scholarly journals Reversal of the Symptoms of Diabetic Neuropathy through Correction of Vitamin D Deficiency in a Type 1 Diabetic Patient

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
David S. H. Bell
Keyword(s):  
Vitamin D ◽  
Diabetic Neuropathy ◽  
Diabetic Patient ◽  
Vitamin D Deficiency ◽  
Diabetic Patients ◽  
Lower Pain ◽  
Microvascular And Macrovascular Complications ◽  
Lower Pain Threshold

Vitamin D deficiency has been associated with both type 1 and type 2 diabetes as well as both the microvascular and macrovascular complications of diabetes. Vitamin D deficiency has been shown to be more common in diabetic patients who have symptoms of distal symmetrical polyneuropathy. In addition, vitamin D deficiency has been associated with a lower pain threshold which increases when vitamin D deficiency is corrected. Herein, I describe a type 1 diabetic patient with neuropathic symptoms so severe that he could not work and for which he needed narcotics for pain management and whose symptoms improved dramatically with correction of the vitamin D deficiency. To my knowledge, this is the first report of an improvement in severe symptoms of diabetic neuropathy with correction of vitamin D deficiency in a single patient.

Is diabetic neuropathy associated with vitamin D status? A meta-analysis

2021 ◽  
pp. 1-35
Author(s):  
Kaissar Yammine ◽  
Joelle Abi Kharma ◽  
Theodore Kaypekian ◽  
Chahine Assi ◽  
Nadine Zeeni
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Diabetic Neuropathy ◽  
Vitamin D Deficiency ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Diabetic Patients ◽  
Random Effects Models

Abstract Several studies have been conducted to investigate the relation between 25-hydroxyvitamin D [25(OH)D] level and diabetic neuropathy (DN). However, there is still no clear conclusion due to differences in study design and cut-off values used in the published work, in addition to the absence of a comprehensive meta-analysis on the topic. The present systematic review and meta-analysis therefore aims at clarifying the association between vitamin D level and peripheral DN in patients with type 2 diabetes mellitus. Primary research studies that explored the association between 25(OH)D level and diabetic peripheral neuropathy in type 2 diabetes were located from Medline, EMBASE, Web of Science, Cochrane Library, CINHAL, and Google Scholar. Twenty-six studies met the inclusion criteria with 6277 participants where 2218 were diabetic with DN, 2959 were diabetic without DN and 406 were healthy. Diabetic patients with DN showed significantly lower serum 25(OH)D compared to patients without DN (standardized mean difference (SMD) of −0.92 (95% CI = −1.18 to −0.65, I2 = 93.3%, p < 0.0001). The pooled OR value of vitamin D deficiency was higher in patients with DN, 1.84 (95% CI = 1.46 to 2.33, p < 0.0001) and 2.87 (95% CI = 1.10 to 7.52, p = 0.03) when using fixed-effects and random-effects models, respectively. Vitamin D deficiency has been found to be highly prevalent among diabetic patients with neuropathy. Since 25(OH)D has been implicated in glucose hemostasis and showed benefit in reducing neuropathy symptoms, its supplementation is warranted for this population of patients.

Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial

2020 ◽  
pp. 1-10
Author(s):  
Giuseppe Derosa ◽  
Angela D’Angelo ◽  
Chiara Martinotti ◽  
Maria Chiara Valentino ◽  
Sergio Di Matteo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Metabolic Control ◽  
Vitamin D3 ◽  
Therapy Group ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Abstract. Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with Vitamin D deficiency. Methods: one hundred and seventeen patients were randomized to placebo and 122 patients to Vitamin D3. We evaluated anthropometric parameters, glyco-metabolic control, and parathormone (PTH) value at baseline, after 3, and 6 months. Results: a significant reduction of fasting, and post-prandial glucose was recorded in Vitamin D3 group after 6 months. A significant HbA1c decrease was observed in Vitamin D3 (from 7.6% or 60 mmol/mol to 7.1% or 54 mmol) at 6 months compared to baseline, and to placebo (p < 0.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p = 0.037, p = 0.048, and p = 0.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p = 0.031, p = 0.037, and p = 0.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.

scholarly journals Association of serum vitamin D and parathormone levels in patients of type 2 diabetes mellitus with diabetic retinopathy

