scholarly journals Phthalocyanine-Based Molecularly Imprinted Polymers as Nucleoside Receptors

2008 ◽  
Vol 2008 ◽  
pp. 1-5 ◽  
Author(s):  
Luigia Longo ◽  
Giuseppe Vasapollo
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Capacity ◽  
Zinc Phthalocyanine ◽  
Scatchard Analysis ◽  
Binding Affinities ◽  
Imprinted Polymer ◽  
Binding Ability ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Combined Use

A molecularly imprinted polymer (MIP) for tri-O-acetyladenosine (TOAA), PPM(TOAA), was prepared by the combined use of methacrylic acid (MAA) and Zn(II)tetra(4'-methacryloxyphenoxy) phthalocyanine as functional monomers. This MIP exhibited a higher binding ability for TOAA compared to the MIP prepared using only MAA, PM(TOAA), in batch rebinding tests. Scatchard analysis gave a higher association constant of PPM(TOAA) for TOAA (2.96×104 M−1) than that of PM(TOAA) (1.48×104 M−1). The MIP prepared using only the zinc-phthalocyanine, PP(TOAA), did not show any binding capacity for TOAA. This means that the phthalocyanine in the MIP contributes to higher affinities, although it barely interacts with TOAA. Since selectivity for this kind of MIPs is more important than binding affinity, the binding of TOAA and a structurally related compound, tri-O-acetyluridine (TOAU), on the polymers was investigated. Both PPM(TOAA) and PM(TOAA) exhibited binding affinities for TOAA while they did not show any binding capacity for TOAU.

Synthesis of nicotinamide-imprinted polymers and their binding performances in organic and aqueous media

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Pattarawarapan Mookda ◽  
Komkham Singha ◽  
Kareuhanon Weeranuch ◽  
Tayapiwatana Chatchai
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Capacity ◽  
Aqueous Media ◽  
Bulk Polymerization ◽  
Molar Ratio ◽  
Imprinted Polymer ◽  
Isolation And Identification ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers

AbstractTo obtain molecularly imprinted polymers capable of selective rebinding with nicotinamide (NAM), NAM imprinted polymers were synthesized via bulk polymerization using various functional monomers and cross-linkers. The NAM recognition properties of these polymers were investigated in organic and aqueous solvents by equilibrium rebinding experiments. The results show that the imprinted polymer prepared using 1:4:4 molar ratio of NAM/MAA/TRIM in dichloromethane exhibited the greatest NAM binding capacity and selectivity. This polymer is potentially valuable for the analysis of NAM in complex matrices where selective isolation and identification are needed.

Cholesterol-Imprinted Receptor Using Chitosan Derivative as the Precursor

2013 ◽  
Vol 699 ◽  
pp. 712-717
Author(s):  
Huai Min Guan ◽  
Yue Jin Tong ◽  
Jin Hua Zheng ◽  
Xiang Li
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Polar Solvent ◽  
Binding Capacity ◽  
Template Molecule ◽  
Chitosan Derivative ◽  
Amino Groups ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Selective Protection ◽  
Selection Of

Research has been focused on the development of molecularly imprinted polymers using a chitosan derivative as the precursor. An O-acyl chitosan was synthesized by the selective protection of amino groups of chitosan in MeSO3H and was cross-linked with glutaraldehyde in the presence/ absence of template molecule, cholesterol. The effect of the degree of the acyl substitution on the selection of precursor was investigated, regarding the solubility of chitosan derivative, interaction between the precursor and imprinted molecule, and degree of the cross-linking of precursor. The rebinding experiments indicated the significant recognition for cholesterol with imprinted polymer as compared with non-imprinted polymer. It was found that a good binding capacity of the imprinted polymer towards cholesterol could be achieved in a less-polar solvent. And the O-acyl chitosan-based molecularly imprinted polymer obtained displayed good recognition selectivity for cholesterol in comparison to similarly strctural analogue, cholesterol acetate.

Preparation and Recognized Characteristic of Histamine Molecularly Imprinted Polymers

2012 ◽  
Vol 550-553 ◽  
pp. 780-786 ◽  
Author(s):  
Xing Nong Zhou ◽  
Yao Yu ◽  
Song Liu ◽  
Shou Lei Yan ◽  
Qing Zhang Wang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Molecularly Imprinted Polymers ◽  
Mixed Solvent ◽  
Binding Capacity ◽  
Scatchard Analysis ◽  
Uv Spectrophotometry ◽  
Binding Ability ◽  
Equilibrium Binding ◽  
Binding Experiment ◽  
Maximum Binding Capacity

