E-cigarette Smoking (Vaping) and Markers of Vascular Wall Damage in Young Subjects without Cardiovascular Disease

Aim: to investigate the effect of nicotine-containing vapes in comparison with traditional tobacco smoking on markers of vascular wall damage: high sensitivity C-reactive protein (hsCRP), albuminuria (AU), and ankle-brachial index (ABI).Material and Methods: We examined 369 young subjects without cardiovascular diseases (age median 21 [20;21] years) (159 men and 210 women). The hsCRP levels in the serum were assessed by immunochromatographic express method. AU was investigated in daily urine by a quantitative reflex photometry. ABI was determined by plethysmography.Results: All subjects were divided into groups: non-smokers (n=196, 53.1%), smokers of traditional cigarettes (n=83, 22.5%) and smokers of nicotine-containing vapes (n=90, 24.4%). The groups did not differ in main anthropometric data. Median hsCRP levels in smokers (14.30 [11; 16.5] mg/l in tobacco-smokers and 13.15 [9.65; 17.5] mg/l in vapers) were significantly higher vs nonsmokers (3.0 [2; 5.6] mg/l). In tobacco-smokers (33.0 [21.5; 60] mg) and vape smokers (45.0 [20; 115] mg), the median AU was statistically significantly higher than in non-smokers (12.0 [10; 20] mg). ABI levels were significantly lower in the groups of tobacco smokers (0.98 [0.91; 0.99]) and vapers (0.85 [0.79; 0.93]) when compared with nonsmokers (1.125 [1.01; 1.18]), and the median ABI in vapers was lower than in tobacco smokers (p<0.001). In the group of tobacco smokers, the hsCRP level correlated with the smoker's index (rs=0.31, p<0.05), and AU (rs=0.54, p<0.05) and ABI (rs=-0.28, p<0.05) with a daily inhaled nicotine dose. In the group of vapers, CRP was associated with smoking experience (rs=0.338, p<0.05), AU with a daily inhaled nicotine dose (rs=0.79, p<0.05), and ABI with BMI (rs=-0.33, p<0.05), heart rate (rs=-0.24, p<0.05) and smoking experience (rs=-0.235, p<0.05). According to the results of multivariate regression analysis the hsCRP level was related with only the smoking experience (B=0.91±0.19, p=0.000005), AU level with the daily inhaled nicotine dose (B=1.59±0.7, p=0.0121) and smoking experience (B=3.07±1.23, p=0.0179), and ABI level with only smoking experience (B=-0.09±0.004, p=0.0419).Conclusion: In smokers, both traditional and vapers, the levels of hsCRP, AU are significantly higher, and the ABI is lower than in healthy young nonsmokers. The most significant influence on the level of hsCRP is exerted by the experience of tobacco and vape smoking; to the AU level – the experience of tobacco and vaping and the daily inhaled nicotine dose, and by the value of the ABI – the experience of vaping.

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High-Sensitivity C-Reactive Protein: An Independent Risk Factor for Left Ventricular Hypertrophy in Patients with Lupus Nephritis

Journal of Biomedicine and Biotechnology ◽

10.1155/2010/373426 ◽

2010 ◽

Vol 2010 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Beili Shi ◽

Zhaohui Ni ◽

Hong Cai ◽

Minfang Zhang ◽

Shan Mou ◽

...

Keyword(s):

Risk Factor ◽

Multivariate Regression ◽

Ventricular Hypertrophy ◽

Independent Risk Factor ◽

High Sensitivity ◽

Multivariate Regression Analysis ◽

Left Ventricular ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

Objective. To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients.Methods. 287 LN patients (age: 38.54 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis.Results. The prevalence of LVH in this cohort was 21.25% (). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22–30.95) versus 3.93 (1.48–9.48) mg/L, , and correlated with left ventricular mass index (LVMI) (, ). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (, ) for LVH in patients with LN.Conclusions. Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provide important clinical information to investigate LVH in LN patients.

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Influence of Myeloperoxidase Levels on Periodontal Disease: An Applied Clinical Study

Applied Sciences ◽

10.3390/app10031037 ◽

2020 ◽

Vol 10 (3) ◽

pp. 1037

Author(s):

Alessandro Polizzi ◽

Salvatore Torrisi ◽

Simona Santonocito ◽

Mattia Di Stefano ◽

Francesco Indelicato ◽

...

