scholarly journals Solvent-Free Synthesis of Flavour Esters through Immobilized Lipase Mediated Transesterification

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Vijay Kumar Garlapati ◽  
Rintu Banerjee
Keyword(s):  
Reaction Time ◽  
Rhizopus Oryzae ◽  
Immobilized Lipase ◽  
Relative Activity ◽  
Solvent Free ◽  
Water Addition ◽  
Octyl Acetate ◽  
Solvent Free Conditions ◽  
Methyl Butyrate ◽  
Molar Conversion

The synthesis of methyl butyrate and octyl acetate through immobilized Rhizopus oryzae NRRL 3562 lipase mediated transesterification was studied under solvent-free conditions. The effect of different transesterification variables, namely, molarity of alcohol, reaction time, temperature, agitation, addition of water, and enzyme amount on molar conversion (%) was investigated. A maximum molar conversion of 70.42% and 92.35% was obtained in a reaction time of 14 and 12 h with the transesterification variables of 0.6 M methanol in vinyl butyrate and 2 M octanol in vinyl acetate using 80 U and 60 U immobilized lipase with the agitation speed of 200 rpm and 0.2% water addition at 32°C and 36°C for methyl butyrate and octyl acetate, respectively. The immobilized enzyme has retained good relative activity (more than 95%) up to five and six recycles for methyl butyrate and octyl acetate, respectively. Hence, the present investigation makes a great impingement in natural flavour industry by introducing products synthesized under solvent-free conditions to the flavour market.

scholarly journals Modeling, Simulation, and Kinetic Studies of Solvent-Free Biosynthesis of Benzyl Acetate

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Vijay Kumar Garlapati ◽  
Annapurna Kumari ◽  
Paramita Mahapatra ◽  
Rintu Banerjee
Keyword(s):  
Reaction Time ◽  
Immobilized Lipase ◽  
Kinetic Studies ◽  
Relative Activity ◽  
Solvent Free ◽  
Surface Model ◽  
Optimization Approach ◽  
Benzyl Acetate ◽  
Algorithm Optimization ◽  
Molar Conversion

Solvent-free biosynthesis of benzyl acetate through immobilized lipase-mediated transesterification has been modeled and optimized through statistical integrated artificial intelligence approach. A nonlinear response surface model has been successfully developed based on central composite design with transesterification variables, namely, molarity of alcohol, reaction time, temperature, and immobilized lipase amount as input variables and molar conversion (%) as an output variable. Statistical integrated genetic algorithm optimization approach results in an optimized molar conversion of 96.32% with the predicted transesterification variables of 0.47 M alcohol molarity in a reaction time of 13.1 h, at 37.5°C using 13.31 U of immobilized lipase. Immobilized lipase withstands more than 98% relative activity up to 6 recycles and maintains 50% relative activity until 12 recycles. The kinetic constants of benzyl acetate, namely,KmandVmaxwere found to be 310 mM and 0.10 mmol h−1 g−1, respectively.

One-Pot, Regioselective Synthesis of Homopropargyl Alcohols using Propargyl Bromide and Carbonyl Compound by the Mg-mediated Reaction under Solvent-free Conditions

2020 ◽  
Vol 17 (6) ◽  
pp. 438-442
Author(s):  
Xiaofang Ma ◽  
Shunxi Li ◽  
Samrat Devaramani ◽  
Guohu Zhao ◽  
Daqian Xu
Keyword(s):  
Reaction Time ◽  
Organic Synthesis ◽  
Carbonyl Compounds ◽  
Solvent Free ◽  
Propargyl Bromide ◽  
Important Goal ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Volatile Organic

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.

