scholarly journals High-Sensitivity C-Reactive Protein: An Independent Risk Factor for Left Ventricular Hypertrophy in Patients with Lupus Nephritis

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Beili Shi ◽  
Zhaohui Ni ◽  
Hong Cai ◽  
Minfang Zhang ◽  
Shan Mou ◽  
...  
Keyword(s):  
Risk Factor ◽  
Multivariate Regression ◽  
Ventricular Hypertrophy ◽  
Independent Risk Factor ◽  
High Sensitivity ◽  
Multivariate Regression Analysis ◽  
Left Ventricular ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Objective. To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients.Methods. 287 LN patients (age: 38.54 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis.Results. The prevalence of LVH in this cohort was 21.25% (). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22–30.95) versus 3.93 (1.48–9.48) mg/L, , and correlated with left ventricular mass index (LVMI) (, ). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (, ) for LVH in patients with LN.Conclusions. Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provide important clinical information to investigate LVH in LN patients.

scholarly journals Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e035880 ◽  
Author(s):  
Tong Liu ◽  
Sarah Tan Siyin ◽  
Nan Yao ◽  
Ning Duan ◽  
Guoshuai Xu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Independent Risk Factor ◽  
Gallstone Disease ◽  
High Sensitivity ◽  
Secondary Outcome ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

ObjectivesGallstone disease (GSD) can be caused by various health and clinical factors such as obesity, dyslipidaemia and an unhealthy diet, all of which are associated with higher high-sensitivity C reactive protein (hs-CRP) concentrations. Whether hs-CRP represents an independent risk factor for GSD is still unclear. We prospectively investigated hs-CRP in relation to the occurrence of GSD based on the Kailuan study.Study designProspective cohort study.SettingThe Kailuan cohort study was conducted in Tangshan City in northern China.Participants95 319 participants who were free from GSD were recruited in this study. Epidemiological data, anthropometric parameters and biochemical data of participants were collected.Primary and secondary outcome measuresCox proportional hazards regression models were used to evaluate the association between hs-CRP concentrations and the risk of GSD after adjustments for potential confounders.ResultsDuring the mean 7.58 years of follow-up among 95 319 participants, 4205 participants were identified as newly diagnosed with GSD or having undergone cholecystectomy for cholelithiasis. Compared with the hs-CRP<1 mg/L group, elevated hs-CRP concentrations were significantly associated with higher risk of GSD with the corresponding HR of 1.11 (95% CI 1.03 to 1.19), 1.12 (95% CI 1.04 to 1.22) in the 1≤hs-CRP≤3 mg/L and hs-CRP>3 mg/L group, respectively. The multivariate model which included hs-CRP not only had a better line of fitness but also had better predictive values to help identify new cases of GSD during follow-up.ConclusionElevated hs-CRP concentration is an independent risk factor for new-onset GSD among the Chinese population.Trial registration numberChiCTR-TNC-11001489.

Basal high-sensitivity-C-reactive protein levels in patients with spontaneous venous thromboembolism

2005 ◽  
Vol 93 (03) ◽  
pp. 488-493 ◽  
Author(s):  
Rainer Vormittag ◽  
Thomas Vukovich ◽  
Verena Schönauer ◽  
Stephan Lehr ◽  
Erich Minar ◽  
...  
Keyword(s):  
Risk Factor ◽  
Venous Thromboembolism ◽  
Statistical Significance ◽  
Factor V Leiden ◽  
High Sensitivity ◽  
Prothrombin G20210a ◽  
Factor V ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

