scholarly journals Simulation of Magnetophoretic Separation Processes in Dispersions of Superparamagnetic Nanoparticles in the Noncooperative Regime

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Jordi S. Andreu ◽  
Pablo Barbero ◽  
Juan Camacho ◽  
Jordi Faraudo
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Separation ◽  
Magnetic Particles ◽  
Colloidal Particles ◽  
Low Cost ◽  
Superparamagnetic Nanoparticles ◽  
Separation Processes ◽  
Magnetic Separator ◽  
Simulation Strategy ◽  
Magnetophoretic Separation

Magnetic separation has gained much attention due to its implications in different fields, becoming feasible as an alternative to existent technologies at the industrial and lab scale. Substantial efforts are focused to improve the magnetic particles used in these applications. Here we show how a relatively simple and low-cost simulation strategy (tracer simulations) can be employed to predict the effect of various key factors in magnetic separation processes, namely, particle properties and magnetic separator designs. For concreteness, we consider here specific problems in magnetic separation. The first one is the effect of different profiles of the magnetic field in the separation of magnetic nanoparticles, and the second one is the magnetophoresis of colloidal particles in a dispersion of magnetic nanoparticles.

scholarly journals Evaluation of Magnetic Separation Efficiency on a Cassiterite-Bearing Skarn Ore by Means of Integrative SEM-Based Image and XRF–XRD Data Analysis

Minerals ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 390 ◽  
Author(s):  
Markus Buchmann ◽  
Edgar Schach ◽  
Raimon Tolosana-Delgado ◽  
Thomas Leißner ◽  
Jennifer Astoveza ◽  
...  
Keyword(s):  
Magnetic Separation ◽  
Iron Oxides ◽  
Separation Efficiency ◽  
Analysis Data ◽  
Gangue Mineral ◽  
Data Partition ◽  
Local Regression ◽  
Separation Processes ◽  
Magnetic Separator

Image analysis data obtained from scanning electron microscopy provided data for a detailed evaluation of the separation efficiency for various processes involving the beneficiation of particulate materials. A dry magnetic separation by a drum type magnetic separator served as a case study to visualize effects of processing of a skarn ore with a high content of cassiterite as ore mineral (~4 wt%). For this material, iron oxides and silicates are the main gangue mineral groups. Based on the obtained data, partition curves were generated with the help of local regression. From the partition curves, the separation efficiency was evaluated and the relevant particle properties deduced. A detailed analysis of the bias of the quantitative mineralogical data is presented. This bias was monitored and further analyzed in detail. Thorough analysis of feed and products of magnetic separation enabled identification of the most important factors that control losses of cassiterite to the magnetic product, namely the association with iron oxides and particle sizes below ~40 µm. The introduced methodology is a general approach applicable for the optimization of different separation processes and is not limited to the presented case study.

scholarly journals Magnetic Particles for CTC Enrichment

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3525
Author(s):  
Peng Liu ◽  
Pascal Jonkheijm ◽  
Leon W. M. M. Terstappen ◽  
Michiel Stevens
Keyword(s):  
Magnetic Nanoparticles ◽  
Tumor Cells ◽  
Magnetic Separation ◽  
Circulating Tumor Cells ◽  
Magnetic Particles ◽  
Separation Techniques ◽  
Specific Antibodies ◽  
Immunomagnetic Enrichment ◽  
Different Characteristics

Here, we review the characteristics and synthesis of magnetic nanoparticles (MNPs) and place these in the context of their usage in the immunomagnetic enrichment of Circulating Tumor Cells (CTCs). The importance of the different characteristics is explained, the need for a very specific enrichment is emphasized and different (commercial) magnetic separation techniques are shown. As the specificity of an MNP is in a large part dependent on the antibody coated onto the particle, different strategies in the coupling of specific antibodies as well as an overview of the available antibodies is given.

scholarly journals Variables and Applications on Dry Magnetic Separator

2018 ◽  
Vol 53 ◽  
pp. 02019
Author(s):  
Qin Xing Zong ◽  
Luo Zhen Fu ◽  
Lv Bo
Keyword(s):  
Rare Earth ◽  
Magnetic Separation ◽  
Large Scale ◽  
Magnetic Particles ◽  
Water Shortage ◽  
Heavy Mineral ◽  
Magnetic Separator ◽  
New Ideas ◽  
Dry Magnetic Separation ◽  
Separation Equipment

Magnetic separation is an indispensable part of magnetic separation, and the dry magnetic separator can be selected under the condition of water shortage in China to ensure that our country can also be selected under the conditions of lack of some resources. The magnetic separator plays a role in improving the grade of ore, purifying solid and liquid materials, and recycling waste. With the application and development of magnetic separation technology, magnetic separation equipment is constantly updating and replacing, and dry magnetic separation has experienced remarkable technological progress over the past twenty years. There are many new ideas and techniques applied in magnetic separators. So far, dry magnetic separators have developed many different applications for mineral and coal processing, for induction roller magnetic separators for chromite. Cross-belt magnetic separator for removing harmful magnetic particles and paramagnetic particles. The lifting roller magnetic separator is used in the heavy mineral industry to separate garnet from monazite and rutile. Rare earth drum magnetic separator for fine feed dry magnetic separation sorting process and rare earth roller magnetic separator for zircon and rutile in heavy mineral sand industry. These magnetic separators have different applications, and the dry magnetic separator is also moving toward large-scale and easy-to-manufacture.

