The Study of the Effect of Histidine Derivatives as a Novel Antinociceptive and Anti-Inflammatory Activity
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Ft Ir
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This study explains the biochemical activity of histidine derivatives The compounds were identified by CHN analysis, FT-IR and H1NMR. The results certified that the chemical structures of the prepared compounds. The anti-inflammatory and antinociceptive activity was studied by two different tests; the hot plate test and writhing test for analgesic activity and two tests for anti-inflammatory activity they are formalin induced inflammation test and carrageen an induced inflammation test. The histidine derivatives were found to have potent activity as anti-inflammatory and antinociceptive. The active compounds were tested to acute toxicity. It was found that they are safety to the dose 5 g/kg orally in mice without any mortality.
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2019 ◽
Vol 26
(1)
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pp. 77-87
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2010 ◽
Vol 9
(3)
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pp. 28
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2018 ◽
Vol 11
(12)
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pp. 190
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2012 ◽
Vol 67
(1-2)
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pp. 15-21
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2005 ◽
Vol 33
(01)
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pp. 29-40
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