2017 ◽  
Vol 10 (2) ◽  
pp. 61
Author(s):  
Mohammad Shiblee Zaman ◽  
Md. Matiur Rahman ◽  
Subrata Kumar Biswas ◽  
Md. Mozammel Hoque ◽  
Khondakar Alwan Nahid
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Vitamin D Deficiency ◽  
Diabetic Patients ◽  
Control Serum ◽  
25 Hydroxy Vitamin D

<p>The present study was aimed to evaluate the association of serum 25-hydroxy vitamin D and parathormone in 46 patients of type 2 diabetes mellitus with diabetic retinopathy [non-proliferative, (n=27); proliferative (n=19)]. Twenty one diabetic patients without retinopathy were taken as control. Serum 25-hydroxy vitamin D and intact parathyroid hormone were measured by chemiluminescence microparticle immunoassay. Concentration of 25-hydroxy vitamin D differed significantly among groups (p=0.018) and it was significantly lower in proliferative diabetic retinopathy than no diabetic retinopathy (p=0.003). Logistic regression analysis revealed that vitamin D deficiency [25-hydroxy vitamin D &lt;20 ng/mL] was indepen-dently associated with development of diabetic retinopathy (p=0.007, OR 20.90, 95%CI 2.33-187.23). In conclusion, vitamin D deficiency is associated with diabetic retinopathy complicating type 2 diabetes mellitus.</p>

Vitamin D Deficiency Is More Common in Type 2 Than in Type 1 Diabetes

Diabetes Care ◽  
2005 ◽  
Vol 29 (1) ◽  
pp. 174-174 ◽  
Author(s):  
D. J. Di Cesar ◽  
R. Ploutz-Snyder ◽  
R. S. Weinstock ◽  
A. M. Moses
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Deficiency

scholarly journals The effect of vitamin D deficiency state on oxidized low-density lipoprotein alteration in patients with type 2 diabetes

2021 ◽  
Vol 11 (8) ◽  
pp. 347
Author(s):  
Salome Sadat Salehi ◽  
Sahar Karimpour ◽  
Soghra Rabizadeh ◽  
Alireza Esteghamati ◽  
Armin Rajab ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Roc Curve Analysis ◽  
Type 2 Diabetic Patients ◽  
Severe Vitamin

Introduction: The aim of this study was to compare oxidized low-density lipoprotein (oxLDL) and blood glucose in very low and low levels of vitamin D.Methods: A total of 25 type-2 diabetic patients with very low serum levels of 25-hydroxy vitamin D (severe deficiency – <10 ng/ml); and 25 type-2 diabetic patients with low serum levels of 25-hydroxy vitamin D (deficient – 10 to 30 ng/ml) were recruited in this cross-sectional study. Fasting plasma glucose (FBS), postprandial glucose (PPG), HbA1C, oxLDL, and high-sensitivity C-reactive protein (hs-CRP) were measured. Diagnostic accuracies were determined by receiver-operating characteristic (ROC) curve analysis and measuring the area under the curve (AUC).Results: Patients with severe vitamin D deficiency had higher FBS, PPG, HbA1C, and oxLDL than the vitamin D deficient group (P<0.05). We showed that the AUC of FBS, PPG, HbA1C, and oxLDL were in the range of 0.7-0.9, which indicates moderate accuracies in differentiating severe vitamin D deficiency from deficiency condition.Conclusion: In conclusion, diabetic patients with severe vitamin D deficiency had higher FBS, PPG, and oxLDL levels compared with deficient ones. ROC curve analysis of FBS, PPG, HbA1C, and oxLDL showed these markers are independent predictors of severe vitamin D deficiency and significantly discriminate between very low and low levels of vitamin D deficiency in patients with diabetes. Keywords: Type 2 diabetes mellitus. Vitamin D deficiency. OxLDL. Fasting blood glucose. 

scholarly journals Effect of Vitamin D supplementation on vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency

2017 ◽  
Vol 21 (4) ◽  
pp. 555 ◽  
Author(s):  
Sandhiya Selvarajan ◽  
Nishanthi Anandabaskar ◽  
StevenAibor Dkhar ◽  
SadishKumar Kamalanathan ◽  
Kadhiravan Tamilarasu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
And Oxidative Stress ◽  
Type 2 Diabetic
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