SummaryThe role of C-reactive protein (CRP) in venous thromboembolism (VTE) is still under discussion because of controversial results in the literature. Conflicting data may have partly been due to bias by exogenous factors altering CRP levels. We investigated CRP concentrations in patients with spontaneous VTE applying a study design that allowed the measurement of basal high sensitivity (hs)-CRP levels. Patients with a history of deep vein thrombosis (DVT, n=117) and pulmonary embolism (PE, n=97) were compared to healthy individuals (n=104). Hs-CRP levels (mg/dl) were significantly higher in patients (n=214, median/interquartile range: 0.171/0.082–0.366) than in controls (0.099/0.053–0.245, p=0.001). The unadjusted odds ratio (OR) for VTE per 1 mg/dl increase of CRP was 2.8 [95% confidence interval (CI): 1.1–6.8, p=0.03]. This association remained significant after adjustment for factor V Leiden, prothrombin G20210A and factor VIII activity above 230% (OR = 2.9, 95% CI [1.1–7.5]), but became remarkably attenuated and lost its statistical significance after adjustment for BMI alone (OR = 1.7 [0.7–4.0]). CRP was also not independently associated with VTE in subgroups of patients (those with DVT without symptomatic PE, those with PE and patients without established risk factor) in multiple regression analysis. In summary, we observed significantly higher basal hs-CRP levels in patients with spontaneous VTE compared to healthy controls. This association was independent of hereditary and laboratory risk factors for VTE, but lost its significance after adjustment for BMI. Increased basal CRP levels do not appear to represent an independent risk factor for VTE.

scholarly journals Study of Correlation between High Sensitivity C-Reactive Protein and Serum Uric Acid in Acute Stroke

2021 ◽  
Vol 10 (15) ◽  
pp. 1074-1078
Author(s):  
Jayachandra Jayachandra ◽  
Arjun P. Chandrashekar ◽  
Sowrabha S. Bhat ◽  
Yoganand Yoganand ◽  
Chethan Chethan ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Acute Stroke ◽  
Serum Uric Acid ◽  
High Sensitivity ◽  
Risk Marker ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Clinical Records

BACKGROUND Relationship between serum uric acid and cardiovascular system has been recognised since years. High-sensitivity C-reactive protein (hs-CRP) is a known risk factor for cardiovascular and cerebrovascular events. The role of uric acid as a risk factor for vascular disease and acute stroke is controversial and there is little information about it.1 It is unclear as to whether high uric acid concentrations promote or protect against the development of cerebrovascular disease, or simply acts as a passive marker of increased risk. As serum hs-CRP is an established risk factor for stroke, its positive correlation with serum uric acid levels would suggest that high serum uric acid could predict stroke risk. Also, it would prove to be a more cost-effective investigative tool in our present set up. METHODS In this cross-sectional study, we assessed 100 patients admitted with acute stroke in Victoria and Bowring and Lady Curzon Hospital from October 2016 to November 2018. Clinical records, routine investigations, radiological imaging, serum uric acid and hs-CRP of the patients were investigated. RESULTS Majority of the patients (33 %) belonged to the age group of > 70 yrs., followed by 61 - 70 yrs. (26 %). 69 % of the patients were males and 31 % were females. 67 % of them were hypertensive and 32 % were diabetic. 91 % had an hs-CRP level of > 3.0 mg / L and 8 % had hs-CRP levels between 1.0 and 3.0 mg / L. None of the female patients had a serum uric acid value > 6.5 mg / dL and none of the male patients had a uric acid level of > 7.0 mg / dL. There was a correlation between serum uric acid levels and serum hs-CRP levels in patients ≤ 50 yrs. of age. There was no correlation between serum hs-CRP levels and serum uric acid levels in patients more than 50 yrs. of age. CONCLUSIONS Our study showed that stroke is most common in persons > 70 yrs. of age and is more common in males compared to females. Hypertension is an independent risk factor for stroke. hs-CRP is a well-established risk marker for stroke, being raised in majority of stroke patients. Serum uric acid is not raised in all patients of acute stroke. So, it cannot be used as a risk marker for stroke. KEY WORDS hs-CRP, Serum Uric Acid, Acute Stroke

scholarly journals High sensitivity C-reactive protein, left ventricular mass, and systolic function in obese adolescents