Rapid synthesis of homoallylic alcohol from aldehyde with allyltributylstannane under solvent-free conditions

2012 ◽  
Vol 90 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Pranjal P. Bora ◽  
H. Atoholi Sema ◽  
Barisha Wahlang ◽  
Ghanashyam Bez
Keyword(s):  
Reaction Time ◽  
Phosphotungstic Acid ◽  
Catalytic Amount ◽  
Solvent Free ◽  
Reaction Conditions ◽  
Rapid Synthesis ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Solvent Free Reaction

A catalytic amount (2 mol %) of phosphotungstic acid (PTA) is sufficient to synthesize homoallylic alcohol in excellent yields from aldehyde with allyltributylstannane upon grinding under solvent-free reaction conditions. Easy handling, very short reaction time, solvent-free reaction conditions, and aqueous workup free isolation protocol may make our method very useful for synthetic chemists.

scholarly journals Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones

Catalysts ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 301 ◽  
Author(s):  
Sonia Bonacci ◽  
Monica Nardi ◽  
Paola Costanzo ◽  
Antonio De Nino ◽  
Maria Di Gioia ◽  
...  
Keyword(s):  
Reaction Time ◽  
Heterogeneous Catalysis ◽  
Heterogeneous Catalyst ◽  
Environmentally Friendly ◽  
Solvent Free ◽  
Short Reaction Time ◽  
Montmorillonite K10 ◽  
Solvent Free Conditions

A simple and eco-friendly montmorillonite K10 (MK10)-catalyzed method for the synthesis of cyclopentenone derivatives from biomass-produced furfural has been developed. The versatility of this protocol is that the reactions were performed under solvent-free conditions and in a short reaction time under heterogeneous catalysis. Montmorillonite K10 is mostly explored as a heterogeneous catalyst since it is inexpensive and environmentally friendly.

Efficient Synthesis of Novel Quinolinone Derivatives via Catalyst-free Multicomponent Reaction

2020 ◽  
Vol 17 (5) ◽  
pp. 403-407
Author(s):  
Rui Du ◽  
Liangliang Han ◽  
Zhongqiang Zhou ◽  
Victor Borovkov
Keyword(s):  
Reaction Time ◽  
Multicomponent Reaction ◽  
Room Temperature ◽  
Reaction Rates ◽  
Solvent Free ◽  
Hydroxyl Group ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions ◽  
Substituted Benzaldehydes

The synthesis of 3-(aryl(piperidin-1-yl)methyl)-4-hydroxyquinolin-2(1H)-one derivatives via catalyst-free multicomponent reaction is described. The reaction of 4-hydroxyquinolin-2(1H)-one, piperidine, and 4-chlorobenzaldehyde was carried out in different solvents and under solvent-free conditions at room temperature. The best solvent in terms of the yield and reaction time was found to be dichloromethane. Most substituted benzaldehydes reacted with 4-hydroxyquinolin-2(1H)-one and piperidine to afford corresponding products in good-to-excellent yields. Aldehydes with electronwithdrawing groups were more reactive to exhibit higher reaction rates. However, 2-substituted benzaldehydes did not react with 4-hydroxyquinolin-2(1H)-one and piperidine under the reaction condition. Aldehydes bearing a hydroxyl group failed to produce the corresponding products.

Multi-component synthesis of highly substituted imidazoles catalyzed by nanorod vanadatesulfuric acid

2015 ◽  
Vol 69 (11) ◽  
Author(s):  
Masoud Nasr-Esfahani ◽  
Morteza Montazerozohori ◽  
Tooba Abdizadeh
Keyword(s):  
Reaction Time ◽  
High Purity ◽  
Ammonium Acetate ◽  
Chlorosulfonic Acid ◽  
Solvent Free ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
High Yields ◽  
Tetrasubstituted Imidazoles

AbstractNanorod vanadatesulfuric acid (VSA NRs), as a recyclable and eco-benign catalyst, was used for one-pot synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles using aldehydes, benzil, benzoin or 9,10-phenanthrenequinone and ammonium acetate or aniline under solvent-free conditions providing high to excellent yields. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate in high purity. As compared with the conventional procedures, the present protocol offers several advantages such as simplicity of procedure, short reaction time, high yields, easy workup, recoverability and reusability of the catalyst and simple purification of the products.

