scholarly journals Management of a Dog with Poorly Regulated Diabetes Mellitus, Chronic Pancreatitis, and Suspected Atopy with Cyclosporine

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Jörg M. Steiner ◽  
Brian J. Huber
Keyword(s):  
Diabetes Mellitus ◽  
Weight Loss ◽  
Case Report ◽  
Chronic Pancreatitis ◽  
Insulin Therapy ◽  
Second Opinion ◽  
Controlled Study ◽  
Uncontrolled Diabetes ◽  
Control Of Diabetes ◽  
Work Up

A 3-year-and-9-months old male neutered Bichon Frise was presented for a second opinion for diabetes mellitus, weight loss, pruritus, and loss of hair. During further work-up, the dog was diagnosed with uncontrolled diabetes mellitus and concurrent diagnoses of pancreatitis and atopy were also suspected. Multiple adjustments of insulin therapy did not improve control of diabetes mellitus. Also, a variety of different treatments failed to improve pruritus. The dog was seen by a veterinary dermatologist who further suspected atopy and started treatment with cyclosporine. Pruritus improved and coincidentally serum Spec cPL and fructosamine concentrations normalized after therapy, suggesting the possibility that cyclosporine may have controlled pancreatic inflammation and improved control of diabetes mellitus. This case report would suggest that further research into autoimmunity in dogs with chronic pancreatitis is warranted. Also, a controlled study is needed and in progress before the use of cyclosporine in dogs with chronic pancreatitis or a subgroup thereof can be advocated.

Pancreatic Abscess in a Cat with Diabetes Mellitus

2015 ◽  
Vol 51 (3) ◽  
pp. 180-184 ◽  
Author(s):  
Minji Lee ◽  
Ji-Houn Kang ◽  
Dongwoo Chang ◽  
Ki-Jeong Na ◽  
Mhan-Pyo Yang
Keyword(s):  
Diabetes Mellitus ◽  
Weight Loss ◽  
Case Report ◽  
Clinical Signs ◽  
Abdominal Ultrasound ◽  
Pancreatic Abscess ◽  
Cytological Analysis ◽  
Glargine Insulin ◽  
Uncontrolled Diabetes ◽  
History Of

An 11 yr old spayed female Maine coon cat was referred with uncontrolled diabetes mellitus. The cat had a 2 mo history of weight loss and intermittent vomiting. An abdominal ultrasound identified the presence of a large cavity measuring a maximum of 4.6 cm in the pancreas that was filled with a homogeneous echogenic fluid. Cytological analysis and culture of the fluid obtained from the pancreatic mass indicated the presence of a bacterial abscess. The application of nonsurgical drainage and the administration of glargine insulin and antibiotics resolved the clinical signs. The size of the pancreatic abscess was reduced after 5 mo, and the cat achieved diabetic remission and remained healthy at the time this report was prepared. This case report describes the successful treatment of a pancreatic bacterial abscess concurrent with diabetes mellitus in a Maine coon cat.

scholarly journals Rhino-orbital COVID-19 associated mucormycosis- A case report

2021 ◽  
Vol 7 (4) ◽  
pp. 304-307
Author(s):  
Shanmuga Vadivoo Natarajan ◽  
B Usha
Keyword(s):  
Diabetes Mellitus ◽  
Infectious Disease ◽  
Case Report ◽  
Tertiary Care ◽  
Notifiable Disease ◽  
Health Ministry ◽  
First Case ◽  
Uncontrolled Diabetes ◽  
History Of ◽  
Second Wave

COVID-19 Associated Mucormycosis (CAM) is an emerging infectious disease that has caused increased mortality & morbidity in India during this second wave of the pandemic. The country has reported more than 30,000 cases and over 2,000 deaths by Mucormycosis so far, according to sources from Union Health Ministry. CAM is now a notifiable disease. At our Tertiary care teaching hospital, which caters for COVID 19 management, we are reporting the first case of Rhino orbital CAM, which was caused by Rhizopus spp. Our patient had a history of contact with a suspected COVID 19 patient and was recently diagnosed with uncontrolled diabetes mellitus. A direct KOH microscopic examination of purulent material aspirated from the sinonasal polyp of the patient revealed fungal elements, and Rhizopus spp was isolated. Due to a shortage of Amphotericin B, the patient was referred to a government higher speciality centre for further management. The patient was followed up & was noted that he was treated with antifungal and discharged following recovery.

scholarly journals Bilateral Nodules on the Thighs: A Case Report on Insulin Therapy-Induced Palisaded Granulomas

2021 ◽  
Vol 5 (5) ◽  
pp. 563-565
Author(s):  
Tara Snow ◽  
Chelsea D. Harper ◽  
Jonathan Crane ◽  
Muammar Arida
Keyword(s):  
Diabetes Mellitus ◽  
Case Report ◽  
Blood Glucose ◽  
Insulin Therapy ◽  
Unusual Case ◽  
Blood Glucose Control ◽  
Accurate Diagnosis ◽  
Subcutaneous Insulin ◽  
Injection Site Reactions ◽  
Prevalence Of Diabetes Mellitus