Keyword(s):

Coronary Heart Disease ◽

Regression Analysis ◽

Multivariate Regression ◽

Multivariate Regression Analysis ◽

Healthy Controls ◽

Plasma Samples ◽

C Reactive Protein ◽

Periodontal Health ◽

Reactive Protein ◽

And Control

In this trial, we evaluated the influence on plasma and salivary myeloperoxidase (MPO) levels of periodontal health, coronary heart disease (CHD), periodontitis, or both periodontitis and CHD. Clinical and periodontal parameters were collected from periodontitis patients (n = 31), CHD patients (n = 31), patients with both periodontitis and CHD (n = 31), and from healthy patients (n = 31) together with saliva and plasma samples. The median concentrations of salivary and plasma MPO were statistically higher in the CHD patients [plasma: 26.2 (18.2–34.4) ng/mg; saliva 83.2 (77.4–101.5) ng/mL, p < 0.01] and in the periodontitis plus CHD patients [plasma: 27.8 (22.5–35.7) ng/mg; saliva 85.6 (76.5–106.7) ng/mL, p < 0.001] with respect to periodontitis and control patients. Through a univariate regression analysis, c-reactive protein (CRP) and CHD (both p < 0.001) and periodontitis (p = 0.024) were statistically correlated with MPO in plasma. The multivariate regression analysis demonstrated that only CRP was statistically the predictor of MPO in plasma (p < 0.001). The multivariate regression analysis in saliva demonstrated that, regarding MPO levels the only predictors were CRP (p < 0.001) and total cholesterol (p = 0.035). The present study evidenced that subjects with CHD and periodontitis plus CHD had higher plasma and salivary levels of MPO compared to subjects with periodontitis and healthy controls.

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Higher level of high sensitivity C-reactive protein is associated with more fibrocalcific plaque and longer lesion in patients with acute coronary syndrome

European Heart Journal ◽

10.1093/ehjci/ehaa946.1558 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

M Katamine ◽

Y Minami ◽

K Asakura ◽

A Kato ◽

A Katsura ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Morphological Characteristics ◽

High Sensitivity ◽

Current Smoker ◽

Lesion Length ◽

Culprit Lesion ◽

C Reactive Protein ◽

Hscrp Level ◽

Reactive Protein ◽

Coronary Syndrome

Abstract Background The association between the level of high sensitivity C-reactive protein (hsCRP) and coronary plaque characteristics in patients with acute coronary syndrome (ACS) remains to be elucidated. Purpose To clarify the morphological characteristics of culprit lesion in patients with ACS according to the hsCRP levels using optical coherence tomography (OCT). Methods A total of 215 consecutive patients with ACS, who underwent OCT imaging of culprit lesions were included. The patients were classified into either the higher hsCRP group (hsCRP ≥0.14 mg/dL, n=108) or the lower hsCRP group (hsCRP <0.14 mg/dL, n=107) according to the median preprocedural hsCRP level. The morphological characteristics of culprit lesion assessed by OCT were compared between the two groups. Results The higher hsCRP group had higher prevalence of insulin therapy (14 vs. 6%, p=0.037) and current smoker than the lower hsCRP group (37 vs. 18%, p=0.002). The prevalence of long lesion (≥25 mm, 67 vs. 53%, p=0.041) and fibrocalcific plaque (53 vs. 33%, p=0.003) was significantly higher in the higher hsCRP group than in the lower hsCRP group (Figure). On the other hand, the prevalence of plaque rupture (36 vs. 46%, p=0.174) and lipid-rich plaque (47 vs. 64%, p=0.011) was rather lower in the higher hsCRP group than in the lower hsCRP group (Figure). In a multivariate analysis, fibrocalcific plaque (odds ratio [OR]: 2.098, 95% confidence interval [CI]: 1.125–3.913, p=0.019), lesion length (mm, OR: 1.036, 95% CI: 1.010–1.061, p=0.004) and current smoker (OR: 2.757, 95% CI: 1.388–5.476, p=0.003) was independently associated with higher hsCRP level. Conclusions ACS patients with high hsCRP levels had more fibrocalcific plaque and longer lesion than those with low hsCRP levels. The association between high hsCRP levels and vulnerable characteristics of culprit plaque was not demonstrated. Funding Acknowledgement Type of funding source: None

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Association between weekend catch-up sleep and high-sensitivity C-reactive protein levels in adults: a population-based study

SLEEP ◽

10.1093/sleep/zsaa010 ◽

2020 ◽

Vol 43 (8) ◽

Author(s):

Kyu-Man Han ◽

Heon-Jeong Lee ◽

Leen Kim ◽

Ho-Kyoung Yoon

Keyword(s):