HA MIP was prepared in acetonitrile-ethylene glycol mixed solvent ( 20:1，v/v), HA was used as the template, methacrylic acid (MAA) as the functional monomer, azobisisobutyronitrile (AIBN) as the initiator and ethylene glycol dimethaerylate (EGDMA) as the cross-linker. The UV spectrophotometry was used to demonstrate the interaction between HA and MAA. The adsorption characteristics of MIP to HA have been studied by equilibrium binding experiment and Scatchard analysis. The data obtained show that MIP reached equilibrium within 6 h. It is found that within the studied concentration range one HA molecule is entrapped by two MAA molecules The Scatchard chart shows the apparent maximum binding capacity (Bmax) and the dissociation contents (KD) of MIP are 170.5 μmol/g and 0.18 mmol/L, respctively. The MIP synthesized by this method have better binding ability to histamine and can be applied on the separation and detection of histamine.

scholarly journals Ferric Iron-Containing Molecularly Imprinted Polymer as an Adsorbent for Cholesterol

2003 ◽  
Vol 21 (3) ◽  
pp. 261-268 ◽  
Author(s):  
K. Sreenivasan ◽  
R. Sivakumar
Keyword(s):  
Adsorption Capacity ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Ferric Iron ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Chemically Modified

Molecular imprinting is an elegant approach to the synthesis of polymers with predetermined recognition properties, the technique of molecular imprinting involving arranging the functional monomers around the print molecules prior to polymerisation. Molecularly imprinted polymers (MIPs) show a remarkable ability to bind print molecule from a mixture of entities which are close in structure. One of the serious drawbacks of MIPs is their low adsorption capacity and one approach to improving this relies on the use of chemically modified monomers in the synthesis of the MIPs. This report discusses the synthesis and evaluation of an MIP based on ferric acrylate as an adsorbent for cholesterol.

Study on the Effect of Functional Monomer on the Binding Characteristics of Molecularly Imprinted Polymer

2011 ◽  
Vol 239-242 ◽  
pp. 821-824
Author(s):  
Fei Rong ◽  
De Gang Fu ◽  
Wei Wu
Keyword(s):  
Methacrylic Acid ◽  
Molecularly Imprinted Polymers ◽  
Interaction Strength ◽  
Uv Spectra ◽  
Scatchard Analysis ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Binding Characteristics ◽  
Vinyl Pyridine

Three kinds of molecularly imprinted polymers (MIPs) were prepared with S-naproxen as template molecule, and methacrylic acid, acrylamide, 4-vinyl pyridine as functional monomers, respectively. The interaction between template molecule and different monomers were analyzed by UV spectra. Binding experiments and Scatchard analysis were adopted to compare the binding characteristics of MIPs. The results showed that the MIP based on 4-vinyl pyridine possessed the highest adsorption amount of 1.73 μmol for the template molecule, while the MIP based on methacrylic acid presented the lowest binding characteristic, which correlated positively with the interaction strength concluded by UV analysis.

scholarly journals Membrane Emulsification Process as a Method for Obtaining Molecularly Imprinted Polymers

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2830
Author(s):  
Joanna Wolska ◽  
Nasim Jalilnejad Falizi
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Binding Capacity ◽  
Aqueous Media ◽  
Sorption Process ◽  
Imprinted Polymer ◽  
Membrane Emulsification ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Emulsification Process

The membrane emulsification process (ME) using a metallic membrane was the first stage for preparing a spherical and monodisperse thermoresponsive molecularly imprinted polymer (TSMIP). In the second step of the preparation, after the ME process, the emulsion of monomers was then polymerized. Additionally, the synthesized TSMIP was fabricated using as a functional monomer N-isopropylacrylamide, which is thermosensitive. This special type of polymer was obtained for the recognition and determination of trace bisphenol A (BPA) in aqueous media. Two types of molecularly imprinted polymers (MIPs) were synthesized using amounts of BPA of 5 wt.% (MIP-2) and 7 wt.% (MIP-1) in the reaction mixtures. Additionally, a non-imprinted polymer (NIP) was also synthesized. Polymer MIP-2 showed thermocontrolled recognition for imprinted molecules and a higher binding capacity than its corresponding non-imprinted polymer and higher than other molecularly imprinted polymer (MIP-1). The best condition for the sorption process was at a temperature of 35 °C, that is, at a temperature close to the phase transition value for poly(N-isopropylacrylamide). Under these conditions, the highest levels of BPA removal from water were achieved and the highest adsorption capacity of MIP-2 was about 0.5 mmol g−1 (about 114.1 mg g−1) and was approximately 20% higher than for MIP-1 and NIP. It was also observed that during the kinetic studies, under these temperature conditions, MIP-2 sorbed BPA faster and with greater efficiency than its non-imprinted analogue.