As the incidence and prevalence of Diabetes Mellitus is increasing, more cases of dermatologic complications attributed to therapy are being reported. Injection site reactions, most commonly erythema, edema and induration, lipohypertrophy, and lipoatrophy have been associated with subcutaneous insulin therapy. Accurate diagnosis is important to guide clinical management and to ensure appropriate blood glucose control. Herein, we present an unusual case of bilateral nodules on the thighs secondary to insulin injections.

scholarly journals THE IMPACT OF GLP-1 RECEPTOR AGONISTS ON PATIENTS WITH DIABETES ON INSULIN THERAPY

2019 ◽  
Vol 25 (9) ◽  
pp. 935-942 ◽  
Author(s):  
Janelle B. Gyorffy ◽  
Andrea N. Keithler ◽  
Jana L. Wardian ◽  
Lee A. Zarzabal ◽  
Alexander Rittel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Weight Loss ◽  
Insulin Therapy ◽  
Receptor Agonist ◽  
Hemoglobin A1c ◽  
High Dose ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Basal Bolus ◽  
The Impact

Objective: The clinical benefit of adding a glucagon-like peptide-1 receptor agonist (GLP-1RA) to basal-bolus or very high dose insulin regimens is unclear. This study investigated the impact of adding a GLP-1RA to a spectrum of insulin regimens (basal, basal-bolus, and U-500) to determine the impact on hemoglobin A1c (HbA1c), weight loss, and total daily insulin dose (TDD) over the course of 12 months. Methods: A retrospective chart review was conducted on 113 participants with type 2 diabetes mellitus using insulin therapy. Each participant's HbA1c, body weight, and TDD were recorded prior to initiation of GLP-1RA therapy and at the 3, 6, and 12-month time points while on combination therapy. Results: Across all participants, the HbA1c values decreased significantly from a baseline of 8.9 (74 mmol/mol) ± 0.14% to 8.2 (66 mmol/mol) ± 0.14% ( P<.01) in the first 3 months, 8.0 (64 mmol/mol) ± 0.12% ( P<.01) at 6 months, to 8.3 (67 mmol/mol) ± 0.14% ( P<.01) at 12 months. There was no significant decrease in weight or TDD with the addition of a GLP-1RA overall or in different insulin groups. However, there was a clinically significant decrease in weight over the study duration. Conclusion: The results of this study suggest that adding a GLP-1RA to various insulin regimens may help to achieve glycemic goals while avoiding the less desirable side effects of weight gain and increasing insulin regimens. However, the expected weight loss and decrease in TDD may not be as sizable in the clinical setting. Abbreviations: DCOE = Diabetes Center of Excellence; DM = diabetes mellitus; GLP-1RA = glucagon-like peptide-1 receptor agonist; HbA1c = hemoglobin A1c; RCT = randomized controlled trial; TDD = total daily dose

ISOLATION OF RHIZOPUS HOMOTHALLICUS FROM A PATIENT OF RHINO-ORBITAL CEREBRAL MUCORMYCOSIS : A RARE CASE REPORT.

2021 ◽  
pp. 17-18
Author(s):  
Kanwar Bhanu ◽  
Sood Anuradha ◽  
Gupta Veetheeanveshna ◽  
Rana Aditya ◽  
Thakur Daaman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Case Report ◽  
Rare Case ◽  
Fungal Culture ◽  
Uncontrolled Diabetes ◽  
Rare Case Report ◽  
Rhizopus Homothallicus

We report a rare case of Rhino-orbital cerebral mucormycosis ( invasive mucormycosis) caused by Rhizopus homothallicus in patient of uncontrolled diabetes mellitus. The organism was isolated from nasal scrapping and tissue obtained after surgery and was identied after fungal culture.

scholarly journals Reasons for discontinuing insulin and factors associated with insulin discontinuation in patients with type 2 diabetes mellitus: a real-world evidence study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jianmin Wu ◽  
Fritha Morrison ◽  
Zhenxiang Zhao ◽  
Ginger Haynes ◽  
Xuanyao He ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Therapy ◽  
Real World ◽  
Multivariable Analysis ◽  
Factors Associated ◽  
Real World Evidence

Abstract Background Evidence suggests that insulin therapy of patients with type 2 diabetes mellitus (T2DM) is frequently discontinued. However, the reasons for discontinuing insulin and factors associated with insulin discontinuation in this patient population are not well understood. Methods We conducted a retrospective cohort study of adults with T2DM prescribed insulin between 2010 and 2017 at Partners HealthCare. Reasons for discontinuing insulin and factors associated with insulin discontinuation were studied using electronic medical records (EMR) data. Natural language processing (NLP) was applied to identify reasons from unstructured clinical notes. Factors associated with insulin discontinuation were extracted from structured EMR data and evaluated using multivariable logistic regression. Results Among 7009 study patients, 2957 (42.2%) discontinued insulin within 12 months after study entry. Most patients who discontinued insulin (2121 / 71.7%) had reasons for discontinuation documented. The most common reasons were improving blood glucose control (33.2%), achieved weight loss (18.5%) and initiation of non-insulin diabetes medications (16.7%). In multivariable analysis adjusted for demographics and comorbidities, patients were more likely to discontinue either basal or bolus insulin if they were on a basal-bolus regimen (OR 1.6, 95% CI 1.3 to 1.8; p <  0.001) or were being seen by an endocrinologist (OR 2.6; 95% CI 2.2 to 3.0; p <  0.001). Conclusions In this large real-world evidence study conducted in an area with a high penetration of health insurance, insulin discontinuation countenanced by healthcare providers was common. In most cases it was linked to achievement of glycemic control, achieved weight loss and initiation of other diabetes medications. Factors associated with and stated reasons for insulin discontinuation were different from those previously described for non-adherence to insulin therapy, identifying it as a distinct clinical phenomenon.

