scholarly journals Not all colonic growths are malignant

2019 ◽  
Vol 12 (7) ◽  
pp. e229515
Author(s):  
Geethu Rachel Iype ◽  
Sasank Kalipatnapu ◽  
Dipti Masih ◽  
Gigi Varghese
Keyword(s):  
Inflammatory Condition ◽  
Chronic Inflammatory Condition ◽  
Xanthogranulomatous Inflammation

We present the case of a 34-year-old woman who was diagnosed to have adenocarcinoma of the caecum based on the clinical, radiological, histopathological and intraoperative findings. However, postoperative histopathology showed only features of xanthogranulomatous inflammation without any evidence of malignancy. This benign chronic inflammatory condition could present as a histological surprise. It is important for both surgeons and pathologists alike to be aware of this.

scholarly journals Pilonidal Cyst of the Penis Mimicking Carcinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-2
Author(s):  
Luigi Cormio ◽  
Francesca Sanguedolce ◽  
Paolo Massenio ◽  
Giuseppe Di Fino ◽  
Giuseppe Carrieri
Keyword(s):  
Differential Diagnosis ◽  
Pilonidal Sinus ◽  
Rare Case ◽  
Subcutaneous Tissue ◽  
Sinus Tract ◽  
Penile Carcinoma ◽  
Inflammatory Condition ◽  
Pilonidal Cyst ◽  
Chronic Inflammatory Condition

Pilonidal sinus is a long-standing chronic inflammatory condition consisting of a sinus tract from the skin-lined orifice extending into subcutaneous tissue, with hairs attached to the wall of the tract and projecting outside of the opening. Penile location is rare, and differential diagnosis with severe balanoposthitis, epidermal cysts, and neoplasms can be difficult. We report a rare case of pilonidal cyst located between coronal sulcus and prepuce which, due to its ulcerated aspect and absence of a tract with projecting hairs, simulated a penile carcinoma.

TNF-Alpha Inhibitors and Ustekinumab for the Treatment of Psoriasis: Therapeutic Utility in the Era of IL-17 and IL-23 Inhibitors

2022 ◽  
pp. 247553032110474
Author(s):  
Julie J. Hong ◽  
Edward K. Hadeler ◽  
Megan L. Mosca ◽  
Nicholas D. Brownstone ◽  
Tina Bhutani ◽  
...  
Keyword(s):  
Treatment Resistance ◽  
Risk Patient ◽  
Tnf Alpha ◽  
Inflammatory Condition ◽  
Biologic Therapies ◽  
Malignancy Risk ◽  
Patient Demographics ◽  
The Past ◽  
Chronic Inflammatory Condition ◽  
Patient Subgroups

Psoriasis is a chronic inflammatory condition for which eleven FDA-approved biologic therapies are approved. Over the past decade, studies have documented the higher efficacy of IL-17 and IL-23 inhibitors for the treatment of psoriasis compared to the TNF-alpha inhibitors and ustekinumab, an IL-12/23 inhibitor. Despite this, there remains an important role for the use of TNF-alpha inhibitors and ustekinumab in the treatment of psoriasis. Here, we review how considerations of infection and malignancy risk, patient demographics, treatment resistance, and comorbidities may make certain TNF-alpha inhibitors or ustekinumab an excellent choice for therapy in particular patient subgroups.

scholarly journals Cardiopulmonary Manifestations of Ankylosing Spondylitis

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Mahnaz Momeni ◽  
Nora Taylor ◽  
Mahsa Tehrani
Keyword(s):  
Ankylosing Spondylitis ◽  
Cardiac Dysfunction ◽  
Spontaneous Pneumothorax ◽  
Pulmonary Complications ◽  
Inflammatory Condition ◽  
Stepwise Approach ◽  
Conduction Disturbances ◽  
Chronic Inflammatory Condition ◽  
Pulmonary Manifestations ◽  
Valve Diseases

Ankylosing spondylitis is a chronic inflammatory condition that usually affects young men. Cardiac dysfunction and pulmonary disease are well-known and commonly reported extra-articular manifestation, associated with ankylosing spondylitis (AS). AS has also been reported to be specifically associated with aortitis, aortic valve diseases, conduction disturbances, cardiomyopathy and ischemic heart disease. The pulmonary manifestations of the disease include fibrosis of the upper lobes, interstitial lung disease, ventilatory impairment due to chest wall restriction, sleep apnea, and spontaneous pneumothorax. They are many reports detailing pathophysiology, hypothesized mechanisms leading to these derangements, and estimated prevalence of such findings in the AS populations. At this time, there are no clear guidelines regarding a stepwise approach to screen these patients for cardiovascular and pulmonary complications.

