting focused on standards, methods, assays, reagents, and technologies. Needs for plasma and serum proteomics, DNA methylation, and specimen reference collections were discussed, and recommendations from participants were solicited. This report summarizes the discussion and recommendations for proteomics reference materials.


2018 ◽  
Vol 4 (Supplement 3) ◽  
pp. 26s-26s
Author(s):  
Carlos Munoz-Zuluaga ◽  
Armando Sardi ◽  
Mavalynne Orozco-Urdaneta ◽  
Luis Gabriel Parra-Lara ◽  
Andres Perez ◽  
...  

Purpose For Colombian women, breast and cervical cancer are the leading causes of mortality, despite being potentially curable through early detection and timely treatment. Tedious administrative processes and a lack of cancer screening education and awareness hinders early detection. Mobile applications (mApps) have permeated all levels of society and are potential tools by which to deliver personalized information and identify high-risk patients in need of screening tests thereby improving early cancer detection. The aim of this work is to create a free mApp that educates and guides patients to the national screening programs for breast and cervical cancer. Methods An mApp Amate was advertised to women (age ≥ 14 years) in the waiting rooms of a health care facility of a community hospital during a period of 9 months. Amate used educational, evaluative, and risk factor questions to measure the population’s knowledge of breast and cervical cancer. Each question was followed by an explanation. Correct answers yielded points that were redeemable for cellular data. Risk assessment questions identified women who required screening who were subsequently contacted by a health care provider and enrolled in the national cancer care program. Results A total of 4,553 women were contacted from August 2017 to May 2018. Of this group, 830 downloaded Amate and answered all of the questions. On the basis of the risk factor questions, 16% of patients (n = 131) were identified as being at risk for breast and/or cervical cancer and needed to be enrolled in the national screening program. Thus far, 24% of patients (n = 32) have successfully completed their recommended screening tests—mammogram, Papanicolau smear, or both. We also identified specific barriers to enrolling patients in these programs, including an unwillingness to be enrolled, limited available appointments at health care centers, and denied access as a result of health care coverage. Conclusion Amate is a low-cost, accessible tool that identifies women who are at risk for breast and cervical cancer and detects access barriers to early cancer detection. Administrative obstacles still exist and must be addressed to improve early cancer detection and screening. Amate has the potential to reach people from rural areas of Colombia and other underserved countries. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc . Armando Sardi Stock or Other Ownership: Celgene, Johnson & Johnson Mavalynne Orozco-Urdaneta Employment: Partners For Cancer Care And Prevention Foundation, Stamina-in-Action Stock or Other Ownership: Celgene, Johnson & Johnson Luis Gabriel Parra-Lara Research Funding: Merk & Co


2018 ◽  
Vol 4 (Supplement 3) ◽  
pp. 33s-33s
Author(s):  
Tochukwu Charles Orjiako

Purpose Early detection and improvements and advancements in medicine have contributed to an overall decrease in mortality and morbidity rates that result from cancer diagnoses. Despite this improvement in national and global health status, Nigerians continue to be diagnosed at a later stage and with a more aggressive disease state. This is an important observation given the impact that cancer has on the ability of individuals to function physically, psychologically, and socially within the context of their environment. It is important, therefore, to identify and target specific groups that may be less willing to present for early cancer screening. The aim of this work was to understand the characteristics of Nigerians who are likely or not to present for early cancer screening and to address the use of mechanisms by which we can ensure the timely diagnosis of preventable cancers among Nigerians. Methods Adult Nigerians (N = 144), age 18 to 71 years, presented for clinical breast examination, visual inspection with acetic acid, and prostate-specific antigen test screenings after an awareness exercise. Participants completed survey forms that included a personality inventory, early cancer detection behavior scale, and a demography profile. We used multiple regression and analysis of variance to examine predictive patterns and differences between and within groups. Results Our results indicate that income (β = .18; P < .05) is a significant determinant of early cancer detection behavior, such that higher earners were more likely to go for screening. There were also significant gender differences in current cancer detection behavior between males (mean, 0.15; standard deviation, 0.51) and females (mean, 0.47; standard deviation, 0.80). Males are less likely to engage in early detection behavior (F1,145 = 4.76; P = .03). Data also show differences between older (age > 41 years) and younger (age < 40 years) participants in the intention to screen for cancer, with older participants reporting more willingness to engage in cancer screening. Conclusion Our findings enhance our understanding of the profile of groups who are less likely to screen for cancer. Our results also suggest that awareness campaigns and free screening exercises should target these at-risk groups in Nigeria. AUTHOR’S DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc . No COIs from the author.