2016 ◽  
Vol 56 (2) ◽  
pp. 124
Author(s):  
Erling David Kaunang ◽  
Suryani As’ad ◽  
Sarah M. Warouw ◽  
Peter Kabo
Keyword(s):  
Left Ventricular Mass ◽  
Systolic Function ◽  
High Sensitivity ◽  
Left Ventricular ◽  
Growth Chart ◽  
C Reactive Protein ◽  
Obese Adolescents ◽  
Reactive Protein ◽  
Ventricular Mass ◽  
Hs Crp

Background Obesity has been associated with structural and functional cardiac muscle defects. High sensitivity C-reactive protein (hs-CRP) has been utilized as an independent predictor of future cardiovascular disease.Objective To assess for correlations between hs-CRP, left ventricular mass, and systolic function in obese adolescents.Methods This cross-sectional study was conducted from August 2013 to February 2014. Subjects were obese adolescents aged 13-18 years with a body mass index (BMI) >95th percentile, according to the 2000 Centers for Disease Control and Prevention Growth Chart. Subjects underwent laboratory testing of serum hs-CRP levels, as well as left ventricular mass and function measurements by echocardiography. Descriptive analysis was performed on patients’ characteristics and correlation analysis was done by Pearson’s test with a significance level of P<0.05.Results Subjects were 40 obese adolescents. There was no statistically significant correlation between hs-CRP and left ventricular mass (r=0.083; P=0.305). There was a moderate correlation between hs-CRP with ejection fraction (EF) (r=0.372 and P=0.009 ) and fractional shortening (FS) of the left ventricle (r=0.420 and P=0.003).Conclusion In obese adolescents, we find no correlation between hs-CRP and left ventricular mass. However, hs-CRP is moderately correlated with left ventricular EF and FS.

scholarly journals E-cigarette Smoking (Vaping) and Markers of Vascular Wall Damage in Young Subjects without Cardiovascular Disease

2021 ◽  
Vol 17 (4) ◽  
pp. 521-527
Author(s):  
V. I. Podzolkov ◽  
A. E. Bragina ◽  
N. A. Druzhinina ◽  
L. N. Mohammadi
Keyword(s):  
Multivariate Regression ◽  
Ankle Brachial Index ◽  
High Sensitivity ◽  
Vascular Wall ◽  
Multivariate Regression Analysis ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Reactive Protein ◽  
Daily Urine ◽  
Young Subjects

Aim: to investigate the effect of nicotine-containing vapes in comparison with traditional tobacco smoking on markers of vascular wall damage: high sensitivity C-reactive protein (hsCRP), albuminuria (AU), and ankle-brachial index (ABI).Material and Methods: We examined 369 young subjects without cardiovascular diseases (age median 21 [20;21] years) (159 men and 210 women). The hsCRP levels in the serum were assessed by immunochromatographic express method. AU was investigated in daily urine by a quantitative reflex photometry. ABI was determined by plethysmography.Results: All subjects were divided into groups: non-smokers (n=196, 53.1%), smokers of traditional cigarettes (n=83, 22.5%) and smokers of nicotine-containing vapes (n=90, 24.4%). The groups did not differ in main anthropometric data. Median hsCRP levels in smokers (14.30 [11; 16.5] mg/l in tobacco-smokers and 13.15 [9.65; 17.5] mg/l in vapers) were significantly higher vs nonsmokers (3.0 [2; 5.6] mg/l). In tobacco-smokers (33.0  [21.5;  60]  mg)  and  vape  smokers  (45.0  [20;  115]  mg),  the  median  AU  was  statistically  significantly  higher  than  in  non-smokers  (12.0 [10; 20] mg). ABI levels were significantly lower in the groups of tobacco smokers (0.98 [0.91; 0.99]) and vapers (0.85 [0.79; 0.93]) when compared with nonsmokers (1.125 [1.01; 1.18]), and the median ABI in vapers was lower than in tobacco smokers (p<0.001). In the group of tobacco smokers, the hsCRP level correlated with the smoker's index (rs=0.31, p<0.05), and AU (rs=0.54, p<0.05) and ABI (rs=-0.28, p<0.05) with a daily inhaled nicotine dose. In the group of vapers, CRP was associated with smoking experience (rs=0.338, p<0.05), AU with a daily inhaled nicotine dose (rs=0.79,  p<0.05), and  ABI with  BMI (rs=-0.33,  p<0.05), heart  rate (rs=-0.24,  p<0.05) and  smoking experience  (rs=-0.235, p<0.05). According to the results of multivariate regression analysis the hsCRP level was related with only the smoking experience (B=0.91±0.19, p=0.000005), AU level with the daily inhaled nicotine dose (B=1.59±0.7, p=0.0121) and smoking experience (B=3.07±1.23, p=0.0179), and ABI level with only smoking experience (B=-0.09±0.004, p=0.0419).Conclusion: In smokers, both traditional and vapers, the levels of hsCRP, AU are significantly higher, and the ABI is lower than in healthy young nonsmokers. The most significant influence on the level of hsCRP is exerted by the experience of  tobacco  and  vape  smoking;  to  the  AU  level  – the experience of tobacco and vaping and the daily inhaled nicotine dose, and by the value of the ABI – the experience of vaping.