Profiling of histone 3 lysine 27 acetylation reveals its role in a chronic DSS-induced colitis mouse model

2019 ◽  
Vol 15 (4) ◽  
pp. 296-307
Author(s):  
Meng Chen ◽  
Qinglan Li ◽  
Nan Cao ◽  
Yanan Deng ◽  
Lianyun Li ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gastrointestinal Tract ◽  
Mouse Model ◽  
Bowel Disease ◽  
Inflammatory Condition ◽  
Histone 3 ◽  
Chronic Inflammatory Condition ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract.

scholarly journals Periodontal Disease Is an Independent Predictor of Intracardiac Calcification

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Gregg S. Pressman ◽  
Atif Qasim ◽  
Nitin Verma ◽  
Masami Miyamae ◽  
Kumiko Arishiro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Periodontal Disease ◽  
Subclinical Atherosclerosis ◽  
Scoring Systems ◽  
Cross Sectional Study ◽  
Inflammatory Condition ◽  
Cross Sectional ◽  
Calcification Score ◽  
Chronic Inflammatory Condition ◽  
Traditional Risk Factors

Background. Periodontitis is the most common chronic inflammatory condition worldwide and is associated with incident coronary disease.Hypothesis. We hypothesized that periodontal disease would also be associated with cardiac calcification, a condition which shares many risk factors with atherosclerosis and is considered a marker of subclinical atherosclerosis.Methods. Cross-sectional study at two sites (USA and Japan) involving subjects with both clinical echocardiograms and detailed dental examinations. Semiquantitative scoring systems were used to assess severity of periodontal disease and echocardiographic calcification.Results. Fifty-six of 73 subjects (77%) had cardiac calcifications, and 51% had moderate to severe periodontal disease (score > 2). In unadjusted analysis, a significant relationship between periodontal score and cardiac calcification (Spearman rho = 0.4,P=0.001) was noted, with increases in mean calcification score seen across increasing levels of periodontal disease. On multivariate logistic regression, adjusted for age, gender, race, glomerular filtration rate, and traditional risk factors, this association remained significant (P=0.024). There was no significant interaction by study site, race, or gender.Conclusions. In a multiracial population, we found a significant association between the degree of periodontal disease, a chronic inflammatory condition, and cardiac calcification. Further, higher periodontal scores were associated with greater degrees of calcification.

scholarly journals Generalized hypertrophic lichen planus: an atypical presentation of a characteristic disease

2020 ◽  
Author(s):  
Sharan Mirchandani ◽  
Devesh Sanjeev Ballal ◽  
Gabriel Rodrigues ◽  
Kantilatha Pai
Keyword(s):  
Quality Of Life ◽  
Lichen Planus ◽  
Multidisciplinary Approach ◽  
Early Recognition ◽  
Rare Event ◽  
Atypical Presentation ◽  
Inflammatory Condition ◽  
Chronic Inflammatory Condition ◽  
Mucous Membranes

Lichen planus is a common chronic inflammatory condition that affects skin and mucous membranes. Management is often delayed because of patient embarrassment or misdiagnosis by the clinician. Early recognition and treatment is essential to reduce the morbidity of this condition. We present a 58-year-old woman diagnosed with generalized hypertrophic lichen planus, a rare event, reported to occur usually on lower extremities, but found to be generalized in our patient, requiring excision of symptomatic lesions. We suggest a multidisciplinary approach to allay the anxiety and symptoms of these patients and to improve the quality of life and clinical outcomes.

scholarly journals Benign cyst with xanthogranulomatous inflammation involving the transverse colon and the common iliac artery

2020 ◽  
Vol 2020 (9) ◽  
Author(s):  
Kevin Corless ◽  
Amir Samy ◽  
Ahmed Kamil ◽  
Aisling Maria Hogan
Keyword(s):  
Transverse Colon ◽  
Cystic Lesion ◽  
Common Iliac Artery ◽  
Abdominal Discomfort ◽  
Surrounding Tissue ◽  
Mesenteric Cyst ◽  
Inflammatory Condition ◽  
Xanthogranulomatous Inflammation ◽  
The Common ◽  
Abdominal Cyst