Sleep Duration ◽

High Sensitivity ◽

Low Grade ◽

C Reactive Protein ◽

Hscrp Level ◽

Obese People ◽

Cross Sectional ◽

Reactive Protein ◽

Significant Difference ◽

Catch Up

Abstract Study Objectives To investigate the association between weekend catch-up sleep (WCS) and the levels of high-sensitivity C-reactive protein (hsCRP)—a serum inflammatory maker—in adults Methods Data of 5,506 adults aged 19 years or older were obtained from the nationwide cross-sectional Korea National Health and Nutrition Examination Surveys conducted in 2016. Serum hsCRP level, weekday and weekend sleep durations, and sociodemographic and health-related characteristics were assessed. Participants whose weekend sleep duration was more than 1 h longer than their weekday sleep duration were included in the WCS group. hsCRP level was categorized into quartiles (i.e. highest, middle-high, middle-low, and lowest). Obesity was defined by body mass index ≥ 25.0 kg/m2. Results The WCS group included 1,901 participants (34.5%). In the logistic regression analysis controlling for all variables, adults in the WCS group were significantly less likely to show the highest hsCRP level (versus the lowest level) compared with those without WCS in the complete sample (adjusted odds ratio = 0.795, 95% confidence interval [CI] = 0.662 to 0.955). In a subgroup analysis, this association was significant only for those with weekday sleep duration of 6 h or lower. Longer WCS (≥3 h) was not associated with hsCRP levels. Non-obese people with WCS demonstrated a lower risk for high hsCRP levels, while there was no significant difference in obese people with WCS. Conclusions Our findings indicate that WCS may be beneficial for low-grade systemic inflammation in adults, particularly among those with shorter weekday sleep durations. WCS may also interact with obesity.

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High sensitivity C-reactive protein: Potential biomarker of inflammation in acute mTBI

Neurology ◽

10.1212/01.wnl.0000550690.49087.03 ◽

2018 ◽

Vol 91 (23 Supplement 1) ◽

pp. S18.1-S18

Author(s):

Teena Shetty ◽

Cogsil Taylor ◽

Aashka Dalal ◽

Kristin Halvorsen ◽

Kelianne Cummings ◽

...

Keyword(s):

Logistic Regression ◽

Binary Logistic Regression ◽

High Sensitivity ◽

C Reactive Protein ◽

Hscrp Level ◽

Reactive Protein ◽

Blood Biomarker ◽

Diagnosis And Prognosis ◽

Potential Factors ◽

Delayed Time

ObjectiveThis study investigated the utility of high-sensitivity C-Reactive Protein (hsCRP) as a blood biomarker for mild traumatic brain injury (mTBI).BackgroundValidation of a blood biomarker panel will greatly improve mTBI diagnosis and prognosis. hsCRP has been validated as a sensitive biomarker for inflammation. Previous studies have established relationships between CRP levels and TBI, but the utilization of hsCRP levels in assessing mTBI requires further exploration.MethodsRetrospective chart review collected hsCRP values in acute mTBI patients seen within 30 days of injury. Patients with any comorbid diagnosis known to cause elevation of inflammatory proteins were excluded. Continuous hsCRP levels were transformed into quartiles: <0.200 mg/L for Quartile 1 (Q1); 0.200–0.415 mg/L for Quartile 2 (Q2); 0.415–1.100 mg/L for Quartile 3 (Q3); and ≥1.100 mg/L for Quartile 4 (Q4). Multivariable binary logistic regression modeling identified potential factors for elevated hsCRP at first visit. Cox regression analysis identified potential factors for delayed time to recovery.ResultsThree hundred twelve injuries in 311 patients were reviewed (mean age 21 ± 12 years, 53% female). Mean hsCRP was elevated patients who presented within 2 days of injury and was found to significantly decrease between first visit and 4 weeks post-injury (p = 0.016). Initial hsCRP level was positively correlated with age (r = 0.163, p = 0.004) and negatively associated with previous concussion history (p = 0.031). When analyzed as quartiles, patients in Q4 were more likely to have endorsed headache (p = 0.036) or fatigue (p = 0.030). Age significantly increased between quartiles (p = 0.013). Multivariable binary logistic regression showed that increased age (OR: 3.48) and patients presenting with headache (OR: 3.48) or fatigue (OR: 2.16) were significantly associated with increased risk of having an hsCRP level in Q4. Females (HR: 0.32) and increased age (HR: 0.95) were associated delayed time to recovery.ConclusionshsCRP may be a viable addition to acute and longitudinal biomarker panels for diagnosis and prognosis of mTBI.

