Study on the Effect of Functional Monomer on the Binding Characteristics of Molecularly Imprinted Polymer

2011 ◽  
Vol 239-242 ◽  
pp. 821-824
Author(s):  
Fei Rong ◽  
De Gang Fu ◽  
Wei Wu
Keyword(s):  
Methacrylic Acid ◽  
Molecularly Imprinted Polymers ◽  
Interaction Strength ◽  
Uv Spectra ◽  
Scatchard Analysis ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Binding Characteristics ◽  
Vinyl Pyridine

Three kinds of molecularly imprinted polymers (MIPs) were prepared with S-naproxen as template molecule, and methacrylic acid, acrylamide, 4-vinyl pyridine as functional monomers, respectively. The interaction between template molecule and different monomers were analyzed by UV spectra. Binding experiments and Scatchard analysis were adopted to compare the binding characteristics of MIPs. The results showed that the MIP based on 4-vinyl pyridine possessed the highest adsorption amount of 1.73 μmol for the template molecule, while the MIP based on methacrylic acid presented the lowest binding characteristic, which correlated positively with the interaction strength concluded by UV analysis.

scholarly journals Selective recognition of methotrexate by molecularly imprinted polymers

e-Polymers ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Manuela Curcio ◽  
Ortensia Ilaria Parisi ◽  
Giuseppe Cirillo ◽  
Umile Gianfranco Spizzirri ◽  
Francesco Puoci ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Functional Groups ◽  
Methacrylic Acid ◽  
Molecularly Imprinted Polymers ◽  
High Selectivity ◽  
Selective Recognition ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers

AbstractThe aim of this study is the preparation of molecularly imprinted polymers with high selectivity for metotrexate (MTX), a useful antineoplastic drug widely employed in clinical trials. Methacrylic acid, 2-(dimethylamino)ethyl methacrylate and a mixture of them were tested as functional monomers in order to optimize the performance of imprinted materials. The specificity and the selectivity of imprinted polymers was tested by performing rebinding experiments in water at pH 7.4. The best results were obtained by employing both functional monomers in the polymeric feed. In this way, each monomer interacts with complementary functionalities on template molecule, stabilizing the prepolymerization complex and minimizing the repulsive effects (due to the ionization of functional groups) in the rebinding media.

scholarly journals Phthalocyanine-Based Molecularly Imprinted Polymers as Nucleoside Receptors

2008 ◽  
Vol 2008 ◽  
pp. 1-5 ◽  
Author(s):  
Luigia Longo ◽  
Giuseppe Vasapollo
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Capacity ◽  
Zinc Phthalocyanine ◽  
Scatchard Analysis ◽  
Binding Affinities ◽  
Imprinted Polymer ◽  
Binding Ability ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Combined Use

A molecularly imprinted polymer (MIP) for tri-O-acetyladenosine (TOAA), PPM(TOAA), was prepared by the combined use of methacrylic acid (MAA) and Zn(II)tetra(4'-methacryloxyphenoxy) phthalocyanine as functional monomers. This MIP exhibited a higher binding ability for TOAA compared to the MIP prepared using only MAA, PM(TOAA), in batch rebinding tests. Scatchard analysis gave a higher association constant of PPM(TOAA) for TOAA (2.96×104 M−1) than that of PM(TOAA) (1.48×104 M−1). The MIP prepared using only the zinc-phthalocyanine, PP(TOAA), did not show any binding capacity for TOAA. This means that the phthalocyanine in the MIP contributes to higher affinities, although it barely interacts with TOAA. Since selectivity for this kind of MIPs is more important than binding affinity, the binding of TOAA and a structurally related compound, tri-O-acetyluridine (TOAU), on the polymers was investigated. Both PPM(TOAA) and PM(TOAA) exhibited binding affinities for TOAA while they did not show any binding capacity for TOAU.

scholarly journals Quantum Chemical Calculations on the Interaction between Flavonol and Functional Monomers (Methacrylic Acid and 4-Vinylpyridine) in Molecularly Imprinted Polymers

Molecules ◽  
2010 ◽  
Vol 15 (6) ◽  
pp. 4017-4032 ◽  
Author(s):  
Luis Enrique Gómez-Pineda ◽  
Georgina Esther Pina-Luis ◽  
Carlos Martín Cortés-Romero ◽  
Manuel Eduardo Palomar-Pardavé ◽  
Giselle Alicia Rosquete-Pina ◽  
...  
Keyword(s):  
Quantum Chemical Calculations ◽  
Methacrylic Acid ◽  
Molecularly Imprinted Polymers ◽  
Quantum Chemical ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers

scholarly journals Selective adsorption of trypsin using molecularly imprinted polymers prepared with PEG-based hydrogels containing anionic functional monomers