Abstract Xanthogranulomatous inflammation (XGI) is a rare process. Colonic XGI is extremely rare. We present a case report of XGI arising within an intra-abdominal cyst involving the transverse colon. A 28-year-old man presented with abdominal discomfort. He underwent a computed tomography abdomen–pelvis, which found three subcutaneous collections and a large cystic intra-abdominal structure. The decision was made for resection. Intraoperatively, the cyst originated from the pelvis and was adherent to the surrounding tissues. Histology from the lesion revealed XGI extending into the surrounding tissue. XGI is a rare inflammatory condition. Clinically, it can be difficult to distinguish XGI from an infiltrative malignancy. Therefore, it is usually necessary to obtain a pathological diagnosis of XGI. This case describes an atypical cystic lesion with XGI involving the transverse colon. Although rare, it should be considered in the potential differential diagnosis of an infective or malignant mesenteric cyst.

scholarly journals Brassica Bioactives Could Ameliorate the Chronic Inflammatory Condition of Endometriosis

2020 ◽  
Vol 21 (24) ◽  
pp. 9397
Author(s):  
Paula García-Ibañez ◽  
Lucía Yepes-Molina ◽  
Antonio J. Ruiz-Alcaraz ◽  
María Martínez-Esparza ◽  
Diego A. Moreno ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Uterine Cavity ◽  
Inflammatory Condition ◽  
Brassica Spp ◽  
Chronic Inflammatory Condition ◽  
Therapeutic Molecules ◽  
Health Promoting ◽  
Cellular Water ◽  
Gynecological Disorder ◽  
Condition Of Women

Endometriosis is a chronic, inflammatory, hormone-dependent disease characterized by histological lesions produced by the presence of endometrial tissue outside the uterine cavity. Despite the fact that an estimated 176 million women are affected worldwide by this gynecological disorder, risk factors that cause endometriosis have not been properly defined and current treatments are not efficient. Although the interaction between diet and human health has been the focus of many studies, little information about the correlation of foods and their bioactive derivates with endometriosis is available. In this framework, Brassica crops have emerged as potential candidates for ameliorating the chronic inflammatory condition of endometriosis, due to their abundant content of health-promoting compounds such as glucosinolates and their hydrolysis products, isothiocyanates. Several inflammation-related signaling pathways have been included among the known targets of isothiocyanates, but those involving aquaporin water channels have an important role in endometriosis. Therefore, the aim of this review is to highlight the promising effects of the phytochemicals present in Brassica spp. as major candidates for inclusion in a dietary approach aiming to improve the inflammatory condition of women affected with endometriosis. This review points out the potential roles of glucosinolates and isothiocyanates from Brassicas as anti-inflammatory compounds, which might contribute to a reduction in endometriosis symptoms. In view of these promising results, further investigation of the effect of glucosinolates on chronic inflammatory diseases, either as diet coadjuvants or as therapeutic molecules, should be performed. In addition, we highlight the involvement of aquaporins in the maintenance of immune homeostasis. In brief, glucosinolates and the modulation of cellular water by aquaporins could shed light on new approaches to improve the quality of life for women with endometriosis.

Extragenital lichen sclerosus arising in tattooed skin

2022 ◽  
Vol 15 (1) ◽  
pp. e246216
Author(s):  
Aarthy Kanmany Uthayakumar ◽  
Georgios Kravvas ◽  
Christopher Barry Bunker
Keyword(s):  
Rare Case ◽  
Lichen Sclerosus ◽  
Inflammatory Condition ◽  
Koebner Phenomenon ◽  
Chronic Inflammatory Condition ◽  
Anogenital Area ◽  
Male Patients

Lichen sclerosus (LSc) is a chronic inflammatory condition commonly affecting the anogenital area, with extragenital involvement seen in less than 1%–20% of cases. Concomitant extragenital and genital LSc is extremely rare in male patients. The Koebner phenomenon is a recognised feature of LSc; here we present a rare case of extragenital LSc occurring in tattooed skin.

Sign in / Sign up

Export Citation Format

Share Document