scholarly journals Thigmotropism of Malignant Melanoma Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Pascale Quatresooz ◽  
Claudine Piérard-Franchimont ◽  
Fanchon Noël ◽  
Gérald E. Piérard
Keyword(s):  
Malignant Melanoma ◽  
Basement Membrane ◽  
Growth Model ◽  
Growth Phase ◽  
Sweat Gland ◽  
Cell Shape ◽  
Hair Follicles ◽  
Perivascular Space ◽  
Primary Neoplasm ◽  
Contact Sensing

During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape). These specifically located paucicellular aggregates of MM cells do not appear to be involved in the tumorigenic growth phase, but rather they participate in the so-called “accretive” growth model. These MM cell collections are often part of the primary neoplasm, but they may, however, correspond to MM micrometastases and predict further local overt metastasis spread.

scholarly journals The Sweat Glands and Hair Follicles of European Cattle

1972 ◽  
Vol 25 (3) ◽  
pp. 585 ◽  
Author(s):  
D Mcewan Jenkinson ◽  
T Nay
Keyword(s):  
Hair Follicle ◽  
Sweat Gland ◽  
Hair Follicles ◽  
Sweat Glands ◽  
Mean Values ◽  
The Mean ◽  
European Cattle

Measurements were made on the skins of 1363 cattle from different European breeds. The mean values of these measurements have been tabulated for each breed and the skin types present in each breed or group of breeds have been determined using sweat gland shape (LID) and hair follicle depth (FrY) as the principal bases of comparison.

scholarly journals 3D Tissue elongation via ECM stiffness-cued junctional remodeling

2018 ◽  
Author(s):  
Dong-Yuan Chen ◽  
Justin Crest ◽  
Sebastian J. Streichan ◽  
David Bilder
Keyword(s):  
Basement Membrane ◽  
Cell Shape ◽  
Cell Dynamics ◽  
Src Tyrosine Kinase ◽  
Average Cell ◽  
Cellular Behavior ◽  
Cell Behaviors ◽  
Oriented Cell Division ◽  
Morphometric Analyses ◽  
Membrane Stiffness

ABSTRACTOrgans are sculpted by extracellular as well as cell-intrinsic forces, but how collective cell dynamics are orchestrated in response to microenvironmental cues is poorly understood. Here we apply advanced image analysis to reveal ECM-responsive cell behaviors that drive elongation of the Drosophila follicle, a model 3D system in which basement membrane stiffness instructs tissue morphogenesis. Through in toto morphometric analyses of WT and ‘round egg’ mutants, we find that neither changes in average cell shape nor oriented cell division are required for appropriate organ shape. Instead, a major element is a reorientation of elongated cells at the follicle anterior. Polarized reorientation is regulated by mechanical cues from the basement membrane, which are transduced by the Src tyrosine kinase to alter junctional E-cadherin trafficking. This mechanosensitive cellular behavior represents a conserved mechanism that can elongate ‘edgeless’ tubular epithelia in a process distinct from those that elongate bounded, planar epithelia.

Histochemical Differentiation of the Basement Membrane of the Mouse Seminiferous Tubule

1962 ◽  
Vol s3-103 (63) ◽  
pp. 385-391
Author(s):  
A. H. BAILLIE
Keyword(s):  
Basement Membrane ◽  
Protein Metabolism ◽  
Seminiferous Tubule ◽  
Glucuronic Acid ◽  
Chondroitin Sulphate ◽  
Hair Follicles ◽  
Ground Substance ◽  
Seminiferous Tubules ◽  
Active Protein ◽  
Pas Reaction

The ground substance of the testis of the albino mouse is PAS-positive but not metachromatic, and probably highly aggregated. The basement of the seminiferous tubules is intensely PAS-positive, metachromatic, and possibly not so highly aggregated. The reactivity of the ground substance to the PAS reaction and toluidine blue is tentatively ascribed to the presence of chondroitin sulphate C: this compound, previously known to contain N acetyl-galactosamine, glucuronic acid, tyrosine and tryptophane, is associated with arginine. The genesis of the basement membrane of the seminiferous tubule is shown to include the formation of a sheath of atypical elongated fibroblasts, the secretion of a PAS positive, metachromatic substance associated with arginine between this sheath and the seminiferous tubule, the appearance of mitochondria in the cells of the sheath, and lastly, the acquisition of alkaline phosphatase by these fibroblasts and its spread to the intervening ground substance. These changes are thought to be related to the structural and nutritional requirements of the seminiferous tubules. In its intense positive reaction to PAS and in its metachromasy, the basement membrane of the seminiferous tubule agrees with the ground substance adjacent to sites of active protein metabolism, such as growing tumours, embryonic organs, hair follicles, and skin.

Histological and Ultrastructural Study of the «Cortico-medullary Perivenular Lymphoid Sheaths» of the Mouse Thymus

1967 ◽  
Vol 53 (3) ◽  
pp. 245-267 ◽  
Author(s):  
Luigi Mazzarella ◽  
Luciano Fiore-donati
Keyword(s):  
Basement Membrane ◽  
Light And Electron Microscopy ◽  
Blood Stream ◽  
Perivascular Space ◽  
Lymphoid Cells ◽  
Morphological Data ◽  
Mouse Thymus ◽  
Cortical Capillaries ◽  
Vascular Structures ◽  
Reticular Cells