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Takuya Kubo ◽  
Shunsuke Arimura ◽  
Toyohiro Naito ◽  
Koji Otsuka
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Basic Protein ◽  
Selective Adsorption ◽  
Complete Removal ◽  
Template Molecule ◽  
Functional Monomer ◽  
Nacl Solution ◽  
Protein Solution ◽  
Molecularly Imprinted ◽  
Functional Monomers

AbstractMolecularly imprinting (MI) hydrogels for selective adsorption of trypsin are reported. The trypsin imprinted hydrogels were prepared using a polyethylene glycol (PEG)-based dimethacrylate as a crosslinker and anionic functional monomers. The hydrogel prepared without any functional monomers showed significantly low ability to adsorb a variety of proteins. We optimized the concentration and the length of PEG units of the crosslinkers to achieve the complete removal of the template molecule and suitable selective adsorption. Additionally, the functional monomers chosen were anionic since the template, trypsin, is a basic protein. The adsorption tests for proteins, done on the prepared MI gels, indicated that the MI gel prepared with sodium allyl sulfonate (AS) as a functional monomer showed much higher selective adsorption for trypsin, even though a mixture of trypsin and cytochrome c was used as the protein solution. The selective adsorption was more effective in a NaCl solution in which the non-specific adsorption by a sulfonate is suppressed, similarly to our findings in a previous study. The MI gel prepared with acrylic acid also showed the selectivity, although the adsorption strength was lower than that of the MI gel containing AS. We believe that the present study constitutes the first approach for the selective adsorption of trypsin using PEG-based hydrogels.

The Effect on Adsorption Performance of Molecularly Imprinted Polymer Using the Different Functional Monomers

2011 ◽  
Vol 287-290 ◽  
pp. 334-337 ◽  
Author(s):  
Xiao Ying Yin ◽  
Xiang Hong Xu ◽  
Yi Fan Jiang ◽  
Yong Ming Luo ◽  
Ling Ying Luo
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Adsorption Properties ◽  
Template Molecule ◽  
Functional Monomer ◽  
Uv Spectrum ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Adsorption Performance ◽  
Equilibrium Binding ◽  
The One

To prepare molecularly imprinted polymers (MIPs) with good recognition properties，the effect on the MIPs adsorption performance were investigated from the different functional monomers. The MIPs were synthesized by using andrographolide as template, and α-methyl acrylic acid (MAA), acrylamide (AM) and 1 - vinylimidazole were used as functional monomer. Before polymerization, the interaction between the template molecule and the two functional monomers was studied by UV spectrum. After polymerization the different adsorption properties of MIPs prepared by the three types of functional monomers were compared by equilibrium binding. The results showed that the adsorption properties of the MIPs by 1-vinyl imidazole as functional monomer were similar to the MIPs by AM as functional, which the former is slightly higher than the latter and significantly higher than that of the one by MAA as functional monomer.

scholarly journals Theoretical Insight into the Interaction between Chloramphenicol and Functional Monomer (Methacrylic Acid) in Molecularly Imprinted Polymers

2020 ◽  
Vol 21 (11) ◽  
pp. 4139 ◽  
Author(s):  
Lei Xie ◽  
Nan Xiao ◽  
Lu Li ◽  
Xinan Xie ◽  
Yan Li
Keyword(s):  
Hydrogen Bonds ◽  
Methacrylic Acid ◽  
Molecularly Imprinted Polymers ◽  
Density Functional ◽  
Topology Analysis ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Reduced Density Gradient ◽  
Reduced Density

Molecular imprinting technology is a promising method for detecting chloramphenicol (CAP), a broad-spectrum antibiotic with potential toxicity to humans, in animal-derived foods. This work aimed to investigate the interactions between the CAP as a template and functional monomers required for synthesizing efficient molecularly imprinted polymers for recognition and isolation of CAP based on density functional theory. The most suitable monomer, methacrylic acid (MAA), was determined based on interaction energies and Gibbs free energy changes. Further, the reaction sites of CAP and MAA was predicted through the frontier molecular orbitals and molecular electrostatic potentials. Atoms in molecules topology analysis and non-covalent interactions reduced density gradient were applied to investigate different types of non-covalent and inter-atomic interactions. The simulation results showed that CAP was the main electron donor, while MAA was the main electron acceptor. Moreover, the CAP–MAA complex simultaneously involved N-H···O and C=O···H double hydrogen bonds, where the strength of the latter was greater than that of the former. The existence of hydrogen bonds was also confirmed by theoretical and experimental hydrogen nuclear magnetic resonance and Fourier transform infrared spectroscopic analyses. This research can act as an important reference for intermolecular interactions and provide strong theoretical guidance regarding CAP in the synthesis of molecularly imprinted polymers.