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MON-099 The Association Between C-Reactive Protein, Metabolic Syndrome, and Pre-Diabetes in Korean Children and Adolescents

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.015 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Jihyun Kim ◽

Jong Bin Lee ◽

Jung Sub Lim

Keyword(s):

Metabolic Syndrome ◽

Children And Adolescents ◽

Geometric Mean ◽

High Sensitivity ◽

Low Grade ◽

C Reactive Protein ◽

Hscrp Level ◽

Cross Sectional ◽

Korean Children ◽

Reactive Protein

Abstract Objective: Cardiovascular disease (CVD) is a leading cause of death worldwide, including in Korea. In adults, the risk for CVD is increased approximately three-fold in subjects with metabolic syndrome (MetS), and the hazard ratio for subjects with MetS has been reported as 1.37 for mortality from CVD after adjustment for other confounders. Furthermore, MetS in childhood predicts adult MetS and T2DM 25 to 30 years later. Because MetS is a state of chronic low-grade inflammation, measurements of the circulating levels of the inflammatory molecules might provide diagnostic and therapeutic approaches to modulate or alter disease progression. High sensitivity C-reactive protein (hsCRP), a biomarker of inflammation, has emerged as an independent predictor of CVD and T2DM development. The aim of this paper is to evaluate the association between hsCRP and MetS and its components in Korean children and adolescents. Methods: We performed a cross-sectional analysis using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2017. We analyzed the data of 1,247 subjects (633 males, 14.2 ± 2.7 years) from the KNHANES 2016–2017. MetS were defined by the modified NCEP-ATP III criteria. Results: Among the 1,247 subjects (mean age: 14.2 ± 2.7 years), the prevalence of MetS was 5.8% (7.0% in male subjects and 4.6% in female subjects; p = 0.070). The mean hsCRP level was 0.861 ± 1.567 mg/l (median and interquartile range: 0.370 and 0.430mg/l). Subjects with MetS had higher hsCRP levels than subjects without MetS (geometric mean: 1.08 vs. 0.46 mg/l, p < 0.001). The prevalence of MetS in the lowest, second, third, and highest hsCRP quartiles were 1.8%, 2.4%, 3.5%, and 15.2%, respectively. Compared to the lowest quartile, the odds ratio (OR) for having MetS in the highest quartile was 8.414 (3.272–21.638), adjusting for age and sex. The OR for having abdominal obesity and low HDL-C in the highest quartile were 9.657 (4.818–19.355) and 2.408 (1.286–4.510), adjusting for age, sex, and other components of the MetS. Additionally, the OR for having pre-diabetes (HbA1c ≥ 5.7%) in the highest quartile was 2.061 (1.097–3.870). Conclusion: Serum hsCRP level is positively associated with MetS and pre-diabetes in Korean children and adolescents.

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ASSOCIATIONS BETWEEN HIGH-SENSITIVITY C-REACTIVE PROTEIN AND ANKLE BRACHIAL INDEX IN ASYMPTOMATIC OLDER ADULTS

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(12)61648-9 ◽

2012 ◽

Vol 59 (13) ◽

pp. E1647

Author(s):

Jang Hoon Lee ◽

Kyun Hee Kim ◽

Won Suk Choi ◽

Sun Hee Park ◽

Myung Hwan Bae ◽

...

Keyword(s):

Older Adults ◽

Ankle Brachial Index ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein

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Associations between intraoperative nociceptive and early postoperative C-reactive protein levels in patients undergoing non-cardiac surgery under general anesthesia

10.21203/rs.2.208/v1 ◽

2019 ◽

Author(s):

Shiroh Nakamoto ◽

Hiroki Ogata ◽

Ayano Saeki ◽

Ryusuke Ueki ◽

Nobutaka Kariya ◽

...

Keyword(s):