The present study is concerned with morphological investigations on some special vascular structures of the mouse thymus pertinent to the problem of «cellular traffic» in this organ. Thymuses from 20 normal mice of C3Hf/Gs and C57BL strains, ranging in age from 30 to 50 days, were examined by both light and electron microscopy. At the cortico-medullary junction wide post-capillary venules are present, running parallel to the border between cortex and medulla. They receive at right angles narrow capillaries coming especially from the cortex. The wall of these venules is formed of flattened endothelium, its basement membrane and epithelial reticular cells arranged as adventitial cells. The basement membrane of the endothelium is more or less regularly split in two layers (the inner «vascular» layer and the outer «parenchymal» layer) thus delineating a perivascular space containing one or more rows of lymphoid cells. This space, which has on the whole the character of a cylindrical perivascular channel, accompanies the cortico-medullary venules, although not necessarily along their entire course, and it is recognizable even around the cortical capillaries draining into them. The two layers of the basement membrane are lined on the inner side by the laminar cytoplasm of epithelial reticular cells, often interconnected by desmosomes. The ultrastructural characteristics of the perivascular space do not support the hypothesis of its lymphatic nature, as maintained by other authors. Lymphocytes were found in the process of migrating through either the «parenchymal» or «vascular» layer of the basement membrane. Although the direction of migration cannot be determined by static pictures, some morphological data seem to suggest that lymphocytes, at the level of the cortico-medullary venules, move from the thymic parenchyma towards the perivascular space and from there into the circulating blood stream. It is suggested that the perivascular apparatus be termed «cortico-medullary perivenular lymphoid sheath».

scholarly journals Plants as potential active components in treatment of androgenetic alopecia

2014 ◽  
Vol 60 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Renata Dawid-Pać ◽  
Maria Urbańska ◽  
Ilona Dębosz ◽  
Gerard Nowak
Keyword(s):  
Sex Hormones ◽  
Growth Phase ◽  
Hair Growth ◽  
Raw Materials ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Active Components ◽  
Plant Raw Materials ◽  
Reductase Inhibitors ◽  
Hereditary Factors

Summary Androgenetic alopecia is caused by the influence of sex hormones on hair follicles and by hereditary factors. Characteristic for that type of alopecia is shortening of the hair growth phase and elongation of the rest phase caused by disturbance of the process of transformation of testosterone into dihydrotestosterone. Treatment of that type of alopecia involves 5α-reductase inhibitors, antagonists of the androgenic receptor or stimulating proliferation of cells to induce the hair growth. A number of plant raw materials work that way, thus they can be used in treatment of this type of alopecia.

scholarly journals Melanocyte Colonization and Pigmentation of Breast Carcinoma: Pathological and Clinical Aspects

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Marco Mele ◽  
Tinne Laurberg ◽  
Tine Engberg Damsgaard ◽  
Jonas Funder ◽  
Vibeke Jensen
Keyword(s):  
Breast Cancer ◽  
Malignant Melanoma ◽  
Breast Carcinoma ◽  
Basement Membrane ◽  
Histological Examination ◽  
Clinical Aspects ◽  
Pathological Features ◽  
Clinical And Pathological Features

Introduction. Melanocyte colonization of breast carcinoma by nonneoplastic melanocytes of epidermal origin is a rare and serious condition first described in 1977. We report on the exceptional clinical and pathological features of this migration phenomenon in a 74-year-old patient.Discussion. The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential.Conclusion. Histological examination and additional staining of skin are essential to differentiate breast cancer melanosis from malignant melanoma.

scholarly journals Malignant Melanoma Cells and Hair Follicles

2019 ◽  
Vol 152 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Emi Dika ◽  
Giulia Veronesi ◽  
Cosimo Misciali ◽  
Barbara Corti ◽  
Ines Dika ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Melanoma Cells ◽  
Hair Follicles

Promoting effect of acylated homoserine lactone on the healing of tissue damage in model rats with incontinence-associated dermatitis

2021 ◽  
Vol 30 (Sup9a) ◽  
pp. XIi-XIxi
Author(s):  
Yuko Mugita ◽  
Takeo Minematsu ◽  
Gojiro Nakagami ◽  
Hiromi Sanada
Keyword(s):  
Basement Membrane ◽  
Therapeutic Approach ◽  
Healing Process ◽  
Healthcare Setting ◽  
Homoserine Lactone ◽  
Hair Follicles ◽  
Promoting Effect ◽  
Keratinocyte Migration ◽  
Vehicle Treatment

Objective: One of the most common complications in patients with incontinence is incontinence-associated dermatitis (IAD). This study was conducted to determine the pathophysiology of the healing process of IAD and to develop an effective therapeutic approach according to its pathophysiology. Method: IAD was reproduced on a dorsal rat skin by applying agarose gel containing water and enzymes, and inoculating it with bacteria. Examination of the IAD healing process suggested that the promotion of keratinocyte migration and improvement of basement membrane enhance keratinocyte layer elongations, which contribute to IAD healing. A therapeutic approach using N-(3-oxotetradecanoyl)-L-homoserine lactone, which is one of the acylated homoserine lactones (AHLs) and can promote keratinocyte migration in vitro, was applied on the IAD area in rats. Results: AHL treatment after IAD development resulted in an earlier tipping point for recovery than the vehicle treatment. Histological and immunohistological analyses revealed that the tissue surface was already covered by the epidermis, indicating the results of elongation of the keratinocyte layer from hair follicles. The characteristics of the alignment of basal keratinocytes, the existence of stratum corneum, and the membrane-like distribution of the components of basement membrane were similar to those of a normal epidermis. Conclusion: These results suggested that AHL application possibly contributed to earlier IAD healing before progressing to a severe state. Although elongation of the keratinocyte layer was observed in both the AHL and vehicle groups, the possibility that AHL application promotes IAD healing was suggested. The new concept of the enhancement of keratinocyte migration as a therapeutic approach for IAD would change the skin care strategy for IAD in the healthcare setting.

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