Study on Unbalanced Competitive Adsorption of Two Ginsenosides by Molecularly Imprinted Polymers

2019 ◽  
Vol 821 ◽  
pp. 144-152
Author(s):  
Wei Zhang ◽  
Yun Jie Ma ◽  
Qian Li ◽  
Shao Yan Wang
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Competitive Adsorption ◽  
High Specific Surface Area ◽  
Poly Vinyl Alcohol ◽  
Template Molecule ◽  
Recognition Mechanism ◽  
Ginsenoside Re ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers

In this study, a kind of homogeneous spherical molecularly imprinted polymers (MIPs) with high specific surface area was prepared, with ginsenoside Re (Re) as template molecule, methacrylic acid (MAA) as functional monomers, ethylglycol dimethacrylate (EGDMA) as crosslinker and poly (vinyl alcohol)-1788 (PVA-1788) as dispersant. The MIPs was characterized by field emission scanning electron microscopy (FESEM) and surface porosity detector, and competitive adsorption behavior of the MIPs was evaluated under different two-component adsorption conditions. The experimental results showed that MIPs had the regular mesopores structure, equilibrium adsorption isotherms of MIPs were in good agreement with Freundlich model under different adsorption conditions (single solute adsorption (SSA), simultaneously competitive adsorption (SCA) and preloaded competitive adsorption (PCA)). The concentration of template (Re) and competitors (Rg1) affect the results of competitive adsorption. Re has obvious priority in competitive adsorption, and this unbalanced competitive adsorption was the results of spatial selectivity and strong inter-molecule forces of MIPs toward Re. The analysis of competitive adsorption of molecularly imprinted materials is helpful to further study the recognition mechanism of molecularly imprinted adsorbent.

scholarly journals A Review on Molecularly Imprinted Polymers Preparation by Computational Simulation-Aided Methods

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2657
Author(s):  
Zhimin Liu ◽  
Zhigang Xu ◽  
Dan Wang ◽  
Yuming Yang ◽  
Yunli Duan ◽  
...  
Keyword(s):  
Molecular Simulation ◽  
Molecularly Imprinted Polymers ◽  
Computational Simulation ◽  
Optimization Methods ◽  
Intermolecular Forces ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Molecular Imprinting Technology

Molecularly imprinted polymers (MIPs) are obtained by initiating the polymerization of functional monomers surrounding a template molecule in the presence of crosslinkers and porogens. The best adsorption performance can be achieved by optimizing the polymerization conditions, but this process is time consuming and labor-intensive. Theoretical calculation based on calculation simulations and intermolecular forces is an effective method to solve this problem because it is convenient, versatile, environmentally friendly, and inexpensive. In this article, computational simulation modeling methods are introduced, and the theoretical optimization methods of various molecular simulation calculation software for preparing molecularly imprinted polymers are proposed. The progress in research on and application of molecularly imprinted polymers prepared by computational simulations and computational software in the past two decades are reviewed. Computer molecular simulation methods, including molecular mechanics, molecular dynamics and quantum mechanics, are universally applicable for the MIP-based materials. Furthermore, the new role of computational simulation in the future development of molecular imprinting technology is explored.

Preparation and Properties of Ginsenoside Rg1 Molecularly Imprinted Polymers

2012 ◽  
Vol 550-553 ◽  
pp. 1715-1718 ◽  
Author(s):  
Li Na Yi ◽  
Xiao Ying Yin ◽  
Yi Fan Jiang ◽  
Qing Shan Liu
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Scatchard Analysis ◽  
Template Molecule ◽  
Ginsenoside Rg1 ◽  
Traditional Herbal Medicine ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Scatchard Equation ◽  
Novel Method

Molecularly imprinted polymers (MIPs) were prepared by precipitation polymerization with ginsenoside Rg1 as the template molecule. The morphology of MIPs was characterized by scanning electronmicroscope (SEM) and its static adsorption capacity was measured by the Scatchard equation. Scatchard analysis revealed that the homogeneous binding sites were formed in the polymers. The application of MIPs with high affinity toward the template molecule might offer a novel method for the enrichment and determination of active compounds in the traditional herbal medicine.

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