Postoperative Complications ◽

Prediction Model ◽

General Anesthesia ◽

Multivariate Regression ◽

Validation Cohort ◽

Multivariate Regression Analysis ◽

C Reactive Protein ◽

Reactive Protein ◽

Major Complications ◽

Duration Of Surgery

Abstract Background: Early detection of postoperative increase in C-reactive protein (CRP) predicts complications after surgery. The preoperative and intraoperative factors associated with postoperative CRP changes are potentially significant in the prophylactic management of postoperative complications. Although ongoing nociception during surgery under general anesthesia is one of potential candidates for these factors, it has not been evaluated with the unavailability of valid nociception measures in clinical practice. Then we adopted averaged values of nociceptive response (NR) throughout surgery as intraoperative nociceptive levels, being examined the association between perioperative factors, early changes in postoperative CRP levels, and postoperative complications Material and Methods: Data from 174 adult patients undergoing elective non-cardiac surgery under general anesthesia on perioperative variables, including age, sex, BMI, American Society of Anesthesiologists-physical status (ASA-PS), duration of surgery, mean NR during surgery as intraoperative nociceptive level, CRP levels before and after surgery on postoperative day (POD) 1, and postoperative complications using the extended Clavien-Dindo classification were retrospectively obtained in a training cohort. Multivariate regression analysis was performed to determine the independent factor of CRP levels on POD1and to develop a prediction model. In two validation cohorts, both 75 patients undergoing mastectomy (validation cohort A) and 139 patients undergoing laparoscopic or open abdominal surgery (validation cohort B) were separately selected, and retrospectively utilized to evaluate the value of the prediction model. Results: CRP levels on POD1 in the training cohort significantly increased in the order of Clavien-Dindo grades. Multivariate regression analysis selected mean NR, BMI, and duration of surgery to set up the prediction model of CRP level on POD1, which showed significant correlation with the measured CRP in both two validation cohorts. To confirm associations between mean NR, postoperative CRP, and major complications (Clavien-Dindo grade ≥ IIIa), we performed a propensity score matching in the validation cohort B, using age, BMI, ASA-PS, and duration of operations, finding that both mean NR and CRP levels on POD1 were significantly higher in patients with major complications than those without major complications. Conclusion: Increases in the intraoperative nociceptive level likely associated with early increases in CRP level after surgery. Keywords: C-reactive protein, Postoperative complications, Nociception.

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HUBUNGAN INDEKS MASSA TUBUH DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN SERUM PADA MAHASISWA OBES DAN TIDAK OBES DI FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO

Jurnal e-Biomedik ◽

10.35790/ebm.1.1.2013.1610 ◽

2013 ◽

Vol 1 (1) ◽

Author(s):

Christy Rattu ◽

Alexander S. L. Bolang ◽

Shirley E. S. Kawengian

Keyword(s):

High Sensitivity ◽

Medical Faculty ◽

Obesity Prevalence ◽

C Reactive Protein ◽

Hscrp Level ◽

Cross Sectional ◽

Reactive Protein ◽

Meaningful Relationship ◽

The Difference ◽

Age Range

Abstract: The increasing of Metabolic syndrome become a problem nowadays. The prevalence of metabolic symbol can be confirmed tend to increase with the increasing of obesity prevalence. The indicator to measure body’s fat is Body Mass Index (BMI). For obesity patient, their adiposity system produce duce protein messenger that cause inflamation. The level of High Sensitivity C-Reactive Protein (hsCRP) is one of the parameter that used to detect inflamation process. This research is conducted with the purpose to know the difference of hsCRP level between Obese students and Non-Obese students in Medical Faculty, to know the relation between BMI and hsCRP level between Obese and Non-Obese students in Medical Faculty. This is an analitic research with cross sectional approach that used 59 sample that consists of 30 Man and 29 woman, with the age range between 18-22 years old. The result of this research shown that there is a big difference of hsCRP level between obese and non-obese students. Cobclusion: There is a meaningful positif relationship between BMI with hsCRP level for obese students, and there is no meaningful relationship between BMI with hsCRP level for the non-obese students in Medical Faculty. Keywords: BMI, hsCRP, obesity Abstrak: Meningkatnya sindroma metabolik menjadi masalah sekarang ini. Prevalensi sindroma metabolik dapat dipastikan cenderung meningkat dengan meningkatnya prevalensi obesitas. Indikator untuk mengukur lemak tubuh adalah indeks massa tubuh (IMT). Pada penderita obesitas, jaringan adiposity menghasilkan protein-protein duta yang menyebabkan adanya inflamasi. Kadar High Sensitivity C-Reactive Protein (hsCRP) merupakan salah satu parameter uji yang dipakai untuk mendeteksi proses inflamasi. Penelitian ini telah dilakukan dengan tujuan untuk mengetahui perbedaan kadar hsCRP pada mahasiswa obes dan non-obes di Fakultas Kedokteran, untuk mengetahui hubungan antara IMT dengan kadar hsCRP pada mahasiswa obes dan non-obes di Fakultas Kedokteran. Penelitian ini bersifat analitik dengan pendekatan cross sectional menggunakan 59 sampel yang terdiri 30 laki-laki dan 29 wanita, berusia 18-22 tahun. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang bermakna kadar hsCRP pada mahasiswa obes dan non-obes. Simpulan: Ada hubungan positif yang bermakna antara IMT dengan kadar hsCRP pada mahasiswa obes, dan tidak terdapat hubungan yang bermakna antara IMT dengan kadar hsCRP pada mahasiswa non-obes di Fakultas Kedokteran. Kata kunci: IMT, hsCRP, obesitas.

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