scholarly journals Multiphysics Modeling Simulation and Optimization of Aerodynamic Drum Magnetic Separator

Minerals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 680
Author(s):  
Jianjun Liu ◽  
Zixing Xue ◽  
Zhenhai Dong ◽  
Xiaofeng Yang ◽  
Yafeng Fu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Separation ◽  
Magnetic Particles ◽  
Magnetic Separator ◽  
Simulation And Optimization ◽  
Finite Element Software ◽  
Coupling Force ◽  
Magnetic Poles ◽  
Separation Behavior ◽  
The Magnetic Field

Aerodynamic Drum Magnetic Separator (ADMS) uses an adjustable air flow to enhance the separation of magnetic particles from gangue. In order to explore the matching relationship between the magnetic field, the flow field, and the gravity field, as well as the capture and separation behavior of particles under the action of multi-physics, a related simulation model is established using the finite element software COMSOL Multiphysics and the accuracy of the simulation results is verified by measurement, formula calculation, and magnetic separation experiment. The trajectories and capture probabilities of particles in different magnetic fields and flow fields are calculated, as well as the critical airflow velocity corresponding to a specific capture probability. In addition, the magnetic field characteristics and particle capture effect of N-S alternate arrangement and N-N homopolar arrangement are compared by optimizing the permutation of magnetic poles. This model may provide a reference for the accurate control of magnetic separation enhanced by a coupling force field.

scholarly journals Applications of Thermoresponsive Magnetic Nanoparticles

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Ibrahim Yildiz ◽  
Banu Sizirici Yildiz
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Separation ◽  
Magnetic Nanoparticle ◽  
Magnetic Particles ◽  
Polymeric Coatings ◽  
Biomedical Sciences ◽  
Comprehensive Review ◽  
Material Sciences ◽  
Number Of Publications

In recent years, magnetic nanoparticles carrying thermoresponsive polymeric coatings have gained increasing attention in material sciences due to the fact that resultant platforms offer controllable modalities such as imaging, drug delivery, and magnetic separation. As a result, novel materials including biosensors, therapeutic platforms, imaging agents, and magnetic separators have been realized. Since the number of publications reporting the applications of thermoresponsive magnetic nanoparticle has increased steadily over the years, a comprehensive review will be beneficial. In this paper, we aim to review publications studying applications of thermoresponsive nanoparticles in biomedical sciences as well as in environmental and chemical sciences. The paper also briefly discusses chemical formulations, characterizations, and properties of the thermoresponsive magnetic particles and then provides future outlooks.

scholarly journals Design, Optimization Process and Efficient Analysis for Preparation of Copolymer-Coated Superparamagnetic Nanoparticles

2017 ◽  
Vol 7 (3) ◽  
Author(s):  
Mahnaz Mahdavi Shahri
Keyword(s):  
Electron Microscopy ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Saturation Magnetization ◽  
Magnetic Particles ◽  
Superparamagnetic Nanoparticles ◽  
Effluent Treatment ◽  
Degree Of Saturation ◽  
Transmission Electron ◽  
Average Size

Magnetic nanoparticles (MNPs) are very important systems with potential use in drug delivery systems, ferrofluids, and effluent treatment. In many situations, such as in biomedical applications, it is necessary to cover inorganic magnetic particles with an organic material, such as polymers. A superparamagnetic nanocomposite Fe3O4/poly(maleic anhydride-co-acrylic acid) P(MAH-co-AA) with a core/shell structure was successfully synthesized by a dispersion polymerization route. Iron oxide nanoparticles were used as a core, and P(MAH-co-AA) as a shell was covered on the surface of the Fe3O4 magnetic nanoparticles. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed that the Fe3O4/P(MAH-co-AA) magnetic nanocomposite were highly uniform in size and cubic shape with the average size about 17.06 nm. X-ray diffraction confirmed magnetite cores and also indicated that the binding process did not change the phase of Fe3O4. Vibrational sample magnetometer (VSM) revealed the nanoparticles were superparamagnetic and the saturation magnetization was 83.6 and 46.6 emu g-1 for pure Fe3O4 and composite nanoparticles, respectively. Measurements by VSM also showed that the degree of saturation magnetization increased with increasing iron oxide concentration from 1% to 7 wt % of Fe3O4.