Zinc Mediated Selective Acylation of Ferrocene under Solvent-Free Conditions

2007 ◽  
Vol 2007 (7) ◽  
pp. 426-428 ◽  
Author(s):  
Vishal H. Purecha ◽  
Nitin S. Nandurkar ◽  
Bhalchandra M. Bhanage ◽  
Jayashree M. Nagarkar
Keyword(s):  
Reaction Time ◽  
Carboxylic Acid ◽  
Environmentally Friendly ◽  
Operating Conditions ◽  
Solvent Free ◽  
Acyl Chloride ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Selective Acylation ◽  
Environmentally Friendly Method

A simple, convenient and environmentally-friendly method for selective acylation of ferrocene to monoacylferrocene in the presence of Zn metal under solvent-free conditions is described. The protocol requires mild operating conditions, affording higher yields of desired products both with acyl chloride/carboxylic acid within a short reaction time (15–30 min).

Facile Synthesis of 1,8-dioxooctahydro Xanthenes by Reusable Zinc Sulfide based Ternary Nanocomposite via Hydrothermal Route

2020 ◽  
Vol 9 (1) ◽  
pp. 72-79
Author(s):  
Jhansi R. Sunkara ◽  
Sathish M. Botsa
Keyword(s):  
Catalytic Activity ◽  
Reaction Time ◽  
Metal Oxide ◽  
Solvent Free ◽  
Hydrothermal Route ◽  
One Pot ◽  
Co Catalyst ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Xanthene Derivatives

Background: Metal oxide or metal oxide composite nanoparticles are attaining tremendous importance due to their catalytic activities for various organic transformations. Objective: To report the one-pot synthesis of xanthene derivatives prepared by ZnS-Fe2O3-Ag composite under solvent-free conditions. Method: To prepare nanocomposite by a facile and simple hydrothermal approach. Results: The prepared composite is smaller (17.56 nm) in size and can be easily separable, recycled and reused six times without any significant loss of catalytic activity with excellent yields. In short reaction time, great catalytic activity was perceived with no co-catalyst and any other activator. Conclusion: In conclusion, ZnS-Fe2O3-Ag composite provides a simple, economical, efficient and greener method for the synthesis of one-pot multicomponent reaction of aldehyde with 1,3-diketones under solvent free conditions for the synthesis of 1,8-dioxooctahydro xanthenes. In short reaction time, great catalytic activity was perceived with no co-catalyst and any other activator.

Cyanuric Chloride: an Efficient Catalyst for Ring Opening of Epoxides with Thiols Under Solvent-Free Conditions

2008 ◽  
Vol 61 (3) ◽  
pp. 231 ◽  
Author(s):  
Babasaheb P. Bandgar ◽  
Neeta S. Joshi ◽  
Vinod T. Kamble ◽  
Sanjay S. Sawant
Keyword(s):  
Reaction Time ◽  
Ring Opening ◽  
Solvent Free ◽  
Cyanuric Chloride ◽  
Reaction Conditions ◽  
Efficient Catalyst ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Ring Opening Of Epoxides

2,4,6-Trichloro-1,3,5-triazine-catalyzed convenient and efficient ring opening of epoxides with thiols under solvent-free conditions is described. Short reaction time, mild reaction conditions, inexpensive and readily available catalyst, and excellent yields of products are attractive features of this methodology.

scholarly journals An Efficient One-Pot Synthesis of 1, 5-Benzodiazepine Derivatives Catalyzed by TBAB under Mild Conditions

2012 ◽  
Vol 9 (1) ◽  
pp. 407-414 ◽  
Author(s):  
Mohammad A. Baseer ◽  
Asgar Jafar Khan
Keyword(s):  
Reaction Time ◽  
Solvent Free ◽  
Ammonium Bromide ◽  
One Pot ◽  
Short Reaction Time ◽  
Mild Conditions ◽  
Excellent Yield ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Benzodiazepine Derivatives

2,3-Dihydro-1H-1,5-benzodiazepines were synthesized by reaction ofo-phenylenediamine with ketones (acyclic / cyclic) under solvent free conditions in the presence of tetra butyl ammonium bromide (TBAB) in short reaction time with excellent yield.

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