scholarly journals High-sensitivity C-reactive protein is an independent risk factor for non-vertebral fractures in women and men: The Tromsø Study

Bone ◽  
2015 ◽  
Vol 72 ◽  
pp. 65-70 ◽  
Author(s):  
Kristoffer Dahl ◽  
Luai Awad Ahmed ◽  
Ragnar Martin Joakimsen ◽  
Lone Jørgensen ◽  
Anne Elise Eggen ◽  
...  
Keyword(s):  
Risk Factor ◽  
Vertebral Fractures ◽  
Independent Risk Factor ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Atherosclerosis Prediction with High Sensitivity C-Reactive Protein (hs-CRP) and Related Risk Factor in Patient with Dyslipidemia

2019 ◽  
Vol 7 (22) ◽  
pp. 3887-3890
Author(s):  
Dewa Ayu Swastini ◽  
Ida Ayu Dewi Wiryanthini ◽  
Ni Luh Putu Ariastuti ◽  
Agus Muliantara
Keyword(s):  
Risk Factor ◽  
Univariate Analysis ◽  
Ankle Brachial Index ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Related Risk ◽  
Severity Prediction ◽  
Hs Crp ◽  
Atherosclerosis Severity

BACKGROUND: Inflammation plays a major role in the initiation, destabilization and the progression of atherosclerosis. High Sensitivity C-Reactive Protein (hs-CRP) reflects active systemic inflammation and have shown to be a strong predictor of future cardiovascular events. AIM: The purpose of this study was to determine the role of High Sensitivity C-Reactive Protein (hs-CRP) independent for atherosclerosis severity prediction and to find out which factors largely is affecting hs-CRP level in dyslipidemia patient. METHODS: A total of 388 patients (267 dyslipidemia, 121 controls) were enrolled in this study. We investigated whether plasma hs-CRP is associated with atherosclerosis severity that was quantified by ankle-brachial index (ABI) and Doppler ultrasound. Related risk factor that influence hs-CRP levels in patients with dyslipidemia included determination of age, gender, diabetes, smoking, hypertension, total cholesterol, TG, LDL, HDL, and fasting glucose. RESULTS: Data showed a significant association between hs-CRP concentration level and the severity of atherosclerosis (p < 0.01). Univariate analysis showed that fasting plasma glucose, triglyceride, and BMI were significantly positively correlated with hs-CRP levels. Whereas, HDL cholesterol was negatively correlated with hs-CRP levels. Multivariate regression analysis using model 1 and 2, showed that in determining hs-CRP levels, triglyceride and BMI were taking a big role. CONCLUSION: Hs-CRP correlates with extent of atherosclerosis, and high triglyceride and BMI is closely associated with high hs-CRP levels in patients with dyslipidemia.

Sign in / Sign up

Export Citation Format

Share Document