scholarly journals Examination of the Chemical Composition of Propolis IX. Solid Phase Extraction of Coumarins from Propolis by Using Molecularly Imprinted Polymer

2013 ◽  
Vol 12 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Katarína Hroboňová ◽  
Jozef Lehotay ◽  
Jozef Čižmárik
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Hplc Analysis ◽  
Chromatographic Method ◽  
Solid Phase ◽  
Binding Capacity ◽  
Bulk Polymerization ◽  
Template Molecule ◽  
Synthetic Method ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

Abstract The group selective molecularly imprinted polymers (MIPs) for coumarins, including umbelliferone, herniarin, 4-methylumbelliferone, scoparone were developed. Using umbelliferone as the template molecule, methacrylic acid as functional monomer, ethylene glycol dimethacrylate as linking agent, chloroform as porogen and bulk polymerization as synthetic method, the MIPs were synthesized and characterized with rebinding experiments. The characteristics of MIPs were evaluated by chromatographic method and frontal analysis, and demonstrating good selectivity and high binding capacity (269 μg of umbelliferone per 100 mg of polymer). The group selective MIP was used as sorbent for the SPE pretreatment of coumarins from propolis extracts prior to HPLC analysis. Analysis of the samples showed good recoveries (>70 %). The limits of quantitation (LOQs) for studied compounds were 0.3-10 ng.mL-1 (determined for fluorescence detection).

Application of umbelliferone molecularly imprinted polymer in analysis of plant samples

2013 ◽  
Vol 67 (5) ◽  
Author(s):  
Katarína Hroboňová ◽  
Andrea Spevak ◽  
Ľubica Spišská ◽  
Jozef Lehotay ◽  
Jozef Čižmárik
Keyword(s):  
Molecularly Imprinted Polymers ◽  
High Performance ◽  
Limit Of Detection ◽  
Binding Capacity ◽  
Specific Binding ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Limit Of Determination ◽  
Pre Treatment

AbstractThe molecularly imprinted polymers (MIPs) were synthesised and the influence of the type of porogen, the nature of sample solvent, and the binding capacity of material were tested by high-performance liquid chromatography (HPLC). Umbelliferone was used as the template for imprint formation. Methacrylic acid was used as the monomer and acetonitrile, ethanol, and chloroform as porogen. Non-imprinted polymers (NIPs) were prepared by the same procedure. The highest value of the specific binding capacity (269 μg of umbelliferone per 100 mg of polymer) was obtained for polymers prepared in chloroform as porogen and methanol/water (φ r = 1: 1) as the sample solvent. The group-selective MIP was used as sorbent for the SPE pre-treatment of umbelliferone from plant extracts prior to HPLC analysis. Analysis of the spiked samples showed good recoveries (> 77 %). The limit of detection, limit of determination, and repeatability of the method were also calculated.

scholarly journals Rational Design of Molecularly Imprinted Polymers Using Quaternary Ammonium Cations for Glyphosate Detection

Sensors ◽  
2021 ◽  
Vol 21 (1) ◽  
pp. 296
Author(s):  
Mashaalah Zarejousheghani ◽  
Alaa Jaafar ◽  
Hendrik Wollmerstaedt ◽  
Parvaneh Rahimi ◽  
Helko Borsdorf ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Quaternary Ammonium ◽  
Photoelectron Spectroscopy ◽  
Rational Design ◽  
Water Soluble ◽  
Trimethylammonium Chloride ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Quaternary Ammonium Cations

Molecularly imprinted polymers have emerged as cost-effective and rugged artificial selective sorbents for combination with different sensors. In this study, quaternary ammonium cations, as functional monomers, were systematically evaluated to design imprinted polymers for glyphosate as an important model compound for electrically charged and highly water-soluble chemical compounds. To this aim, a small pool of monomers were used including (3-acrylamidopropyl)trimethylammonium chloride, [2-(acryloyloxy)ethyl]trimethylammonium chloride, and diallyldimethylammonium chloride. The simultaneous interactions between three positively charged monomers and glyphosate were preliminary evaluated using statistical design of the experiment method. Afterwards, different polymers were synthesized at the gold surface of the quartz crystal microbalance sensor using optimized and not optimized glyphosate-monomers ratios. All synthesized polymers were characterized using atomic force microscopy, contact angle, Fourier-transform infrared, and X-ray photoelectron spectroscopy. Evaluated functional monomers showed promise as highly efficient functional monomers, when they are used together and at the optimized ratio, as predicted by the statistical method. Obtained results from the modified sensors were used to develop a simple model describing the binding characteristics at the surface of the different synthesized polymers. This model helps to develop new synthesis strategies for rational design of the highly selective imprinted polymers and to use as a sensing platform for water soluble and polar targets.

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