High-gradient magnetic separation for technical scale protein recovery using low cost magnetic nanoparticles

2015 ◽  
Vol 150 ◽  
pp. 29-36 ◽  
Author(s):  
P. Fraga García ◽  
M. Brammen ◽  
M. Wolf ◽  
S. Reinlein ◽  
M. Freiherr von Roman ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Separation ◽  
Low Cost ◽  
Protein Recovery ◽  
High Gradient Magnetic Separation ◽  
High Gradient

scholarly journals An extracellular polymer at the interface of magnetic bioseparations

2014 ◽  
Vol 11 (100) ◽  
pp. 20140743 ◽  
Author(s):  
Vijaykumar L. Dhadge ◽  
Patricia I. Morgado ◽  
Filomena Freitas ◽  
Maria A. Reis ◽  
Ana Azevedo ◽  
...  
Keyword(s):  
Magnetic Separation ◽  
Magnetic Particles ◽  
Hydrophobic Interactions ◽  
Extracellular Polysaccharide ◽  
Affinity Constant ◽  
Protein Solutions ◽  
Phase System ◽  
Two Phase ◽  
Magnetic Separator ◽  
Extracellular Polymer

FucoPol, a fucose-containing extracellular polysaccharide (EPS) produced by bacterium Enterobacter A47 using glycerol as the carbon source, was employed as a coating material for magnetic particles (MPs), which were subsequently functionalized with an artificial ligand for the capture of antibodies. The performance of the modified MPs (MP–EPS-22/8) for antibody purification was investigated using direct magnetic separation alone or combined with an aqueous two-phase system (ATPS) composed of polyethylene glycol (PEG) and dextran. In direct magnetic capturing, and using pure protein solutions of human immunoglobulin G (hIgG) and bovine serum albumin (BSA), MP–EPS-22/8 bound 120 mg hIgG g −1 MPs, whereas with BSA only 10 ± 2 mg BSA g −1 MPs was achieved. The hybrid process combining both the ATPS and magnetic capturing leads to a good performance for partitioning of hIgG in the desired phase as well as recovery by the magnetic separator. The MPs were able to bind 145 mg of hIgG g −1 of particles which is quite high when compared with direct magnetic separation. The theoretical maximum capacity was calculated to be 410 ± 15 mg hIgG adsorbed g −1 MPs with a binding affinity constant of 4.3 × 10 4 M −1 . In multiple extraction steps, the MPs bound 92% of loaded hIgG with a final purity level of 98.5%. The MPs could easily be regenerated, recycled and re-used for five cycles with only minor loss of capacity. FucoPol coating allowed both electrostatic and hydrophobic interactions with the antibody contributing to enhance the specificity for the targeted products.

Immunofluorescence Assay Using Monoclonal and Polyclonal Antibodies for Detection of Staphylococcal Enterotoxins A in Milk

2019 ◽  
Vol 13 (1) ◽  
pp. 137-145 ◽  
Author(s):  
Tzonka Godjevargova ◽  
Zlatina Becheva ◽  
Yavor Ivanov ◽  
Andrey Tchorbanov
Keyword(s):  
Monoclonal Antibody ◽  
Magnetic Nanoparticles ◽  
Polyclonal Antibody ◽  
Polyclonal Antibodies ◽  
Food Poisoning ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin A ◽  
Fluorescence Immunoassay ◽  
Magnetic Separator ◽  
Milk Samples

Objectives: Staphylococcus aureus is a Gram-positive microorganism. S. aureus can grow in various foods and cause food poisoning by secreting enterotoxins. The most common enterotoxins involved in food poisoning are staphylococcal enterotoxin A and staphylococcal enterotoxin B, but Staphylococcal Enterotoxin A (SEA) is predominant. The main types of food contaminated with SEs are meat and meat products, poultry and eggs, milk and dairy products. The aim of this study was to develop a rapid and sensitive fluorescence immunoassay for detection of staphylococcal enterotoxin A in milk. Methods: Monoclonal and polyclonal antibodies for SEA were produced and characterized. Competitive fluorescence immunoassay based on Magnetic Nanoparticles (MNPs) was performed and optimized. MNPs were used as a solid carrier of the antibodies. The first step of the assay was immunoreaction between the immobilized antibody onto MNPs and SEA in milk sample. Then the fluorescein-SEA conjugate was added to the sample. Thus, competitive immunoreaction between MNP-mAb/MNP-pAb with SEA and SEA-FITC was performed. These immuno-complexes were separated by a magnetic separator and the obtained supernatants were analyzed. The fluorescent signal from the excess of conjugated SEA was proportional to the SEA contained in the milk. The assay duration was only 30 min. Results: The fluorescence immunoassays performed with polyclonal antibody had linear ranges from 5 pg/mL to 100 ng/mL SEA in a buffer, and from 50 pg/mL to 50 ng/mL SEA in spiked milk samples. While the same assays performed with monoclonal antibody had linear ranges from 1 pg/mL to 20 ng/mL SEA in buffer, and from 10 pg/mL to 10 ng/mL SEA in spiked milk samples. The detection limits of the developed immunoassays performed in milk were: 48 pg/mL with polyclonal antibody and 9 pg/mL with monoclonal antibody. Conclusion: A rapid and sensitive fluorescence immunoassay based on magnetic nanoparticles with a polyclonal and monoclonal antibody for determination of staphylococcal enterotoxin A in milk was developed.

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