Author(s):  
Minetta C. Liu

SummaryEarly cancer detection should lead to an overall stage shift, less-intensive treatments and better patient outcomes. Current recommended screening programmes are limited to a handful of individual cancers. A multi-cancer early detection test that simultaneously detects and localises multiple cancers could reduce the morbidity and mortality associated with cancer.


2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Tatsha C. Bholah ◽  
Vidushi S. Neergheen-Bhujun ◽  
Nikolas J. Hodges ◽  
Sabrina D. Dyall ◽  
Theeshan Bahorun

The search for biomarkers to detect the earliest glimpse of cancer has been one of the primary objectives of cancer research initiatives. These endeavours, in spite of constant clinical challenges, are now more focused as early cancer detection provides increased opportunities for different interventions and therapies, with higher potential for improving patient survival and quality of life. With the progress of the omics technologies, proteomics and metabolomics are currently being used for identification of biomarkers. In this line, cytoglobin (Cygb), a ubiquitously found protein, has been actively reviewed for its functional role. Cytoglobin is dynamically responsive to a number of insults, namely, fibrosis, oxidative stress, and hypoxia. Recently, it has been reported that Cygb is downregulated in a number of malignancies and that an induced overexpression reduces the proliferative characteristics of cancer cells. Thus, the upregulation of cytoglobin can be indicative of a tumour suppressor ability. Nevertheless, without a comprehensive outlook of the molecular and functional role of the globin, it will be most unlikely to consider cytoglobin as a biomarker for early detection of cancer or as a therapeutic option. This review provides an overview of the proposed role of cytoglobin and explores its potential functional role as a biomarker for cancer and other diseases.


2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 54s-54s
Author(s):  
R.C.W. Chidebe ◽  
T.C. Orjiako ◽  
D.K. Atakere ◽  
O.O. Arowosegbe ◽  
D. Onu ◽  
...  

Background: Early detection and improvements/advancements in medicine have contributed to an overall decrease in mortality and morbidity rates resulting from cancer diagnoses. Despite this improvement in national and global health status, Nigerians continue to be diagnosed at a later stage, with a more aggressive disease state. This is an important observation given the impact cancer has on the abilities of individuals to function physically, psychologically, and socially within the context of their environment. It is important therefore to identify and target specific groups that may be less willing to present for early cancer screening. Aim: To understand the characteristics of people who are likely or not likely to present for early cancer screening among Nigerians, and to address the use of mechanisms by which to ensure a timely diagnosis of preventable cancers among Nigerians. Methods: Adult Nigerians (N=144), 18-71 years of age who presented for clinical breast exam (CBE), visual inspection with acetic acid (VIA) and prostate specific antigen test (PSA) screenings after an awareness exercise; completed survey forms which included a personality inventory, early cancer detection behavior scale and a demography profile. Multiple regression and ANOVA were used to examine predictive patterns as well as differences between and within groups. Results: Results showed income ( b = 0.18, P < .05) to be a significant determinant of early cancer detection behavior, such that higher income earners were more likely to go for screening. There were also significant gender differences in current cancer detection behavior between males (M = 0.15, SD = 0.51) and females (M= 0.47, SD = 0.80); males are less likely to engage in early detection behavior ( F(1,145) = 4.76, P = .03). Data further show differences between older (≥ 41) and younger (≤ 40) participants in intention to screen for cancer, with older participants reporting more willingness to engage in cancer screening. Conclusion: Our finding enhances our understanding of the profile of the groups who are less likely to screen for cancer. Also, it suggests that awareness campaign and free screening exercises should target these at-risk groups in Nigeria.


2021 ◽  
pp. 1-6
Author(s):  
Ulf Strömberg ◽  
Brandon L. Parkes ◽  
Amir Baigi ◽  
Carl Bonander ◽  
Anders Holmén ◽  
...  

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