scholarly journals Retrospective analysis of pregnancies resulted from assisted reproductive technology in women with type 2 diabetes mellitus

2019 ◽  
Vol 68 (3) ◽  
pp. 25-34
Author(s):  
Elena V. Misharina ◽  
Natalia V. Borovik
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Therapy ◽  
Diabetes Complications ◽  
Reproductive Technology ◽  
Prepregnancy Care ◽  
The Mean

Hypothesis/aims of study. Type 2 diabetes mellitus (T2D) is one of the most widespread diseases in the world. The etiology of this disease is associated with genetic, age and ethnic factors. It is generally accepted that a sedentary lifestyle and obesity can cause T2D. This illness has serious complications that affect the women’s health and quality of life. It is well known that obesity and T2D are a common cause of anovulatory infertility in women of reproductive age. The number of T2D patients who are planning pregnancy by assisted reproductive technology (ART) has increased over the past 10 years. This study was aimed at investigating the effect of carbohydrate metabolism compensation in the preconception period on the outcomes of pregnancies resulted from in vitro fertilization (IVF) in T2DM women. Study design, materials, and methods. 51 T2D pregnancies after ART and their outcomes were analyzed retrospectively. Results. The age of the patients who applied to ART departments ranged from 27 to 46 years. The mean body mass index was 33.9 ± 6.5 kg/m2. The duration of infertility varied from 3 to 18 years. Infertility was caused by tubal occlusion in 17 cases, by anovulation in 16 cases, by male factor in 9 cases, by genital endometriosis in 7 cases, and by hypergonadotropic hypogonadism in 2 cases. One of the patients underwent IVF procedure twice in 4 years. All T2D patients received prepregnancy care including weight loss, diabetes compensation, diabetes complications treatment, and, if necessary, a transfer to insulin therapy and insulin treatment education for 1–2 months before entering into the IVF protocol. Angiotensin-converting enzyme inhibitors and statins should be stopped if they were prescribed in case of hypertension or dyslipidemia and other medications allowed during pregnancy should be started. 26 women (51%) did not take periconceptional multivitamin supplementation before IVF procedure. The level of glycated hemoglobin (HbA1c) in this group was 6.4 ± 0.5%. 25 patients (49%) underwent incomplete preparation for pregnancy before entering into the IVF protocol but not in full. An important stage of prepregnancy care was weight loss in women with overweight and obesity. The duration of a prepregnancy care program varied from 2 to 6 months and on average was 3.8 ± 1.7 months. The mean HbA1c level in this group was 5.8 ± 0.4%. All cases of IVF pregnancies in women with T2D resulted with live birth. The incidence of preeclampsia, cesarean section delivery, and preterm labor was lower in the group of women who had been given prepregnancy care. Conclusion. Proper prepregnancy care including weight loss, diabetes compensation, early start of insulin therapy, and diabetes complications treatment before conception is an effective method of preventing perinatal complications in women with T2D.

scholarly journals Lower motor neuron facial palsy secondary to parotid abscess - first sign of uncontrolled diabetes mellitus: a case report

2020 ◽  
Vol 6 (6) ◽  
pp. 1206
Author(s):  
Lakshmi Menon Ravunniarth ◽  
Safina Kauser
Keyword(s):  
Diabetes Mellitus ◽  
Case Report ◽  
Parotid Gland ◽  
Facial Nerve ◽  
Facial Palsy ◽  
Nerve Palsy ◽  
Facial Nerve Palsy ◽  
Mouth Opening ◽  
Rare Condition ◽  
Uncontrolled Diabetes

<p class="abstract">Facial paralysis associated with parotid disease is usually caused by a malignant process. Facial nerve palsy due to parotid gland abscess is very rare with only about 10 previously reported cases. Parotid abscess with facial palsy may be the first presenting symptom of underlying diabetes mellitus. We report a case of a 35-year-old man, not a known case of diabetes or hypertension, who presented with a right sided parotid abscess and difficulty in mouth opening with grade 4 facial nerve palsy, who on investigation was found to have underlying uncontrolled diabetes mellitus. Parotid abscess is mainly seen in elderly, diabetic and immunocompromised. Facial nerve palsy secondary to parotid abscess is a rare condition but probably underreported. Facial nerve palsy associated with parotid abscess is rare and may be one of the first presenting feature of uncontrolled diabetes mellitus.</p>

Sign in / Sign up

Export Citation Format

Share Document